MONITORING PRODUCT ATTRIBUTES IN BIOPHARMACEUTICAL DEVELOPMENT AND QC WITH LC/MS

MONITORING PRODUCT ATTRIBUTES IN BIOPHARMACEUTICAL DEVELOPMENT AND QC WITH LC/MS Scott J. Berger, Liuxi Chen, Henry Shion, Min Du, Ying Qing Yu Waters Corp, Milford, MA, United States INTRODUCTION RESULTS AND DISCUSSION • LC/MS peptide mapping acquisition workflows used for…

BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…

Automated Quantitative Analysis of Antibody Drug Conjugates Using an Accurate Mass Screening Workflow in the UNIFI Scientific Information System Liuxi Chen, Steven Cubbedge, Ying Qing Yu, and Rose Lawler Waters Corporation, Milford, MA, USA A P P L I C…