Compliant Monitoring of Monoclonal Antibody Titer and Primary Structure Attributes Using a 2D-LC/MS System with UNIFI Informatics

[ APPLICATION NOTE ] Effective Determination of Pharmaceutical Impurities by Two Dimensional Liquid Chromatography Zhimin Li, Paula Hong, and Patricia McConville Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Increase productivity through targeted Analysis of many pharmaceutical compounds…

Agilent 1290 Infinity II 2D-LC Solution Biopharmaceutical Polymer Analysis WCBP Jan 2017 Washington, DC 1 Overview • Resolving power and how to measure it • Why two-dimensional LC? • Setup of a 2D-LC System • Different modes of 2D-LC •…

Biopharma Compendium Accelerate Your CQA Efficiency and Approach it with Multi-Attribute Methodology Breakthroughs to Increase the Efficiency of Critical Quality Attribute (CQA) Testing and Allow for a Multi- Attribute Method (MAM) Production of therapeutic monoclonal antibodies (mAbs) relies on living…

Characterization of Biotherapeutics: ACQUITY UPLC H-Class Bio with 2D Part 3 of 3: On-line Enrichment of Low Abundance Species Robert Birdsall, Vera Ivleva, Sean M. McCarthy, and Weibin Chen Waters Corporation, Milford, MA, USA A P P L I C…