Improvements in Sensitivity for Quantification of Steroid Phosphate Drugs Using ACQUITY PREMIER and MaxPeak HPS Columns

Improvements in the bioanalytical method performance for steroid phosphates using a hybrid surface barrier to minimize analyte-metal surface interactions Nikunj Tanna & Robert Plumb, Waters Corporation INTRODUCTION Hydrocortisone Phosphate 100 Column Column Temp. Sample Temp. Inj Volume Flow Rate Mobile…

Application Note Utilization of the Arc Premier System and XSelect Premier Columns for Sensitive LCMS Quantitation of the Steroid Phosphates, Betamethasone, Dexamethasone, and Hydrocortisone Mary Trudeau, Fadi L. Alkhateeb, Paul D. Rainville Waters Corporation This is an Application Brief and…

IMPROVING CHROMATOGRAPHIC PERFORMANCE FOR METAL SENSITIVE ANALYTES USING HYBRID SURFACE BARRIER TECHNOLOGY Nikunj Tanna, Robert S. Plumb, Kim Mulder Waters Corporation, 34 Maple Street, Milford, MA , USA INTRODUCTION RESULTS Analytes with electron rich moieties such as phosphate and carboxylate…

MaxPeak Premier Columns Small Molecule Application Notebook CONTENTS Introduction Non-Specific Adsorption: Unwanted Interactions................................................................................... 3 How Do Scientists Solve This Problem Today?......................................................................................... 4 Precision Chemistry for Particles and Surfaces........................................................................................ 5 Fundamentals Waters™ Premier Standards to Investigate the Inertness of Chromatographic Systems....................................................................................................................................7…