<p><strong>Multiscale materials are assembled from different types of nanomaterials, which themselves have unusual properties. By combining and integrating them into higher-order hierarchies, smart matter with unique functionalities and surprising applications in many different fields can be obtained. A consortium of eight partners from academia and research, led by the J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, has received financial support from the Programme Johannes Amos Comenius of the Ministry of Education, Youth and Sports in the amount of CZK 480 million for research with this focus. Specifically, it was the Excellent Research Call aimed at supporting research with the potential for excellent results applicable in practice.</strong></p>
<p>The development of advanced materials with the required parameters and their integration into functional structures while maintaining their maximum utility value is the common denominator of modern materials research. Current directions in materials science draw inspiration from nature, where beyond naturally occurring elements and compounds, nature enables so-called material genetics, i.e. the targeted folding and &quot;cross-breeding&quot; of material components in 3D space.</p>
<p>Scientists are combining zero-dimensional (quantum dots), one-dimensional (e.g. nanotubes), and two-dimensional (e.g. graphene) materials in the lab to give them new and unusual properties. The challenge is to develop advanced, so-called multiscale materials with a wide range of applications, e.g. in electrical engineering, medicine, or environmental technologies.</p>
<p>Eight partners cooperate in the AMULET (Advanced MUltiscaLe materials for key Enabling Technologies) project. The coordinator is the <a href="https://www.jh-inst.cas.cz/"><strong>J. Heyrovsky Institute of Physical Chemistry of the CAS</strong></a>. Other members of the consortium involve the Institute of <a href="https://lcms.labrulez.com/companies/62"><strong>Organic Chemistry and Biochemistry of the CAS</strong></a> (PI: <a href="https://cigler.group.uochb.cz/cs"><strong>Dr. Petr Cígler</strong></a>), the Faculty of Science of Jan Evangelista Purkyně University in Ústí nad Labem, the Institute of Photonics and Electronics of the CAS, the Institute of Physics of the CAS, the Faculty of Mathematics and Physics and the Faculty of Science of Charles University, the Nuclear Physics Institute of the CAS and the <a href="https://lcms.labrulez.com/companies/11"><strong>University of Chemistry and Technology in Prague</strong></a>.</p>
<p>Linking the above institutions aims to promote the widest possible use of the anticipated newly developed unique materials. Experts will investigate how multiscale materials interact with the biological environment, whether they can be used for electrochemical or optical sensors, in electro-photochemical catalysis for the removal of pollutants from air and water, and last but not least, they will test new nano/micro-devices that can be used for energy conversion, production, and storage.</p>
<p>The AMULET project succeeded in the competition of 66 projects submitted to the Excellent Research call in the Programme Johannes Amos Comenius. This call is aimed at supporting research with the potential for excellent results applicable in practice. In total, 26 projects were supported for a total value of CZK 12.2 billion. The money is earmarked for excellent research teams, which will help Czech scientific institutions deepen their relations with foreign partners and strengthen the Czech Republic&#39;s competitiveness in the long run.</p>


Material genetics will be pursued by the AMULET project, which succeeded in the Excellent Research Call

Quantitative determination of olefins in pyrolysis oils from waste plastics and tires using selective adsorption by Ag–SiO2 followed by GC×GC-FID

<h3><strong>Chiral ION-QN &amp; Chiral ION-QD</strong></h3><p><i>Weak Anion-Exchanger (WAX) stationary phases for reliable chiral separation of acidic compounds</i></p><h4><strong>Transform Your Chiral Analysis</strong></h4><p>One of the main challenges of today’s liquid chromatography is chiral separation of ionised and ionisable analytes, e.g., organic acids, amino acids, N-protected amino acids, amino acid mimics, etc. The most efficient approach to purify and resolve such troublesome racemates utilises ion exchange-type stationary phases that facilitate strong interactions between the chiral selector and the analyte.</p><p>Galochrom introduces its own generic series of weak anion-exchangers, based on <i>tert</i>-butyl-carbamoylated Cinchona alkaloids quinine (QN) and quinidine (QD). These chiral phases have demonstrated excellent selectivity and improved peak resolution, resulting in highly accurate and replicable analyses. Our innovative manufacturing and strict quality control ensure that these generic columns not only outperform commercial alternatives, but also meet your technical requirements.</p><blockquote><p><span style="font-size:20px;"><strong>Chiral ION-QN &amp; Chiral ION-QD represent the most efficient approach to purify and resolve even the most challenging mixtures.</strong></span></p></blockquote><h4><strong>Applications</strong></h4><p>Chiral ION-QN &amp; Chiral ION-QD are ideal for enantioseparations of:</p><ul><li><strong>N-protected amino acids</strong></li><li><strong>Aminophosphonic &amp; Aminosulfonic acids</strong></li><li><strong>Lactic &amp; Thiolactic acids</strong></li><li><strong>Clenbuterol &amp; Thyroxin</strong></li></ul><h4><strong>Upgrade your separation performance and gain:</strong></h4><ul><li><strong>Premium enantioselectivity</strong></li><li>Elegant <strong>switch of the elution order of enantiomers</strong></li><li><strong>High-stability</strong> against all common HPLC solvents</li><li><strong>Seamless method transfer</strong></li></ul><h3><strong>Powerful Selectivity</strong></h3><p><i>Aim for the best resolution and selectivity possible</i></p><p>In collaboration with dozens of researchers, we have selected the best-performing derivatives of both quinine (QN) and quinidine (QD). As a result, the Chiral ION-QN features O-9-(tert-butylcarbamoyl)quinine, which is immobilized on fully-porous spherical silica (see below). The unique chiral scaffold of the cinchona backbone provides exceptional selectivity for wide array of acidic compounds.</p><p>The Chiral ION-QD features structurally similar selector to Chiral ION-QN. As a result, these selectors, while being diastereomers, act as pseudo-enantiomers. <strong>This feature enables elegant switch of elution order of enantiomers, which is often challenging for other chiral stationary phases.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_3_18e49ab8ee.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - Transform Your Chiral Analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_3_18e49ab8ee.jpg 241w," sizes="100vw" width="1908" height="1238"></p><h4><strong>Molecular recognition</strong></h4><p>The prime driving force for specific molecular association are electrostatic or ionic interactions. Once analyte reaches close proximity of the selector, weaker non-bonding interactions such as H-bonding, <span class="symbol">π</span>−<span class="symbol">π</span> stacking and steric interactions apply. These directive interactions result in different column retention per each enantiomer.</p><p><strong>Since analytes differ in combination and strength of these binding increments, our chiral stationary phase delivers superior molecular recognition.</strong></p><h4><strong>Supporting professionals across many industries</strong></h4><ul><li>Forensic Science</li><li>Chemical Manufacturing</li><li>Biotechnology</li><li>Agriculture</li><li>Academic Research&nbsp;</li><li>Pharmaceuticals</li><li>Food &amp; Quality Control</li></ul><h3><strong>Popular chiral columns</strong></h3><p><i>Essential tools with a wide range of applications</i></p><h4><strong>Find your best match</strong></h4><p>There are hundreds of chiral stationary phases available on the market. The selection of chiral HPLC columns below represents the most popular and top-performing choices for analysis and resolution of chiral acidic compounds. Displayed data are relevant to analytical and semi-preparative scale</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_4_5d48236baa.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - Transform Your Chiral Analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_4_5d48236baa.jpg 224w," sizes="100vw" width="1508" height="1052"></p><h4><strong>Take Full Advantage Of Unique Selectivity And Expand Your Research Possibilities</strong></h4><p>Chiral ION-QN &amp; Chiral ION-QD now available at <strong>ANALYTICAL &amp; PREPARATIVE</strong> scale</p><h3><strong>Order information</strong></h3><h4><strong>Analytical Columns</strong></h4><h5><strong>Chiral ION-QN</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 3</strong></li><li>Porosity: [Å] 200</li><li>Cat. No.: ION01-A150</li><li><strong>Price [€]: 1 300</strong></li></ul><h5><strong>Chiral ION-QD</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 3</strong></li><li>Porosity: [Å] 200</li><li>Cat. No.: ION02-A150</li><li><strong>Price [€]: 1 300</strong></li></ul><p><span style="font-size:12px;">*As an alternative, we can also offer 150x3 mm, 3 μm with 120 Å</span></p><h4><strong>Preparative Columns</strong></h4><h5><strong>Chiral ION-QN</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION03-P150</li><li><strong>Price [€]: 9 800</strong></li></ul></li><li><strong>Dimensions [mm]: 250 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION04-P250</li><li><strong>Price [€]: 11 300</strong></li></ul></li></ul><h5><strong>Chiral ION-QD</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION05-P150</li><li><strong>Price [€]: 9 800</strong></li></ul></li><li><strong>Dimensions [mm]: 250 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION06-P250</li><li><strong>Price [€]: 11 300</strong></li></ul></li></ul><blockquote><h3><strong>SPECIAL OFFER 1+1</strong></h3><p><span style="font-size:22px;"><strong>Buy 1 preparative column and get analytical column for FREE</strong></span></p><p>You can choose 150x4 or 250x4 column with the same sorbent as your preparative column.</p></blockquote>

Chiral ION-QN & Chiral ION-QD HPLC columns - Transform Your Chiral Analysis

<h3><strong>Method Development</strong></h3><p><i>Develop robust methods that are easily transferable across laboratories</i></p><h4><strong>Engineered for reliable method development</strong></h4><p>Successful methods rely on results that can tolerate minor variations in chromatographic parameters. It is very important<br>to have proper tools to easily and quickly develop robust methods. Chiral ION-QN and Chiral ION-QD are designed to<br>provide you with accurate and consistent results, that are transferable across different LC system platforms. You can<br>rapidly develop methods in several chromatographic modes:</p><ul><li><strong>Normal-phase</strong></li><li><strong>Reversed-phase</strong></li><li><strong>Polar organic</strong></li><li><strong>SFC</strong></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1241"><strong>Chiral ION-QN</strong></a><strong> &amp; </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1240"><strong>Chiral ION-QD</strong></a></h4><ul><li><strong>Consistent performance:</strong> Make your results easily transferable</li><li><strong>Remarkable selectivity:</strong> Easily separate closely eluting peaks</li><li><strong>Ideal for method development:</strong> Reduce your time and costs spent</li></ul><h4><strong>How can Galochrom columns enhance your methods?</strong></h4><ul><li><strong>Consistent reproducibility: </strong>Eliminate process variance and achieve your results with confidence</li><li><strong>Seamless method scale-up: </strong>Transform your analytical method into preparative purification</li><li><strong>Save time and money: </strong>Spend more time on efficient separations and less time on troubleshooting</li><li><strong>Better peak shapes: </strong>Easily resolve even the most challenging mixtures</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Method_Development_and_Preparative_Chiral_ION_QN_and_Chiral_ION_QD_columns_Consistent_reproducibility_Seamless_method_scale_up_Save_time_and_money_Better_peak_shapes_4b220cd029.jpg" alt="Galochrom: Consistent reproducibility, Seamless method scale-up, Save time and money, Better peak shapes." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Method_Development_and_Preparative_Chiral_ION_QN_and_Chiral_ION_QD_columns_Consistent_reproducibility_Seamless_method_scale_up_Save_time_and_money_Better_peak_shapes_4b220cd029.jpg 245w," sizes="100vw" width="921" height="175"></p><h3><strong>Preparative columns</strong></h3><p><i>Obtain higher throughput while maintaining your product quality</i></p><h4><strong>Optimized loading parameters</strong></h4><p>Our preparative columns provide optimized properties for the purification of wide array of compounds. Some of their inherent parameters include:</p><ul><li>High surface area for increased loading</li><li>Smooth silica for stable packed beds</li><li>Optimal particle and pore size for outstanding performance</li><li>Exceptional quality of silica for column longevity</li></ul><h4><strong>Uniform media with intact particles</strong></h4><p>Our state-of-art packing process eliminates potential bed collapse and ensures longer column lifetime. The combination of optimal slurry amounts and packing<br>pressure significantly reduces column-to-column variability. As a result, each column contains uniform stationary phase with optimal packing density.</p><h4><strong>Technical information</strong></h4><ul><li><strong>Particle Size [μm]:</strong> 5</li><li><strong>Pore Size [Å]:</strong> 120</li><li><strong>Surface Area [m²/g]:</strong> 300</li><li><strong>pH Stability:</strong> 2-8</li><li><strong>Max. Pressure [bar]: </strong>200</li><li><strong>Max. Temperature:</strong> 50 °C</li><li><strong>Silica Morphology:</strong> Spherical, fully porous</li><li><strong>Endcapping:</strong> Yes</li></ul><p>Moreover, you can order custom column dimensions along with preferred particle size.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Method_Development_and_Preparative_Chiral_ION_QN_and_Chiral_ION_QD_columns_Preparative_Chiral_ION_QN_and_Chiral_ION_QD_columns_ac8fd1acff.jpg" alt="Galochrom: Preparative Chiral ION-QN &amp; Chiral ION-QD columns." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Method_Development_and_Preparative_Chiral_ION_QN_and_Chiral_ION_QD_columns_Preparative_Chiral_ION_QN_and_Chiral_ION_QD_columns_ac8fd1acff.jpg 245w," sizes="100vw" width="2026" height="1229"></p><h3><strong>Order information</strong></h3><h4><strong>Analytical Columns</strong></h4><h5><strong>Chiral ION-QN</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 3</strong></li><li>Porosity: [Å] 200</li><li>Cat. No.: ION01-A150</li><li><strong>Price [€]: 1 300</strong></li></ul><h5><strong>Chiral ION-QD</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 3</strong></li><li>Porosity: [Å] 200</li><li>Cat. No.: ION02-A150</li><li><strong>Price [€]: 1 300</strong></li></ul><p><span style="font-size:12px;">*As an alternative, we can also offer 150x3 mm, 3 μm with 120 Å</span></p><h4><strong>Preparative Columns</strong></h4><h5><strong>Chiral ION-QN</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION03-P150</li><li><strong>Price [€]: 9 800</strong></li></ul></li><li><strong>Dimensions [mm]: 250 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION04-P250</li><li><strong>Price [€]: 11 300</strong></li></ul></li></ul><h5><strong>Chiral ION-QD</strong></h5><ul><li><strong>Dimensions [mm]: 150 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION05-P150</li><li><strong>Price [€]: 9 800</strong></li></ul></li><li><strong>Dimensions [mm]: 250 x 20</strong><ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION06-P250</li><li><strong>Price [€]: 11 300</strong></li></ul></li></ul><blockquote><h3><strong>SPECIAL OFFER 1+1</strong></h3><p><span style="font-size:22px;"><strong>Buy 1 preparative column and get analytical column for FREE</strong></span></p><p>You can choose 150x4 or 250x4 column with the same sorbent as your preparative column.</p></blockquote>

Method Development & Preparative Chiral ION-QN & Chiral ION-QD columns

Synthesis and absolute configuration of cyclic synthetic cathinones derived from α-tetralone

<p><strong>On 14–15 April 2025, the Faculty of Pharmacy of Charles University in Hradec Králové hosted the First Annual International Conference of the project New Technologies for Translational Research in Pharmaceutical Sciences (NETPHARM), co-funded by the Jan Amos Komenský Operational Programme (OP JAK). The project aims to bridge cutting-edge pharmaceutical research with clinical practice and the application sphere, advancing the development of new therapeutic approaches, (nano)formulations, and advanced drug delivery systems.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_3_b6c493b2d0.jpg" alt="FF UK/Ing. Jan Škop/Mgr. Martina Kopecká Jurčeková: Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_3_b6c493b2d0.jpg 208w," sizes="100vw" width="1200" height="900"></p><p>The conference was opened with an introductory speech by the Dean of the Faculty of Pharmacy of Charles University, <strong>Assoc. Prof. Jaroslav Roh</strong>, followed by an overview of the NETPHARM project, which was presented by the research project manager <strong>Prof. Petr Pávek</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/FF_UK_Successful_Gathering_of_Leading_Scientists_The_First_Annual_International_NETPHARM_Conference_298129dde1.jpg" alt="FF UK/Ing. Jan Škop/Mgr. Martina Kopecká Jurčeková: Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference (Assoc. Prof. Jaroslav Roh)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_FF_UK_Successful_Gathering_of_Leading_Scientists_The_First_Annual_International_NETPHARM_Conference_298129dde1.jpg 208w," sizes="100vw" width="1200" height="900"></p><p>On 16 April 2025, the second <strong>International Scientific Advisory Board (ISAB)</strong> meeting was held after the conference, which provided valuable recommendations for further development of the project based on the presentations delivered.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_5_65b5668094.jpg" alt="FF UK/Ing. Jan Škop/Mgr. Martina Kopecká Jurčeková: Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_FF_UK_Uspesne_setkani_spickovych_vedcu_Prvni_vyrocni_mezinarodni_konference_projektu_NETPHARM_5_65b5668094.jpg 208w," sizes="100vw" width="1200" height="900"></p><p>In his closing remarks, Professor Petr Pávek expressed his gratitude to all attendees for their active participation and extended his appreciation for the insightful guidance provided by the ISAB.</p><p>Both the conference and the ISAB meeting received overwhelmingly positive evaluations in terms of scientific content as well as organizational and technical aspects. Participants appreciated the high level of presentations, the welcoming and friendly atmosphere, and the professional background of the entire event.</p><p>The First Annual Conference of the NETPHARM project clearly demonstrated the tremendous potential of international collaboration in advancing scientific excellence and education. The NETPHARM project is already delivering significant scientific results, fostering personal connections, and strengthening international partnerships.</p><p>The organizing team and all involved extend their sincere thanks to the project partners, ISAB members, and young promising researchers for their commitment, enthusiasm, and outstanding contributions.</p><p><strong>We wish everyone continued success in achieving the next project milestones and look forward to future NETPHARM events!</strong></p><blockquote><p><strong>For more information about the project, please visit:</strong></p><p><a target="_blank" rel="noopener noreferrer" href="https://www.faf.cuni.cz/NETPHARM/?lang=cs-cz"><strong>NETPHARM | Farmaceutická fakulta Univerzity Karlovy</strong></a></p><p><a target="_blank" rel="noopener noreferrer" href="https://portal.faf.cuni.cz/Projects/NETPHARM-project/"><strong>NETPHARM project | Vědecký portál - Farmaceutická fakulta UK</strong></a></p><p><a target="_blank" rel="noopener noreferrer" href="https://www.faf.cuni.cz/NETPHARM-Conference/Programme/"><strong>Programme | Charles University, Faculty of Pharmacy</strong></a></p></blockquote>

Successful Gathering of Leading Scientists: The First Annual International NETPHARM Conference

<p><strong>Fired cartridge cases are common evidence at shooting crime scenes. While fingerprints are often damaged and insufficient for identification, human scent traces may remain intact even after a gun is fired.</strong></p><p>In this pilot study, a simulated crime scene was created in which a volunteer loaded a weapon before firing. The scent remaining on fired cartridge cases was analyzed and compared to reference samples from several volunteers using olfactronics and olfactorics. Results suggest that scent analysis can support investigations by linking cartridge cases to the individual who handled the ammunition.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c06231"><strong>Analysis of the Human Scent on Fired Cartridge Cases from a Simulated Crime Scene</strong></a></h4><p>Ulrika Malá*, Václav Vokálek, Pavel Vrbka, Jana Čechová, Petra Pojmanová, Oleksii Kaminskyi, Veronika Škeříková, Štěpán Urban</p><p>Anal. Chem. 2025, 97, 7, 3799–3803</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.analchem.4c06231">https://doi.org/10.1021/acs.analchem.4c06231</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><p>Forensic olfactronics is a new field of forensic analysis whose aim is to analyze scent samples using advanced analytical chemistry techniques. <a href="javascript:void(0);">(1−3)</a> Unlike olfactorics (the odorology method using specially trained canines), forensic olfactronics is an objective method. On the other hand, the olfactory system of a canine is still more sensitive than the best contemporary instruments of analytical chemistry usable for human scent analysis. This is why both methods should be used for these purposes in the future during criminal investigations, so they can complement each other and be a desirable chain of evidence to present before the court. Cartridge cases are often one of the traces that can appear on the crime scenes usually connected with a shooting, mainly in the cases of very serious crimes. Unfortunately, the fingerprints tend to be partially spoiled; thus, they cannot be compared with the dactyloscopy database. In a previous study, <a href="javascript:void(0);">(4)</a> it was found that the less volatile substances that seem to be more significant for the individual identification of human scent <a href="javascript:void(0);">(5)</a> resist high temperatures for a short time (up to 500 °C for 1 min). That led to a presumption that at least a part of the human scent remaining on the cartridge after loading the gun and even after the gun’s firing would be sufficient for an individual identification. <a href="javascript:void(0);">(4)</a></p><h4><strong>Experimental Section</strong></h4><h5><strong>Instrumentation</strong></h5><p>For this experiment, only one gun type was used (a Sauer 38H, Sauer Sohn Germany, caliber 7.65 Browning, ammunition, type FMJ 73 grs, produced by Sellier Bellot, Czech Republic).</p><p>The samples were measured by a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7980B"><strong>7980B GC two-dimensional gas chromatograph</strong></a> (Agilent, USA) coupled with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=24&amp;search=Pegasus+BT+4D"><strong>Pegasus BT 4D time-of-flight analyzer mass spectrometer</strong></a> (LECO, USA). The columns were connected in reverse order. The primary column was a semipolar <strong>Rtx-200MS</strong> (30 m + 2 m precolumn, Restek, USA), and the secondary column was a nonpolar <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1745"><strong>TG5-HT</strong></a> (1.1 m, Thermo Fisher Scientific, USA). The diameter of the columns was 0.25 mm, and the thickness of the stationary phase was 0.25 μm. Helium (purity 5.5, Linde CZ) was used as a carrier gas for gas chromatography. The sample was injected in a volume of 1 μL in splitless mode (2 min) at a temperature of 280 °C. The temperature gradient on the primary column started at 40 °C, held for 2 min, and ended at 320 °C, held for 10 min. The temperature increased at a rate of 5 °C/min. The temperature on the secondary column was always 5 °C higher than that on the primary column. The modulator between the two columns always had a temperature 15 °C higher than the secondary column. The cryogenic modulation at −80 °C with three modulation periods of 6, 8, and 10 s were used. The carrier gas flow rate was 1.5 mL/min. The interface between GC and MS was heated to 280 °C. The mass detector used electron ionization with an energy of 70 eV ionizing electrons, and the temperature of the ion source was 250 °C. Data collection took place in TIC (total ion current) mode, with a mass interval of 29–800 (<i>m</i>/<i>z</i>); data collection took place at a speed of 200 spectra/s. The time required to elute the solvent was set to 500 s. To increase the detection sensitivity, a 200 V higher voltage was set on the detector compared to tuning. The ratio of the signal and the noise was set at S/N 300.</p><h4><strong>Results and Discussion</strong></h4><p>By comparing the chromatograms of the scent samples collected on the original and the prewashed cartridges, significant differences supporting the necessity of the cleaning procedure before the collection itself were not found. The chromatogram area where the lubricant peaks were found was more concentrated on the original cartridges, but the differences were not significant. From a practical point of view, that is efficient for our experiments, as it gets closer to reality at the crime scene. Other experiments were carried out on nonprewashed ammunition based on these results.<named-content></named-content><named-content></named-content></p><p>Our olfactronic analysis showed successful individual separation/variance between different volunteers on the glass beads (see <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c06231#fig3">Figure 3</a>). However, the system could not link the human scent extracted from the gun-fired cartridge cases to the volunteers. This could have been caused by the different kinds of background material that was provided by glass beads (see <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c06231#fig1">Figure 1</a>) and cartridge cases (see <a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c06231#fig2">Figure 2</a>), despite the fact that data editing was done in an attempt to eliminate these differences. Another option could be that even if the significant substances for the identification withstand high temperatures, the explosion heat could slightly change them. Therefore, one of the solutions could be to equalize the conditions before the extraction by heating the glass beads to the same temperature to which the bullets are exposed when fired. Nevertheless, the surface differences from which the unknown trace was collected at the crime scene do not seem to play a significant role. This is important for further investigation, as the cartridge cases remaining at the crime scene could lay on many kinds of surfaces, and the analyses of the evidence must not depend on them. The inconsistency of the result from the previous experiment <a href="javascript:void(0);">(4)</a> where the cartridge cases were successfully linked to the volunteer who had loaded the gun before the shooting could be based on the fact that another mass spectrometer (Pegasus BT-4D) with new commercial software (ChromaTOF, version 5.51.06.0) was used for this experiment. The software having issues with processing the chromatograms (mainly peak areas) may have contributed to the inconsistency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2025_97_7_3799_3803_Figure_1_Chromatogram_of_a_volunteer_s_sample_from_our_small_database_captured_on_the_glass_beads_f34c95896c.jpg" alt="Anal. Chem. 2025, 97, 7, 3799–3803: Figure 1. Chromatogram of a volunteer’s sample from our small database captured on the glass beads. The x axis represents the retention time of the first column [s], and the y axis represents the retention time of the second column [s]. The areas corresponding to individual groups of substances are indicated in the image." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2025_97_7_3799_3803_Figure_1_Chromatogram_of_a_volunteer_s_sample_from_our_small_database_captured_on_the_glass_beads_f34c95896c.jpg 215w," sizes="100vw" width="2100" height="1524"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2025_97_7_3799_3803_Figure_2_Chromatogram_of_an_unknown_sample_from_the_cartridge_case_736c975356.jpg" alt="Anal. Chem. 2025, 97, 7, 3799–3803: Figure 2. Chromatogram of an unknown sample from the cartridge case. The x axis represents the retention time of the first column [s]; the y axis represents the retention time of the second column [s]. The areas corresponding to individual groups of substances are indicated in the image." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2025_97_7_3799_3803_Figure_2_Chromatogram_of_an_unknown_sample_from_the_cartridge_case_736c975356.jpg 207w," sizes="100vw" width="2100" height="1577"></p><h4><strong>Conclusions</strong></h4><p>Two methods for comparing four scent traces from a simulated crime scene with 22 different volunteer scent samples were used. The aim was to find a certain volunteer who loaded the gun using eight analogous cartridges. Four samples of cartridge cases were then subjected to olfactronic analysis. These were collected from a heterogeneous crime scene. These four analogous samples were also compared by trained police canines. The olfactory method was successful and correctly identified the shooter. Both methods indicated that the surface (plastic sheet, wooden palette, and concrete floor) from which the scent traces were collected does not play a significant role in the identification. The results from the forensic olfactronic method showed the ability to distinguish each volunteer sampled on the glass beads; however, it has not yet been possible to link the fired cartridge cases to any of the volunteers. In the future, this problem can be eliminated by solving the problems with processing the peaks with commercial software that comes with the two-dimensional gas chromatograph. On the other hand, the issue could also be solved by equalizing the parameters on both surfaces (cartridge cases and glass beads) by heating the glass beads after the scent is collected on them. This heating would partly simulate the process of firing the gun.</p><p>Additionally, olfactronic identification could also be complemented by a dactyloscopy comparison as well. Since both can be crucial for the investigation and together can form a desirable chain of evidence. The only question is in which order should the methods be used for the optimal analysis of both.</p><p>The future prospects for the study include expanding the research to involve more volunteers and diversifying the types of weapons and ammunition tested. Additionally, further optimization of the sample preparation process is necessary, particularly to determine whether heating the glass beads to simulate gunfire can effectively link unknown samples to the shooter. Finally, addressing the issue of data alignment will be a critical step moving forward.</p>

Analysis of the Human Scent on Fired Cartridge Cases from a Simulated Crime Scene

<p><strong>From September until the end of 2025, the global GC/MS community can look forward to a diverse program of conferences, scientific schools, and training courses. These events are a great opportunity to discover new trends, learn advanced methods, and network with peers from around the world. Whether you are interested in fundamental research, applied solutions, or software training, there is plenty to choose from in the upcoming months.</strong></p><h5><strong>Shimadzu at 10th Lipidomics Forum</strong></h5><ul><li>14–17 September 2025 | Vienna, Austria</li><li><strong>Organizer:</strong> Shimadzu Corporation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/907">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Shimadzu_at_10th_Lipidomics_Forum_aae43f6640.jpg" alt="Shimadzu: Shimadzu at 10th Lipidomics Forum" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Shimadzu_at_10th_Lipidomics_Forum_aae43f6640.jpg 245w," sizes="100vw" width="1390" height="390"></p><h5><strong>10th Lipidomics Forum</strong></h5><ul><li>14–17 September 2025 | Vienna, Austria</li><li><strong>Organizer: </strong>University of Vienna</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/896">More information and registration at this link</a></li></ul><h5><strong>14th International Conference on Instrumental Methods of Analysis (IMA-2025)</strong></h5><ul><li>14–17 September 2025 | Kefalonia, Greece</li><li><strong>Organizer:</strong> National Technical University of Athens</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/795">More information and registration at this link</a></li></ul><h5><strong>53rd Conference on Synthesis and Analysis of Drugs 2025</strong></h5><ul><li>17–19 September 2025 | Kurdějov, Czech Republic</li><li><strong>Organizer: </strong>Masaryk University</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/678">More information and registration at this link</a></li></ul><h5><strong>21th ISC ‘Modern Analytical Chemistry’</strong></h5><ul><li>18–19 September 2025 | Prague, Czech Republic</li><li><strong>Organizer: </strong>European Chemical Society (EuChemS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/839">More information and registration at this link</a></li></ul><h5><strong>MSACL 2025 – 15th Annual Conference &amp; Exhibits</strong></h5><ul><li>21–26 September 2025 | Montréal, Canada</li><li><strong>Organizer:</strong> MSACL</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/731">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MSACL_2025_cover_image_762faaf59f.jpg" alt="MSACL: MSACL 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MSACL_2025_cover_image_762faaf59f.jpg 245w," sizes="100vw" width="1920" height="1080"></p><h5><strong>7th International Mass Spectrometry School (IMSS) 2025</strong></h5><ul><li>21–26 September 2025 | Vorau, Styria, Austria</li><li><strong>Organizer:</strong> International Mass Spectrometry Foundation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/906">More information and registration at this link</a></li></ul><h5><strong>Mass Spectrometry Symposium 2025</strong></h5><ul><li>23–26 September 2025 | Costa Mesa, CA, USA</li><li><strong>Organizer: </strong>Local MS societies (CASSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/897">More information and registration at this link</a></li></ul><h5><strong>ISSS 2025 – 29th International Symposium on Separation Sciences</strong></h5><ul><li>25–27 September 2025 | Belgrade, Serbia</li><li><strong>Organizer:</strong> International Symposium on Separation Sciences (ISSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/730">More information and registration at this link</a></li></ul><h5><strong>GDCh Science Forum Chemistry 2025</strong></h5><ul><li>29 September – 1 October 2025 | Karlsruhe, Germany</li><li><strong>Organizer:</strong> Gesellschaft Deutscher Chemiker (GDCh)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/755">More information and registration at this link</a></li></ul><h5><strong>International Symposium on Preparative and Process Chromatography (PREP) 2025</strong></h5><ul><li>29 September – 2 October 2025 | Philadelphia, PA, USA</li><li><strong>Organizer: </strong>LD Organisation srl</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/899">More information and registration at this link</a></li></ul><h5><strong>21st Raman Imaging Symposium</strong></h5><ul><li>29 September – 1 October 2025 | Ulm, Germany</li><li><strong>Organizer: </strong>Oxford Instruments</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/898">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/21st_Raman_Imaging_Symposium_13c3033654.jpg" alt="Oxford: 21st Raman Imaging Symposium" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_21st_Raman_Imaging_Symposium_13c3033654.jpg 245w," sizes="100vw" width="1200" height="627"></p><h5><strong>SciX 2025</strong></h5><ul><li>5–10 October 2025 | Covington, KY, USA</li><li><strong>Organizer</strong>: The Federation of Analytical Chemistry and Spectroscopy Societies (FACSS)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/796">More information and registration at this link</a></li></ul><h5><strong>ASMS – 39th Asilomar Conference on Mass Spectrometry</strong></h5><ul><li>10–15 October 2025 | Monterey, CA, USA</li><li><strong>Organizer: </strong>ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/747">More information and registration at this link</a></li></ul><h5><strong>Gulf Coast Conference (GCC) 2025</strong></h5><ul><li>14–15 October 2025 | Galveston, Texas, USA</li><li><strong>Organizer: </strong>Gulf Coast Conference</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/905">More information and registration at this link</a></li></ul><h5><strong>Live from the Lab: Solutions for Environmental and Food Contaminant Testing</strong></h5><ul><li>16–23 October 2025 | Europe / North America / Online</li><li><strong>Organizer:</strong> Thermo Fisher Scientific</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/920">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Live_from_the_Lab_Solutions_for_Omics_Research_9cbb774bb0.jpg" alt="Thermo Fisher Scientific: Live from the Lab - Solutions for environmental and food contaminant testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Live_from_the_Lab_Solutions_for_Omics_Research_9cbb774bb0.jpg 245w," sizes="100vw" width="1541" height="686"></p><h5><strong>SOFT 2025</strong></h5><ul><li>26–31 October 2025 | Portland, OR, USA</li><li><strong>Organizer: </strong>Society of Forensic Toxicologists</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/767">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/SOFT_2025_1c3812bfee.jpg" alt="Society of Forensic Toxicologists Inc.: SOFT 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_SOFT_2025_1c3812bfee.jpg 245w," sizes="100vw" width="1360" height="747"></p><h5><strong>ASMS – 36th Fall Workshop</strong></h5><ul><li>3–4 November 2025 | Seattle, WA, USA</li><li><strong>Organizer</strong>: ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/746">More information and registration at this link</a></li></ul><h5><strong>The International Doctoral Conference on Advances in Chemistry (IDCAC 2025)</strong></h5><ul><li>7–8 November 2025 | University of Chemistry and Technology, Prague</li><li><strong>Organizer: </strong>UCT Prague</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/911">More information and registration at this link</a></li></ul><h5><strong>AAPS 2025 PHARMSCI 360</strong></h5><ul><li>9–12 November 2025 | San Antonio, TX, USA</li><li><strong>Organizer: </strong>AAPS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/753">More information and registration at this link</a></li></ul><h5><strong>24th Human Proteome Organization World Congress (HUPO) 2025</strong></h5><ul><li>9–13 November 2025 | Toronto, Canada</li><li><strong>Organizer: </strong>HUPO</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/732">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/HUPO_2025_24th_Human_Proteome_Organization_World_Congress_cover_image_jpg_1256bb4d21.jpg" alt="HUPO 2025: 24th Human Proteome Organization World Congress" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_HUPO_2025_24th_Human_Proteome_Organization_World_Congress_cover_image_jpg_1256bb4d21.jpg 245w," sizes="100vw" width="1280" height="720"></p><h5><strong>SETAC North America 46th Annual Meeting</strong></h5><ul><li>16–20 November 2025 | Portland, Oregon, USA</li><li><strong>Organizer:</strong> SETAC</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/754">More information and registration at this link</a></li></ul><h5><strong>Eastern Analytical Symposium (EAS) 2025</strong></h5><ul><li>17–19 November 2025 | Plainsboro, NJ, USA</li><li><strong>Organizer: </strong>Eastern Analytical Symposium and Exposition</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/902">More information and registration at this link</a></li></ul><h5><strong>Invited Lecture – Jana Roithová</strong></h5><ul><li>18 November 2025 | IOCB Prague</li><li><strong>Organizer: </strong>IOCB Prague</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/709">More information and registration at this link</a></li></ul><h5><strong>TIAFT 2025</strong></h5><ul><li>23–27 November 2025 | Auckland, New Zealand</li><li><strong>Organizer: </strong>The International Association of Forensic Toxicologists</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/768">More information and registration at this link</a></li></ul><h5><strong>The Gas Chromatographers’ Training Seminar</strong></h5><ul><li>24–25 November 2025 | Online</li><li><strong>Organizer: </strong>Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/741">More information and registration at this link</a></li></ul><h5><strong>Sample Preparation Seminar</strong></h5><ul><li>2–3 December 2025 | Online</li><li><strong>Organizer:</strong> Phenomenex</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/742">More information and registration at this link</a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenomenex_Training_Courses_2025_c4712b0acc.jpg" alt="Phenomenex: Phenomenex Training Courses 2025" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenomenex_Training_Courses_2025_c4712b0acc.jpg 245w," sizes="100vw" width="1539" height="907"></p>

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The Faculty of Pharmacy, with its seat in the town of Hradec Králové, was established by a government decree in 1969. This Faculty of Pharmacy has continued in the old and long-time tradition of the education of pharmacy at Charles University.

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

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