Intact Trastuzumab Monoclonal Antibody Quantification Using the Xevo G2-XS QTof High Resolution Mass Spectrometer

BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…

[ APPLICATION NOTE ] Antibody-Drug Conjugate (ADC) Drug-to-Antibody Ratio (DAR) Analysis in Serum Using IA-LC-HRMS Armand Ngounou and Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Robust and reliable IA-UPLC-HRMS Antibody-drug conjugates (ADCs) are comprised of a…

[ APPLICATION NOTE ] High Sensitivity Intact Monoclonal Antibody (mAb) HRMS Quantification Yun Wang Alelyunas, Henry Shion, Mark Wrona Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION mAb LC-MS method which enables Biotherapeutics have emerged as one of…

[ TECHNOLOGY BRIEF ] Optimizing Xevo G2-XS QTof Quadrupole Settings to Increase Sensitivity and Dynamic Range for the Analysis of Trastuzumab Marian Twohig, Yun Alelyunas, Caitlin Dunning, and Mark Wrona Waters Corporation, Milford, MA, USA The development of complex biotherapeutic…