Fragment-Based Drug Discovery: Comparing Labeled and Label-Free Screening of β-Amyloid Secretase (BACE-1) Using Fluorescence Spectroscopy and Ultrafast SPE/MS/MS Application Note Authors Introduction Lauren E. Frick and William A. LaMarr Agilent Technologies, Inc. Wakefield, MA, USA Fragment-based screening offers advantages over…
Key words
unlabeled, lfs, substrate, hits, labeled, ums, lms, rapidfire, were, peptide, assays, fluorescently, hit, autofluorescence, inhibition