Exploring Extra Sensitivity Using ionKey/MS with the Xevo G2-XS QTof HRMS for Small Molecule Pharmaceutical Analysis in Human Plasma

High Sensitivity Bioanalysis for Small Drug-Like Compounds in Human Plasma using Microflow LC and High Resolution Mass Spectrometry Yun Wang Alelyunas, Mark Wrona, Jim Murphy, Kelly Doering Waters Corporation, Milford, Massachusetts, USA Abstract Introduction. Bioanalysis to support PK-PD studies and…

[ ion key / MS ] APPLICATION COMPENDIUM Dear Colleague, The 2014 introduction of the ionKey/MS System was a turning point for LC-MS. The promise of increased levels of sensitivity from smaller sample sizes was finally a reality. We were…

[ APPLICATION NOTEBOOK ] PEPTIDE AND PROTEIN BIOANALYSIS [ OUR SCIENTISTS ] Yun Alelyunas, PhD Before coming to Waters in 2012, Yun Alelyunas was a principal scientist and team leader at AstraZeneca for 20 years where she was involved in…

Improving the Detection of Thyroglobulin in Human Plasma for Clinical Research by Combining SISCAPA Enrichment and Microflow LC-MS Jay S. Johnson,1 Morteza Razavi,2 James Murphy,1 Selena Larkin,2 and Paul Rainville1 1 Waters Corporation, Milford, MA, USA; 2 SISCAPA Assay Technologies,…