Enabling Intelligent Data Capture for Intact Mass Analysis of Monoclonal Antibodies and Subunits using a Vion IMS QTof HRMS

[ TECHNOLOGY BRIEF ] Peptide Mapping Using Intelligent Data Capture on Vion IMS QTof Samantha Ippoliti, Ying Qing Yu, and Russell Mortishire-Smith Waters Corporation, Milford, MA, USA Real-time file size and noise reduction to speed up data processing and provide…

Application Note Comprehensive Biosimilar Comparability Assessment via Intact and Subunit RP-MS and IEX-UV-MS Using the Xevo™ G3 QTof System Samantha Ippoliti, Owen Cornwell, Lisa Reid, Ying Qing Yu, Emma Harry, Mark Towers Waters Corporation Abstract With the increasing prevalence of…

Application Note Intelligent Data Capture (IDC) Enables Optimal Xevo G2-XS Data Acquisition and Processing for Multi-Attribute Method (MAM) Studies Nilini Ranbaduge, Ying Qing Yu Waters Corporation Abstract The application note demonstrates the benefits of applying an acquisition-centric data reduction algorithm,…

[ APPLICATION NOTEBOOK ] Multi-Attribute Methods for Biopharmaceutical Analysis Application Notes [ APPLICATION NOTEBOOK ] Introduction The adoption of LC-MS-based multi-attribute method (MAM) analysis for routine monitoring of biotherapeutic variation has progressed greatly over the last five years. The ability…