Simultaneous in vivo Quantification and Metabolite Identification of Plasma Samples Using High Resolution QTof and Routine MSE Data Analysis

Determination of Mass Resolution, Sensitivity, and Linear Dynamic Range of Small Molecules in Human Plasma Using ACQUITY UPLC I-Class and Xevo G2-S QTof Yun Alelyunas, Craig Dorschel, Mark Wrona, and Paul Rainville G OA L The sensitivity of the high…

Effect of MS Scan Speed on UPLC Peak Separation and Metabolite Identification: Time-of-Flight HRMS vs. Orbitrap Yun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C…

[ APPLICATION NOTE ] Metabolite Identification: Working with Large Preclinical Multispecies Data Sets Mark Wrona, 1 Sherri Naughton, 1 Yun Alelyunas, 1 Russell Mortishire-Smith, 2 and Jayne Kirk 2 1 Waters Corporation, Milford, MA, USA 2 Waters Corporation, Wilmslow, UK…

Quantitation by High Resolution Mass Spectrometry: Using Target Enhancement and Tof-MRM to Achieve Femtogram-level On-column Sensitivity for Quantitation of Drugs in Human Plasma Yun W. Alelyunas, Mark D. Wrona, Russell J. Mortishire-Smith, Nick Tomczyk, and Paul D. Rainville Waters Corporation,…