Coumarin-Based Photolabile Solid Support Facilitates Nonchromatographic Purification of RNA Oligonucleotides
A coumarin-based photocleavable solid support allows visible-light release and nonchromatographic purification of RNA oligonucleotides, including UV-sensitive phosphorothioate backbones.
Single-atom-enhanced membrane for simultaneous bacteria and heavy metal on-site water treatment
A portable graphene-based single-atom membrane enables one-step removal of bacteria and heavy metals using a hand-powered vacuum, achieving high efficiency and reusability for off-grid water treatment.
Evaluation of a Prototype Orbitrap Astral Zoom Mass Spectrometer for Quantitative Proteomics Beyond Identification Lists
Benchmarking revealed that the Orbitrap Astral Zoom prototype outperforms the standard Astral MS, sampling more ions per peptide and delivering improved sensitivity and quantitative precision in DIA proteomics.
Comparative Assessment of the Chemical Composition of Locally Cultivated and Imported Hops (Humulus lupulus L.) in Brazil Using Chemometrics
Chemometric GC×GC–MS analysis revealed that Brazilian hop cultivars are chemically similar to imported hops of the same type, with differences in selected terpenes relevant to brewing quality.
Evaluation of the Long-Term Administration of Proton Pump Inhibitors (PPIs) in the Mineral Nutrient’s Bioavailability
Long-term administration of proton pump inhibitors affected mineral bioavailability and blood parameters in rats, suggesting risks of iron, calcium, and copper deficiency.
Sequential versus Simultaneous Quantitative Analysis of Biomarkers in Individual Cells by ICP-MS and Mass Cytometry: A Focus on Immunotherapy
Sequential and simultaneous single-cell analysis by ICP-MS and mass cytometry provided comparable biomarker quantification, supporting their use in immunotherapy-related studies.
Exploring Domestic Discharge Patterns in Wastewater through LC-HRMS Screening and Temporal Clustering
LC-HRMS screening combined with temporal clustering identified daily domestic discharge patterns in wastewater, enabling improved interpretation of population chemical exposure.
Persistence-Directed Testing of Chemicals Discharged from Offshore Oil Platforms Combined with Nontargeted Analysis
A novel persistence-directed testing approach combined with nontarget GC-MS and LC-HRMS revealed a significant fraction of persistent chemicals in offshore oil platform produced waters.
Enhancing addiction care: Benefits of urinary screening with LC-HRMS (liquid chromatography-high resolution mass spectrometry) for psychoactive substances and drugs
LC-HRMS detected more prescribed and non-prescribed drugs than immunoassays and would have influenced clinical decisions for 25% of patients, mainly those with opioid-use history.
The 13th Conference of Czech Society for Mass Spectrometry & 11th Informal proteomic meeting - Day 1
Day 1 in České Budějovice featured an Orbitrap plenary by Alexander Makarov, sessions on exposome, proteomics and structural MS, sponsor talks, flash talks and an evening networking reception.
