The Waters ACQUITY UPLC I-Class Binary Solvent Manager is a high-pressure binary pump designed for fast and precise UPLC separations using sub-2 µm particles. Two independent solvent-delivery channels combine through high-pressure mixing to provide accurate gradients, low system dwell volume, and highly reproducible retention times. The module operates from 0.010 to 2.000 mL/min and supports pressures up to 18,000 psi at flow rates up to 1 mL/min.
Technical Specifications
- Module Type: High-pressure binary pump
- Technique: UPLC / LC / LC-MS
- Gradient Formation: High-pressure binary mixing
- Number of Solvents: up to 4, selected as:
- A1 or A2
- B1 or B2
- Operating Flow Range: 0.010–2.000 mL/min
- Flow Increment: 0.001 mL/min
- Maximum Pressure:
- 1,241 bar / 18,000 psi up to 1.0 mL/min
- 827 bar / 12,000 psi up to 2.0 mL/min
- Composition Accuracy: ±0.5% absolute
- Composition Precision: <0.2% RSD or 0.02 min SD
- Flow Precision: 0.075% RSD or 0.01 min SD
- Compressibility Compensation: Automatic and continuous
- Wet Prime Flow: 4 mL/min
- Gradient Profiles:
- linear
- 2 step
- 4 concave
- 4 convex
- Active Seal Wash: Yes
- Primary Check Valve: Intelligent Intake Valve (i²Valve)
Solvent Degassing
The Binary Solvent Manager incorporates a six-channel vacuum degassing system:
- four channels for chromatographic solvents
- two channels for Sample Manager wash solvents
This helps minimize bubble formation, pressure fluctuations, and gradient instability.
Physical Specifications
- Height: 22.9 cm
- Width: 34.3 cm
- Depth: 66.0 cm
- Weight: 26.3 kg
- Power: 100–240 VAC
- Frequency: 50/60 Hz
- Maximum Power Draw: 360 VA
Typical Applications
- Sub-2 µm UPLC separations
- Fast gradient methods
- Pharmaceutical analysis
- Quality control
- LC/MS
- Bioanalytical workflows
- Complex sample analysis
- High-throughput chromatography
