IMPROVED SELECTIVITY AND ACQUISITION SPEED USING DESI QUADRUPOLE BASED MASS SPECTROMETER

Improved molecular detection and acquisition speed using DESI mass spectrometry imaging quadrupole based mass spectrometer Emmanuelle Claude1, Wei Rao1, Zoltan Takats2, Emrys Jones1 1 Waters Corporation, Stamford Rd, Wilmslow, SK9 4AX, UK; 2 Department of Metabolism, Digestion and Reproduction, Imperial…

NOVEL TARGETED DESI MRM TQ SYSTEM PROVIDING INCREASED SENSITIVITY AND ACQUISITION SPEED FOR MASS SPECTROMETRY IMAGING Emmanuelle Claude1, Steven Pringle1, Joanne Ballantyne1 1 Waters Corporation, Wilmslow, UK INTRODUCTION Gefitinib was detected with a S/N ~ 2,500 and was at least…

[ TECHNOLOGY BRIEF ] DESI-Mass Spectrometry Imaging Investigation of Discrete and Cassette Drug Dosed Tissues Philippa J Hart,¹ Andreas Danhorn,² Mark Towers,¹ and Emmanuelle Claude¹ ¹Waters Corporation, Wilmslow, UK, ²Imperial College, London, UK Mass spectrometry imaging for the distribution of…

TARGETED DESI IMAGING MS OF DRUG DISTRIBUTION AND DRUGINDUCED LIVER INJURY (DILI) METABOLITES FROM METHAPYRILENE IN THE MALE WISTAR RAT Anthony Midey,1 Emmanuelle Claude,2 Lisa Reid,2 Bindesh Shrestha,1 Steven K Lai,1 Ian D Wilson,3 Robert S Plumb,1 and Roy Martin1…