Measuring Drug-to-Antibody Ratio (DAR) for Antibody-Drug Conjugates (ADCs) with UHPLC/Q-TOF

Analysis of Antibody Drug Conjugate Through the Characterization of Drug Antibody Ratios Using an Agilent 1290 Infinity Binary LC System Coupled to an Agilent 6550 iFunnel Q-TOF Application Note Biopharma Authors Introduction Ravindra Gudihal and Jing Chen Antibody drug conjugates…

An Integrated Workflow for Automated Calculation of Antibody‑Drug Conjugate (ADC) Drug‑to-Antibody Ratio (DAR) Using Automated Sample Preparation, Agilent MassHunter Walkup, and Agilent MassHunter BioConfirm DAR Calculator Software Application Note Biotherapeutics and Biosimilars Authors Abstract David L. Wong, Tanner Stevenson, and…

Drug-to-Antibody Ratio (DAR) Calculation of Antibody-Drug Conjugates (ADCs) Using Automated Sample Preparation and Novel DAR Calculator Software Application Note Authors Introduction Jing Chen and Steve Murphy Antibody-drug conjugates (ADCs) are a new class of biotherapeutics that represent a rapidly growing…

Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…