Transfer of USP Methods for Impurities Analysis of Ziprasidone HCl between HPLC Systems and to UPLC

Transfer of Two USP Compendial Methods for Impurities of Ziprasidone HCL to a Single UPLC Method Margaret Maziarz, Michael D. Jones, Warren B. Potts, and Frederic Forini Waters Corporation, Milford, MA, USA A P P L I C AT I…

[ APPLICATION NOTEBOOK ] IMPURITIES Developing Safe and Effective Drugs INT RODUCTION NAVIGATION T he pharmaceutical industry is integral in maintaining public health by providing therapeutic and preventative medicines. T he cornerstones of bringing new medicines to market are quality,…

Scaling Reverse-Phase and Hydrophilic Interaction Liquid Chromatography (HILIC) Methods to HPLC Authors: Margaret Maziarz, Paul Rainville, Stephanie Harden Affiliations: Waters Corporation, 34 Maple Street, Milford MA 01757 2.0 mL/min Step Time %A 1 Initial 90.0 %B 5.0 %C Curve 5.0…

[ APPLICATION NOTEBOOK ] METHOD DEV ELOPMENT The Path to Successful Drug Development Starts with Purposeful Method Development [ INTRODUCTION ] T he Path to Successful Drug Development Starts with Purposeful Method Development The goal of method development in pharmaceutical…