Taking Advantage of MaxPeak High Performance Surfaces Technology (HPS) in Multi-Dimensional Liquid Chromatography for Enhanced Recovery of a Phosphorothioated Oligonucleotide

Application Note Improving Recovery and Quantitation of Oligonucleotide Impurities Using ACQUITY PREMIER with MaxPeak HPS Technology Brooke M. Koshel, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Ion-pair reversed-phase chromatography is a commonly used technique for the separation of…

Application Note Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides Suma Veeramachineni, Mark D. Wrona Waters Corporation Abstract This application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for…

Improving Chromatographic Separations Of Biopharmaceuticals With MaxPeak High Performance Surfaces (HPS) Technology Analytical Solutions Using MaxPeak High Performance Surfaces (HPS) Technology for Biopharmaceutical Therapeutics Biopharmaceutical therapeutics have consistently been the fastest growing segment within the pharmaceutical space and require advances…

MaxPeak Premier Columns Small Molecule Application Notebook CONTENTS Introduction Non-Specific Adsorption: Unwanted Interactions................................................................................... 3 How Do Scientists Solve This Problem Today?......................................................................................... 4 Precision Chemistry for Particles and Surfaces........................................................................................ 5 Fundamentals Waters™ Premier Standards to Investigate the Inertness of Chromatographic Systems....................................................................................................................................7…