Intact Mass Confirmation Analysis on the BioAccord LC-MS System for a Variety of Extensively Modified Oligonucleotides

[ APPLICATION NOTE ] An Automated Compliance-Ready LC-MS Workflow for Intact Mass Confirmation and Purity Analysis of Oligonucleotides Catalin Doneanu, 1 Jonathan Fox, 2 Emma Harry, 2 Chris Knowles, 3 Ying Qing Yu,1 Joseph Fredette, 1 and Weibin Chen1 1…

Application Note HILIC as an Alternative Separation Mode for Intact Mass Confirmation of Oligonucleotides on the BioAccord System Catalin E. Doneanu, Ying Qing Yu, Joseph Fredette, William J. Warren, Weibin Chen Waters Corporation Abstract HILIC chromatography provides a clean, cost-effective…

Application Note LC-MS Analysis of siRNA, Single Guide RNA and Impurities Using the BioAccord™ System with ACQUITY™ Premier and New Automated INTACT Mass Application Catalin E. Doneanu, Patrick Boyce, Henry Shion, Joseph Fredette, Scott J. Berger, Heidi Gastall, Ying Qing…

Application Note Analysis of Oligonucleotide Impurities on the BioAccord System with ACQUITY Premier Catalin E. Doneanu, Chris Knowles, Jonathan Fox, Emma Harry, Ying Qing Yu, Joseph Fredette, Weibin Chen Waters Corporation Abstract This application note demonstrates an automated, compliance-ready LC-MS…