The Agilent G1948B Electrospray Ionization (ESI) Source is a robust and reliable ion source designed for efficient ion generation in LC/MS systems. It supports soft ionization of polar and thermally labile compounds, making it ideal for a wide range of applications in pharmaceutical, environmental, biochemical, and food analysis.
Key Features
- Proven ESI technology for efficient ionization of polar, non-volatile, and thermally labile molecules
- Compatible with a wide range of Agilent LC/MS systems (e.g., 6100, 6200, 6400 Series)
- Produces high sensitivity and stable ion signals across diverse compound classes
- Soft ionization minimizes fragmentation, ideal for molecular weight determination
- Supports both positive and negative ion modes
- Adjustable nebulizer and drying gas parameters for method flexibility
- Easy maintenance and quick removal for cleaning or switching ion sources
- Ideal for LC/MS workflows in pharmaceutical R&D, clinical research, metabolomics, and food safety
Technical Specifications
- Ionization type: Electrospray Ionization (ESI)
- Operating modes: Positive and negative ion polarity
- Spray configuration: Coaxial nebulization with heated drying gas
- Gas requirements:
– Nebulizer gas (N₂): Typically 20–60 psi
– Drying gas (N₂): Flow rate adjustable, up to ~13 L/min
– Temperature range: Adjustable, up to 350 °C (typical) - Capillary voltage: Adjustable (commonly +3000 to +5000 V)
- Compatibility: Agilent single quadrupole, triple quadrupole, Q-TOF, and TOF LC/MS instruments
- Applications: Small molecules, peptides, metabolites, drugs, environmental contaminants
