The Shimadzu iMScope with iMLayer Matrix Sprayer is an integrated imaging mass spectrometry (IMS) platform that uniquely combines optical microscopy and MALDI mass spectrometry imaging in a single instrument, enabling precise molecular visualization directly correlated with tissue morphology.
The device has been used very sporadically and is in excellent condition!
Key features
- Fully integrated optical microscope and MALDI-MS imaging system
- High spatial resolution molecular imaging directly correlated with histological features
- iMLayer matrix sprayer for uniform, reproducible matrix deposition
- Seamless transition between optical observation and MS imaging
- Designed for biological, pharmaceutical, and clinical research
Mass spectrometry and imaging performance
- MALDI ion source optimized for imaging applications
- High mass accuracy and sensitivity suitable for lipids, metabolites, peptides, and drugs
- Flexible imaging resolution depending on application and sample type
- Reliable signal reproducibility across large tissue sections
Optical microscopy integration
- Built-in optical microscope for sample observation and region-of-interest (ROI) selection
- Direct overlay of optical and MS images without external alignment
- Supports histological workflows and correlative analysis
iMLayer matrix sprayer
- Automated matrix application system optimized for MALDI imaging
- Uniform matrix coating improves ionization efficiency and image quality
- Reproducible spraying conditions reduce operator-dependent variability
- Suitable for common MALDI matrices used in biological imaging
Software and data handling
- Integrated Shimadzu imaging and MS control software
- Tools for image reconstruction, molecular distribution mapping, and data comparison
- Supports correlation of MS data with optical images and histological stains
Typical applications
- Spatial metabolomics and lipidomics
- Drug distribution studies in tissues
- Biomarker discovery
- Pathology and translational research
- Pharmaceutical development and toxicology
