MaxPeak Premier Protein SEC 250 Å Column Lifetimes at Physiological pH for Polysorbate (Tween) Formulated Biosimilar Monoclonal Antibodies

Application Note Rapid Size Variant Analysis of Monoclonal Antibodies Using UPLC™ and HPLC Compatible MaxPeak™ Premier Protein SEC Columns Stephan M. Koza, Ying Qing Yu Waters Corporation Abstract High-throughput and rapid size-exclusion chromatography (SEC) methods can be useful to support…

Application Note Modern Size-Exclusion Chromatography Separations of Biosimilar Antibodies at Physiological pH and Ionic Strength Stephan M. Koza, Hua Yang, Ying Qing Yu Waters Corporation Abstract The state of protein derived self-associated, aggregated, and fragmented impurities in therapeutics are critical…

Application Note USP Monograph mAb SEC Method Robustness on the XBridge Premier Protein SEC Column Hua Yang, Stephan M. Koza, Ying Qing Yu Waters Corporation Abstract Size-exclusion chromatography (SEC) has been widely used for size-based impurity analysis. We show here…

Application Note Evaluation of SEC-MALS Data Quality with Premier Protein SEC Columns Hua Yang, Stephan M. Koza, Ying Qing Yu Waters Corporation Abstract Size Exclusion Chromatography (SEC) coupled with multiangle light scattering (MALS) and UV/RI detection has been increasingly used…