THE USE OF A TRIPLE DETECTION SYSTEM (UV, ELSD, MS) FOR PHARMACEUTICAL DEGRADATION STUDIES

USE OF A TRIPLE DETECTION (UV-ELSD-MS) SYSTEM FOR MASS BALANCE IN FORCED DEGRADATION OF PHARMACEUTICALS Paula Hong and Patricia R. McConville INTRODUCTION RESULTS AND DISCUSSION Forced degradation studies are typically performed using HPLC and UV detectors to understand the degradation…

USE OF A TRIPLE DETECTION (UV-ELSD-MS) SYSTEM FOR MASS BALANCE IN FORCED DEGRADATION OF PHARMACEUTICALS Paula Hong and Patricia R. McConville INTRODUCTION RESULTS AND DISCUSSION Forced degradation studies are typically performed using HPLC and UV detectors to understand the degradation…

STRATEGIES TO EVALUATE AND MONITOR FORCED DEGRADATION STUDIES USING A DUAL DETECTION (UV-MS) SYSTEM Paula Hong, and Patricia R. McConville Waters Corporation, Milford, MA 01757 INTRODUCTION Forced degradation studies are typically performed to understand the degradation pathway of pharmaceuticals. Given…

[ APPLICATION NOTEBOOK ] IMPURITIES Developing Safe and Effective Drugs INT RODUCTION NAVIGATION T he pharmaceutical industry is integral in maintaining public health by providing therapeutic and preventative medicines. T he cornerstones of bringing new medicines to market are quality,…