An Integrated LC-MS Workflow with ProMass HR for Synthetic Peptide Impurity Analysis

[ APPLICATION NOTE ] Developing a Novel, Integrated LC-MS Workflow for High-resolution Monitoring and Characterization of Oligonucleotides Henry Shion, Robert Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Optimized RP-UPLC mobile phase Methods that…

[ APPLICATION NOTE ] LC-UV-MS-based Synthetic Peptide Identification and Impurity Profiling Using the ACQUITY QDa Detector with ProMass Software Ximo Zhang, Brooke Koshel, Jing Fang, William Alley, Robert Birdsall, and Yinq Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS…

[ APPLICATION NOTE ] Synthetic Peptide Characterization and Impurity Profiling Using a Compliance-Ready LC-HRMS Workflow Nilini Ranbaduge and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ A compliance-ready solution for peptide Peptide-based therapeutics are alpha amino…

[ APPLICATION NOTEBOOK ] APPLICATION SOLUTIONS FOR OLIGONUCLEOTIDES Table of Contents Introduction – UPLC Analysis of Synthetic Oligonucleotides......................................................................................................................... 4 [ HPLC & UPLC Separations ] Real-Time Analysis of RNAi Duplexes ....................................................................................................................................................................... 8 Semi-Preparative Scale Single-Stranded RNA Purification .......................................................................................................................... 11 Oligonucleotide…