Multi-site assessment of precision and reproducibility of high-throughput capillary-flow LC-MS proteome profiling with novel ultra-high-pressure LC coupled to HRAM MS

LC-MS Fast, sensitive, and reproducible nano- and capillary-flow LCMS methods for high− throughput proteome profiling using the Vanquish Neo UHPLC system hyphenated with the Orbitrap Exploris 480 MS Authors Introduction Runsheng Zheng , Tabiwang N Arrey , Amirmansoor Hakimi ,…

Beyond the Boundaries of LC-MS Sensitivity and Throughput with the Next Generation All-In-One Nano-, Capillary-, and Micro-Flow UHPLC System Alexander Boychenko1, Runsheng Zheng1, Christopher Pynn1, Tabiwang Arrey2, Amirmansoor Hakimi3, Stephan Meding1, Wim Decrop1, Martin Samonig1, Susanne Moyer1 1Thermo Fisher Scientific,…

LC-MS TECHNICAL NOTE Vanquish Neo UHPLC system sets new performance standards for single-shot nanoLCMS bottom-up proteomics Authors biomarker discovery and precision medicine. The enormous variety and dynamic range of proteins found in biofluids such Runsheng Zheng , Christopher Pynn ,…

Long-term stability and reproducibility of nano-, capillary- and micro-flow LC-MS separations: the impact of hardware and separation column Christopher Pynn1, Runsheng Zheng1; Tabiwang Arrey2; Amirmansoor Hakimi3; Alec Valenta1; Susanne Moyer1 1Thermo Fisher Scientific, Germering, Germany; 2Thermo Fisher Scientific, Bremen, Germany;…