Rapid Metabolite Tof Screening, Structure Elucidation and Clearance Estimates Using Informatics-HRMS Approaches

Direct Detection of Glutathione Conjugates in Human Liver Microsomes Using ACQUITY UPLC I-Class, Xevo G2-S QTof, and UNIFI Yun W. Alelyunas, Mark D. Wrona, and Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C AT…

A P P LICAT ION SOLUT IONS FO R M ETABOLIT E IDENT IFICAT ION A P P L I C AT I O N S O L U T I O N S F O R M E TA…

Technical note | 003277 Software Detection and identification of isotope-labeled glutathionetrapped reactive drug metabolites A streamlined solution using the Orbitrap Exploris 240 MS and Compound Discoverer software Authors Application benefits Zhixin Miao1, Allison Schmittou1, John Ulrich1, • Accomplish high-throughput metabolites…

Effect of MS Scan Speed on UPLC Peak Separation and Metabolite Identification: Time-of-Flight HRMS vs. Orbitrap Yun W. Alelyunas, Mark D. Wrona, Kevin Cook, Stephen McDonald, Paul D. Rainville Waters Corporation, Milford, MA, USA A P P L I C…