Practical Instrument Considerations for Ion-Exchange Chromatography-Mass Spectrometry (IEX-MS)

[ APPLICATION NOTE ] Practical Considerations for Optimizing MS Quality during IEX-MS Andrew Schmudlach and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Improve mass spectral quality MS cleanliness is a surprisingly overlooked aspect of protein LC-MS…

[ APPLICATION NOTE ] Optimizing LC-MS Separations of mAbs using a BioResolve SCX mAb Column and IonHance CX-MS pH Concentrates Andrew Schmudlach, Samantha Ippoliti, Qi Wang, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION A novel…

[ APPLICATION NOTE ] Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION…

[ TECHNOLOGY BRIEF ] Mass Spectral Effects from Using Ammonium Bicarbonate for Protein IEX-MS Andrew Schmudlach and Matthew Lauber Waters Corporation, Milford, MA, USA Native MS-based proteomics should avoid the use of either ammonium bicarbonate or carbonate. IdeS Digest Subunit…