Middle Down Analysis of HERCEPTIN and its Biosimilar on a Quadrupole-Ion Trap-Orbitrap Mass Spectrometer using Multiple Fragmentations

Technical note | 003318 Biopharma In-depth characterization of monoclonal antibodies Intact mass analysis and middle-down mass spectrometry approaches on an Orbitrap Ascend BioPharma Tribrid mass spectrometer Authors Goal Jingjing Huang, Christopher Mullen, To assess the performance of the Thermo Scientific™…

APPLICATION NOTE 73885 Complete characterization of monoclonal antibodies under native and denaturing conditions Kristina Srzentić1, Eugen Damoc2, Kai Scheffler3, Tom Buchanan4, Krisztina Radi4, Jennifer Sutton1 Thermo Fisher Scientific, 1 Cambridge, Massachusetts, US 2 Bremen, Germany 3 Germering, Germany 4 Hemel…

In-Depth Characterization of Monoclonal Antibodies Using Intact Mass Analysis and Middle-down Approaches on Orbitrap Ascend BioPharma Tribrid Mass Spectrometer Jingjing Huang, Christopher Mullen, Kristina Srzentić, Graeme McAlister, Vlad Zabrouskov, Rafael Melani Thermo Fisher Scientific, San Jose, California, USA Abstract Purpose:…

Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher…