Characterization of Adeno-Associated Viral assemblies on an Ultra-High Mass Range Hybrid Quadrupole-Orbitrap Mass Spectrometer

Application note | 002599 Biopharma Characterization of adeno-associated viral proteins proteoforms using a top-down MS approach on a UHPLC-Orbitrap Ascend Tribrid mass spectrometer Application benefits Authors Reiko Kiyonami , Rafael Melani , 1 1 • Confident determination of PTM localization…

APPLICATION NOTE 000253 Highly sensitive intact mass analysis of AAV capsid proteins using a UHPLC-FLDHRAM MS platform Authors: Reiko Kiyonami¹, Kristina Srzentić², Rosa Viner¹, Weijing Liu¹, Min Du², Katy Irvin³, Kenneth Thompson³, Chao Yan Liu³, Jon Zmuda³ ¹ Thermo Fisher…

Application note | 001120 Biopharma Assessing key attributes of adeno-associated viral proteins using HPLC-FLD-intact mass analysis Authors Application benefits Reiko Kiyonami1, Roberto Gamez1, Min • Rapid ratio assessment of adeno-associated virus (AAV) structural proteins VP1:VP2:VP3 through sensitive fluorescence detection •…

Assessing key attributes of adeno-associated viral proteins using UHPLC-FLD-intact accurate mass analysis Reiko Kiyonami1, Roberto Gamez1, Min Du2, Kenneth Thompson3, Chao Yan Liu3, Julia Kraegenbring4, Catharina Crone4 1Thermo Fisher Scientific, San Jose, CA, USA; 2Thermo Fisher Scientific, Cambridge, MA, USA;…