The Xevo® G2-S QTOF is a high-performance quadrupole time-of-flight mass spectrometer engineered for advanced qualitative and quantitative workflows. Featuring Waters’ StepWave™ ion optics, QuanTof™ technology, and intelligent data acquisition, the Xevo G2-S delivers exceptional sensitivity, resolution, dynamic range, and mass accuracy for complex applications in pharmaceutical R&D, biopharma characterization, metabolomics, proteomics, food safety, forensics, and environmental analysis.
Its robust design, fast polarity switching, and compatibility with UPLC® systems make it ideal for multi-purpose laboratories requiring high productivity and high-quality spectral information.
Key Features
- High-resolution QTOF platform with accurate mass capability
- StepWave™ ion guide for enhanced sensitivity and transmission
- QuanTof™ technology delivering high resolution and exceptional dynamic range
- LockSpray™ for real-time mass correction and excellent mass accuracy
- Fast polarity switching for comprehensive screening workflows
- Ideal for screening, structural elucidation, quantitation, and intact mass analysis
- Supports MSE, HDMSE (ion mobility model-dependent), and data-independent acquisition
- Seamless integration with ACQUITY UPLC® systems
- Controlled through UNIFI or MassLynx software platforms
Typical Technical Specifications
- Mass range: typically m/z 20–80,000
- Resolving power: up to ~40,000 FWHM
- Mass accuracy: < 1–2 ppm with LockSpray™
- Sensitivity: low-femtogram detection (compound-dependent)
- Dynamic range: 5–6 orders of magnitude
- Scan speed: up to 20–30 spectra/sec
- Polarity switching: < 20 ms
- Ionization sources: ESI, APCI, APPI, ASAP, UniSpray (optional)
- Software: MassLynx®, UNIFI®
Applications
- Metabolomics & lipidomics
- Proteomics (peptides, intact proteins)
- Small-molecule identification & quantitation
- Impurity profiling, structure elucidation
- Food safety, forensic toxicology
- Environmental monitoring
