<h3 id="h-expedited-screening-improves-outcomes-for-individuals-with-drug-toxicity" data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Expedited screening improves outcomes for individuals with drug toxicity</strong></h3><p><strong>In the field of clinical research and toxicology, the detection and quantification of drugs in human samples with suspected drug overdose or acute drug toxicity are critical. This blog post explores the potential of paper spray mass spectrometry (PS-MS) such as </strong><a target="_blank" rel="noreferrer noopener" aria-label="Thermo Scientific VeriSpray PaperSpray ion source - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/verispray-paperspray-ion-source-mass-spectrometry.html$thermoscientificverispraypapersprayionsource"><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/verispray-paperspray-ion-source-mass-spectrometry.html"><strong>Thermo Scientific VeriSpray PaperSpray ion source</strong></a></a><strong>, for faster and more efficient drug toxicity screening in emergency room applications.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Collaboration_Advances_POC_Solutions_Using_Paper_Spray_Mass_Spec_for_Drug_Tox_Screening_0531bbdb29.jpg" alt="Thermo Fisher Scientific: Collaboration Advances POC Solutions Using PaperSpray Mass Spec for Drug Tox Screening." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Collaboration_Advances_POC_Solutions_Using_Paper_Spray_Mass_Spec_for_Drug_Tox_Screening_0531bbdb29.jpg 234w," sizes="100vw" width="1200" height="800"></p><article aria-label="Collaboration Advances POC Solutions Using PaperSpray Mass Spec for Drug Tox Screening"><div><p>Researchers from <a target="_blank" rel="noreferrer noopener" aria-label="King’s College London - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://www.kcl.ac.uk/forensics$king’scollegelondon"><a target="_blank" rel="noopener noreferrer" href="https://www.kcl.ac.uk/forensics"><strong>King’s College London</strong></a></a> (KCL) are collaborating with <strong>Guy’s and St Thomas’ NHS Foundation Trust</strong> and leveraging the capabilities of <strong>paper spray-mass spectrometry (PS-MS) </strong>to analyze blood samples from individuals with acute drug toxicity in the emergency room. The aim is to <strong>develop routine methods for detecting and quantifying drugs</strong>, ultimately improving health outcomes for individuals in need of immediate care and making drug toxicity screening at the bedside a possibility in the future.</p><p>KCL researchers are conducting extensive testing and optimization of PS-MS technology. Preliminary results shared at <strong>The International Association of Forensic Toxicologists (TIAFT) 2023</strong> annual meeting in Rome have shown promising linearity across various concentrations for a number of cathinones. The goal is to refine the process and enhance accuracy, with the potential implementation of PS-MS into clinical practice.</p><h3 id="h-advantages-of-verispray-paperspray-mass-spectrometry"><strong>Advantages of VeriSpray PaperSpray mass spectrometry</strong></h3><p><strong>PS-MS with the</strong> <a target="_blank" rel="noreferrer noopener" aria-label="Thermo Scientific™ TSQ Altis™ Plus Triple Quadrupole - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://www.thermofisher.com/order/catalog/product/tsq03-10002$thermoscientific™tsqaltis™plustriplequadrupole"><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/404"><strong>Thermo Scientific™ TSQ Altis™ Plus Triple Quadrupole</strong></a></a> mass spectrometer offers several advantages over traditional orthogonal techniques. It enables rapid analysis, eliminating the need for lengthy sample preparation and chromatography-based separation. Additionally, the technique provides quantitative or screening results, is easy to use, reduces the risk of cross-contamination, and has barcoded tracking for LIMS compatibility with robotic automated systems such as Hamilton. Plus, it minimizes the use of chemicals and solvents, making it more environmentally friendly.</p><p>PS-MS offers a fast (2 minutes or less) turnaround time for high-throughput screening, enabling quick analysis of single samples from individuals and identify the presence of drugs or substances. The system’s ease of use and ability to process 240 samples unattended make it efficient and time-saving. The aim is to make drug toxicity screening at the bedside a reality, reducing waiting times for results and improving overall care.</p><h3 id="h-great-potential-for-poc-toxicity-screening"><strong>Great potential for POC toxicity screening</strong></h3><p>The collaboration between KCL, Guy’s and St Thomas’ NHS Foundation Trust, and research on PS-MS holds great potential for improving point-of-care drug toxicity screening. PS-MS offers a rapid, efficient, and accurate alternative to traditional methods, enabling faster and more efficient care for individuals presenting with acute drug toxicity. By implementing this technology, hospitals can reduce waiting times and ultimately improve outcomes in emergency settings. To learn more, <a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/posts/ema-ru%C5%BEi%C4%87-5ba70b133_paper-spray-mass-spectrometry-simplifies-activity-7196531937463750656-0FgR?utm_source=share&amp;utm_medium=member_desktop">download the recent case study</a>.</p><blockquote><h3 id="h-related-information"><strong>Related information</strong></h3><ol><li><a target="_blank" rel="noreferrer noopener" aria-label="Thermofisher.com/verispray - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/verispray-paperspray-ion-source-mass-spectrometry.html$thermofisher.com/verispray"><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/verispray-paperspray-ion-source-mass-spectrometry.html">Thermofisher.com/verispray</a></a></li><li><a target="_blank" rel="noreferrer noopener" aria-label="Toxicology in the emergency department: what’s new? - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://pubmed.ncbi.nlm.nih.gov/36193928/#:~:text=intentional%20and%20accidental%20drug%20overdose,morbidity%20and%20prolonged%20hospital%20admissions.$toxicologyintheemergencydepartment:what’snew?"><a target="_blank" rel="noopener noreferrer" href="https://pubmed.ncbi.nlm.nih.gov/36193928/#:~:text=Intentional%20and%20accidental%20drug%20overdose,morbidity%20and%20prolonged%20hospital%20admissions.">Toxicology in the emergency department: what’s new?</a></a></li><li><a target="_blank" rel="noreferrer noopener" aria-label="Thermo Fisher Scientific collaboration offers potential for faster, more efficient analysis of samples from drug toxicity patients - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://www.kcl.ac.uk/news/thermo-fisher-scientific-collaboration-offers-potential-for-faster-more-efficient-analysis-of-samples-from-drug-toxicity-patients$thermofisherscientificcollaborationofferspotentialforfaster,moreefficientanalysisofsamplesfromdrugtoxicitypatients"><a target="_blank" rel="noopener noreferrer" href="https://www.kcl.ac.uk/news/thermo-fisher-scientific-collaboration-offers-potential-for-faster-more-efficient-analysis-of-samples-from-drug-toxicity-patients">Thermo Fisher Scientific collaboration offers potential for faster, more efficient analysis of samples from drug toxicity patients</a></a></li><li><a target="_blank" rel="noreferrer noopener" aria-label="Paper spray mass spectrometry simplifies and expedites turnaround of drug toxicity screening: Thermo Fisher Scientific Case Study - open in a new tab" data-uw-rm-ext-link="" uw-rm-external-link-id="https://view.highspot.com/viewer/6644c7d165ad350931b0517c$paperspraymassspectrometrysimplifiesandexpeditesturnaroundofdrugtoxicityscreening:thermofisherscientificcasestudy"><a target="_blank" rel="noopener noreferrer" href="https://view.highspot.com/viewer/6644c7d165ad350931b0517c">Paper spray mass spectrometry simplifies and expedites turnaround of drug toxicity screening: Thermo Fisher Scientific Case Study</a></a></li></ol></blockquote></div></article><section><blockquote><h4>Courtney Patterson</h4><div itemprop="description">Courtney Patterson is an Application Scientist at Thermo Fisher Scientific, specializing in the development of LC-MS applications for forensic and clinical toxicology using targeted and untargeted approaches to quantify and confirm drugs of abuse.</div></blockquote></section>

Collaboration Advances POC Solutions Using PaperSpray Mass Spec for Drug Tox Screening

<h5><strong>Why compromise between performance and price when you can have both?</strong></h5><p><strong>With Thermo Scientific factory-certified, pre-owned </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3"><strong>mass spectrometers</strong></a><strong>, you can access legendary LC-MS technology—trusted around the world—at a fraction of the cost of buying new. Our refurb program delivers the quality, precision, and reliability you expect from Thermo Fisher Scientific, while helping you stay within budget and on top of your analytical goals.</strong></p><h3><strong>Factory-Certified for confidence</strong></h3><p>Every certified pre-owned system goes through a <strong>rigorous factory reconditioning process</strong>. From updated hardware and software to comprehensive performance testing, each instrument is restored to meet the same high standards as our new products.</p><h4><strong>What’s included?</strong></h4><p>When you choose a certified LC-MS system, you get more than just an instrument—you get the <strong>complete Thermo Scientific experience</strong>:</p><ul><li><strong>Full 1-year factory warranty</strong> for peace of mind</li><li><strong>29-point inspection checklist</strong>, re-certification, and final quality testing</li><li><strong>Software and hardware updates</strong> to current revisions</li><li>Re-certification using <strong>only genuine Thermo Scientific factory parts</strong></li><li><strong>Professional installation</strong> by Unity Lab Services field engineers</li><li><strong>Optional training and application support</strong> to get you up and running fast</li></ul><h4><strong>What gets replaced?</strong></h4><p>Our reconditioning process is comprehensive. These critical components are replaced on <strong>every</strong> system:</p><ul><li>All hoses</li><li>Probes</li><li>Ion sources</li><li>Ion transfer tube</li><li>Multiplier</li><li>Mechanical pumps</li><li>Acquisition PC and software</li><li>PCBs (when required for revision)</li></ul><h3><strong>Maximize uptime with expert support</strong></h3><p>Behind every certified system is a global team of Thermo Fisher specialists committed to helping your lab succeed. Support doesn’t stop after installation:</p><ul><li><strong>Flexible service contract options</strong> through Unity Lab Services</li><li><strong>Guaranteed response times</strong> for select contracts</li><li><strong>Financing solutions</strong> to meet your budget</li><li><strong>System qualifications and validations</strong></li><li><strong>Technology refresh solutions</strong> to keep you ahead of the curve</li></ul><h3><strong>A smarter, more sustainable choice</strong></h3><p>Investing in a factory-certified pre-owned system isn’t just cost-effective—it’s a sustainable solution that extends the life of high-performance equipment and reduces waste. You get the data quality and instrument reliability your work depends on, while making an environmentally conscious choice.</p><h3><strong>More ways to access Thermo Scientific excellence—affordably</strong></h3><p>We understand that every lab’s financial situation is different. That’s why Thermo Fisher offers <strong>multiple paths</strong> to help you acquire the right mass spectrometry solution, when you need it.</p><h4><strong>1. </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs/factory-certified-refurbished-mass-spectrometers.html"><strong>Factory-certified refurbished systems</strong></a></h4><p>Already covered above, this option gives you fully reconditioned, factory-tested LC-MS instruments at a lower price point—without compromising performance or support.</p><p>View our brochure for a comprehensive overview.</p><h4><strong>2. </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs/mass-spectrometer-trade-upgrade.html"><strong>Trade-in and trade-up</strong></a><strong>: Turn your old into increased productivity</strong></h4><p>Already own a system—Thermo Fisher or otherwise? Trade it in and upgrade to a newer model with greater capabilities and sensitivity.</p><p><strong>How it works:</strong></p><ul><li>Receive a discount on your next system based on the residual value of your current instrument</li><li>Avoid the hassle of selling or decommissioning your old system</li><li>Transition with minimal downtime and disruption</li></ul><p><strong>Why labs choose this path:</strong></p><ul><li>Keeps productivity high while moving to new technology</li><li>Eases the financial burden of upgrading</li><li>Helps labs stay competitive with improved system performance</li></ul><h4><strong>3. Personalized equipment </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/products-and-services/services/financial-leasing-services.html"><strong>financing &amp; leasing options</strong></a></h4><p>If upfront capital is limited, our tailored financing and leasing plans offer flexibility that aligns with your lab’s budget and growth plans.</p><h5><strong>Ready to get started?</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/mass-spectrometer-price-affordability-programs.html"><strong>Explore our certified systems, trade-in opportunities, and financing solutions.</strong></a></li></ul><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;</strong>#affordabiliy #LCMS #sustainability #productivity</p><blockquote><h5><strong>Ema Ruzic</strong></h5><p>Vertical Marketing Manager, Chromatography and Mass Spectrometry Division (CMD)</p></blockquote>

Unlock High-Performance LC-MS with Factory-Certified Systems from Thermo Fisher Scientific

<p><strong>At the January 2025 CFSRE Seized Drugs Symposium, a Thermo Fisher Scientific–sponsored workshop showcased the potential of </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2240"><strong>Thermo Scientific VeriSpray PaperSpray mass spectrometry </strong></a><strong>(PS-MS) to transform drug analysis workflows in both forensic and clinical toxicology. Three researchers from King’s College London (KCL)—PhD candidate Stefania Boccuzzi and MSc graduates Marwa AlJanahi and Saeed Almheiri—presented their findings on how to optimise this cutting-edge technique for faster, more sensitive, and more cost-effective detection of drugs of abuse.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Advancing_Drug_Analysis_with_Veri_Spray_Paper_Spray_Mass_Spectrometry_040182cb06.jpg" alt="Thermo Fisher Scientific: Advancing Drug Analysis with VeriSpray PaperSpray Mass Spectrometry: Thermo Fisher Scientific’s Edward Goucher and Alexandra Graham pictured beside KCL’s Stefania Boccuzzi and Vincenzo Abbate" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Advancing_Drug_Analysis_with_Veri_Spray_Paper_Spray_Mass_Spectrometry_040182cb06.jpg 245w," sizes="100vw" width="1024" height="512"></p><h3><strong>Why VeriSpray? A simpler, faster path to results</strong></h3><p>Traditional LC-MS workflows can be powerful, but when labs are overwhelmed by backlogs, the time and complexity of sample preparation and chromatography can be limiting. <strong>VeriSpray offers a remarkably simplified path to MS analysis</strong>, directly ionizing complex matrices using a paper substrate—no LC step required.</p><h5><strong>Key benefits include:</strong></h5><ul><li><strong>&lt;2-minute results</strong> thanks to minimal sample prep and elimination of LC</li><li><strong>Reduced cost per test</strong> by cutting solvent use and simplifying training requirements</li><li><strong>Automation-ready</strong> with support for unattended operation of up to 240 samples</li><li><strong>Seamless integration</strong> with Thermo Scientific triple quadrupole systems</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Advancing_Drug_Analysis_with_Veri_Spray_Paper_Spray_Mass_Spectrometry_2_eb1f7dacc2.jpg" alt="Thermo Fisher Scientific: Advancing Drug Analysis with VeriSpray PaperSpray Mass Spectrometry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Advancing_Drug_Analysis_with_Veri_Spray_Paper_Spray_Mass_Spectrometry_2_eb1f7dacc2.jpg 245w," sizes="100vw" width="700" height="317"></p><h3><strong>Enhancing emergency toxicology with direct MS analysis</strong></h3><p>In the emergency room, timely drug identification is critical, but clinicians often rely on patient self-report or symptom-based assessments. Stefania’s PhD research seeks to change that. Her team is developing <strong>a rapid, extraction-free method</strong> using VeriSpray PS-MS for the <strong>targeted analysis of plasma samples</strong> from patients presenting with acute drug toxicity.</p><p>By using <strong>dried matrix spots </strong>on a paper substrate and coupling this with a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/404"><strong>Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer</strong></a>, Stefania’s work provides an alternative screening technique to chromatography, <strong>delivering faster, actionable results to guide early clinical decision-making</strong>.</p><h5><strong>Key takeaways:</strong></h5><ul><li>Paper spray MS is an ambient ionization technique suitable for emergency toxicology due to its rapid results and minimal sample prep.</li><li>Enhancing the paper substrate and adding microextraction steps can <strong>boost sensitivity without sacrificing speed.</strong></li></ul><h3><strong>Substrate matters: boosting detection with paper treatment</strong></h3><p>One key limitation of PS-MS is the <strong>interference that can arise from the paper substrate itself</strong>. Marwa’s research explored nine different paper treatments, ranging from acids to solvents, to <strong>improve the signal-to-blank (S/B) ratio</strong> when analyzing eight common drugs in whole blood.</p><p>The most promising results came from <strong>formic acid </strong>and <strong>nitric acid</strong> treatments, which significantly enhanced analyte detection. Although these methods are currently time-consuming, Marwa envisions future industrial-scale production of pre-treated cartridges to support <strong>scalable clinical workflows</strong>.</p><h5><strong>Key takeaways:</strong></h5><ul><li>Substrate optimization can significantly reduce background noise in PS-MS analysis.</li><li><strong>Acid-treated paper enhances S/B ratios</strong>, enabling more reliable detection of drugs in blood.</li><li>Industrial pre-treatment could make these improvements broadly accessible.</li></ul><h3><strong>DLLME meets paper spray: improving sensitivity in plasma</strong></h3><p>Saeed Almheiri’s presentation focused on dispersive liquid-liquid microextraction (<strong>DLLME) as a sample prep technique</strong> to increase sensitivity for PS-MS analysis of drugs in plasma, without adding significant complexity to the workflow.</p><p>Using DLLME prior to VeriSpray analysis, Saeed demonstrated <strong>improved detection limits (as low as 0.3 ng/mL)</strong> across a panel of 10 drugs, including buprenorphine, cocaine, and MDMA. Importantly, this method maintained the fast, minimal-prep advantages that make paper spray ionization so appealing.<br><strong>Key takeaways:</strong></p><ul><li>DLLME enhances analyte extraction from plasma, <strong>reducing matrix effects</strong> and improving quantitation.</li><li>Combining DLLME with VeriSpray maintains a <strong>low-complexity, high-speed workflow.</strong></li></ul><h3><strong>Conclusion: a new frontier for forensic and clinical toxicology</strong></h3><p>The data shared at this workshop underscores the <strong>transformational potential of VeriSpray PaperSpray MS</strong>. Whether it’s detecting drugs in plasma for emergency toxicology, enhancing substrate performance, or integrating clever microextraction steps, researchers at KCL are proving that <strong>simplified workflows can still deliver high sensitivity and accuracy</strong>.<br><br>As toxicology labs continue to face growing backlogs and limited resources, adopting a <strong>faster path to MS analysis</strong> with VeriSpray could dramatically change how drugs of abuse are detected and quantified, <strong>getting results faster, cutting costs, and ultimately supporting better outcomes</strong> in both forensic and clinical environments.</p><h3><strong>Resources</strong>:</h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://thermofishermarcom.app.box.com/s/gmmhe84v1x9el0fqmh695uszk936iei6"><strong>Watch the full workshop on Box- 2025 Seized Drugs Symposium Workshop and the tag is Toxicology</strong></a></li><li>Explore the <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/labrulez-bucket-strapi-h3hsga3/br_65405_verispray_paperspray_ion_source_br65405_en_756e8e3ec9.pdf"><strong>VeriSpray product brochure</strong></a></li><li>Case study – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cs_002678_lsms_clinical_verispray_toxicology_cs002678_na_en_a6096123ef.pdf"><strong>Paper spray mass spectrometry simplifies and expedites turnaround of drug toxicity screening King’s College London aims to investigate its use in emergency department applications</strong></a></li><li>Case study – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/cs_000866_ms_verispray_vancouver_island_univ_cs000866_en_0f5ecbd835.pdf"><strong>How paper spray mass spectrometry facilitated harm reduction drug checking</strong></a></li><li>Past blogs in this toxicology series<ul><li>Sample prep – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6189"><strong>Sample Preparation Strategies Demystified: Choosing the Right Fit for Your Toxicology Workflow</strong></a></li><li>Tox Explorer – <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/6587"><strong>Beyond Blood: Sheffield Teaching Hospitals NHS Foundation Trust Develops HRAM-Powered Method for Post-Mortem Toxicology Analysis</strong></a></li></ul></li><li>Stay tuned to register for next years symposium at <a target="_blank" rel="noopener noreferrer" href="http://www.forensicsymposium.org">www.forensicsymposium.org</a></li><li>Check out our <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/forensics/forensic-toxicology/drug-screening-confirmation.html">drug screening and confirmation webpage</a></li></ul><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a><strong>&nbsp;#PSMS #VeriSpray #PaperSprayMS #Toxicology</strong></p><blockquote><h5><strong>Ema Ruzic</strong></h5><p>Vertical Marketing Manager, Chromatography and Mass Spectrometry Division (CMD)</p></blockquote>

Advancing Drug Analysis with VeriSpray PaperSpray Mass Spectrometry

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