Method for the Analysis and Quantitation of Pharmaceutical Counterions Utilizing Hydrophilic Interaction Liquid Chromatography

METHOD FOR THE ANALYSIS AND QUANTITATION OF PHARMACEUTICAL COUNTERIONS UTILIZING HYDROPHILIC INTERACTION LIQUID CHROMATOGRAPHY Brianna Clements, Margaret Maziarz, Evelien Dejaegere*, Paul Rainville Waters Corporation, 34 Maple Street, Milford MA, 01757, USA *Corresponding author: [email protected]: Waters NV/SA, The ultimate building -…

M0930-06-32 Method for the Analysis and Quantitation of Pharmaceutical Counterions Utilizing Hydrophilic Interaction Liquid Chromatography Brianna Clements, Margaret Maziarz, Paul Rainville Waters Corporation CONTACT INFORMATION:34 Maple Street, Milford, MA 01757 USA. [email protected] PURPOSE CONCLUSIONS RESULTS Background More than 50% of…

Application Note Quantification of Inorganic Counterions Using Hydrophilic Liquid Chromatography Coupled with Charged Aerosol Detection (CAD) Margaret Maziarz, Stephanie Harden, Paul Rainville Waters Corporation, United States Published on July 16, 2026 Abstract Analysis of counterions during pharmaceutical development is critical…

Table of contents Summary Overview Excipient function Measurement Charged Aerosol Detector Universal detection Uniform response Working principles (U)HPLC Systems with CAD Columns choice Excipients overview Adjuvants Amino acids Carbohydrates Counterions Nonionic surfactants Polyethylene glycol Proteins and excipients HPLC-Charged Aerosol Detection…