Transferring Methods for Monoclonal Antibody Analysis from an Agilent 1260 Infinity Quaternary LC System to an ACQUITY Arc System

Transfer of an SEC Method for Monoclonal Antibody Analysis from HPLC to UHPLC Using the ACQUITY Arc System Brooke M. Koshel and Sean M. McCarthy Waters Corporation, Milford, MA, USA A P P L I C AT I O N…

[ APPLICATION NOTE ] Impact of Instrument and Detector Characteristics on Size Exclusion Chromatography Method Transfer Across Biocompatible UHPLC Systems Zhimin Li, Paula Hong, and Patricia R. McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Biocompatible system…

[ APPLICATION NOTEBOOK ] SIZE-EXCLUSION CHROMATOGRAPHY (SEC) OF PEPTIDES, PROTEINS, AND AAVs [ SIZE-EXCLUSION CHROMATOGRAPHY ] [ SIZE-EXCLUSION CHROMATOGRAPHY ] Introduction Gel-permeation chromatography (GPC), size-exclusion chromatography (SEC), and gel-filtration chromatography (GFC) are commonly used terms to describe a liquid chromatographic…

[ APPLICATION NOTE ] Impact of LC System Dispersion on the Size-Exclusion Chromatography Analysis of Monoclonal IgG Antibody Aggregates and Fragments: Selecting the Optimal Column for Your Method Stephan M. Koza, Corey E. Reed, and Weibin Chen Waters Corporation, Milford,…