Application Note Modernized Impurity Analysis of the Kinase Inhibitor Imatinib by High-Resolution LC With MS-Compatible Mobile Phases

Application Note Structural Elucidation of Unknown Impurities in the Kinase Inhibitor Imatinib Using UHPLC and High-Resolution Mass Spectrometry Peng Chen, Matthew A. Lauber Waters Corporation Abstract A UHPLC-HRMS method has revealed previously unidentified impurities in the synthesis of the kinase…

Application Note Using the Systematic Screening Protocol and MaxPeak™ Premier Columns to Separate Seven Janus Kinase Inhibitors Kenneth D. Berthelette, Christopher Collins, Jamie Kalwood, Kim Haynes Waters Corporation Abstract Developing analytical methods can be a challenging endeavor, particularly for structurally…

Session F6 A Systematic Approach Towards UPLC® Method Development Esa Lehtorinne [email protected] Tel: +358-9-5659 6288 Fax: +358-9-5659 6282 Waters Finland Kutomotie 16 00380 Helsinki ©2011 Waters Corporation 1 Challenges of Method Development
Chromatographic methods are developed for different applications…

UPLC COLUMNS AND CONSUMABLES UPLC Columns www.waters.com/uplccolumns 109 TABLE OF CONT ENTS Introduction........................................................................................................................................................................ 111 UPLC Columns........................................................................................................................................................................111 Waters UPLC Particle Technology..........................................................................................................................................111 CORTECS UPLC 1.6 µm Columns.................................................................................................................................... 112 CORTECS UPLC C18+ Columns...............................................................................................................................................112 CORTECS UPLC C18 Columns.................................................................................................................................................113 CORTECS UPLC HILIC Columns..............................................................................................................................................113 ACQUITY UPLC…