<p>Dear colleagues and guests,</p>
<p>On behalf of the organizing committee and organizing institutions, it is a great pleasure to welcome you to <a href="http://ms-prague2021.uochb.cas.cz/index.php"><strong>the Prague meeting on historical perspectives of mass spectrometry</strong></a>. The conference is held on the inauguration of <a href="https://www.ms-museum.org/"><strong>the Czech Mass Spectrometry Museum</strong></a> and celebrates the <strong>70th anniversary of mass spectrometry</strong> in our country.</p>
<p><a href="http://ms-prague2021.uochb.cas.cz/registration.php"><strong>REGISTRATION</strong></a></p>
<p><a href="http://ms-prague2021.uochb.cas.cz/index.php"><strong>Prague Meeting on Historical Perspectives of Mass Spectrometry</strong></a></p>
<h3><strong>Confirmed Speakers</strong></h3>
<ul>
<li><a href="http://www.biosciences-labs.bham.ac.uk/cooper/"><strong>Prof. Helen J. COOPER</strong></a> (University of Birmingham, Birmingham, UK)</li>
<li><a href="https://www.hecklab.com/"><strong>Prof. Albert J. R. HECK</strong></a> (Utrecht University, Utrecht, The Netherlands)</li>
<li><a href="https://holcapek.upce.cz/"><strong>Prof. Michal HOLČAPEK</strong></a> (University of Pardubice, Pardubice, Czech Republic)</li>
<li><a href="https://orcid.org/0000-0003-3158-0637"><strong>Prof. Karel LEMR</strong></a> (Palacky University Olomouc, Olomouc, Czech Republic)</li>
<li><a href="https://faculty.skoltech.ru/people/evgenynikolaev"><strong>Prof. Evgeny NIKOLAEV</strong></a> (Skolkovo Institute of Science and Technology, Moscow, Russia)</li>
<li><a href="https://www.jh-inst.cas.cz/jh_employee/polasek"><strong>Dr. Miroslav POLÁŠEK</strong></a> (Heyrovský Institute of Physical Chemistry of the CAS, Prague, Czech Republic)</li>
<li><a href="https://bart.chemi.muni.cz/index.php/en/"><strong>Prof. Jan PREISLER</strong></a> (Masaryk University, Brno, Czech Republic)</li>
<li><a href="https://www.chem.tu-berlin.de/helmut.schwarz/"><strong>Prof. Helmut SCHWARZ</strong></a> (Technische Universität Berlin, Berlin, Germany)</li>
<li><a href="https://www.ice.mpg.de/ext/?id=438"><strong>Dr. Aleš SVATOŠ</strong></a> (Max Planck Institute for Chemical Ecology, Jena, Germany)</li>
<li><a href="http://www.jh-inst.cas.cz/~spanel/"><strong>Prof. Patrik ŠPANĚL</strong></a> (Heyrovský Institute of Physical Chemistry of the CAS, Prague, Czech Republic)</li>
<li><a href="https://sites.google.com/a/uw.edu/turecek-group/"><strong>Prof. František TUREČEK</strong></a> (University of Washington, Seattle, WA, USA)</li>
</ul>
<p>The origins of mass spectrometry in the Czech Republic date back to the <strong>1950s</strong> when <strong>the first mass spectrometer was built</strong>. Despite the post-war shortage and considerable international isolation of socialist Czechoslovakia, the device was successfully completed and used in the newly founded <strong>Czechoslovak Academy of Sciences</strong>. Later, commercial instruments started to appear. Mass spectrometry became increasingly important and the community started to grow. Since 1985, summer courses <strong>&quot;School of Mass Spectrometry&quot;</strong> have been organized regularly. The number of participants in this popular annual one-week event is now <strong>over two hundred</strong>. <strong>National scientific conferences on mass spectrometry</strong> have been organized biennially since 2011. Mass spectrometry has become a very important and widely used technique for research and industry.</p>
<p><a href="https://www.ms-museum.org/"><strong>The Czech Mass Spectrometry Museum</strong></a> has been established at <strong>the Institute of Organic Chemistry and Biochemistry of the CAS</strong> in Prague. The museum aims to collect and display <strong>artifacts related to mass spectrometry</strong>, especially those associated with the local geographical region. The technical museum mostly shows the key <strong>components of mass spectrometers</strong> used in the past and in contemporary laboratory practice. It also collects and displays <strong>historical documents</strong>, <strong>photographs</strong>, <strong>books</strong>, etc. The museum&#39;s mission is expressed in two words: <strong>education</strong> and <strong>inspiration</strong>. It demonstrates technologies hidden behind the cover and inside the vacuum systems, thus allowing a better understanding of how the mass spectrometers actually work. Displayed technical solutions, prototypes, ideas, and stories can be inspiring for students, scientists, as well as instrument designers.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/8619b6eab01a4ec18b531bf1a7d20dff/obrazek.png" alt="IOCB Prague: The Czech Mass Spectrometry Museum"/></p>
<p>The Prague Meeting on Historical Perspectives of Mass Spectrometry is a <strong>two-day conference</strong> devoted to history, status and future perspectives of mass spectrometry. The event will bring an exciting program combining <strong>presentations</strong> from honorable <strong>Czech</strong> and <strong>international scientists</strong>, <strong>representatives of producing companies</strong> mapping the historical development of their instruments, and <strong>young colleagues</strong> early in their careers. The early evening poster session will be conveniently followed by a social evening with dinner. The organizing committee will make any possible effort to make sure that your participation will be a scientifically rewarding and pleasurable experience.</p>
<h5><strong>Josef Cvačka</strong></h5>
<p><em>Chair of the PMHPMS</em></p>
<p><a href="https://ms.group.uochb.cz/en"><strong>Mass Spectrometry Research-Service Group</strong></a></p>
<p><a href="https://www.uochb.cz/en"><strong>Institute of Organic Chemistry and Biochemistry of the CAS</strong></a></p>


Prague Meeting on Historical Perspectives of Mass Spectrometry - Early registration!

<h3><strong>Conference Program</strong></h3>
<h3><strong>13th October 2021 (Wednesday)</strong></h3>
<h5><strong>7:30 - 8:20 REGISTRATION</strong></h5>
<h5><strong>8:20 - 8:40 OPENING OF THE CONFERENCE</strong></h5>
<h4><strong>SESSION I (in NLT)</strong></h4>
<p>(Chair: František Tureček (University of Washington, United States))</p>
<h5><strong>8:40 - 9:30 Computational and Gas-phase Studies in Service of Catalysis Research: Identification of the &quot;Aristocratic Atoms&quot;</strong></h5>
<ul>
<li><em>Helmut Schwarz (Technische Universität Berlin, Germany)</em><h5><strong>9:30 - 10:00 Mass Spectrometry at the J. Heyrovský Institute of Physical Chemistry</strong></h5>
</li>
<li><em>Miroslav Polášek (Heyrovský Institute of Physical Chemistry of the CAS, Czech Republic)</em><h5><strong>10:00 - 10:30 Gas Phase Ion-molecule Reactions in Czechia over 60 Years</strong></h5>
</li>
<li><em>Patrik Španěl (Heyrovský Institute of Physical Chemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>COFFEE BREAK</strong></h5>
<h4><strong>SESSION II (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=michal+holcapek">Michal Holčapek</a> (<a href="https://lcms.cz/companies/15">University of Pardubice</a>, Czech Republic))</p>
<h5><strong>11:00 - 11:30 Past, Present and Future of Orbitrap Mass Spectrometry (virtual presentation)</strong></h5>
<ul>
<li><em>Alexander Makarov (Thermo Fisher Scientific, Germany)</em></li>
</ul>
<h5><strong>11:30 - 12:00 Development of Novel Ion-less Matrices for Profiling and Imaging Mass Spectrometry</strong></h5>
<ul>
<li><em>Aleš Svatoš (Max Planck Institute for Chemical Ecology, Germany)</em></li>
</ul>
<h5><strong>12:00 - 12:30 Mass Spectrometry at the Institute of Organic Chemistry and Biochemistry &amp; Museum Opening</strong></h5>
<ul>
<li><em>Josef Cvačka (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>LUNCH BREAK</strong></h5>
<h4><strong>SESSION III (in NLT)</strong></h4>
<p>(Chair: Miroslav Polášek (Heyrovský Inst. of Physical Chemistry of the <a href="https://lcms.cz/companies/10">CAS</a>, Czech Republic))</p>
<h5><strong>14:00 - 14:50 High-resolution Native Mass Spectrometry</strong></h5>
<ul>
<li><em>Albert J. R. Heck (Utrecht University, The Netherlands)</em></li>
</ul>
<h5><strong>14:50 - 15:20 Noncanonical Ionized DNA Nucleobases and Nucleosides. A Dark Matter of DNA Ionization?</strong></h5>
<ul>
<li><em>František Tureček (University of Washington, United States)</em></li>
</ul>
<h5><strong>15:20 - 15:50 Mass Spectrometry at the University of Pardubice: Focus on Lipidomics</strong></h5>
<ul>
<li><em>Michal Holčapek (University of Pardubice, Czech Republic)</em></li>
</ul>
<h5><strong>15:50 - 16:20 Forty Year Evolution of High Throughput Mass Spectrometry: A Perspective (virtual presentation)</strong></h5>
<ul>
<li><em>Tom Covey (SCIEX, Canada)</em></li>
</ul>
<h5><strong>BREAK</strong></h5>
<h4><strong>POSTER SESSION &amp; DINNER (in OWTP)</strong></h4>
<h5><strong>17:30 - 19:00 POSTER SESSION</strong></h5>
<h5><strong>19:00 - 23:00 SOCIAL EVENT - Conference dinner, concert performance, guided underground tours</strong></h5>
<h3><strong>14th October 2021 (Thursday)</strong></h3>
<h4><strong>SESSION IV (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=jan+preisler">Jan Preisler</a> (<a href="https://lcms.cz/companies/12">Masaryk University</a>, Czech Republic))</p>
<h5><strong>8:40 - 9:30 FT ICR Mass Spectrometry. Is There Room for Further Improvements? (virtual presentation)</strong></h5>
<ul>
<li><em>Evgeny Nikolaev (Skolkovo Institute of Science and Technology, Russia)</em></li>
</ul>
<h5><strong>9:30 - 10:00 Mass Spectrometry: from Metabolites to Art</strong></h5>
<ul>
<li><em>Karel Lemr (Palacký University Olomouc, Czech Republic)</em></li>
</ul>
<h5><strong>10:00 - 10:30 Historical Perspectives on Bruker’s Involvement in Mass Spectrometry and the Development of Modern Q-TOF Mass Spectrometry</strong></h5>
<ul>
<li><em>Gary H. Kruppa (Bruker, Czech Republic)</em></li>
</ul>
<h5><strong>COFFEE BREAK</strong></h5>
<h4><strong>SESSION V – YOUNG SCIENTISTS (in NLT)</strong></h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=karel+lemr">Karel Lemr</a> (<a href="https://lcms.cz/companies/17">Palacký University Olomouc</a>, Czech Republic))</p>
<h5><strong>11:00 - 11:15 Identification of Novel Fatty Acids in Vernix Caseosa using UV Photodissociation Mass Spectrometry in Combination with Fixed-charge Photo-labile Derivatives</strong></h5>
<ul>
<li><em>Lukáš Cudlman (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>11:15 - 11:30 Mass Spectrometry-based Chemical Proteomics in Protein Post-translational Modifications Analysis</strong></h5>
<ul>
<li><em>Pavel Kielkowski (Ludwig-Maximilians-Universität München, Germany)</em></li>
</ul>
<h5><strong>11:30 - 11:45 Mapping of Regional and Subregional Unbound Drug Transport Across Blood-Brain Barrier Enabled by Quantitative Mass Spectrometry Imaging</strong></h5>
<ul>
<li><em>Dominika Luptáková (Uppsala University, Sweden)</em></li>
</ul>
<h5><strong>11:45 - 12:00 Visualization of Polyamines and Amino Acids Alterations in Neonatal Brain Hypoxic-Ischemic Injury in Rats by Mass Spectrometry Imaging</strong></h5>
<ul>
<li><em>Hynek Mácha (Institute of Microbiology of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>12:00 - 12:15 Temperature-Controlled Electrospray: A Window into Solution Thermochemistry of Non-Canonical Nucleic Acid Complexes</strong></h5>
<ul>
<li><em>Adam Pruška (ETH Zurich, Switzerland)</em></li>
</ul>
<h5><strong>12:15 - 12:30 Freeing Aspergillus fumigatus of Polymycovirus Infection renders it More Resistant to Competition with Pseudomonas aeruginosa due to Altered Iron-acquiring Tactics</strong></h5>
<ul>
<li><em>Rutuja Patil (Institute of Microbiology of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>LUNCH BREAK</strong></h5>
<h4><strong>SESSION VI (in NLT)</strong></h4>
<p>(Chair: Aleš Svatoš (Max Planck Institute for Chemical Ecology, Germany))</p>
<h5><strong>14:00 - 14:50 Native Ambient Mass Spectrometry: Mass Spectrometry Imaging of Intact Proteins and Protein Complexes (virtual presentation)</strong></h5>
<ul>
<li><em>Helen J. Cooper (University of Birmingham, United Kingdom)</em></li>
</ul>
<h5><strong>14:50 - 15:20 A (Time of) Flight from Ames to Brno: Laser Desorption Mass Spectrometry at Masaryk University</strong></h5>
<ul>
<li><em>Jan Preisler (Masaryk University, Czech Republic)</em></li>
</ul>
<h5><strong>15:20 - 15:50 The History of Time-of-Flight Mass Spectrometry at: VG - Micromass - Waters (virtual presentation)</strong></h5>
<ul>
<li><em>Mike Morris (Waters Corporation, Manchester, United Kingdom)</em></li>
</ul>
<h5><strong>15:50 - 16:20 Mass Spectrometry Innovation at Agilent Technologies (virtual presentation)</strong></h5>
<ul>
<li><em>George Stafford (Agilent Technologies, United States)</em></li>
</ul>
<h5><strong>16:20 - 16:30 CONFERENCE CLOSING</strong></h5>
<h4><strong>IOCB ChemBioDrug Workshop (in NLT</strong>)</h4>
<p>(Chair: <a href="https://lcms.cz/articles?search=josef+cvacka"> Josef Cvačka</a> (<a href="https://lcms.cz/companies/62">IOCB</a>, Czech Republic))</p>
<h5><strong>17:00 - 17:05 OPENING</strong></h5>
<h5><strong>17:05 - 17:25 Orbitrap Fusion Lumos: A Versatile Mass Spectrometer for Biomolecules</strong></h5>
<ul>
<li><em>Martin Hubálek (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>17:25 - 17:45 Protein Structure and Interactions Studied by Cross-Linking Mass Spectrometry</strong></h5>
<ul>
<li><em>Petra Junková (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>17:45 - 18:05 Protein Structure and Interactions Studied by Hydrogen Deuterium Exchange Mass Spectrometry</strong></h5>
<ul>
<li><em>Jakub Sýs (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>18:05 - 18:30 HPLC/ESI-MS2 – Based Lipidomic Analysis and MALDI Imaging of Lipids</strong></h5>
<ul>
<li><em>Vladimír Vrkoslav, Štěpán Strnad (Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic)</em></li>
</ul>
<h5><strong>18:30 - 19:00 Discussion / User Meeting</strong></h5>
<h5><strong>WORKSHOP CLOSING</strong></h5>
<p>Program je k dispozici také jako pdf na webu <a href="http://ms-prague2021.uochb.cas.cz/program.php">Prague Meeting on Historical Perspectives of Mass Spectrometry</a></p>


Conference Program Prague Meeting on Historical Perspectives of Mass Spectrometry

<p><strong>Dear friends and fans of mass spectrometry,</strong></p>
<p><strong>The history of a method for studying of matter known as mass spectrometry dates back more than a century. The foundations have mostly been laid by physics studying discharges in gases. After about five decades mass spectrometry entered the domain of chemistry and evolved into an excellent tool for studying the structure of chemical compounds. Recently we are witnessing its expansion into the field of cellular, molecular, and structural biology. The technology of mass spectrometry developed immensely over the time. Let us take a tour into the history and learn about the past technologies. Let us explore the state-of-art mass spectrometry.</strong></p>
<p>A technical museum focused on unique and significant part of science, the Czech Museum of Mass Spectrometry will display and explain laboratory instrumentation that encompasses physics, chemistry, engineering and informatics and combines them into a device that contributes to many parts of our daily life.</p>
<p>Czech and English speaking visitors will have an opportunity to learn about the principles and applications of mass spectrometry, its history, and important scientists including Nobel price winners, while experiencing a remarkable collection of mass spectrometers. Founded by mass spectrometry enthusiasts Jaroslav Pol (Thermo Scientific) and Josef Cvacka (Institute of Organic Chemistry and Biochemistry) and sponsored by Frantisek Turecek (University of Washington, Seattle), the Czech Museum of Mass Spectrometry is now being assembled and will open in Prague in 2017. Donations of mass spectrometry artifacts are gratefully appreciated; those willing to contribute please contact the curators.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d3e7627196634c0a8fa129f95fef6edd/obrazek.png" alt="The Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Mass spectrometry</strong></h3>
<p>Study of matter through the formation of gas-phase ions that are characterized using mass spectrometers by their mass, charge, structure, and/or physico-chemical properties.</p>
<h3><strong>Mass Analyzers</strong></h3>
<h5><strong>Fourier Transform Ion Cyclotron Resonance</strong></h5>
<p>Mass spectrometer based on the principle of ion cyclotron resonance in which an ion in a magnetic field moves in a circular orbit at the cyclotron frequency that is characteristic of its m/z value. Ions are coherently excited to a larger radius orbit using a pulse of radio frequency electric field, and their image charge is detected on receiver plates as a time domain signal. Fourier transformation of the time domain signal results in a frequency domain signal that is converted to a mass spectrum based on the inverse relationship between cyclotron frequency and m/z.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/1628c6d87adf47538f70c2d7ce971db9/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Ion Trap</strong></h5>
<p>Device for spatially confining ions using electric and magnetic fields alone or in combination.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/bcc0887a778f4df29f488bcd87ce8718/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Linear Ion Trap</strong></h5>
<p>Two-dimensional Paul ion trap in which ions are confined in the axial dimension by means of a static electric potential.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/6d35a6cdb4ee4baa95ad2d831b20db19/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Orbitrap</strong></h5>
<p>Ion trapping device that consists of an outer barrel-like electrode and a coaxial inner spindle-like elec- trode that form an electrostatic </p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/4c8de0a71fef446fa44829e9d37c8b62/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Sector</strong></h5>
<p>Device that produces a magnetic field perpendicular to a charged particle beam that deflects the beam to an extent that is proportional to the ratio of particle momentum and charge.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/240ae6e09cb443508bf7dce8309b2928/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Time of Flight</strong></h5>
<p>Mass spectrometer that separates ions by m/z in a field-free region after acceleration through a fixed accelerating potential. Ions of the same initial translational energy and different m/z require different times to traverse a given distance in the field-free region.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/0d0eaa3a8aa544d1abcca833a9e6e9ae/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Triple Quadrupole</strong></h5>
<p>Tandem mass spectrometer comprising two transmission quadrupole mass spectrometers in series, with a (non-selecting) RF-only quadrupole (or other multipole) between them to act as a collision cell.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/b6e4bd36ccb44cd8a93e84353b28a357/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h3><strong>Ion Sources</strong></h3>
<h5><strong>Atmospheric pressure chemical ionization</strong></h5>
<p>Atmospheric pressure chemical ionization (APCI) is chemical ionization of a sample that is a gas or nebulized liquid, using an atmospheric pressure corona discharge or beta emitter such as 63Ni.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/d562c1ce1a9f43c78d8a93a2c6c43932/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Atmospheric pressure photoionization</strong></h5>
<p>Atmospheric pressure photoionization (APPI) is direct ionization of molecules at atmospheric pressure by electron detachment induced by photons forming M+•, or atmospheric pressure chemical ionization in which the reactant ions are generated by photoionization of suitable dopant species and subsequent ion/molecule reactions of their molecular ions.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/828a17ec377a4313bdd59f9275192e87/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Desorption electrospray ionization</strong></h5>
<p>Desorption electrospray ionization (DESI) is formation of gas-phase ions from a solid or liquid sample at atmospheric pressure through the inter- action of electrosprayed droplets with the sample surface.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/86624af57b96403586bd27b3bafccec3/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Electrospray ionization</strong></h5>
<p>Electrospray ionization (ESI) is spray ionization process in which either cations or anions in solution are transferred to the gas phase via formation and desolvation at atmospheric pressure of a stream of highly charged droplets that result from applying a potential difference between the tip of the electrospray needle containing the solution and a counter electrode.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/673ec39a73b64561805cf60670486635/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Fast atom bombardment ionization</strong></h5>
<p>Fast atom bombardment ionization (FAB) is ionization of molecules initiated by a beam of neutral atoms with translational energies in the keV range. Labile molecules susceptible to dissociation are dissolved in an involatile liquid matrix that absorbs the energy of the bombarding atoms to form a selvedge region above the liquid surface in which ionization of the molecules occurs.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/afda171085f54f6e856bc930cf873fca/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Matrix-assisted laser desorption/ionization</strong></h5>
<p>Matrix-assisted laser desorption/ionization (MALDI) is formation of gas-phase ions from molecules present in a solid or liquid matrix that is irradiated with a laser. The matrix is a material that absorbs the laser energy and promotes ionization.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/39f899169e27496f938621f0d25a0f12/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>
<h5><strong>Secondary ion mass spectrometry</strong></h5>
<p>Secondary ion mass spectrometry (SIMS) is technique in which a focused beam of primary ions produces secondary ions by sputtering from a solid surface. The secondary ions are analyzed by mass spectrometry.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/fd584fd784ab4c5197b461de5c42c5ee/obrazek.png" alt="The Czech Museum of Mass Spectrometry/Martin Strohalm"/></p>


The Czech Museum of Mass Spectrometry

<h3><strong>HOW TO WEIGH A MOLECULE?</strong></h3>
<p>Imagine that you want <strong>to weigh a water molecule</strong>. You cannot just place it on a weighing pan because it certainly would not work. You need a much more sophisticated device called <strong>a mass spectrometer</strong>.</p>
<p><strong>The first such instrument was constructed by J. J. Thomson in 1912</strong>. Since then, mass spectrometry has developed into a fascinating field with many practical applications.</p>
<p><a href="https://lcms.labrulez.com/library?categoryItems=12&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=newborn+screening"><strong>Newborn screeningg</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=3&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=doping"><strong>doping tests of athletes</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=1&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=contaminants"><strong>analysis of pollutants</strong></a>, <a href="https://lcms.labrulez.com/library?categoryItems=5&amp;instrumentationItems=31&amp;publicationTypeItems=1-7-2-5-4&amp;search=drug"><strong>testing of new drugs</strong></a> or <strong>space exploration</strong> are only a few <strong>examples of the application of mass spectrometry</strong>. Yet there are many more.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_Mass_Spectrometer_d6267dd11d/Czech-Museum-of-MS-Mass-Spectrometer.jpg" alt="Czech Museum of MS: Mass Spectrometer"/></p>
<h3><strong>MASS SPECTROMETER</strong></h3>
<p><strong>A mass spectrometer</strong> is a remarkable instrument that <strong>provides information about the mass and structure of molecules</strong>. In essence, it is a very accurate scale for electrically charged molecules. However, such a scale does not resemble the traditional ones known from kitchens and pharmacies. It is an ingenious device that <strong>uses electric and magnetic fields to manipulate, separate and detect charged molecules</strong>. Some instruments also make it possible to break charged molecules into pieces, which is useful for deducing the molecular structure.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_gridless_two_stage_reflectron_from_the_MALDI_TOF_system_Biflex_II_manufactured_by_Bruker_Daltonics_690d1900fb/Czech-Museum-of-MS-A-gridless-two-stage-reflectron-from-the-MALDI-TOF-system-Biflex-II-manufactured-by-Bruker-Daltonics.jpg" alt="Czech Museum of MS: A gridless two-stage reflectron from the MALDI-TOF system Biflex II manufactured by Bruker Daltonics"/></p>
<h3><strong>OUR MISSION</strong></h3>
<p>The museum aims <strong>to collect</strong> and <strong>display artifacts in mass spectrometry</strong>, especially those <strong>associated with our geographical region</strong>. Students professionals and the general public can look a the key components of spectrometers and understand <strong>how mass spectrometers work</strong>. The technical solutions and stories behind the exhibits can inspire young scientists as wall as experienced designers of scientific instruments.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_Mass_Spectrometry_history_in_Czech_Republic_fce8ca9112/Czech-Museum-of-MS-Mass-Spectrometry-history-in-Czech-Republic.jpg" alt="Czech Museum of MS: Mass Spectrometry history in Czech Republic"/></p>
<h3><strong>EXHIBITION</strong></h3>
<p>The exhibition shows instrument components tha are often <strong>hidden in inaccessible vacuum chambers of mass spectrometers</strong>. You can take a closer look at them, understand their function, and at the same time admire their technical perfection and beauty. Use your smartphone to learn more about the exhibit you are currently viewing. <strong>The posters on the walls will teach you about mass spectrometry and its history</strong>.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_grid_cell_of_LTQ_FT_Ultra_Thermo_Electron_Corporation_7e8ae7d076/Czech-Museum-of-MS-A-grid-cell-of-LTQ-FT-Ultra-(Thermo-Electron-Corporation).jpg" alt="Czech Museum of MS: A grid cell of LTQ FT Ultra (Thermo Electron Corporation)"/></p>
<h3><strong>DONATE AN EXHIBIT</strong></h3>
<p>The museum accepts <strong>donations</strong> to its collection, especially <strong>instruments</strong> or <strong>parts of them</strong> (even broken, damaged or worn), <strong>documents</strong>, and <strong>photographs related to mass spectrometry and its history</strong>. All donations are highly appreciated.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_EI_source_from_the_single_quadrupole_mass_spectrometer_TRIO_1000_manufactured_by_VG_Masslab_Altrincham_UK_9824bf2fd9/Czech-Museum-of-MS-EI-source-from-the-single-quadrupole-mass-spectrometer-TRIO-1000-manufactured-by-VG-Masslab-(Altrincham-UK).jpg" alt="Czech Museum of MS: EI source from the single quadrupole mass spectrometer TRIO 1000 manufactured by VG Masslab (Altrincham, UK)"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Czech_Museum_of_MS_A_triple_stage_quadrupole_LC_MS_mass_spectrometer_TSQ_Vantage_manufactured_by_Thermo_Scientific_fbf31e162f/Czech-Museum-of-MS-A-triple-stage-quadrupole-LC-MS-mass-spectrometer-TSQ-Vantage-manufactured-by-Thermo-Scientific.jpg" alt="Czech Museum of MS: A triple stage quadrupole LC-MS mass spectrometer TSQ Vantage manufactured by Thermo Scientific"/></p>
<h3><strong>FIND US HERE</strong></h3>
<h5><a href="https://www.uochb.cz/en"><strong>Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences</strong></a></h5>
<ul>
<li>Building A, 2nd floor</li>
<li>Flemingovo náměstí 542/2</li>
<li>160 00 Praha 6</li>
<li>Czech Republic</li>
</ul>
<h3><strong>HOURS AND ADMISSION</strong></h3>
<p>The museum is <strong>open daily from 8 am to 6 pm.</strong> A guide is required to move around the building.</p>
<p><strong>Please call in advance</strong> to check the guide‘s availability.</p>
<ul>
<li><strong>Inquiries:</strong> Josef Cvačka</li>
<li>+420 731 447 868</li>
<li>josef.cvacka@uochb.cas.cz</li>
</ul>
<p><strong>The admission is free for all visitors.</strong></p>
<p><strong>The Czech Academy of Sciences has contributed financially to the promotion of the museum.</strong></p>


Czech Museum of Mass Spectrometry

<p><strong>An international team of scientists led by Tomáš Pluskal from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) has introduced a new generation of software enabling scientists to analyze large volumes of data from mass spectrometry, a technique that separates chemicals by their weights. The open-source project MZmine provides a new window into the chemical space that surrounds us and lives within. The latest advances in <a href="http://mzmine.github.io/">MZmine 3</a> are now published in a <a href="https://www.nature.com/articles/s41587-023-01690-2">Nature Biotechnology</a> paper.</strong></p>
<h3><strong>Challenges of biochemical analysis</strong></h3>
<p><strong>Analytical chemists of the world, unite!</strong> This paraphrase could characterize the joint efforts of scientists across the globe, who, using the <strong>methods of mass spectrometry</strong>, strive to decipher and analyze the chemical composition of complex samples from various origins, especially in biological and clinical studies. Each individual sample can contain hundreds of thousands of different chemical compounds that scientists need to trace, quantify, and identify to understand their impact on human health or their ecological role.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Robin_Schmid_Pocet_spustni_modulu_M_Zmine_v_letech_2017_2022_152c3eae85/UOCHB-Robin-Schmid-Pocet-spustni-modulu-MZmine-v-letech-2017-2022.jpg" alt="IOCB Prague/Robin Schmid: MZmine module runs in 2017–2022 (in millions)"/></p>
<p>Even relatively small studies result in gigabytes of ‘raw’ data to be processed and interpreted. It is the <strong>processing</strong>, <strong>analysis</strong>, and <strong>comparison</strong> of a multitude of molecular data that constitutes some of the most challenging steps in biochemical analysis today. This is also a major bottleneck that limits the ability of scientists to expand knowledge and come up with exciting new discoveries.</p>
<h3><strong>Community-driven development</strong></h3>
<p>For this reason, a group of international scientists started in 2005 to develop the <strong>open-source software MZmine</strong> to aid <strong>the analysis of mass spectrometry data</strong>. The community developing this software has been co-established by Czech scientist <a href="https://pluskal.group.uochb.cz/en"><strong>Tomáš Pluskal</strong></a>, who has been coordinating the project almost since its inception and is currently a group leader at IOCB Prague.</p>
<p><em>“The greatest strength of the MZmine project is the international community of experts that has formed around the project. At conferences, presentations on MZmine are always well received,”</em> says <strong>Tomáš Pluskal</strong> about the project.</p>
<p><strong>Robin Schmid from IOCB Prague</strong> and <strong>UC San Diego (CA, USA)</strong>, one of the first authors of the paper, adds: <em>“It&#39;s fantastic when we meet researchers from other countries for the first time and they tell us that MZmine and our support has saved their PhD thesis or projects. That&#39;s the best appreciation one can hope for.”</em></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Tomas_Bellon_Tomas_Pluskal_vlevo_a_Robin_Schmid_oba_z_UOCHB_92138f0c1d/UOCHB-Tomas-Bellon-Tomas-Pluskal-(vlevo)-a-Robin-Schmid-(oba-z-UOCHB).jpg" alt="IOCB Prague/Tomáš Belloň: Tomáš Pluskal (left) and Robin Schmid (both from IOCB Prague)"/></p>
<p>The first version of MZmine has enabled scientists <strong>to automate the processing of datasets generated by analytical devices</strong> at an unprecedented scale. The second generation of MZmine, released in 2010, made the project more widely known and led to the formation of a worldwide community of researchers using the software and continuing to expand its functions with additional modules and applications. The publication introducing the second generation of MZmine has since collected more than <strong>2,200 citations in scientific articles</strong> and the tool itself <strong>has been used to process millions of different measurements</strong>.</p>
<h3><strong>Third generation</strong></h3>
<p>The newest <strong>MZmine 3</strong> brings several major improvements. Whereas the previous version allowed scientists to analyze hundreds of samples in a matter of days, the new generation makes it possible <strong>to process thousands of samples per hour</strong>. Besides vastly <strong>accelerating data processing</strong>, the new version of the software can also be used, for the first time, <strong>to link different data types</strong>, especially time-resolved and imaging data.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nature_Biotechnology_M_Zmine_open_source_komunitni_projekt_pro_integrativni_zpracovani_dat_LC_IMS_MS_a_IMS_MS_6d9b3759d1/UOCHB-Nature-Biotechnology-MZmine-open-source-komunitni-projekt-pro-integrativni-zpracovani-dat-LC-IMS-MS-a-IMS-MS.jpg" alt="IOCB PRague/Nature Biotechnology: MZmine, an open-source community project for integrative LC–IMS–MS and IMS–MS data processing"/></p>
<p>This opens up opportunities for researchers to more easily <strong>analyze</strong> and <strong>interpret complex biological samples</strong>. MZmine is a tool <strong>to investigate the causes</strong> and <strong>mechanisms of diseases</strong>, <strong>detecting useful clinical biomarkers for diagnostics</strong> and <strong>identifying chemicals</strong> in the environment. This includes previously unknown chemical structures, which might prove valuable for <strong>the discovery and development of new drugs</strong> for medical applications.</p>
<p>The third generation of MZmine was announced in a paper prepared, besides Tomáš Pluskal as the corresponding author, by the first authors Robin Schmid (IOCB Prague and UC San Diego), and Steffen Heuckeroth and Ansgar Korf (both from University of Münster, Germany), joined by over three dozen other contributors from around the world.</p>
<p><em>“MZmine has established itself as a trusted tool for mass spectrometry researchers over the past decade. Its modular framework has fostered community participation in the development of the MZmine code, leading to significant advancements featured in the newly released MZmine 3,”</em> says <strong>Ansgar Korf of University of Münster</strong>.</p>
<p>The development of the MZmine project has been supported by the Czech Science Foundation (project No. 21-11563M).</p>
<ul>
<li>Literature for using the MZmine software <a href="https://lcms.labrulez.com/library?search=MZmine"><strong>in the LabRulezLCMS library</strong></a></li>
<li>Literature for using the MZmine software <a href="https://gcms.labrulez.com/library?search=MZmine"><strong>in the LabRulezGCMS library</strong></a></li>
</ul>


A breakthrough in big data processing helps trace chemicals in complex mixtures

<p><strong>The origins of mass spectrometry in Czechia date back to the 1950s when a group of young scientists in the newly founded Czechoslovak Academy of Sciences started to build the first mass spectrometer in the country. Over the years, mass spectrometry gradually developed and gained in importance. The conference will explore the history, status and perspectives of mass spectrometry. It will mark the opening of the Czech Mass Spectrometry Museum and contribute to celebrations of 70th anniversary of mass spectrometry in our region.</strong></p>
<h3><strong>Organizing institutions</strong></h3>
<p><a href="https://gcms.cz/companies/22">ÚOCHB/IOCB PRAGUE</a></p>
<p><a href="https://gcms.cz/companies/21">Czech Society for Mass Spectrometry/Česká společnost pro hmotnostní spektrometrii</a></p>
<p><a href="https://gcms.cz/companies/7">Ioannes Marcus Marci Spectroscopic Society/Spektroskopická společnost Jana Marka Marci</a></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/03cce7b42575402eb5c91750579dec76/obrazek.png" alt="ÚOCHB/IOCB PRAGUE - Czech Society for Mass Spectrometry/Česká společnost pro hmotnostní spektrometrii -  Ioannes Marcus Marci Spectroscopic Society/Spektroskopická společnost Jana Marka Marci"/></p>
<h3><strong>Conference program</strong></h3>
<p>Available on <a href="http://ms-prague2020.uochb.cas.cz/program.php">Prague Meeting on Historical Perspectives of Mass Spectrometry website</a></p>
<h3><strong>Venue</strong></h3>
<p>The conference will take place in three localities in Prague districts Dejvice and Bubeneč: National Library of Technology (lectures), Institute of Organic Chemistry and Biochemistry of the CAS (vernissage tours), and Old Wastewater Treatment Plant (poster session &amp; dinner).</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/0827c374acec4191b3ff1610c02ae928/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Prague Meeting on Historical Perspectives of Mass Spectrometry"/></p>
<h3><strong>Czech Museum of Mass Spectrometry</strong></h3>
<p>The museum aims to collect and display artifacts related to mass spectrometry, especially those associated with our geographical region. The technical museum shows key components of mass spectrometers used in the past and in contemporary laboratory practice, and it also displays historical documents, photographs, books, etc. The museum&#39;s mission is expressed in two words: education and inspiration. It demonstrates technologies hidden behind the cover and inside the vacuum systems, thus allowing a better understanding how the mass spectrometers actually work. Displayed technical solutions, prototypes, ideas, and stories can be inspiring for students, scientists, and designers of instruments.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/8619b6eab01a4ec18b531bf1a7d20dff/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Exhibition</strong></h3>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/3bc183e590444d81a74ce5538a9b5b59/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Website</strong></h3>
<p>The <a href="http://www.ms-museum.org/">website</a> will store the museum database with a detailed description of exhibits and bring topics from MS history.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/c4771b1119d84181929ea3cd97c56e76/obrazek.png" alt="ÚOCHB/IOCB PRAGUE: Czech Museum of Mass Spectrometry"/></p>
<h3><strong>Donations</strong></h3>
<p>The Czech Museum of Mass Spectrometry welcomes donations to its collection: instruments or their parts (broken, damaged, unused), and documents, photographs or books related to MS history. </p>


Prague Meeting on Historical Perspectives of Mass Spectrometry and  the Czech Mass Spectrometry Museum

<p><strong>Scientists gathered around the international software project <a href="https://lcms.labrulez.com/library?search=MZmine">MZmine</a>, led by Dr. Robin Schmid and <a href="https://pluskal.group.uochb.cz/en">Dr. Tomáš Pluskal</a> from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, have come up with a new piece of software that significantly speeds up and simplifies the identification of chemicals in tissues. It enables researchers to confidently recognize chemicals and visualize their distribution in organs. Compared to established workflows, the new pipeline requires less work in the laboratory to gain similar insights into the chemistry happening within, for example, tumours and inflammatory lesions. The paper presenting this software to the global scientific community has just been published in the influential scientific journal Nature Communications.</strong></p>
<p>At IOCB Prague, Dr. Robin Schmid is mostly involved in developing the software SIMSEF (spatial ion mobility-scheduled exhaustive fragmentation) together with his colleagues from the group of Prof. Dr. Karst at the University of Münster, Germany, where he was previously based. The work is done in collaboration with the developers of the timsTOF fleX state-of-the-art mass spectrometer from Bruker Daltonics, which enables high-level elucidation of the composition of molecules by measuring the mobility of ions.</p>
<p><em>‘Up until now, scientists could tell with a mass spectrometer that this was the formula of the molecule they were looking at, but then when they looked at the database and tried to identify this substance, it was very difficult. The reason is that biological samples can contain numerous distinct lipids and combinations of molecules that are often biologically very different. Now, thanks to the new algorithm, it is possible to look inside the molecule, learn what it is made up of and even compare images with each other,’</em> explains Robin Schmid. This can provide important information, for example that a specific part of the brain contains a different type of lipid than another part of this essential organ and that this particular lipid is absent in other tissue.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_zobrazovaci_metoda_biologickych_vzorku_pomuze_vedcum_a_lekarum_rychleji_identifikovat_napriklad_rakovinne_tkane_Dr_Tomas_Pluskal_c1948c1c8b/UOCHB-Nova-zobrazovaci-metoda-biologickych-vzorku-pomuze-vedcum-a-lekarum-rychleji-identifikovat-napriklad-rakovinne-tkane-Dr.Tomas-Pluskal.jpg" alt="IOCB Prague/Tomáš Belloň: A new imaging method for biological samples will help scientists and doctors to more quickly identify, for example, cancerous tissue"/></p>
<p>The SIMSEF algorithm was developed in collaboration with medical experts from German and Swiss universities. Crucially for medical doctors, the detection of clinical biomarkers for diagnostic purposes is also significantly accelerated. Learning very quickly, for example, whether they are dealing with a lipid or metabolite that is only found in cancerous tissue plays a critical role in deciding on further treatment. Needless to say, this has great implications for its outcome.</p>
<p>The new algorithm is part of the open-source software package MZmine, which has been helping experts worldwide to analyse mass spectrometry data since 2005. Steffen Heuckeroth from the MZmine team and the Institute of Inorganic and Analytical Chemistry at the University of Münster has been the main developer of the SIMSEF algorithm and is the first author of the paper now published in Nature Communications. He adds: <em>‘The article in question does not contain any specific discovery in the field of biology. However, thanks to our new method, many scientists can improve and accelerate their work, which opens up room for new discoveries.’</em></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Nova_zobrazovaci_metoda_biologickych_vzorku_pomuze_vedcum_a_lekarum_rychleji_identifikovat_napriklad_rakovinne_tkane_ce3d99705c/UOCHB-Nova-zobrazovaci-metoda-biologickych-vzorku-pomuze-vedcum-a-lekarum-rychleji-identifikovat-napriklad-rakovinne-tkane.jpg" alt="ÚOCHB/Tomáš Belloň: Nová zobrazovací metoda biologických vzorků pomůže vědcům a lékařům rychleji identifikovat například rakovinné tkáně"/></p>
<p><em>‘I always think it&#39;s great when we enable other people to improve the working conditions for their research and also to communicate it to other scientists. Thanks to the feedback from the scientific community using MZmine, the program itself directly pushes their research forward,’</em> adds Robin Schmid from IOCB Prague.</p>
<p>The director of IOCB Prague Prof. Jan Konvalinka points out: <em>‘Everybody is talking about machine learning and artificial intelligence these days. Our colleagues from Dr. Pluskal’s team are using it to solve highly specific problems in research as well as in clinical praxis.’</em></p>
<p>The third generation of MZmine, <a href="https://lcms.labrulez.com/article/2726"><strong>reported</strong></a> in spring 2023 in the journal Nature Biotechnology, can process thousands of samples per hour. The algorithms newly developed by this international team thus further enhance existing capabilities to link different types of data, including combining data from analytical and imaging methods, which until now has not been possible with any academic or commercial software.</p>


A new imaging method for biological samples will help scientists and doctors to more quickly identify, for example, cancerous tissue

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

A new imaging method for biological samples will help scientists and doctors to more quickly identify, for example, cancerous tissue

A breakthrough in big data processing helps trace chemicals in complex mixtures

Czech Museum of Mass Spectrometry

Conference Program Prague Meeting on Historical Perspectives of Mass Spectrometry

Prague Meeting on Historical Perspectives of Mass Spectrometry - Early registration!

Prague Meeting on Historical Perspectives of Mass Spectrometry and the Czech Mass Spectrometry Museum

The Czech Museum of Mass Spectrometry

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