Comparing ELSD and CAD Performance on Polysorbate Quantification in Infliximab Drug Products

ELSD Performance on Polysorbate Quantification in Infliximab Drug Products Duanduan Han, Robert Birdsall, Jennifer Simeone, Michael Fogwill, Ying Qing Yu Waters Corporation, Milford, MA INTRODUCTION Polar head-group METHODS Principles of evaporative light scattering Hydrophobic ester tail Step 3: Detection PS80…

Application Note Quantification of Polysorbates Using the Waters Charged Aerosol Detector Pawel Bigos, Robert E. Birdsall, Xiangsha Du, Duanduan Han, Nikhil Bhiwankar Waters Corporation, United States Published on July 13, 2026 Abstract Non-ionic surfactants such as polysorbate 20 (PS20) and…

QUANTIFICATION OF POLYSORBATE IN MONOCLONAL ANTIBODY FORMULATIONS USING CHARGED AEROSOL DETECTION Pawel Bigos, Duanduan Han, Robert Birdsall, Nikhil Bhiwankar Waters Corporation RESULTS AND DISCUSSION column Polysorbate 80 (PS80) and polysorbate 20 (PS20) are non-ionic surfactants widely used in pharmaceutical and…

Simultaneous analysis of polysorbate 80 and poloxamer 188 in biopharmaceutical formulations using charged aerosol detector and single quadrupole mass spectrometer Xuepu Li 1, Sissi White 2, Mauro De Pra 3, Yu Cui 1, Min Du 2 1Thermo Fisher Scientific, Shanghai,…