This review outlines IEX fundamentals and explores advanced strategies—like pH gradients, ultra-short columns, and coupling with MS—for characterizing complex biotherapeutics.

Waters Column Coach is a helpful tool for comparing reversed-phase column selectivity. It uses the Neue Test to assess hydrophobicity and selectivity under consistent, standard conditions.

This week we bring you application notes by Agilent Technologies, Knauer, Shimadzu, Thermo Fisher Scientific and Waters Corporation!

This week we bring you application notes by Agilent Technologies, Shimadzu, Thermo Fisher Scientific and Waters Corporation!

This study evaluates matrix effects in untargeted HILIC-MS plasma metabolomics using post-column infusion, identifying optimal conditions and improving method reliability for metabolite analysis.

This week we bring you application notes by Agilent Technologies, Mestrelab Research, Shimadzu and Waters Corporation, poster by GC Image / MDCW and technical note by Thermo Fisher Scientific!

This study presents an HPLC-ICP-MS method for precise quantification of Gd complexes in Gadoquatrane, enabling detection of trace by-products to optimize synthesis and drug control strategies.

This study optimizes a HILIC method for collagen peptide mapping, evaluating stationary phases, injection techniques, and MS coupling to enhance peptide separation and hydroxylation analysis.

This study investigates how mobile phases and chromatographic conditions affect siRNA duplex stability, using DSC and chromatography to measure melting temperatures.

This study introduces a novel remote deep-UV laser ablation dual-ionization source for molecular mass spectrometry and imaging with enhanced spatial resolution.