Purification of Single-Stranded RNA Oligonucleotides Using High‑Performance Liquid Chromatography

Application Note Biopharma/Pharma Fast and Selective Purification of Oligonucleotides Using Preparative HPLC/MS and Software Support mAU UV 800 400 0 cps 80,000 2 4 6 8 10 12 min 2 4 6 8 10 12 min 2 4 6 8…

Application Note Biopharma/Pharma Superficially Porous Columns for Semi-Preparative Purification of Synthetic Oligonucleotides Method development and scale-up using same analytical LC instrumentation Authors Abstract Andrea Angelo P. Tripodi and Andrew Coffey Agilent Technologies, Inc. Synthetic oligonucleotides inevitably contain many impurities due…

Application Note Biopharma/Pharma Efficient Purification of Synthetic Peptides at High and Low pH mAU 2,000 1,500 1,000 500 0 mAU 1,500 Generic Focused 1 2 3 4 5 6 7 8 min 1 2 3 4 5 6 7 min…

Time-, Peak-, and Mass-Based Fraction Collection with the Agilent 1290 Infinity II Preparative Open-Bed Fraction Collector Technical Overview Author Abstract Florian Rieck The Agilent 1290 Infinity II Preparative Open-Bed Fraction Collector sets new Agilent Technologies, Inc. benchmarks in efficient and…