The Waters Arc™ Premier System is a high-performance liquid chromatography platform designed for robust HPLC/UHPLC separations, method development, method transfer, and routine QA/QC workflows. The offered configuration includes a Quaternary Solvent Manager, Sample Manager FTN, column heater, Arc Premier 2489 UV/Vis Detector, PC workstation, software, and licenses.
A key feature is MaxPeak™ High Performance Surfaces (HPS) Technology, which minimizes nonspecific interactions between metal-sensitive analytes and metallic surfaces in the sample flow path. This can improve recovery, peak shape, reproducibility, and overall data quality for compounds prone to metal interactions.
Offered System Configuration
- Waters Arc Premier System
- Quaternary Solvent Manager-R (QSM-R)
- Sample Manager FTN-R
- Column Heater
- Arc Premier 2489 UV/Visible Detector
- PC / workstation
- Software and licenses
Quaternary Solvent Manager-R
The QSM-R is a low-pressure-mixing, high-pressure quaternary solvent delivery module capable of dynamically blending four degassed solvents.
QSM-R Specifications
- Gradient: Quaternary low-pressure mixing
- Solvent channels: 4
- Flow range: 0.001–5.000 mL/min
- Maximum pressure: 655 bar / 9500 psi
- Standard mixer: 340 µL titanium
- Integrated degassing: four channels
- Flow accuracy: ±1.0% under specified conditions
- Flow precision: 0.05% RSD or 0.01 min SD
- Composition accuracy: ±0.5% absolute
- Composition precision: 0.15% RSD or 0.02 min SD
- Leak sensing
- Programmable seal wash
- Automatic Prime
- Flow Ramping
- Auto•Blend Plus.
Sample Manager FTN-R
The SM FTN-R uses a flow-through-needle mechanism in which the sample is aspirated into the needle and the needle becomes part of the high-pressure flow path during injection.
SM FTN-R Specifications
- Standard injection range: 0.1–50 µL
- Optional range: up to 0.1–1000 µL
- Standard extension loop: 50 µL
- Maximum operating pressure: 655 bar / 9500 psi
- Flow range: 0–5 mL/min
- Sample temperature range: 4–40 °C
- Temperature increment: 0.1 °C
- Heating: up to approx. 25 °C above ambient
- Cooling: up to approx. 19 °C below ambient
- Temperature sensor accuracy: ±0.5 °C
- Temperature stability: ±1.0 °C
- Residual sample volume: 3 µL with Total Recovery vial
- UV carryover: <0.002% caffeine under specified test conditions.
Injection Reproducibility
- ≤1% RSD at 0.5–0.9 µL
- ≤0.5% RSD at 1.0–4.9 µL
- ≤0.25% RSD at ≥5.0 µL.
Column Heater
For the standard Column Heater-Active (CH-A) configuration:
- One column
- Maximum column ID: 4.6 mm
- Maximum length: 150 mm including filter or guard column
- Temperature range: 20–90 °C
- Temperature accuracy: ±0.5 °C
- Temperature stability: ±0.3 °C
- Active preheating standard
- Optional passive preheating
- eCord™ column tracking.
If the offered system instead includes the CH-30A, columns up to 300 mm can be accommodated.
Arc Premier 2489 UV/Visible Detector
The Arc Premier 2489 UV/Vis Detector is a dual-wavelength absorbance detector incorporating MaxPeak HPS technology in the inlet and outlet fluidics of the flow cell.
2489 UV/Vis Specifications
- Detection: Dual-wavelength UV/Vis
- Wavelength range: 190–700 nm
- Bandwidth: ≤5 nm
- Wavelength accuracy: ±1 nm
- Wavelength repeatability: ±0.1 nm
- Measurement range: 0.0001–4.0000 AU
- Sampling rate: up to 80 points/s
- Single-wavelength baseline noise: ≤5 × 10⁻⁶ AU
- Drift: ≤1 × 10⁻⁴ AU/hour
- Light source: Deuterium arc lamp
- Analytical path length: 10 mm
- Analytical cell volume: 16.3 µL
- Flow-cell pressure limit: 1000 psi
- Flow-cell design: TaperSlit™
- MaxPeak HPS inlet/outlet fluidics.
Overall System Performance
For the QSM-R configuration:
- Total system bandspread (4σ): ≤30 µL
- Total dwell volume: ≤1150 µL
- Gradient delay volume: ≤750 µL
- Flow range: 0.001–5.000 mL/min
- Maximum operating pressure: 655 bar / 9500 psi
- Injection-to-injection cycle time: ≤30 s.
Typical Applications
- Pharmaceutical development
- QA/QC
- HPLC method transfer
- UHPLC analysis
- Impurity profiling
- Assay
- Metal-sensitive analytes
- Phosphorylated compounds
- Nucleotides
- Organic acids
- Food analysis
- Environmental analysis
- Chemical materials
- Routine UV/Vis quantitation
