<h4>Welcome to “Analytically Speaking,” the podcast from LCGC International and Spectroscopy.</h4>
In this episode, podcast host Dr. Dwight Stoll talks with Dr. Katelynn Perrault Uptmor, <a href="https://gcms.labrulez.com/articles?search=Pierre-Hugues+Stefanuto">Dr. Pierre-Hugues Stefanuto</a>, and <a href="https://gcms.labrulez.com/articles?search=Petr+Vozka">Dr. Petr Vozka</a> about the multidimensional chromatography workshop, better known as the MDCW for short. Kate, PH, Petr, and Dwight are co-organizers of the MDCW workshop, which was held most recently at California State University, Los Angeles.
In their conversation they discuss how the MDCW is different from, and similar to, conventional scientific conferences. They reflect on <a href="https://gcms.labrulez.com/events/436">the most recent (15th) meeting</a>, including highlights from both the technical and social programs, and in the impact on the local student community at Cal State LA. Then, they switch gears and look forward to <a href="https://gcms.labrulez.com/events/518">the 16th MDCW</a>, which will be held February 3-5 at the University of Liege, in Liege, Belgium.
<blockquote>
Audio 🎧 <a href="https://soundcloud.com/analytically-speaking/ep-22-around-the-world-with-the-multidimensional-chromatography-workshop">Analytically Speaking: Ep. 22: Around the world with The Multidimensional Chromatography Workshop</a> 
</blockquote>
<h5>Resources Discussed</h5>
<ul>
<li><a href="http://www.multidimensionalchromatography.com/">MDCW Website</a></li>
<li><a href="https://labrulez.com/">LabRulez Website</a></li>
</ul>
<blockquote>
💡 Recordings of lectures available at <a href="https://www.youtube.com/playlist?list=PLg-M6fM-05MrGrDggkl_UKzzcHPWPmssh">YouTube playlist The Multidimensional Chromatography (MDC) Workshop</a>
</blockquote>
<blockquote>
💡 Further information can be found on <a href="https://gcms.labrulez.com/companies/218">The Multidimensional Chromatography (MDC) Workshop profiles on LabRulezGCMS and LabRulezLCMS portals</a>
</blockquote>
<h4>More about our hosts:</h4>
<h5>Dwight Stoll, PhD:</h5>
Dwight R. Stoll is a professor of chemistry at Gustavus Adolphus College in St. Peter, Minnesota. He received his PhD from the University of Minnesota, under Professor Peter Carr, working on the development of fast, comprehensive two-dimensional liquid chromatography (2D-LC). Stoll’s current primary research focus is on the development of 2D-LC for both targeted and untargeted analyses. Active research projects in his laboratory touch on most aspects of multidimensional separation methodologies, including optimization strategies, characterization of selectivity in reversed-phase LC, instrument development, and applications in biopharmaceutical analysis. Stoll is the author or co-author of more than 80 peer-reviewed publications and six book chapters and has instructed numerous short courses in 2D-LC. In 2011 he was the recipient of LCGC’s Emerging Leader in Chromatography Award. In 2017 he received the Georges Guiochon Faculty Fellowship, and was recognized with an Agilent Technologies Thought Leader Award. He is also a member of LCGC’s editorial advisory board and is the editor of the “LC Troubleshooting” column in LCGC.
<h5>Jerome Workman, Jr., PhD:</h5>
Jerome (Jerry) J. Workman, Jr. is the Senior Technical Editor for LCGC and Spectroscopy. He has held positions as CTO, executive VP, senior research fellow, director, and senior scientist at companies of all sizes, from start-ups to world-leading corporations. He has been an adjunct faculty member of four universities and advised multiple graduate students. He has more than 75 U.S. and international patent applications and 30 issued U.S. and international patents and multiple trade secrets, as well as 500+ technical publications, and 20 reference book volumes on a broad range of spectroscopy and data processing techniques. He has received multiple awards from scientific societies, and has taught annual courses in spectroscopy, chemometrics, and statistics for the AOAC, ACS, ISA, FACSS, and at several universities and corporations. He is a Fellow of the American Institute of Chemists (FAIC), the American Society for Testing and Materials (ASTM), and the Royal Society of Chemistry in the UK (FRSC, CChem, CSci). Jerry holds B.A and M.A degrees from Saint Mary&#39;s University of Minnesota, and a PhD degree from Columbia Pacific University working in near-infrared spectroscopy. He is an alumnus of both Columbia University Business School and the MIT Sloan School of Management.
<h4>About the Analytically Speaking Podcast:</h4>
Analytically Speaking, the podcast from LCGC and Spectroscopy, addresses important issues in separation science and analytical spectroscopy. Topics include new analytical techniques, methods, and approaches; the latest trends; advances in instrument and software technology; practical solutions for specific applications; recent papers in the scientific literature and their applicability; challenges and solutions for data analysis and interpretation; analytical chemistry theory and fundamentals (from advanced research to tutorials and troubleshooting); and more. Our regular hosts are Dwight Stoll, PhD, a professor of chemistry at Gustavus Adolphus College in St. Peter, Minnesota, and Jerry Workman, PhD, a spectroscopist, noted author, and currently the Senior Technical Editor of Spectroscopy and LCGC. Dwight covers separation science and Jerry addresses spectroscopy related topics.

Around the world with The Multidimensional Chromatography Workshop

Los Angeles, CA – This January, Cal State LA became a hub for scientists and researchers as it hosted the 15th Multidimensional Chromatography Workshop. From January 10 to 12, 2024, the event brought together leading experts and those new to the field of multidimensional chromatography, focusing on the latest techniques and developments.
Organized by Drs. Katelynn Perrault Uptmor (William &amp; Mary), Pierre-Hugues Stefanuto (University of Liège), Dwight Stoll (Gustavus Adolphus College), and Petr Vozka (California State LA), the workshop featured talks and presentations on key trends in multidimensional gas and liquid chromatography from both academic and industry leaders.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Complex_Chemical_Composition_Analysis_Lab_C_AL_Cal_State_LA_hosts_15th_Multidimensional_Chromatography_Workshop_2_a9147b68cc.jpg" alt="Complex Chemical Composition Analysis Lab (C³AL): Cal State LA hosts 15th Multidimensional Chromatography Workshop."/>
The workshop featured keynote and contributed presentations and discussion groups on important topics like new technology, data analysis, and practical applications in various fields. A highlight was the poster session, where researchers competed for awards sponsored by the American Chemical Society, showcasing the workshop&#39;s role in supporting new scientific discoveries.
Thanks to the generous backing of sponsors such as LECO, JEOL, SepSolve Analytical, GC Image, Spectral Works, RESTEK, Thermo Fisher, TRAJAN, VICI DBS, Chemistry Matters and the Cal State LA Scholarship, and Creative Activities, along with CREST CATSUS and Sikand SITI Center, admission to the workshop was free.
<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Complex_Chemical_Composition_Analysis_Lab_C_AL_Cal_State_LA_hosts_15th_Multidimensional_Chromatography_Workshop_3_4c2502883b.jpg" alt="Complex Chemical Composition Analysis Lab (C³AL): Cal State LA hosts 15th Multidimensional Chromatography Workshop."/>
Dr. Krishna Foster, Chair of the Department of Chemistry and Biochemistry, opened the event with a welcoming speech that underscored the importance of chromatography in research, particularly in her own field of atmospheric chemistry. She highlighted California State University, Los Angeles&#39;s unique character as a &quot;people&#39;s university&quot; that champions diversity, equity, and nurturing talent from all backgrounds. Dr. Foster&#39;s speech set the tone for the event and spotlighted the university&#39;s commitment to sustainability and the integration of natural and social sciences.
Special thanks are extended to the students of <a href="https://gcms.labrulez.com/companies/219">C3AL</a> for their invaluable assistance during the event.
The conference is held annually, and further information about future events can be found at <a href="www.multidimensionalchromatography.com">www.multidimensionalchromatography.com</a>
<h4>Presentations from the 15th Multidimensional Chromatography Workshop were recorded and are available online.</h4>
Watch the <a href="https://www.youtube.com/playlist?list=PLGv1zjkq8eaB87EPMLGrAm473bAmsgbjj">whole playlist</a> or follow the links below for particular lecture.
<ul>
<li><a href="https://www.youtube.com/watch?v=mYxG6SdiiyQ">GC×GC-TOFMS/FID hydrocarbon group-type analysis of plastic-derived oils (Christina Kelly, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=aDa3pApEPKY">Multi-omics workflow for blood serum screening using GC×GC-TOFMS (Pierre-Hugues Stefanuto, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=PxVRSslhoF4">Off-line LC×SFC-HRMS/MS non-target analysis of depolymerised lignin (Eliise Tammekivi, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=Q2U73RcxnRk">Alkene quantification in plastic waste-derived fuels using GC×GC-FID (Genesis Barzallo, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=4vk8bUGHwGM">Streamlining group type analysis with GC×GC templates V-A alignment (Daniel Geschwender, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=scQGzl54RAs">Don’t let the realityof GC×GC-MS data burst your bubble! (James Harynuk, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=DtHpfwil5nQ">Chemical characterization of the aircraft cabin environment by GC×GC-TOFMS (Kevin Hayes, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=pWMEkg4Yn6c">Sampling body odor for healthcare monitoring: how to avoid the pitfalls (Elsa Boudard, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=_N8urY1yl8I">Exploring arson investigations with multi-dimensional chromatography (Gwen O&#39;Sullivan, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=Qo9ywERlTH4">Automated online multicolumn 2D-LC screening as a rapid and efficient tool (Heather Wang, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=y7P6PJ_K8Sk">Extending boiling point range using PLOT columns and GC×GC-MS (Lina Mikaliunaite, MDCW 2024)</a>
</li>
<li><a href="https://www.youtube.com/watch?v=SpsGHl5erqw">Sensory-classified roasted arabica coffee with GC×GC-TOFMS and chemometrics (Caitlin Cain, MDCW 2024)</a>
</li>
<li><a href="https://gcms.labrulez.com/companies/218">Expanding the scope of tile-based GC×GC–TOFMS data analysis (Robert Synovec, MDCW 2024)</a>
</li>
<li><a href="https://gcms.labrulez.com/companies/218">Changes validate breath signatures of acute respiratory exacerbations (Michael Wilde, MDCW 2024)</a>
</li>
</ul>

Cal State LA hosts 15th Multidimensional Chromatography Workshop

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 23rd September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Shimadzu, Thermo Fisher Scientific, and a presentation by LECO!<h4>1. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_09_SSK_019_en_5e1bde719c.pdf">Analysis of Epichlorohydrin in Water using HS- GC/MS</a></h4><ul><li>Application</li></ul>User Benefits<ul><li>Water samples can be analyzed with a simple preparation.</li><li>Using a headspace autosampler, the analysis of epichlorohydrin in water quality can be performed conveniently.</li></ul>IntroductionEpichlorohydrin (ECH) is primarily used in the production of various resins (epoxy, ion exchange, etc.) and synthetic glycerin. Additionally, it is used as a stabilizer for carbon containing products in surfactants, plasticizers, dyes, and pharmaceuticals1). Some studies have demonstrated that damage to the nasal passages, respiratory tract and kidneys occurred in rodents exposed to epichlorohydrin. It has been observed that exposure to ECH induced a high nasal cancer response in rats, therefore, the United States Environmental Protection Agency (EPA) has classified epichlorohydrin as a “probable” human carcinogen (Group B2).According Water Pollutants of Water Environment Conservation Act, the permissible discharge limits of ECH in water were 0.03 to 0.3 mg /L by the classified area. The test method for ECH analysis in water is "Epichlorohydrin-Solvent Extraction/Gas Chromatography-Mass Spectrometry (ES 04608.1)" as the official test method of water pollution.2)The ES 04608.1 was used to extraction method with a large volume of solvent, it caused high consumption of solvent and long time of preparation. To solve these disadvantages, analysis of ECH in water in this application was performed using HS-20 NX headspace sampler without sample pretreatment.This application demonstrates the validation of a method for analysis of ECH in water samples using HS-GC/MS (Fig. 1) to meet the demanded levels of ES 04608.1 in Korea.ConclusionsThis Application news demonstrated the use of a Shimadzu GCMS-QP2020 NX coupled HS-20 NX for measurement of ECH in water. The proposed analytical method was with good validation parameters, such as linearity, MDL, LOQ, accuracy and precision which was satisfied the criteria of standard method (ES 04608.1) in Korea.<h4>2. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_ethylene_oxide_2_chloroethanol_8890_7010_gcms_5994_7720en_agilent_337dc4394d.pdf">Estimation of Ethylene Oxide and 2-Chloroethanol in Spices and Oilseeds Using QuEChERS Extraction and GC/MS/MS</a></h4><ul><li>Application</li></ul>AbstractThis application note demonstrates the use of an Agilent 8890 GC system coupled with an Agilent 7010 GC/MS triple quadrupole mass spectrometry system to detect and quantify ethylene oxide (EtO) and 2-chloroethanol (2-CE) simultaneously in foodstuffs such as flaxseed, cumin powder, and red chili powder. Sample preparation was done using QuEChERS extraction and a dispersive cleanup process followed by injection into GC/MS/MS through liquid injection. A limit of quantification (LOQ) of 10 ppb for both compounds was achieved in matrix. Average recoveries ranged from 75 to 86% for both compounds.IntroductionEtO is used to sterilize foods to eliminate insects and bacteria, such as salmonella. Ethylene chlorohydrin, or 2-CE, is a derivative produced by the reaction of EtO with chlorine ions present in foodstuff. Use of EtO is banned in the European Union (EU) due to its carcinogenic and toxic properties.Previously, methods for analysis of EtO (EtO and 2-CE) have been developed that include acidic conversion of EtO to 2-CE. These methods are time-consuming, labor-intensive, and require large quantities of harmful solvents. Due to the volatile nature of EtO, sample preparation is crucial. In December 2020, the EU Reference Laboratories (EURL) for Residues of Pesticides recommended a single-residue method for the analysis of EtO and 2-CE in sesame seeds using QuEChERS extraction followed by GC/MS/MS analysis. The method adopted in this work demonstrates the use of an automated liquid sampler for sample introduction to the 8890 GC system coupled with a 7010 GC/MS triple quadrupole mass spectrometry system.ConclusionAn accurate and rugged method was developed which meets the requirements of the EURL for a single-residue method that uses QuEChERS extraction followed by GC/MS/MS analysis for the analysis of EtO and 2-CE in flaxseed, cumin powder, and red chili powder. The LOQ of the method was demonstrated at 10 ng/g for all the tested matrices. Repeatable results are found for 6 successive replicates of matrix-based standards at 10 ng/g concentration levels for EtO and 2-CE. Excellent recoveries were obtained for both EtO and 2-CE in all tested matrices at 20 and 50 ng/g spiked concentration levels. Thus, this study demonstrates the usefulness of the developed method for the routine analysis of food samples for EtO and 2-CE at trace levels.<h4>3. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/An_advanced_integrated_GC_MS_MS_and_LC_MS_MS_workflow_for_the_comprehensive_analysis_of_pesticide_residues_in_food_a5878f2c6b.pdf">An advanced integrated GC-MS/MS and LC-MS/MS workflow for the comprehensive analysis of pesticide residues in food</a></h4><ul><li>Application</li></ul>GoalAnalysis of proficiency test (PT) samples to demonstrate the benefits of combining GC-MS/MS and LC-MS/MS with the innovative Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) for improving laboratory efficiency in the analysis of multi-class pesticide residues in food.Keywords: Pesticide residues analysis, comprehensive pesticides workflows, QuEChERS, LC-MS/MS, GC-MS/MS, Chromeleon CDS, cross-confirmation, targeted quantitation, automated data review.BackgroundAccording to the World Health Organization, more than one thousand different pesticides are used to protect crops from pests to increase crop yields and to minimize deterioration of agricultural products during post-harvest storage and transportation. However, inappropriate use of pesticides can result in contamination of the food supply, making it essential to define and monitor pesticide residue targets to protect consumer health, support trade, and establish food regulatory control.1Consequently, laboratories are tasked to develop methods to detect, correctly identify, and quantitate hundreds of different pesticides and their transformation products in hundreds of different sample matrices, in compliance with Maximum Residue Levels (MRLs) set by regulatory bodies.Data analysis of pesticide residues in food typically requires numerous performance checks including retention time, ion ratios, calibration curves, recovery, and precision. Data review of thousands of data values in a single chromatographic run and checking compliance against quality control criteria such as the EC SANTE guidelines2 are some of the most time-consuming tasks in pesticides analysis.Therefore, it is essential that workflows cover a broad pesticides scope, are sensitive and robust, and are as productive and efficient as possible to achieve compliance with regulations while meeting business goals such as return on investment (ROI), sample turnaround times, and cost-per-sample targets.An innovative approachIn response to this challenge, new pre-configured “out of the box” pesticide workflows based on the latest Thermo Scientific™ GC-MS/MS and LC-MS/MS instruments and Chromeleon CDS 3 have been specifically designed for multi-class pesticides analysis.These solutions include the hardware, software, built-in instrument acquisition methods, and customizable data processing methods including view settings and report templates, along with details of sample extraction and consumables for fast implementation.This new approach, which enables the detection, identification, and quantitation of up to 700 pesticides by GC-MS/MS and LC-MS/MS, combines results in a unique software user interface to confirm the identity of residues quickly and accurately, especially those amenable by both techniques.This automated cross-confirmation increases confidence in the data by minimizing the risk of false positive and false negative results while increasing productivity by reducing the need for repeat sample injections when either the LC-MS/MS or GC-MS/MS analysis is subject to interference. This is especially the case for more difficult samples that contain high amounts of matrix co-extractives.Proof statementLaboratories are often required to undertake blind analysis of PT samples containing an unknown number of unspecified pesticides. Assessing PT samples is an independent and more realistic test of the laboratory’s methods and procedures.In this application brief, the analysis of PT samples was undertaken to evaluate the analytical performance of the new integrated GC-MS/MS and LC-MS/MS pesticides workflow and to illustrate the benefits of the new software features.<h4>4. LECO: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_12_Characterization_and_Quantitative_Hydrocarbon_Group_Type_Analysis_of_Plastic_Derived_Pyrolysis_Oils_by_G_Cx_GC_TOFMS_FID_0a253a5d5e/O-12-Characterization-and-Quantitative-Hydrocarbon-Group-Type-Analysis-of-Plastic-Derived-Pyrolysis-Oils-by-GCxGC-TOFMS-FID.pdf">Characterization and Quantitative Hydrocarbon Group-Type Analysis of Plastic-Derived Pyrolysis Oils by GCxGC-TOFMS/FID</a></h4><ul><li>Presentation / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/218">MDCW</a></li></ul>Outline<ul><li>Pyrolysis Oils Characterization Workflow</li><li>Plastic-Derived Pyrolysis Oil Samples</li><li>Choosing a GCxGC system</li><li>Benefits of the Pegasus BT 4D MS</li><li>Benefits of the Paradigm Shift System</li><li>Choosing a GCxGC column set…</li><li>Mapping out the GCxGC Space</li><li>Group-Type Analysis of Pyrolysis Oils</li><li>ChromaTOF TILE</li><li>Areas of Interest + PCA</li><li>Comparing Trends of Multiple Features</li><li>Benefits of the Pegasus HRT+ 4D</li><li>Benefits of the Multi-Mode Source (MMS)</li><li>Pegasus HRT+ 4D Data Processing Workflows</li><li>High-Resolution, Accurate Mass Data</li><li>Mass Defect: Nitrogen-Containing Species</li><li>Mass Defect: Sulfur-Containing Species</li><li>Leveraging High Resolution Mass Accuracy</li><li>Conclusion</li></ul>

News from LabRulezGCMS Library - Week 39, 2024

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Measuring what matters: water quality analysis with UV-Visible spectrophotometry

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Mastering Geological Sample Preparation: Strategies for Complete Digestion and Low Blanks