<p><strong>In the week of July 15, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p>
<blockquote>
<h4><a href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Shimadzu Corporation: Fuelling a Sustainable Future: Innovations in Catalyst Analysis</strong></h5>
<ul>
<li>Tu, 16.7.2024, 08:30 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4056">Registration</a></li>
</ul>
<p>Join us to explore the complexities of catalyst analysis and understand its impact on creating a sustainable future.</p>
<h5><strong>2. SCIEX: Automating data processing</strong></h5>
<ul>
<li>Tu, 16.7.2024, 11:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/3856">Registration</a></li>
</ul>
<p>Elevate your analytical expertise with advanced techniques and workflows.</p>
<h5><strong>3. Agilent Technologies: Care and Feeding of Your HPLC System: Preventive Maintenance Tips</strong></h5>
<ul>
<li>Tu, 16.7.2024, 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/3899">Registration</a></li>
</ul>
<p>We’ll provide an overview of the LC system, from solvent bottles to detector, with a focus on preventive maintenance and keeping systems running at optimal performance.</p>
<h5><strong>4. Mettler-Toledo: Multiparameter Analysis for the Lab: from Complexity to Simplicity</strong></h5>
<ul>
<li>We, 17.7.2024, 09:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4099">Registration</a></li>
</ul>
<p>A Live Webinar for Optimizing Workflows for pH, Refractometry, and Density Determination.</p>
<h5><strong>5. Agilent Technologies: Advance Your Peptide Product Commercialization: Quality and Characterization Considerations</strong></h5>
<ul>
<li>We, 17.7.2024, 11:30 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/3991">Registration</a></li>
</ul>
<p>Join us for thought provoking webinar series on the entire value chain of therapeutic peptides.</p>
<h5><strong>6. SelectScience/Thermo Fisher Scientific: HPLC Reloaded: LC-MS Hyphenated Techniques for Biopharma</strong></h5>
<ul>
<li>We, 17.7.2024, 16:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4098">Registration</a></li>
</ul>
<p>Progress, challenges, and learnings from MS-based workflows at Symphogen and overview of a novel mono-disperse ion-exchange technology for strong cation and anion exchanger.</p>
<h5><strong>7. Agilent Technologies: Digitize Your PFAS Workflows with Agilent SLIMS</strong></h5>
<ul>
<li>We, 17.7.2024, 17:00 CET</li>
<li><a href="https://lcms.labrulez.com/webinar/4121">Registration</a></li>
</ul>
<p>SLIMS complements chromatography and mass spectrometry software by automatically importing results and generating reports for review before sharing them with customers.</p>
<h5><strong>8. SCIEX: Detecting and identifying known and novel per/polyfluoroalkyl substances (PFAS) in a marine apex predator</strong></h5>
<ul>
<li>We, 17.7.2024, 19:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/3868">Registration</a></li>
</ul>
<p>Stay on the leading edge of all things PFAS with this enlightening monthly webinar series on testing workflows and cutting-edge technology that will demystify these “forever chemicals”.</p>
<h5><strong>9. Shimadzu Corporation: Harnessing the Power of Collaboration: Shimadzu’s SFC Journey</strong></h5>
<ul>
<li>We, 17.7.2024, 20:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4122">Registration</a></li>
</ul>
<p>Join us as we discuss the introduction of Shimadzu’s Nexera UC analytical SFC systems and the Pharma-focused creation and launch of the Nexera UC Prep semi-preparative SFC systems.</p>
<h5><strong>10. Waters Corporation: Going Beyond the Boundaries of Retaining and Separating Polar Compounds</strong></h5>
<ul>
<li>Th, 18.7.2024, 16:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4107">Registration</a></li>
</ul>
<p>The pain can be minimized by understanding the mechanisms for polar analyte retention and using the proper column designed for these difficult separations.</p>
<h5><strong>11. SelectScience/Metrohm: Athlete-Centric Innovations in Anti-Doping Testing</strong></h5>
<ul>
<li>Th, 18.7.2024, 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4100">Registration</a></li>
</ul>
<p>In this webinar, Gabe Baida of InnoVero will outline the current landscape of anti-doping testing today and the new innovations that are advancing the field.</p>
<h5><strong>12. Waters Corporation: USP Chapter 129 Updates and SEC-MALS</strong></h5>
<ul>
<li>Th, 18.7.2024, 19:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4123">Registration</a></li>
</ul>
<p>USP general chapter &lt;129&gt; Analytical Procedures for Recombinant Therapeutic Monoclonal Antibodies is being revised to include a SE-UHPLC method in addition the existing SE-HPLC method.</p>
<h5><strong>13. C&amp;EN: Integrating Ion Chromatography in a Chemical Manufacturing Environment</strong></h5>
<ul>
<li>Th, 18.7.2024, 19:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4101">Registration</a></li>
</ul>
<p>This webinar will discuss where to start with determining IC as the right tool, how it can replace more tedious methods, and what you’ll need to get started.</p>


 Webinars LabRulezLCMS Week 29/2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 1st July 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://lcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p>
</blockquote>
<h4><strong>1. Thermo Fisher Scientific: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002748_ic_combustion_ic_system_environmental_an002748_na_en_a379c1e9d2.pdf">Screening of PFAS compounds in wastewater using adsorbable organic fluorine with combustion ion chromatography (CIC)</a></strong></h4>
<ul>
<li><p>Application note</p>
</li>
<li><p>Results from U.S. EPA draft Method 1621 Collaboration Study</p>
</li>
<li><p>Keywords: EPA Method 1621, AOF, CIC, PFOA, PFHxS, GAC, Dionex, IonPac AS24 column, PFAS, (per- and polyfluoroalkyl substances), combustion ion chromatography (CIC), adsorbable organic fluorine (AOF), granular activated carbon (GAC)</p>
</li>
</ul>
<p><strong>Conclusion:</strong> This application note demonstrated our results from the multi-laboratory collaboration study of EPA draft Method 1621. This method shows that CIC is an excellent tool to measure AOF andscreen for PFAS in wastewater. Along with its ease of use, RFIC provides more accurate results as fluoride is well separated from the water dip, ensuring optimized automated peak integration. The method is sensitive, with MBs of 1 ng/mL and MDLs of 2.5 ng/mL, and accurate, with recoveries of 80–120%. Together, these data highlight the power of CIC in eliminating the sample matrix and measuring only the adsorbable organically bound fluorine content in samples, successfully achieving the goals outlined in EPA draft Method 1621.</p>
<h4><strong>2. Metrohm: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_cic_035_download_032bfd1511.pdf">Halogens and sulfur in solid samples according to EN 17813</a></strong></h4>
<ul>
<li>Application note</li>
<li>Rapid analysis with combustion ion chromatography (CIC)</li>
</ul>
<p><strong>Conclusion:</strong> Combustion ion chromatography is a straightforward analytical technique to determine halogens and sulfur in environmental and solid matrices. The ceramic setup is especially suitable for CIC analysis of sample matrices with high amounts of alkali metals and/or alkaline earth metals. With the ceramic setup, the robustness of the analysis and the lifetime of consumables is drastically improved. The ease-of-use is further advanced by the possibility to inject different sample volumes – depending on the analyte concentration in the samples – to guarantee that these fit into the calibration range.</p>
<p>Overall, users of this whole validated procedure profit from easy and standardized handling, the precise determination of the analytes, automatic eluent roduction, calibration, and results calculation, low maintenance, and a single-manufacturer setup.</p>
<h4><strong>3. Waters Corporation: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008215_en_4dd8a24507.pdf">Cyclic™ Ion Mobility Unravels Sites of Chemically Induced Deamidation</a></strong></h4>
<ul>
<li>Application note</li>
</ul>
<p><strong>Abstract:</strong> Acid deamidation can mimic the action of tissue transglutaminase in deamidation of specific peptide glutamine residues, and possibly increase the immunotoxicity of the deamidated gluten food ingredient and convey an increased risk to those with coeliac disease. Peptides with multiple deamidation sites may co-elute under the same chromatographic peak and therefore other methods of site determination are required such as ion mobility mass spectrometry, increasing confidence in profiling these post-translational modifications (PTMs).</p>
<h4><strong>4. Waters Corporation: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008330_en_3f714eaa91.pdf">Sample Preparation and Analysis Workflow to Address the PFAS Primary National Drinking Water Regulation</a></strong></h4>
<ul>
<li>Application note</li>
</ul>
<p><strong>Abstract:</strong> The newly announced PFAS National Primary Drinking Water Regulation has set enforceable levels of six PFAS compounds in drinking water for the first time in the United States. Regulatory levels of individual compounds range from 4–10 ng/L (or ppt). The Waters™ PFAS Solution for sample preparation through sample analysis is presented to make implementation of the new PFAS regulations straightforward and accurately reach far below the lowest regulated Maximum Contamination Level of 4 ng/L.</p>
<h4><strong>5. Agilent Technologies: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_catecholamine_ultivo_poroshell_5994_7446en_agilent_e7e1512a7d.pdf">Determination of Catecholamines by Agilent Ultivo LC/TQ with an InfinityLab Poroshell 120 Aq‑C18 Column</a></strong></h4>
<ul>
<li>Application note - Clinical Research</li>
</ul>
<p><strong>Abstract:</strong> In this application note, a quantification method was established for catecholamines (3-MT, DA, E, NE, MN, and NMN) using the Agilent Ultivo liquid chromatography/triple quadrupole mass spectrometer (LC/TQ) system with a newly developed Agilent InfinityLab Poroshell 120 Aq-C18 column. The Poroshell 120 Aq-C18 column shows good performance with baseline separation of these six catecholamine compounds. The validation test results give a wide linearity range of 5 to 500 pg/mL in bovine serum albumin (BSA) matrices with excellent accuracy.</p>
<h4><strong>6. Shimadzu: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_ssi_lcms_156_en_671b194ea2.pdf">Oligonucleotide Characterization for Quality Control on the Shimadzu Single Quad Mass Spectrometer LCMS-2050</a></strong></h4>
<ul>
<li>Application News</li>
</ul>
<h5>User Benefits:</h5>
<ul>
<li>The Shimadzu LCMS-2050 single quadrupole mass spectrometer and SPD-M30A photodiode array detector offer a straightforward workflow for quantitating oligonucleotides, streamlining the analysis process.</li>
<li>Confident mass confirmation can be obtained over a wide mass range of nucleotide oligomers.</li>
<li>The Shimadzu LCMS-2050 enables the detection and identification of lower levels of impurities commonly found in synthetic oligomers.</li>
</ul>
<h4><strong>7. Shimadzu: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c197_e004_1a77445226.pdf"><strong>Ion Chromatography Solutions for Environmental Analysis</strong></a></strong></h4>
<ul>
<li><p>Guide</p>
</li>
<li><p>Overview of Environment Analysis</p>
</li>
<li><p>Relevance of Ion Chromatography in Environmental Analysis</p>
</li>
<li><p>Overview of Ion Chromatography</p>
</li>
<li><p>Introduction of Ion Exchange Chromatography</p>
</li>
<li><p>Shimadzu’s Ion Chromatography Solutions</p>
</li>
<li><p>LabSolutions Software</p>
</li>
<li><p>Lineup of Columns</p>
</li>
</ul>


News from LabRulezLCMS Library Week 27, 2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 15th July 2024? Check out new documents from the field of gas phase, especially GC and GC/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://gcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p>
</blockquote>
<p>This week we bring to you poster presentations from <a href="https://gcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> by <strong>LECO</strong>, <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, and <strong>Thermo Fisher Scientific</strong>!</p>
<h4><strong>1. LECO: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Environmental_Samples_HRT_G_Cx_GC_TOFMS_Multi_Mode_Source_DA_ASMS_24_LPSS_328_6ce93525c3.pdf">Non-Targeted Analysis of Complex Environmental Samples Using Thermal Desorption, Multidimensional Gas Chromatography, Multi-Mode Ionization Methods, and High-Resolution Time-of-Flight Mass Spectrometry</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<p><strong>Introduction</strong></p>
<ul>
<li>Confident analysis of environmental samples (e.g., air, water, dust/soil) is critical for the monitoring of harmful substances such as persistent organic pollutants</li>
<li>Many of these harmful chemical substances have been classified as carcinogens and endocrine disruptors</li>
<li>Study Objective: To use GCxGC-HRTOFMS for the analysis of complex environmental samples.</li>
</ul>
<p><strong>Challenge:</strong> Complex environmental samples are difficult to analyze</p>
<ul>
<li>Very large number of sample constituents</li>
<li>Wide concentration range</li>
<li>Varying physiochemical properties</li>
</ul>
<p><strong>Summary:</strong></p>
<ul>
<li>HRT and MMS technology are powerful tools for the analysis of complex environmental samples (dust, food, air)</li>
<li>Compounds were annotated using:<ul>
<li>Database comparisons</li>
<li>Formula determinations using high-resolution accurate mass ions</li>
<li>Chemical ionization data resulted in increased confidence for compound annotation</li>
</ul>
</li>
</ul>
<h4><strong>2. Agilent Technologies: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_5977c_mh_method_translator_epa_1628_asms_2024_thp331_en_agilent_400389553c.pdf">Two Methods to Perform the New US EPA Method 1628 with GC/MSD: Traditional Helium Carrier Gas and Hydrogen Carrier Gas</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Polychlorinated Biphenyl (PCBs) and the Environment </p>
<p>Polychlorinated Biphenyls (PCBs) are synthesized compounds that belong to the chlorinated hydrocarbon family of compounds. PCBs were used in a variety of industrial applications such as electrical components, plasticizers and pigments/dyes, until they were banned in 1979 by the Toxic Substances Control Act (TSCA)1. PCBs are considered to persistent organic pollutants (POPs) as they do not easily degrade in the environment. PCBs, which are classified as probable human carcinogens, can be found in the air, water, and soil and have been known to bioaccumulate in marine life. Overall, users of this whole validated procedure profit from easy and standardized handling, the precise determination of the analytes, automatic eluent roduction, calibration, and results calculation, low maintenance, and a single-manufacturer setup.</p>
<p><strong>Conclusions:</strong> Two Robust methods for EPA Method 1628 was developed to analyze 209 native and 35 labeled PCB Congeners</p>
<ul>
<li>Using EPA Method 1628 guidelines and requirements, a robust method was developed with helium carrier gas.</li>
<li>Using MassHunter method translator, a faster method that meets EPA Method 1628 guidelines was developed using Hydrogen carrier gas.</li>
<li>Both methods can detect and quantitate PCB compound down to the single digit ppb levels.</li>
</ul>
<h4><strong>3. Agilent Technologies: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_gcxgc_rfm_essential_oils_asms_2024_thp332_en_agilent_55394464d2.pdf">Analysis of Essential Oils Using a Comprehensive GCxGC with a Reverse Flow Modulator Combined with High Resolution GC/MS</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Essential oils are typically analyzed to determine their chemical composition contributing to flavor and quality as well as to evaluate their authenticity and identify adulterants. Essential oils are often complex samples with high number of volatile and semi-volatile components that include many isomers with highly similar spectra and close Retention Indices (RIs) when separated on a single column. Hence, a comprehensive GCxGC approach is preferable to achieve an appropriate chromatographic separation for this sample matrix. In this study we used comprehensive GCxGC coupled to a high-resolution accurate mass GC/MS to identify the essential oil components. Here we also investigate approaches for comparison of the complex GCxGC essential oil data.</p>
<p><strong>Conclusions:</strong></p>
<ul>
<li>Several comprehensive GCxGC configurations and method using the high-resolution GC/Q-TOF and RFM were developed and optimized using a diesel sample.</li>
<li>Essential oils were analyzed using the optimized GCxGC approach, and the workflows for compound identification and statistical analysis were evaluated.</li>
</ul>
<h4><strong>4. Shimadzu: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/MP_205_GC_3_Deferiprone_ASMS_GC_poster_ba23d98e92.pdf">Ultra-sensitive dynamic headspace GC-MS/MS method for trace level quantitation of Nitrosamines in Deferiprone API</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Regulatory bodies related to pharmaceutical industry have extensively investigated the presence of genotoxic impurities, called Nitrosamines (NSA), in many drugs. Deferiprone is an iron chelator used to treat patients with transfusional iron overload caused by thalassemia syndromes. This drug is admired in high dose with long term treatment. Hence it is imperative to make Deferiprone drug available with safe levels of NSA. </p>
<p>Pharmaceutical drug product which contains Deferiprone, is supposed to consume for a longer time. Maximum daily intake is of 99 mg/kg/day. Considering worst case scenario, calculated Maximum Daily Dose (MDD) will be 9000 mg/day when weight of the patient as 90 kg. Hence, it is imperative to determine NSA with Limit of Quantitation (LOQ) &lt; 0.1 ppb. Limits were calculated as per MDD of 9000 mg / day and reported in Table-1 with established LOQ’s for each NSA impurity. Developing method for determining total NSA at such low level in Active Pharmaceutical Ingredient (API) &amp; Finish Dosage Form (FDF) creates challenges in pharmaceutical industry.</p>
<p>This poster describes a validated dynamic headspace GC-MS/MS procedure for quantification of various NSAs like N-nitroso-dimethylamine (NDMA), N-nitroso-diethylamine (NDEA), N-nitroso-ethylisopropylamine (NEIPA), N-nitroso-diisopropylamine (NDIPA), N-nitroso-dipropylamine (NDPA), and Nnitroso-dibutylamine (NDBA) in Deferiprone Active Pharmaceutical Ingredient (API). </p>
<p><strong>Conclusion:</strong></p>
<ul>
<li>Dynamic headspace mode, seamlessly meet the current regulatory limits, delivering high sensitivity compared to static headspace as well as liquid injection mode for nitrosamines analysis.</li>
<li>Shimadzu GCMS-TQ8050 NX has features like a highly efficient shielded detector and superior noise reduction technology enhances sensitivity and enables quantitation of nitrosamines even at trace levels.</li>
</ul>
<h4><strong>5. Shimadzu: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/MP_206_GC_4_E_L_ASMS_GC_poster_b9636fc55a.pdf">Simultaneous determination of known and unknown Extractables in pharmaceuticals packaging material by tandem mass spectrometry using Scan-MRM mode</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> The purpose of Extractable &amp; Leachable (E&amp;L) studies in the regulatory references, is to identify the traces of potential chemical substances. Because these substances may be harmful to patient due to their toxicity, or the activity of drug product may impact because of their presence. Hence, to ensure the safety and efficacy of the drug till its shelf-life period, E&amp;L study plays an important role. Extractables are organic or inorganic entities which are released from container closure system (CCS) into an extraction medium under laboratory condition. Whereas, leachable are the foreign organic or inorganic chemical substances which are present in the packaged drug product during normal as well as accelerated stability conditions.</p>
<p>Samples of CCS will be used for identification of extractables. However, packaged drug product sample will be used for the evaluation of leachable. Ophthalmic drug product packaging material was used for this study (Figure 1) and the analysis was carried out on Shimadzu triple quadrupole system GCMS-TQ8040 NX equipment (Figure 2).</p>
<p><strong>Conclusion:</strong></p>
<ul>
<li>The migration of extractables from the CCS includes a wide range of compounds. Highly sensitive and robust techniques is required for detection at trace level. Also, Data need to be acquired in both SCAN and SIM/MRM modes to detect known and unknown extractables simultaneously without affecting sensitivity.</li>
<li>Shimadzu’s GCMS TQ-8040 NX triple quadrupole ultra fast mass spectrometer offers a SCAN speed of 20,000 amu/sec, 800 MRM transitions per second along with Advanced Scan Speed Protocol (ASSP) function, facilitates detection and identification extractables even at trace levels.</li>
</ul>
<h4><strong>6. Thermo Fisher Scientific: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_141_helium_technology_quantitation_furans_gc_ms_po141_asms2024_en_3c83cf3bb0.pdf">Utilizing cost effective helium saving technology for low level quantitation of Polychlorinated dibenzo-p- dioxins/furans using gas chromatograph mass spectrometry</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<h5><strong>Abstract</strong></h5>
<ul>
<li><strong>Purpose:</strong> To demonstrate high sensitivity and robustness of a cost-effective and sustainable Helium saving injector for the analysis of polychlorinated dibenzo-pdioxins/furans (PCDD/PCDF).</li>
<li><strong>Methods:</strong> Sample analysis was carried out on the Thermo Scientific TSQ 9610 GC-MS/MS equipped with the new Thermo Scientific iConnect HeSaver-H2Safer split/splitless (SSL) injector. A sample volume of 1.5 μL was injected for chromatographic separation using a TG-Dioxin (60 m × 0.25 mm, 0.25 μm) capillary GC column with previously described conditions.1The GC-MS/MS system was equipped with an advanced electron ionization (AEI) source to increase sensitivity for analyte detection. Quantification was performed using isotopic dilution in Thermo Scientific Chromeleon Chromatography Data System software using the Dioxin Analyzer workflow.</li>
<li><strong>Results:</strong> The He saver demonstrated excellent robustness, precision, and sensitivity for PCDD/F analysis in soil extracts (analyzed with no prior clean-up) at fg levels while consuming 8 times less helium compared to the standard SSL injector.</li>
</ul>


News from LabRulezGCMS Library Week 29, 2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 15th July 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://lcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p>
</blockquote>
<p>This week we bring to you poster presentations from <a href="https://lcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, <strong>Thermo Fisher Scientific</strong>, and <strong>Waters Corporation</strong>!</p>
<h4><strong>1. Agilent Technologies: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_fluoromatch_asms_2024_tp113_en_agilent_93ee360315.pdf">Leveraging the MS1 Dimension and Formula Prediction in Non-Targeted Analysis of PFAS using New FluoroMatch Algorithms: Assessing Confidence and Coverage</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<p><strong>FluoroMatch Covers the Entire Data-Processing Workflow, and Supports Various Acquisition Modes</strong></p>
<ul>
<li>Data was acquired on an Agilent 6546 LC/Q-TOF for this study to assess PFAS in dried blood spot cards (paper) and blood on dried blood spot cards</li>
</ul>
<p><strong>Conclusions:</strong></p>
<ul>
<li>FluoroMatch can be used to rapidly annotate PFAS in an automatic fashion, determine unknowns and expand annotation using an interactive visualizer. Formula prediction provides a significant benefit by providing evidence for annotation for molecules which are considered tentative using other lines of evidence, or for which the signal is too low to get quality MS/MS.</li>
<li>The FluoroMatch formula prediction algorithm is highly sophisticated and has several new or optimized approaches for formula prediction of fluorine containing compounds. With the additional use of homologous series assigning the predicted formula with the most common motifs for all members of a series, the resulting annotations are highly confident (0% false positives in this case for the four series with confident assignments).</li>
</ul>
<h4><strong>2. Agilent Technologies: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_exd_6545xt_mabs_glycopeptide_asms_2024_mp665_en_agilent_01a5c15cdd.pdf">Peptide Mapping of Tryptic Digests for mAbs using a novel ECD cell on the 6545XT AdvanceBio LC/Q-TOF Mass Spectrometer</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong></p>
<p>Post-translation modifications (PTMs) on monoclonal antibodies (mAb) play an important role in the safety, efficacy, and binding of a therapeutic to its target [1]. Common examples of PTMs that seek to be identified include glycosylation and phosphorylation. One challenge in the identification of these PTMs is that dissociation techniques such as collision-induced dissociation (CID) can break apart these fragile modifications. Here, we describe the use of an electron-based dissociation technique (ExD) that supplies low-energy electrons for the fragmentation of tryptic digests that contain glycosylation at asparagine consensus sites (NXS/T). The fragmentation of trastuzumab tryptic digest on a 6545XT AdvanceBio LC/Q-TOF using CID is compared to illustrate that CID alone will fragment these labile PTMs.</p>
<p><strong>Conclusions:</strong> The Agilent 6545XT AdvanceBio LC/Q-TOF with ExD cell enables glycopeptide analysis with excellent sequence coverage assessed using MassHunter BioConfirm 12.1</p>
<ul>
<li>LC/MS conditions were optimized to detect low-abundant glycopeptide species from NIST and trastuzumab</li>
<li>MS/MS spectra for glycopeptides using ExD show peptide fragments with intact glycans and excellent sequence coverage along the peptide backbone</li>
<li>For CID mode, no intact glycan fragments are observed. Instead, HexNAc glycan fragment at m/z 204.086 is observed</li>
</ul>
<h4><strong>3. Shimadzu: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ASMS_2024_Th_P_178_e34df60086.pdf">Quantitation of free amino acids in human plasma by Single Quadrupole LC-MS</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Amino acids are organic compounds that combine to form proteins. They are typically known as the building blocks of protein. Quantitative analysis of amino acids from biological fluids is of great importance in the clinical diagnosis of inborn errors of amino acid metabolism. The assessment of amino acids in body fluids is needed for the diagnosis and treatment of metabolic diseases. We have here performed a high-throughput method for analysis of amino acids in plasma samples. The method combines classical protein hydrolysis and derivatization with fast separation by UHPLC and detection by a single quadrupole mass spectrometer</p>
<p><strong>Conclusion:</strong></p>
<ul>
<li>Liquid chromatography triple quadrupole mass spectrometry (LCMS/MS) analysis of amino acids is becoming the method of choice by more and more laboratories because of its speed, sensitivity, and increased specificity. Although LC-MS/MS instruments are more selective and sensitive than LC-MS single quadrupole instruments, LC-MS can also be used in the quantitative analysis of amino acids when the necessary conditions are provided.</li>
<li>The required sensitivity and chromatographic separation were achieved with the single quadrupole LC-MS.</li>
<li>The method can quantitatively analyze 37 Amino acids in biological fluids such as plasma in less than 20 minutes.</li>
</ul>
<h4><strong>4. Shimadzu: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ASMS_2024_TP_198_Shimadzu_MALDI_IHC_Benchtop_bad9f3fdc3.pdf">Benchtop Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Human Tonsil Proteins using MALDI HiPLEX-IHC Probes</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong></p>
<ul>
<li>MALDI mass spectrometry imaging (MSI) is a versatile technique capable of characterising lipid, polysaccharide, metabolite, pharmaceutical, protein and peptide distributions within a wide variety of samples. Recently, MSI has been combined with commercially available antibody probes containing photocleavable mass-tags (PC-MTs) which target specific proteins in what has been termed MALDIimmunohistochemistry (MALDI-IHC) MSI.</li>
<li>In this study, we show imaging of FFPE human tonsil sections on an entry level benchtop MALDI-8020 using both a multiplex of 6 antibodies and a cancer marker screening panel consisting of a multiplex of 20 antibodies at a stage step size of 30μm, demonstrating a reliable, lowcost approach with good quality results.</li>
<li>Analysis of a follicular hyperplasia tissue sample showed visible differences from normal human tonsil tissue relating to structural features and cell distributions (Fig. 1)</li>
</ul>
<p><strong>Conclusion:</strong></p>
<ul>
<li>We have successfully mapped up to 20 biomarkers with a stage step size of 30µm using a low cost, linear benchtop MALDI-TOF mass spectrometer in conjunction with the Miralys probe kit.</li>
<li>The spectra were well-resolved allowing for clear and specific imaging in both normal and clinically significant samples.</li>
<li>The Shimadzu MALDI-8020 and MALDI-8030 MALDI-TOF mass spectrometers are robust systems with class leading sensitivity and resolution capable of a wide variety of applications including, as demonstrated here, MALDI imaging. These systems can provide an<br/>invaluable contribution to any research laboratory.</li>
</ul>
<h4><strong>5. Thermo Fisher Scientific: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_144_transformation_protac_metabolites_multi_stage_lc_hram_ms_po144_asms2024_en_4db8598a6b.pdf">Confident transformation site localization of PROTAC drug metabolites facilitated by multi-stage fragmentation LC-HRAM-MS</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<h5><strong>Abstract:</strong></h5>
<ul>
<li><strong>Purpose:</strong> Confident characterization of PROTAC drug metabolites for transformation site localization and soft-spot analysis.</li>
<li><strong>Methods:</strong> Drug metabolites were analyzed using MSn fragmentation data acquisition on a Thermo Scientific Orbitrap Ascend Biopharma Tribrid mass spectrometer and data interpretation in Thermo Scientific Compound Discoverer 3.3 SP3 software.</li>
<li><strong>Results:</strong> PROTAC drug metabolism was found to be extensive for the investigated compounds. Among the detected metabolites, several isomeric compounds were found where MSn fragmentation data could be used to reduce ambiguity in the transformation site localization, especially for metabolites with higher molecular weights.</li>
</ul>
<p><strong>Conclusions:</strong></p>
<ul>
<li>The utility of flexible MS data acquisition methods for metabolite identification could be demonstrated with two representative PROTAC compounds, MZ1 and dBET1, which exhibit extensive metabolism in vitro.</li>
<li>MSn fragmentation data helped to enhance the precision of transformation site localization, particularly for isomeric metabolites and those with high molecular weights.</li>
</ul>
<h4><strong>6. Thermo Fisher Scientific: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_145_unleashing_power_ht_dia_orbitrap_exploris_240_ms_accurate_quantitation_po145_asms2024_en_2a2f215fdf.pdf">Unleashing the power of HT-DIA acquisition on Orbitrap Exploris 240 MS – Precise and accurate quantitation at 260 SPD</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<h5><strong>Abstract:</strong></h5>
<p>Assessing and demonstrating the qualitative and quantitative performance of fast data-independent acquisition (DIA) gradients (&lt;270SPD) on a Thermo Scientific Orbitrap Exploris 240 mass spectrometer (MS), Thermo Scientific Vanquish Neo UHPLC system and micropillar array-based 5.5 cm Thermo Scientific µPAC Neo high-throughput HPLC column.</p>
<p><strong>Conclusions:</strong> The performance of a novel high throughput (HT) DIA workflow for label-free quantitation was demonstrated by combining an Orbitrap Exploris 240 mass spectrometer with fast capillary flow chromatography on a high throughput µPAC Neo HPLC column and Vanquish Neo UHPLC system. Key performance criteria of the setup/workflow include:</p>
<ul>
<li>Excellent quantitation accuracy and precision for small amounts of bacterial and fungal proteomes from mammalian background proteomes</li>
<li>Increased sample throughput with minimal impact on the quality of the obtained data and proteome coverage </li>
<li>Outstanding instrument productivity at sample turnover rates up to 250 samples per day </li>
<li>Interlaboratory reproducibility, long-term stability, and robustness essential for large cohort and multi center studies PO002624</li>
</ul>
<h4><strong>7. Waters Corporation: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/2024_asms_hatch_mushroom_coffee_9c919673f3.pdf">NON-TARGETED ANALYSIS OF MUSHROOM-CONTAINING COFFEE PRODUCTS USING ION MOBILITY-HIGH RESOLUTION MASS SPECTROMETRY</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>INTRODUCTION:</strong></p>
<ul>
<li>In recent years, the health benefits of mushrooms—including anti-  inflammatory effects1 and improved cognitive function2—have led to huge  growth in the number of food and supplement products containing so-  called &quot;functional&quot; mushrooms.</li>
<li>There is a wide variety of coffee products currently on the market that are blended with extracts from an assortment of different mushroom species.</li>
<li>In this study, we characterized mushroom coffee products containing up to  three mushroom species: chaga, cordyceps, and lion&#39;s mane. The chemical  fingerprints were compared with that of traditional coffee.</li>
</ul>
<p><strong>Conclusion:</strong></p>
<ul>
<li>A series of oligosaccharides were observed in mushroom coffees and  cordyceps capsules, but not chaga or lion’s mane capsules, nor in  traditional coffee. These oligosaccharides may contribute to enhanced  health benefits of mushroom coffee.</li>
<li>Trehalose disaccharide displayed variability among the mushroom  coffees, but was relatively consistent across the cordyceps, chaga, and  lion’s mane capsules.</li>
<li>Taken together, these observations suggest that the extraction process  (and/or the parts of the mushrooms extracted) governs the  oligosaccharide content more than the specific mushroom species  included in a product, though further testing is needed.</li>
</ul>
<h4><strong>8. Waters Corporation: <a href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/2024_asms_sarah_characellides_828ec17fb4.pdf">Ion Mobility Separation Of Marine Natural Products: Characellides from the Deep-sea Sponge Characella pachastrelloides</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> <em>Characella pachastrelloides</em> was first described in 1876 as part of a collection of deep-  sea sponges.1 Deep-sea sponges are a source of unique natural products partly due to  the extreme environment they inhabit. This study looks at a group of glycolipopeptides  known as characellides that were isolated from <em>C. pachastrelloides</em> and found to be  bioactive metabolites.2,3 While HRMS can be used for some structural characterization,  full elucidation of natural product structures remains challenging. The ‘gold-standard’  method for structural characterization of natural product compounds is nuclear  magnetic resonance (NMR). However, certain compounds can be difficult to isolate or  at concentrations too low for quality NMR analysis. This study investigates if ion  mobility (IMS) can be another tool for structural assignments of these compounds.</p>
<p><strong>Conclusions:</strong></p>
<ul>
<li>The structurally similar characellide isomers A and B were able to be separated in ion mobility space by utilizing multiple passes in the Cyclic IMS device</li>
<li>The added separation power of IMS led to the discovery of two new compounds with the same molecular formula as Characellides C and D.</li>
<li>Additional related compounds were identified with molecular networking and their CCS values were calculated to give insights into the structural diversity of this unique set of compounds.</li>
</ul>


News from LabRulezLCMS Library Week 29, 2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the weeks Weeks 27-29, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://icpms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p>
</blockquote>
<h4><strong>1. Agilent Technologies: <a href="https://icpms.cz/labrulez-bucket-strapi-h3hsga3/ICP_MS_Intelli_Quant_Analysis_Technical_Overview_f68dc39e11.pdf">Agilent ICP-MS IntelliQuant Analysis</a></strong></h4>
<ul>
<li>Technical Overview: An overview of QuickScan, IntelliQuant, and Star Rating</li>
</ul>
<p><strong>Introduction:</strong> Introduced in Agilent ICP-MS MassHunter version 4.6, IntelliQuant for ICP-MS provides an automated semiquantitative analysis for every sample. Calibration and background correction are automatically made with no user intervention,  and data is presented in an easily understood periodic table heat map format and a comprehensive data table.</p>
<p>IntelliQuant is possible because a QuickScan can be performed when measuring each sample. The optional two second QuickScan acquires a complete mass spectrum of the entire measurable mass range, facilitating semiquantitative and Total Matrix Solids (TMS) calculations of every sample.</p>
<p>TMS levels are calculated from the IntelliQuant data. Similar to Total Dissolved Solids (TDS), TMS is the sum of the key matrix elements in each sample. Included in the TMS calculation are the elements typically considered to contribute to matrix effects, such as ionization suppression and matrix deposition on interface cones and lenses. Gas elements, including elements in acids such as HCl and HNO₃ , do not cause appreciable matrix effects in ICP-MS, so they are excluded from the calculation.</p>
<h4><strong>2. Agilent Technologies: <a href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_7850_icpms_elemental_impurities_oligo_asms_2024_mp131_en_agilent_e8292cc884.pdf">Analysis of Elemental Impurities in Synthetic Oligonucleotides by ICP-MS In compliance with USP &lt;232&gt;/&lt;233&gt; and ICH Q3D(R2)/Q2(R1)</a></strong></h4>
<ul>
<li>Poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Synthetic oligonucleotides are short chains (oligomers) of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules. They are used in applications such as polymerase chain reaction (PCR) tests, DNA sequencing and novel therapeutic products.</p>
<p>The synthesis of oligonucleotides involves a four-step cyclic process followed by multi-step downstream purification. This manufacturing process as well as environment, packaging, and container closure systems can be potential sources of contamination leading to inorganic impurities formation.</p>
<p>To control and monitor product safety, permitted daily exposure (PDE) limits of 24 elements are defined in ICH guideline Q3D(R2)1 and USP chapter &lt;232&gt;2 . ICH Q2(R1)3 and USP&lt;233&gt; 4 describe analytical measurement requirements and procedures for the measurement of those elemental impurities. Although oligonucleotide products have not been included in those regulatory guidelines yet, the industry common practice is to follow those guidelines.</p>
<p>In this study, an analytical workflow (Figure1) was developed in accordance with the ICH/USP guidelines for the analysis of elemental impurities in an oligonucleotide sample using an Agilent 7850 ICP-MS. Data was acquired to evaluate the accuracy, specificity, reproducibility, and ruggedness of the method.</p>
<p><strong>Conclusions:</strong> The study has demonstrated the suitability of the Agilent 7850 ICP-MS for the identification and quantification of 24 elements in a synthetic oligonucleotide sample in compliance with existing USP and ICH guidelines. Instrument and method performance requirements for stability, detectability, precision, specificity, ruggedness, accuracy, and spike recovery were all achieved per the criteria given in USP &lt;232&gt;/&lt;233&gt; and ICH Q3D(R2)/Q2(R1).</p>
<p>As the development and use of oligonucleotides in therapeutic applications continue to advance, the elemental impurities analysis of oligonucleotides using 7850 ICP-MS can safeguard the product quality and safety.</p>
<h4><strong>3. Thermo Fisher Scientific: <a href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002822_tea_icap_rqplus_food_an002822_em_en_7e73327401.pdf">Accurate and reliable multielement analysis of alternative protein foods using ICP-MS</a></strong></h4>
<ul>
<li>Application note - Food safety</li>
</ul>
<p><strong>Goal:</strong> To demonstrate the applicability of the Thermo Scientific™ iCAP™ RQplus ICP-MS instrument for fast and accurate, highly sensitive, and reliable determination of nutritional and toxic trace elements in alternative protein food samples.</p>
<p><strong>Keywords:</strong> ICP-MS, AGD, He-KED, half-mass correction, accuracy, robustness, toxic elements, nutritional elements</p>
<h4><strong>4. Thermo Fisher Scientific: <a href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002822_tea_icap_rqplus_food_an002822_em_en_7e73327401.pdf">Analysis of process water from hydrogen fuel cells using triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS)</a></strong></h4>
<ul>
<li>Application note - Industrial</li>
</ul>
<p><strong>Goal:</strong> To demonstrate the analysis of process water from hydrogen fuel cells for inorganic trace contaminants with high sensitivity and accuracy using triple quadrupole ICP-MS.</p>
<p><strong>Keywords:</strong> Fluorine, fuel cell, high resolution, ICP-MS, KED, PEM, process water, triple quadrupole, TQ-O₂  mode</p>
<h4><strong>5. Thermo Fisher Scientific: <a href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002822_tea_icap_rqplus_food_an002822_em_en_7e73327401.pdf">Combining full spectrum read-out and innovative automation capabilities for the robust and fast analysis of major and trace elements in fertilizers using ICP-OES</a></strong></h4>
<ul>
<li>Application note - Environmental</li>
</ul>
<p><strong>Goal:</strong> To demonstrate the capabilities of the Thermo Scientific™ iCAP™ PRO XP ICP-OES Duo instrument, in conjunction with the Thermo Scientific™ iSC-65 Autosampler, for the fast and robust elemental analysis of fertilizers.</p>
<p><strong>Keywords:</strong> ICP-OES, robustness, method validation, sensitivity, Step Ahead, limits of quantitation, analytical testing, toxic elements.</p>


News from LabRulezICPMS Library Weeks 27-29, 2024

<p><strong>In the 2 weeks from July 22, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p>
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Technology Networks/Agilent Technologies/PAL System: Advances in Food and Beverage Testing 2024 (Day 1)</strong></h5>
<ul>
<li>We, 24.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4138">Registration</a></li>
</ul>
<p>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</p>
<h5><strong>2. LECO: New Dimensions in Non-Targeted Screening of Complex Aroma Profiles</strong></h5>
<ul>
<li>Th, 25.7.2024 14:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4154">Registration</a></li>
</ul>
<p>Secure your spot now and embark on a journey of discovery in chemical analysis, with each instalments of our monthly webinar series delivering fresh perspectives and invaluable insights.</p>
<h5><strong>3. Technology Networks: Advances in Food and Beverage Testing 2024 (Day 2)</strong></h5>
<ul>
<li>Th, 25.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4139">Registration</a></li>
</ul>
<p>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</p>
<h5><strong>4. Markes International: Simplifying sample preparation for GC–MS</strong></h5>
<ul>
<li>Tu, 30.7.2024 12:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4131">Registration</a></li>
</ul>
<p>This webinar addresses the use of an innovative, robust and cost-effective sampling device, the Micro-Chamber/Thermal Extractor, combined with the thermal desorption GCMS.</p>
<h5><strong>5. Agilent Technologies: GC and GC/MS Frequently Asked Questions</strong></h5>
<ul>
<li>Tu, 30.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3896">Registration</a></li>
</ul>
<p>To help you improve your chromatographic know-how, we’ve compiled a list of some of our most frequently asked questions.</p>
<h5><strong>6. Agilent Technologies: Simplified Measurement of Content Distribution of Pharma Tablets</strong></h5>
<ul>
<li>Tu, 30.7.2024 21:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3905">Registration</a></li>
</ul>
<p>Content distribution of entire pharma tablets can be quickly measured using the component-specific workflow of the LDIR.</p>
<h5><strong>7. Agilent Technologies: Analysis of Per- and Polyfluoroalkyl Substances in Different Media: Produce, Wastewater, and Air</strong></h5>
<ul>
<li>We, 31.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4134">Registration</a></li>
</ul>
<p>This presentation will summarize analytical methods to determine PFAS concentrations in produce from the vicinity of a fluorochemical plant, wastewater, and air near wastewater treatment plants.</p>


Webinars LabRulezGCMS Week 30-31/2024

<p><strong>In the week of July 22, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p>
<blockquote>
<h4><a href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. SCIEX: SCIEX OS software summer school - Hardware configuration and instrument verification</strong></h5>
<ul>
<li>Tu, 23.7.2024</li>
<li><a href="https://lcms.labrulez.com/webinar/4155">Registration</a></li>
</ul>
<p>Join us for our summer school series dedicated to enhancing your proficiency with SCIEX OS software.</p>
<h5><strong>2. Agilent Technologies: Decoding LC: Troubleshooting and Maintenance Challenges.</strong></h5>
<ul>
<li>Tu, 23.7.2024</li>
<li><a href="https://lcms.labrulez.com/webinar/4127">Registration</a></li>
</ul>
<p>This exclusive session is designed specifically to address and help you overcome most pressing maintenance and troubleshooting hurdles in HPLC operation.</p>
<h5><strong>3. Bruker: A complete imaging solution with automated workflows using neofleX™</strong></h5>
<ul>
<li>Tu, 23.7.2024</li>
<li><a href="https://lcms.labrulez.com/webinar/4125">Registration</a></li>
</ul>
<p>Learn about MALDI Imaging with neofleX™, the newest benchtop mass spectrometer from Bruker.</p>
<h5><strong>4. Phenomenex: Batch Reproducibility and Effect of Gradient Delay Volume on Separation of Impurities of Chlorhexidine Digluconate</strong></h5>
<ul>
<li>Tu, 23.7.2024 19:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4108">Registration</a></li>
</ul>
<p>The current European Pharmacopeia chlorhexidine digluconate monograph has proved problematic. In this webinar the proposed draft monograph is evaluated.</p>
<h5><strong>5. Bruker: Advancing Multiomics, Biopharma, and MS Imaging - Latest MS Technologies</strong></h5>
<ul>
<li>We, 24.7.2024 06:30 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4153">Registration</a></li>
</ul>
<p>At ASMS 2024, Bruker&#39;s Life Science division unveiled a range of cutting-edge products, including the timsTOF Ultra 2 with significant increases in sensitivity for deep proteome analysis.</p>
<h5><strong>6. Technology Networks/Agilent Technologies/PAL System: Advances in Food and Beverage Testing 2024 - (Day 1)</strong></h5>
<ul>
<li>We, 24.7.2024 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4138">Registration</a></li>
</ul>
<p>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</p>
<h5><strong>7. Agilent Technologies: Benefits of Co-Solvation Methods for Non-target PFAS Analyte</strong></h5>
<ul>
<li>We, 24.7.2024 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4128">Registration</a></li>
</ul>
<p>This presentation explores the unique advantages of direct inject methods and helps transition from non-target compounds to quantitative actionable results.</p>
<h5><strong>8. Thermo Fisher Scientific: The new Stellar MS - Instrumentation that scales analytical throughput reliably and practically</strong></h5>
<ul>
<li>Th, 25.7.2024 11:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4151">Registration</a></li>
</ul>
<p>With the new Thermo Scientific Stellar MS, it’s now easier than ever to go from discovery to validation with unrivaled quantitation at scale.</p>
<h5><strong>9. Technology Networks: Advances in Food and Beverage Testing 2024 (Day 2)</strong></h5>
<ul>
<li>Th, 25.7.2024 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4139">Registration</a></li>
</ul>
<p>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</p>
<h5><strong>10. Agilent Technologies: Applications for Predictive Dissolution Testing</strong></h5>
<ul>
<li>Th, 25.7.2024 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/3582">Registration</a></li>
</ul>
<p>With the discussions and initiatives around real-time release testing, we want to look at how this topic could influence what dissolution testing looks like in the future.</p>


 Webinars LabRulezLCMS Week 30/2024

<p><strong>In the week from July 22, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p>
<blockquote>
<h4><a href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Agilent Technologies: Analysis of Multiple Elements in Lithium Salts using an Autodilution ICP-OES Workflow</strong></h5>
<ul>
<li>Tu, 23.7.2024 21:30 CEST</li>
<li><a href="https://icpms.labrulez.com/webinar/3902">Registration</a></li>
</ul>
<p>ICP-OES is an ideally suited technique for the analysis of lithium salts due to its analytical performance and robustness and combined with the state-of-the-art Lithos autodilutor.</p>
<h5><strong>2. Separation Science/Agilent Technologies: Next-Gen Automation Solutions: Boosting Lab Productivity with ICP-MS and ADS 2</strong></h5>
<ul>
<li>We, 24.7.2024 11:00 CEST</li>
<li><a href="https://icpms.labrulez.com/webinar/4129">Registration</a></li>
</ul>
<p>Join us for an insightful webinar in which we&#39;ll focus exclusively on the advancements and applications of inductively coupled plasma mass spectrometry (ICP-MS) and ADS 2 technologies.</p>
<h5><strong>3. Technology Networks/Agilent Technologies/PAL System: Advances in Food and Beverage Testing 2024 (Day 1)</strong></h5>
<ul>
<li>We, 24.7.2024 17:00 CEST</li>
<li><a href="https://icpms.labrulez.com/webinar/4138">Registration</a></li>
</ul>
<p>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</p>
<h5><strong>4. Mettler-Toledo: Thermal Analysis of Organic Compounds</strong></h5>
<ul>
<li>Th, 25.7.2024 08:00 CEST</li>
<li><a href="https://icpms.labrulez.com/webinar/3904">Registration</a></li>
</ul>
<p>Discover Key Techniques for Characterizing and Understanding Organic Materials</p>
<h5><strong>5. Technology Networks: Advances in Food and Beverage Testing 2024 (Day 2)</strong></h5>
<ul>
<li>Th, 25.7.2024 17:00 CEST</li>
<li><a href="https://icpms.labrulez.com/webinar/4139">Registration</a></li>
</ul>
<p>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</p>
<h5><strong>6. Metrohm: Innovating Process Analysis with XRF</strong></h5>
<ul>
<li>Th, 25.7.2024 19:00 CEST</li>
<li><a href="https://icpms.labrulez.com/webinar/4130">Registration</a></li>
</ul>
<p>Join this webinar to learn more about the principles of XRF and, for the very first time, see how XRF technology is now available in the 2060 Process Analyzer.</p>
<h5><strong>7. Agilent Technologies: Trace level Analysis of NonTraditional elements and MultiElement Nanoparticles in Solvents by ICP-QQQ: A Semiconductor Workshop</strong></h5>
<ul>
<li>Th, 25.7.2024 20:00 CEST</li>
<li><a href="https://icpms.labrulez.com/webinar/3903">Registration</a></li>
</ul>
<p>Trace level Analysis of NonTraditional elements and MultiElement Nanoparticles in Solvents by ICP-QQQ: A Semiconductor Workshop.</p>


Webinars LabRulezICPMS Week 30/2024

<p><strong>In the 2 weeks from July 29, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p>
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Markes International: Simplifying sample preparation for GC–MS</strong></h5>
<ul>
<li>Tu, 30.7.2024 12:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4131">Registration</a></li>
</ul>
<p>This webinar addresses the use of an innovative, robust and cost-effective sampling device, the Micro-Chamber/Thermal Extractor, combined with the thermal desorption GCMS.</p>
<h5><strong>2. Agilent Technologies: GC and GC/MS Frequently Asked Questions</strong></h5>
<ul>
<li>Tu, 30.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3896">Registration</a></li>
</ul>
<p>To help you improve your chromatographic know-how, we’ve compiled a list of some of our most frequently asked questions.</p>
<h5><strong>3. Agilent Technologies: Simplified Measurement of Content Distribution of Pharma Tablets</strong></h5>
<ul>
<li>Tu, 30.7.2024 21:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3905">Registration</a></li>
</ul>
<p>Content distribution of entire pharma tablets can be quickly measured using the component-specific workflow of the LDIR.</p>
<h5><strong>4. Agilent Technologies: Analysis of Per- and Polyfluoroalkyl Substances in Different Media: Produce, Wastewater, and Air</strong></h5>
<ul>
<li>We, 31.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4134">Registration</a></li>
</ul>
<p>This presentation will summarize analytical methods to determine PFAS concentrations in produce from the vicinity of a fluorochemical plant, wastewater, and air near wastewater treatment plants.</p>
<h5><strong>5. Phenomenex: Solid Phase Extraction Introduction and Theory</strong></h5>
<ul>
<li>Tu, 6.8.2024 19:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4159">Registration</a></li>
</ul>
<p>Understand the benefit of using SPE than other sample preparation techniques.</p>
<h5><strong>6. C&amp;EN/Metrohm: Smart and Actionable: Spectroscopy PAT-Supported Process Operations</strong></h5>
<ul>
<li>We, 7.8.2024 19:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4175">Registration</a></li>
</ul>
<p>How Albemarle Corporation approached the implementation of Spectroscopy PAT to obtain smarter process operations and what you can do to help drive a mindset change in your business.</p>
<h5><strong>7. Agilent Technologies: Advanced GC/MS | GC/HR-MS Based Workflow for Extractable and Leachable Analysis</strong></h5>
<ul>
<li>Th, 8.8.2024 11:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4136">Registration</a></li>
</ul>
<p>Whether you are scouting or conducting a targeted screening, suspect screening, or nontargeted screening, Agilent can help with a wide range of analytical technologies.</p>


Webinars LabRulezGCMS Week 31-32/2024

<p><strong>In the week of July 29, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p>
<blockquote>
<h4><a href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. SCIEX: Excel strategies for mass spectrometry data analysis</strong></h5>
<ul>
<li>Tu, 30.7.2024 11:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/3857">Registration</a></li>
</ul>
<p>Elevate your analytical expertise with advanced techniques and workflows.</p>
<h5><strong>2. CTC Analytics: Advancing PFAS Analysis: Robotic Automation and Streamlined LC-MS Workflows</strong></h5>
<ul>
<li>We, 31.7.2024 09:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4137">Registration</a></li>
</ul>
<p>This webinar showcases the latest advancements in LC-MS workflows and robotic automation.</p>
<h5><strong>3. Waters Corporation: Exploring Enhanced Macromolecular and Nanoparticle Analysis through the Integration of DLS/ELS/SLS with the ZetaStar Instrument</strong></h5>
<ul>
<li>We, 31.7.2024 11:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4132">Registration</a></li>
</ul>
<p>The DynaPro ZetaStar instrument provides the capability for automated, unattended screening of a large range of sample and buffer conditions, which increases efficiency and reduces time to market.</p>
<h5><strong>4. Separation Science/SCIEX: PFAS Analysis in Food: A Robustness Study in Sensitivity and Stability</strong></h5>
<ul>
<li>We, 31.7.2024 11:30 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4112">Registration</a></li>
</ul>
<p>Learn how cutting-edge mass spec technology can co-exist with stability and robustness. It doesn’t have to be a compromise.</p>
<h5><strong>5. The Analytical Scientist/SCIEX: An approach to streamline and simplify the identification of crucial metabolites from targeted protein degraders</strong></h5>
<ul>
<li>We, 31.7.2024 15:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4110">Registration</a></li>
</ul>
<p>Fragment information from EAD and CID spectra were processed in a single result file to achieve confident structure assignment of and localization of metabolites.</p>
<h5><strong>6. Agilent Technologies: Analysis of Per- and Polyfluoroalkyl Substances in Different Media: Produce, Wastewater, and Air</strong></h5>
<ul>
<li>We, 31.7.2024 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4134">Registration</a></li>
</ul>
<p>This presentation will summarize analytical methods to determine PFAS concentrations in produce from the vicinity of a fluorochemical plant, wastewater, and air near wastewater treatment plants.</p>
<h5><strong>7. Waters Corporation: Structural characterization of functional polymers via light scattering and differential viscometry</strong></h5>
<ul>
<li>We, 31.7.2024 17:00 CEST</li>
<li><a href="https://lcms.labrulez.com/webinar/4111">Registration</a></li>
</ul>
<p>This webinar will explore polymer characterization by multi-angle light scattering (MALS) and differential viscometry, coupled with size-exclusion chromatography or field-flow fractionation.</p>


 Webinars LabRulezLCMS Week 31/2024

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Webinars

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Academy

Video

Poster

Scientists

Plastics

Environment

Food

Water

Health

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Scientific article

Interview

Toxicology

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Science and research

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Covid-19

Career

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LabRulez

LECO Training Course CS-744/844 Series & ON/ONH-736/836 Series

SCIEX at SOFT/TIAFT

Waters at SOFT/TIAFT 2026

Automatic ICP-OES Analysis of Lubricating Oils Using SPECTRO GENESIS DSOI and ACAROS Automation

Detection and Identification of Microplastics in Water and Other Matrices Using the Agilent Laser Infrared Spectroscopy Microscope

Unlocking New Analytical Possibilities with Waters APGC Solutions