Enantiomeric Separation of the Active Metabolite of Risperidone and its Application for Monitoring Metabolic Stability using UPC2/MS/MS

Enantiomeric Separation of Warfarin and Propranolol and their Associated Hydroxylated Metabolites using UPC2-MS/MS Jennifer Simeone and Paul Rainville G OA L UltraPerformance Convergence Chromatography™ To illustrate the effectiveness of convergence chromatography for the separation of compounds with chiral centers. Adding…

Investigating the Chiral Metabolism of an Achiral Drug Using Agilent SFC‑MS/MS Technology Application Note Pharma Discovery Authors Abstract Siji Joseph A robust SFC-MS/MS method was developed for the quantification of achiral Agilent Technologies, Inc. risperidone and its enantiomeric hydroxy metabolite.…

AGROCHEMICAL SOLUTIONS APPLICATION NOTEBOOK Accelerate Synthesis, Purification, and Formulation AGROCHEMICAL SOLUTIONS APPLICATION NOTEBOOK Developing next-generation crop protection solutions To accelerate the development of highly effective, environmentally friendly agrochemicals, laboratories must perform analyses that generate more information, are completed more rapidly…

Separation of Diastereomeric Chiral Metabolites Using UPC 2 MS/MS Chester L. Bowen,1 Hermes Licea-Perez,1 Paul D. Rainville,2 Tom DiPillipo,2 Denise Heyburn,2 Robert S. Plumb,2 and Christopher Evans1 1 Bioanalytical Sciences and Toxicokinetics, PTS DMPK, GlaxoSmithKline, King of Prussia, PA, USA…