An Integrated LC-MS Platform for Multi-Attribute Monitoring of CQA’s of mAbs at the Subunit Level

[ APPLICATION NOTE ] Automated Protein Modification Characterization of the Intact and Subunit NIST Monoclonal Antibody Reference Standard with Waters UNIFI Scientific Information System Nilini Ranbaduge, Henry Shion, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…

[ APPLICATION NOTE ] High-Performance Vion IMS QTof for Monoclonal Antibody Intact and Subunit Mass Analysis Henry Shion and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Minimal tuning effort for intact protein Biotherapeutic protein products,…

Application Note Establishment of a Robust mAb Subunit Product Quality Attribute Monitoring Method Suitable for Development, Process Monitoring, and QC Release Samantha Ippoliti, Ying Qing Yu, Nilini Ranbaduge, Weibin Chen Waters Corporation Abstract This application note presents a subunit MAM…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…