Determination of genotoxic nitrosamines in Valsartan with gas chromatography and mass spectrometry

APPLICATION NOTE 21922 Determination of genotoxic nitrosamines in Valsartan with gas chromatography and mass spectrometry Authors Introduction Yanggang Zhang, Jinshui Che and Shen Wang Thermo Fisher Scientific, Shanghai, China Valsartan is a widely used anti-hypertensive drug known to reduce human…

CASE STUDY 73263 Overcoming the challenges of nitrosamine impurities in drugs What pharmaceutical QA/QC laboratories need to know: Advanced GC-MS capabilities for cGMP nitrosamine testing Why we need to analyze nitrosamine impurities in drugs Unacceptable levels of nitrosamine impurities were…

CASE STUDY 73263 Overcoming the challenges of nitrosamine impurities in drugs What pharmaceutical QA/QC laboratories need to know: Advanced GC-MS capabilities for cGMP nitrosamine testing Why we need to analyze nitrosamine impurities in drugs Unacceptable levels of nitrosamine impurities were…

APPLICATION NOTE 000235 Simultaneous quantitation of nine nitrosamines using a highly sensitive and LC-HRAM mass spectrometry method in multiple drug products Authors: Krishna Mane, Pratip Saha, Venkatesh Chanukuppa, Biswajayee Patra, Saravanan Kumar Thermo Fisher Scientific, Bengaluru, India Keywords: Nitrosamine quantitation,…