High-throughput Mass Spectrometry Analysis of Synthetic Oligonucleotides: A Comparison of Data from Fast LC and RapidFire Methods

Application Note High-throughput Mass Spectrometry Analysis of Synthetic Oligonucleotides A comparison of data from Fast LC and RapidFire methods Authors Peter Rye, PhD and Yanan Yang, PhD Agilent Technologies, Inc. Introduction Liquid chromatography (LC) and mass spectrometry (MS) play a…

RapidFire for Automated High-Throughput LC/MS Proven. Rapid. Complete. Application Compendium Table of Contents Introduction3 Application Notes Method Development High-Throughput (Sub-2.5 Second) Direct Injection Analysis by  Mass Spectrometry 4 Automated Method Development Using the Agilent RapidFire  High-Throughput Mass Spectrometry…

Poster Reprint ASMS 2025 Poster number ThP 565 High-throughput Ion-Pairing Free Reversed Phase Analysis of Oligonucleotides using RapidFire Quadrupole Time-of-Flight Mass Spectrometry Guannan Li and Lee Bertram Agilent Technologies, Inc., Santa Clara, CA Introduction Experimental Oligonucleotides are commonly analyzed by…

Application Note High-throughput, Ion-Pairing-Free, HILIC Analysis of Oligonucleotides Using Agilent RapidFire Coupled to Quadrupole Time-of-Flight Mass Spectrometry Author Abstract Peter Rye, PhD Agilent Technologies, Inc. This application note describes a high-throughput, ion-pairing-free method for oligonucleotide characterization using the Agilent RapidFire…