Determination of Drug-to-Antibody Distribution in Cysteine-Linked ADCs

Application Note Antibody-Drug Conjugate (ADC) Analysis with the Agilent ProteoAnalyzer System Author Abstract Whitney Pike, Agilent Technologies, Inc. This application note demonstrates the use of the Agilent ProteoAnalyzer system for antibody-drug conjugate (ADC) analysis by capillary electrophoresis with sodium dodecyl…

Agilent Biocolumns Critical Quality Attributes Application Compendium Contents Introduction 05 1 Titer determination 07 1.1 1.2 1.3 1.4 1.5 Background Getting Started How to Guide - Affinity Chromatography for Titer Determination Featured Application Notes Cell Clone Selection Using the Agilent…

Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…

Agilent BioHPLC columns Characterization of Antibody-Drug Conjugate Critical Quality Attributes Application compendium Contents Introduction3 Featured application notes 2 PLRP-S Polymeric Reversed-Phase Column for LC/MS Separation of mAbs and ADC (5991-7163EN) 5 Intact- and Peptide-Level Characterization of Trastuzumab Emtansine In Vitro…