<p><strong>In the research article recently published in ACS <em>Analytical Chemistry</em> journal the international team of researchers from International Tomography Center SB RAS, Kiel University, University of York, and Wayne State University analyzed the dissociation rates of model substrates in Signal Amplification By Reversible Exchange (SABRE) NMR spectroscopy experiment, evaluating kinetic models, and determining key activation parameters.</strong></p>
<p>The article discusses the process of nuclear spin hyperpolarization via Signal Amplification By Reversible Exchange (SABRE), which significantly enhances NMR signal intensities for various analytes. SABRE relies on the interaction of parahydrogen with organometallic complexes, allowing for the transfer of hyperpolarization to analytes through chemical exchange. The study focuses on analyzing the dissociation rates of specific model substrates, evaluating kinetic models, and determining key activation parameters. This research also aims to establish a reliable methodology for quantifying chemical exchange in SABRE, facilitating the optimization of SABRE-based catalysts.</p>
<blockquote>
<h4><strong>The original article</strong></h4>
</blockquote>
<blockquote>
<h5><a href="https://pubs.acs.org/doi/10.1021/acs.analchem.4c01374"><strong>Modeling Ligand Exchange Kinetics in Iridium Complexes Catalyzing SABRE Nuclear Spin Hyperpolarization</strong></a></h5>
<p>Oleg G. Salnikov, Charbel D. Assaf, Anna P. Yi, Simon B. Duckett, Eduard Y. Chekmenev, Jan-Bernd Hövener, Igor V. Koptyug, and Andrey N. Pravdivtsev</p>
<p><em>Analytical Chemistry</em> <strong>2024</strong> <em>96</em> (29), 11790-11799</p>
<p>DOI: 10.1021/acs.analchem.4c01374</p>
<h6>licensed under <a href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6>
</blockquote>
<h5>Selected sections from the article follow.</h5>
<h3><strong>Abstract</strong></h3>
<p>Large signal enhancements can be obtained for NMR analytes using the process of nuclear spin hyperpolarization. Organometallic complexes that bind parahydrogen can themselves become hyperpolarized. Moreover, if parahydrogen and a to-be-hyperpolarized analyte undergo chemical exchange with the organometallic complex it is possible to catalytically sensitize the detection of the analyte via hyperpolarization transfer through spin–spin coupling in this organometallic complex. This process is called Signal Amplification By Reversible Exchange (SABRE). Signal intensity gains of several orders of magnitude can thus be created for various compounds in seconds. The chemical exchange processes play a defining role in controlling the efficiency of SABRE because the lifetime of the complex must match the spin–spin couplings. Here, we show how analyte dissociation rates in the key model substrates pyridine (the simplest six-membered heterocycle), 4-aminopyridine (a drug), and nicotinamide (an essential vitamin biomolecule) can be examined. This is achieved for the most widely employed SABRE motif that is based on IrIMes-derived catalysts by 1H 1D and 2D exchange NMR spectroscopy techniques. Several kinetic models are evaluated for their accuracy and simplicity. By incorporating variable temperature analysis, the data yields key enthalpies and entropies of activation that are critical for understanding the underlying SABRE catalyst properties and subsequently optimizing behavior through rational chemical design. While several studies of chemical exchange in SABRE have been reported, this work also aims to establish a toolkit on how to quantify chemical exchange in SABRE and ensure that data can be compared reliably.</p>
<h3><strong>Introduction</strong></h3>
<p>Nuclear spin hyperpolarization techniques are reshaping the field of NMR spectroscopy and imaging by dramatically enhancing sensitivity. (1) Dissolution dynamic nuclear polarization (dDNP) (2) employs high thermal equilibrium polarization of electron spins at low temperatures and high magnetic fields as a source of hyperpolarization, with polarization transfer induced by the application of microwave irradiation of the solid sample with a subsequent rapid sample dissolution. (3) As a result, the dDNP technique requires expensive and complex equipment. Alternatively, the sensetivity of liquid-state NMR spectroscopy can be enhanced using the singlet nuclear spin isomer of dihydrogen (parahydrogen, pH2) as a hyperpolarization source. (4) Here, hyperpolarization is often achieved by pairwise addition of pH2 to an unsaturated substrate in the parahydrogen-induced polarization (PHIP) (5,6) experiment, or by transient coordination of both pH2 and a substrate to an organometallic complex in the signal amplification by reversible exchange (SABRE) experiment (Figure 1). (7,8) In the latter case, the transiently formed organometallic complex enables polarization transfer from the nascent H atoms that originate from pH2 to the nuclear spins of the coordinated substrate. This polarization transfer can be achieved spontaneously (by free evolution in an appropriate magnetic field) (7) or driven by specially designed radiofrequency (RF) pulse sequences. (9)</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Analytical_Chemistry_Anal_Chem_2024_96_29_11790_11799_Figure_1_Scheme_of_SABRE_hyperpolarization_of_pyridine_p_H2_and_a_substrate_here_pyridine_Py_bind_to_form_a_transien_558944bdca.jpg" alt="Anal. Chem. 2024, 96, 29, 11790-11799: Figure 1. Scheme of SABRE hyperpolarization of pyridine. pH2 and a substrate (here: pyridine, Py) bind to form a transient complex, [Ir(H)2(IMes)(Py)3]Cl. Spin–spin interactions then drive spin order from IrHH (the pH2-derived hydride spins) to the Py substrate, resulting in two hyperpolarized equatorial substrate ligands (red Py) and orthohydrogen (oH2). IMes stands for 1,3-bis(2,4,6-trimethylphenyl)imidazole-2-ylidene. The two equatorial chemically equivalent pyridine ligands exchange via a dissociative (SN1) mechanism. (22)"/></p>
<p>...</p>
<h3><strong>Methods</strong></h3>
<p>...</p>
<h4><strong>NMR Measurements</strong></h4>
<p>Each sample was supplied with H2 at 15 standard cubic centimeters per minute (sccm) gas flow rate, 7.9 bar, and room temperature until the SABRE precatalyst was converted completely into the SABRE-active dihydride complex, according to 1H NMR spectroscopy (25 min for Py, 30 min for NAM, 120 min for 4AP). Next, the sample was depressurized, and the catheter used to supply H2 to the solution was pulled up out of the solution by ∼12 cm (still inside the NMR tube), followed by reinitiation of H2 flow through the catheter. As a result, the sample resided under an H2 atmosphere at ambient pressure during the measurements; at the same time, gradual solvent evaporation was avoided since the gas flowed several centimeters above the solution.</p>
<p>NMR spectra were acquired on a 7.05 T Bruker AV 300 NMR spectrometer at several specified temperatures with a 5 mm probe without gradients. At each temperature, the following 1H NMR spectra were recorded: a 2D EXSY spectrum with a mixing time dmix (using Bruker TopSpin noesyph pulse sequence, Figure 2A), a regular 1D spectrum (zg Bruker TopSpin sequence), and several 1D selective EXSY (SEXSY) spectra with variable mixing times (dmix here is the variable d8 in a selno Bruker TopSpin pulse sequence, Figure 2B). The selective RF excitation (90° Gauss-shaped pulse, 40 ms, corresponding to 52.5 Hz excitation bandwidth) was tuned to excite the frequency of equatorially bound substrate protons (α-protons for Py, H-5 protons for NAM, and β-protons for 4AP). Hence, the corresponding resonances for the equilibrium concentration of the free materials were initially unencoded, and they only became visible through chemical exchange.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Analytical_Chemistry_Anal_Chem_2024_96_29_11790_11799_Figure_2_EXSY_A_and_SEXSY_B_NMR_pulse_sequences_The_rounded_pulse_in_the_diagram_is_frequency_selective_Several_delays_e71759fc48.jpg" alt="Anal. Chem. 2024, 96, 29, 11790-11799: Figure 2. EXSY (A) and SEXSY (B) NMR pulse sequences. The rounded pulse in the diagram is frequency-selective. Several delays were applied: d1 stands for relaxation delay, d0 is indirect dimension encoding delay, d14 stands for evolution after shaped pulse, and dmix (typically d8 in TopSpin) stands for mixing time. Phases: φ1 = [0°, 180°], φ2 = 0°, and φ3 = [0°, 0°, 180°, 180°, 90°, 90°, 270°, 270°], φrec = [0°, 180°, 180°, 0°, 90°, 270°, 270°, 90°]. In SEXSY sequence, the phase φ1 and dmix were selected with a random deviation (: r) up to 5%."/></p>
<p>For T1 relaxation measurements, the sample preparation and handling procedures were the same as described above, except that the iridium catalyst was not added to the solution. The samples were bubbled with H2 at 15 sccm, 7.9 bar, at room temperature for 30–50 min to displace any dissolved air. T1 was measured using conventional inversion recovery sequence (t1ir sequence in Bruker TopSpin).<br/>Corresponding chemical shifts, T1 relaxation times of protons of these substrates, and detailed acquisition parameters are provided in Supporting Information (SI).</p>
<h4><strong>Data Processing</strong></h4>
<p>All spectra were analyzed using spectral data analyzing software Bruker TopSpin (4.0.7), Bruker Dynamics Center (2.5.5), <a href="https://icpms.labrulez.com/library?mainauthorItems=464&amp;search=Mestrenova"><strong>MestReNova</strong></a> (14.2.2), and Origin (2021). Data were modeled using Origin or the MATLAB (R2021a) MOIN spin-library (24) as described in the text. The standard deviation for dissociation rates kd of SEXSY experimental data obtained using models CSS2↔CSS+S and CSS2↔S2 are calculated using the MATLAB nonlinear regression function “nlinfit”. For EXSY experimental data using model CSS2↔S2, dissociation rate deviation was calculated using eq 32 of ref. (44) As instructed, the intensity variances have been estimated by assuming a precision (noise and errors due to signal overlapping) of 10% for diagonal and cross peaks.</p>
<p>...</p>
<h3><strong>Conclusions</strong></h3>
<p>The EXSY sequence is generally more time-consuming and less robust than the SEXSY sequence. Lower spectral resolution in indirect dimension in EXSY reduces the precision of spectral integration. However, it has benefits at higher temperatures where rapid chemical exchange occurs during the selective pulse of SEXSY. Therefore, SEXSY is preferable and more accurate than EXSY for a relatively slow exchange compared to the selective excitation pulse duration. Both SEXSY and EXSY sequences could not be applied to acetonitrile and metronidazole (data not shown here) as the substrate 1H chemical shifts almost do not change upon association with IrIMes. In such cases, or when deuterium labeling is used to prolong relaxation, one should use heteronuclei labeling and EXSY, spin order transfer, or a combination of both. (35)</p>
<p>Using two different exchange models, three approaches for fitting SEXSY and one approach for fitting EXSY experiments, we obtained comparable exchange rates. We demonstrated a connection between the complete SABRE model CSS2↔CSS+S and the reduced model CSS2↔S2 often used for the polarization transfer simulations. (23) As a result, we identified some new limitations for using the CSS2↔S2 model: effective lifetime of the complex and mass balance conditions cannot be immediately satisfied. An ideal solution for spin-dynamic simulations would be to use the model CSS2↔CSS+S; however, such an approach is slow because this model is inevitably nonlinear, and we do not have sufficient information on the elusive intermediate CSS. An important aspect is that for bidentate ligands like pyruvate (13) the exchange model C0S↔S, the often-used SABRE model, should work without any identified restraints. Hence, it can be used to optimize spin order transfer to pyruvate, which was already utilized for in vivo imaging. (41,42)</p>


Modeling Ligand Exchange Kinetics in Iridium Complexes Catalyzing SABRE Nuclear Spin Hyperpolarization

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 26th August 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://gcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p>
</blockquote>
<p>This week we bring to you a posters from <a href="https://gcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> by <strong>LECO</strong>, <strong>Agilent Technologies</strong>,  <strong>Shimadzu</strong>, and <strong>Thermo Fisher Scientific</strong>!</p>
<h4><strong>1. LECO: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Long_Lifetime_Ion_Detector_GC_G_Cx_GC_TOFMS_MS_ASMS_24_LPSS_326_4c9e1fb7a1.pdf">A Novel Long-Lifetime Ion Detector for GC-TOFMS and GCxGC-TOFMS with Sub-Femtogram Detection Limits</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<p><strong>Introduction:</strong> Ion detection efficiency and fast response times are critical aspects of the ion detectors used in time-of-flight mass spectrometry (TOFMS). With modern advancements in ionization, ion optics, and ion transfer efficiency, TOFMS systems are capable of generating high ion flux onto the ion detectors. Having an ion detector that is capable of maintaining optimal performance over a long period of time while accepting high amounts of ion flux is a significant challenge in development of TOFMS instrumentation. Improvements in detector life will minimize maintenance costs and improve TOFMS user experience. A novel long-lifetime ion detector was developed in partnership with El Mul Technologies for use in LECO’s Pegasus® BTX GC and GCxGCTOFMS. The system was thoroughly evaluated for sensitivity and robustness, including longevity of the detector.</p>
<p><strong>Conclusions:</strong> The Pegasus BTX GC(GCxGC)-TOFMS with a novel Long-Lifetime Ion Detector has demonstrated the following performance characteristics:</p>
<ul>
<li>Sub-2 fg IDL for GC-TOFMS and Sub-fg IDL for GCxGC-TOFMS</li>
<li>Linear dynamic range of 5 orders of magnitude in GC-TOFMS and 4 orders of magnitude in GCxGC-TOFMS</li>
<li>Robust operation: the detector bias remains consistent and BTX peak intensity remains consistent over long periods of time, even with large numbers of samples acquired and significant amounts of charge accumulation on the detector.</li>
</ul>
<h4><strong>2. Thermo Fisher Scientific: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_153_dioxin_analysis_gc_orbitrap_capabilities_po153_asms2024_en_f72a355ee6.pdf">Meeting the challenges of Dioxin analysis and more with GC-Orbitrap high mass resolution capabilities</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<h5><strong>Abstract</strong></h5>
<p><strong>Purpose:</strong> Evaluate the performance of gas chromatography (GC) Orbitrap high mass resolution spectrometry for trace analysis of polychlorinated dibenzo-p-dioxins/furans (PCDD/PCDF) at current maximum allowable limits in soil according to EPA 1613 method criteria.¹ </p>
<p><strong>Method summary:</strong> Sample analysis was carried out on the Thermo ScientificOrbitrap Explorisᵀᴹ GC 240 mass spectrometer. A sample volume of 1.5 μL was injected for chromatographic separation using a TG-Dioxin (60 m × 0.25 mm, 0.25 μm) capillary GC column with a Thermo Scientific TRACE 1610 GC. Ion source conditions were optimized to fulfill sensitivity criteria of EPA 1613. Performance was evaluated through analysis of a raw soil extract previously analyzed using a regulatory compliant method². Quantification was performed using isotopic dilution in Thermo Scientific Chromeleon Chromatography Data System (CDS) software using the Dioxin Analyzer workflow . </p>
<p><strong>Results:</strong> The Orbitrap GC mass spectrometer fulfilled the high sensitivity, mass accuracy and resolution criteria of EPA 1613 at femtogram (fg) levels within a raw soil extract. Combined with a large dynamic range (0.05 – 100 pg•μL⁻¹), the OE GC provides users with an alternative analytical approach to deliver sensitive and accurate analysis of PCDD/F while enabling laboratories to meet future analytical challenges with high resolution accurate mass data.</p>
<h4><strong>3. Shimadzu: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Th_P_347_ASMS_Poster_Cafe_Ana_V6_239x117_03f5bcb26c.pdf">Ensuring food safety through the study of potential extractables and leachables in roasted coffee packaging by ultra-sensitive Headspace GC/MS</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<p><strong>Introduction</strong></p>
<ul>
<li>The main function of food product packaging is to protect food against any contaminant. However, in some circumstances, this packaging can release possible substances that pose a risk to human health. These are extractables and leachables (E&amp;L) compounds that migrate from materials into the product, especially under factors such as temperature, time, and solvents.</li>
<li>Notably, Brazilian legislation lacks a consolidated assessment to monitor these compounds in the food industry.</li>
<li>The Headspace Shimadzu HS-20 NX trap model allows the concentration of compounds, up to 10 times, in a trap material. This means that even very small traces of these contaminants can be detected and quantified accurately.</li>
<li>When coupled with GCMS-QP2020 NX (Fig.1), the HS-20 NX becomes a powerful tool for identifying and analyzing potential toxic contaminants, significantly contributing to food safety and compliance with quality regulations.</li>
</ul>
<p><strong>Conclusion</strong></p>
<ul>
<li>The use of HS-20 NX in Trap mode with GC/MS enabled the identification of over 100 compounds, comparing the spectra with the National Institute of Standard and Technology (NIST) library. Among these compounds are potential E&amp;L substances, as well as coffee aroma components.</li>
<li>This technique demonstrates high versatility and efficiency by providing high analytical sensitivity capable of identifying compounds even at low concentrations, something unachievable by conventional methods. This evolution represents a notable advancement in coffee and food quality control, enabling precise detection of essential characteristics and components to ensure the excellence of the final product and consumer health.</li>
</ul>
<h4><strong>4. Agilent Technologies: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Th_P_347_ASMS_Poster_Cafe_Ana_V6_239x117_03f5bcb26c.pdf">Faster Qualitative Analysis of Essential Oils Using GC/MS with Hydrogen Carrier Gas and a Hydrogen Optimized EI Source</a></strong></h4>
<ul>
<li>poster / <a href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li>
</ul>
<p><strong>Introduction:</strong> Due to the price of helium (He), many laboratories are looking for alternative carrier gases for their gas chromatography/mass spectrometry (GC/MS) methods. This work describes the conversion of a GC/MS method for the identification of flavor and fragrance compounds in essential oils from helium to hydrogen (H₂). A single quadrupole GC/MS system was used with hydrogen carrier gas and an EI source optimized to provide spectral fidelity with hydrogen. To increase confidence in compound identifications, deconvoluted mass spectra and linear retention indices (RI) were searched against the NIST23 mass spectral library. A column and chromatographic conditions for hydrogen were chosen that reduce the analysis time by 2.5 times compared to the helium method and generates results comparable to helium.</p>
<p><strong>Conclusions:</strong> The data presented here shows that H₂ can successfully be used as a carrier gas for flavor and fragrance analyses with the proper conversion steps.</p>
<ul>
<li>The choice of the 20 m x 0.18 mm id x 0.18 µm film HP-5MSUI column allowed a 2.5 times faster analysis with equivalent chromatographic resolution.</li>
<li>The Method Translation calculator provided chromatographic conditions that maintained the same elution order as with the He method, resulting in excellent agreement of the RI values measured with both methods.</li>
<li>The use of MassHunter Unknowns Analysis software to deconvolute spectra and search them with RI filtering against the NIST23 library significantly simplified identification of the flavor components.</li>
<li>The HydroInert EI source minimized in-source reactions with H₂, resulting in higher LMS values.</li>
</ul>
<p>For further details on this work, please see reference 3. Reference 4 provides more information on flavor components that can react with H₂ in the source, and which benefit from the use of HydroInert. Note that if He is available at an acceptable price, it is the preferred carrier for GC/MS and should be used. However, as shown in this work, H2 can be used if appropriate method adjustments are made to accommodate its use.</p>


News from LabRulezGCMS Library - Week 35, 2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 26th August 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><h4>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></a></h4></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring to you posters from <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/592"><strong>52nd HPLC</strong></a> by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, <strong>Thermo Fisher Scientific,</strong> and <strong>Waters Corporation</strong>!</p><h4><strong>1. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enhancing_high_throughput_preparative_hplc_poster_06b9abadd0.pdf"><strong>Enhancing High Throughput Preparative HPLC: Offline Regeneration of Identical Superficially Porous Particle Preparative Columns Utilizing The 1290 Infinity II Preparative LC System and Agilent InfinityLab Poroshell 120 Preparative LC Columns to extend Column Lifetime, Minimize Sample Carryover and Increase Throughput</strong></a></h4><ul><li>poster / <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/303"><strong>HPLC</strong></a></li></ul><p><strong>Abstact:</strong> High throughput sample purification and analysis are important tasks in many industries. With the increasing number of samples synthesized– HPLC purification should not be the bottleneck in discovery and development. The throughput on the Prep system can be increased by optimizing the chromatographic method and by optimizing the instrument hardware. In this poster we show how the throughput can be enhanced even further by using two identical Poroshell Preparative HPLC columns in the system and operating them alternately optimizing the 1290 Infinity II Preparative LC System for Off-Line Column Regeneration. The greatest benefit of the offline column cleanup and equilibration is the increase in sample throughput, but added benefits include extended column lifetime and a reduction in sample carryover.</p><p><strong>Conclusions:</strong> Faster run times and higher throughput is desirable when doing preparative HPLC. Using higher flow rates, shorter and lower pressure columns as well as optimized equipment can help to achieve these goals. Higher backpressure limits of the Agilent Inf II Prep pumps along with high pressure valves further reduce cycle times by allowing configuration of automated offline column regeneration. This means two columns are alternatively used via a 2-position/14-port valve. Cleaning and equilibration time can be excluded from the cycle time and 50% more runs were performed.</p><h4><strong>2. Waters Corporation: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/2024_hplc_maziarz_hydrophilic_hilic_f04a258724.pdf"><strong>Scaling Reverse-Phase and Hydrophilic Interaction Liquid Chromatography (HILIC) Methods to HPLC</strong></a></h4><ul><li>poster / <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/303"><strong>HPLC</strong></a></li></ul><p><strong>INTRODUCTION:</strong></p><p>Achieving identical chromatographic separation and equivalent results are critical when scaling and migrating methods between different liquid chromatography (LC) instruments.</p><p>In this work, two different methods developed on 1.7 μm particle size columns using a low dispersion system were scaled to HPLC. In first example, a reverse-phase method for naphazoline hydrochloride, pheniramine maleate and associated related substances was scaled from 1.7 μm to a 2.5 μm particle column. A second method for the analysis of ribavirin and related compounds, operated under HILIC conditions, was scaled from 1.7 μm to 2.5 and 3.5 μm particle columns and run on different HPLC platforms. The scaled methods generated equivalent chromatographic performance and assay results as the original method.</p><p><strong>CONCLUSION:</strong></p><ul><li>Reverse-phase and HILIC methods were successfully scaled from 1.7 µm particle size columns to HPLC.</li><li>The target LC systems including ACQUITY Arc, Arc HPLC and Alliance iS HPLC Systems generated equivalent performance as the original method run on an ACQUITY UPLC H-Class Plus System.</li><li>Dwell and extra-column volumes were accounted for to ensure quality of the chromatographic data for method scaling and migration across different LC platforms.</li></ul><h4><strong>3. Thermo Fisher Scientific: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_003231_hplc_peptide_level_analysis_monoclonal_antibodies_evaluation_po003231_na_en_31f6f13cf1.pdf"><strong>Performance evaluation of a new reversed-phase column for peptide mapping and monitoring of monoclonal antibodies</strong></a></h4><ul><li>poster / <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/303"><strong>HPLC</strong></a></li></ul><h5><strong>Abstract</strong></h5><p><strong>Purpose:</strong> Demonstrating the benefits of the newly introduced Thermo Scientific Hypersil GOLD Peptide C18 column with 1.9 µm particle and 175 Å average pore size, in the dimension of 150 x 2.1 mm (L x ID) for the analysis of tryptic mAb digest samples.</p><p><strong>Methods:</strong> UHPLC-MS/MS peptide mapping and UHPLC-UV-MS peptide monitoring.</p><p><strong>Results:</strong> The Hypersil GOLD Peptide column enables to uniquely meet the demands of peptide level analysis where consistent lot-to-lot and column-to-column performance is required.</p><h5><strong>Conclusions</strong></h5><p>The two studies of peptide mapping and peptide monitoring demonstrate the benefits of the Hypersil GOLD Peptide column for peptide level biopharma analysis based on a comprehensive dataset obtained from rituximab and adalimumab digest samples.</p><ul><li>SET and SST criteria of retention time and peak area precision are easily met when using the Hypersil GOLD Peptide column.</li><li>The Hypersil GOLD Peptide column provides<ul><li>peaks with good asymmetry values, strong retention time and peak area reproducibility.</li><li>retains and separates hydrophilic peptides and has very good chromatographic resolution values for deamidated species in the PENNYK region.</li><li>excellent column lot-to-lot reproducibility with % RSD RT ≤ 0.6, and % RSD peak area ≤ 6.2 for peptides across the entire elution window.</li><li>consistent column-to-column results for the quantification of glycopeptides with % RSD of relative abundance ≤ 3.0.</li></ul></li></ul><h4><strong>4. Shimadzu: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ASMS_2024_LEIPP_WP_119_45a784b1d5.pdf"><strong>Development of a blood-based multiplex quantitative LC-MS method for neurodegenerative diseases patient stratification : towards an innovative diagnostic tool</strong></a></h4><ul><li>poster / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li></ul><p><strong>Introduction and objectives:</strong> Current neurodegenerative biomarkers measurements for diagnosis purposes are performed using CSF samples which requires invasive procedures for the patient. Besides, AD and other associated dementias are very complex pathologies that can have intricate symptoms and pathological deleterious effects. Therefore, the developed quantitative multiplex method includes 22 blood neuroinflammatory, brain function-linked, genetic and general state biomarkers for disease state evaluation and monitoring, patient stratification and differential diagnosis purposes.</p><p><strong>Conclusions and Perspectives:</strong> Further analytical validation would be performed to fully assess method performances (stabilities, intra-laboratory reproducibility). Then, large patient cohorts would be analyzed to evaluate and clinically validate this innovative tool and its capacity to differentiate diseases, severity and co-pathologies. Such tool would bring dementia diagnosis within the landscape of personalized medicine fostering better patient care.</p>

News from LabRulezLCMS Library - Week 35, 2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in week 35, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!</strong></p><blockquote><h4>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES</strong></a></h4></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring to you a poster from <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> by <strong>Agilent Technologies</strong>, applications by <strong>Shimadzu</strong>, <strong>Thermo Fisher Scientific</strong>, and <strong>Metrohm</strong>!</p><h4><strong>1. Agilent Technologies: </strong><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_8900_esi_microfast_yeast_asms_2024_wp774_en_agilent_06b2ce4cfb.pdf"><strong>Elemental Analysis in Yeast Cells and Selenium Enriched Yeast Cells by ICP-MS with Automated Micro-Flow Sample Introduction</strong></a></h4><ul><li>poster / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/296"><strong>ASMS 2024</strong></a></li></ul><p><strong>Introduction: </strong>Nanoparticle and single cell elemental analysis by ICP-MS has become popular in recent years due technological advancements in ICP-MS, as well as increasing needs for many other advancing fields of applications (1). In the current study, an automated, micro-flow autosampler in combination with an Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) is used in the elemental analysis of nanoparticles and yeast cells. The sample introduction system is designed to deliver intact single cells or cell clusters to the plasma, while the ICP-MS offers high sensitivity for elemental determination within the cell or cell cluster. The preliminary results from this current study can potentially be applied to other applications, offering an easy and efficient way for high-throughput sample analysis.</p><p><strong>Conclusions:</strong> There is good agreement in the number of detected cells that contained the four elements, confirming the feasibility of the scICP-MS method for the measurement of multiple elements in single cells.</p><h4><strong>2. </strong><style type="text/css"></style><strong>Shimadzu: </strong><style type="text/css"></style><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00718_en_8760c1a035.pdf"><strong>Screening Analysis of 24 Elemental Impurity Elements in Drugs Using ICPMS-2040/2050</strong></a></h4><ul><li>Application</li></ul><p><strong>User Benefits</strong></p><ul><li>Controlled elements can be verified by a screening analysis of 24 elemental impurity elements.&nbsp;</li><li>Use of the preset method in LabSolutions™ ICPMS makes it possible to begin the analysis simply without laborious study of conditions.</li><li>Study of candidate elements for internal standard correction is possible.</li></ul><p><strong>Introduction:</strong> The ICH Q3D Guideline for Elemental Impurities 1) establishes permitted daily exposure (PDE) levels for 24 elements of toxicological concern. The elementsthat should be considered in risk assessments differ, depending on the administration route of the drug product. For oral preparations, only seven elements of Class 1 and 2A should be considered, except for the intentional addition of elements such as catalyst utilization during synthesis. However, the origins of contamination by elemental impurities are diverse, including not only the components of the drug substance and additives, but also manufacturing equipment and implements. Therefore, a screening analysis was carried out for all 24 elements, considering potential elemental impurities. In addition, when internal standard correction is to be used, as in a related article a, the content of candidate internal standard elements in the specimens must be verified in advance. In this article, a simple concentration analysis of the 24 elements in a drug product as elemental impurities was carried out using the preset method for screening analysis of drug products, which is included in the ICPMS-2040/2050 (Fig. 1). The concentration of the elements used in internal standard correction in the drug was also measured, and it was found that the elements can be used in correction.</p><p><strong>Conclusion:</strong> In this article, a simultaneous screening analysis of 24 elemental impurity elements in an oral drug product and candidate elements for internal standard correction was carried out using an ICPMS-2040/2050. The time and work necessary in study and registration of the analysis conditions and measured masses of the large number of elements in this experiment can be greatly reduced by using the preset method of the LabSolutionsICPMS software.</p><h4><strong>3. </strong><style type="text/css"></style><style type="text/css"></style><strong>Thermo Fisher Scientific: </strong><style type="text/css"></style><style type="text/css"></style><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an41218_oe_basic_inclusion_analysis_en_024ffa9f51.pdf"><strong>Iron and steel - ARL iSpark Plus Optical Emission Spectrometer - Basic inclusion analysis</strong></a></h4><ul><li>Application</li></ul><p><strong>Benefits&nbsp;</strong></p><ul><li>Ultra-fast evaluation of some main inclusion types</li><li>Close to real-time inclusion check in up to hundreds of samples a day</li><li>More effective control of inclusiondependent steel properties</li><li>Helps reduce the number of costly issues caused by inclusions</li></ul><p><strong>Basic inclusion analysis</strong></p><p>Non-metallic inclusions dramatically affect steel properties and cause process issues like nozzle clogging. The costs associated with bad steel properties, process issues or customer complaints may amount to several hundred thousand dollars every year. Controlling the formation and the modification of non-metallic inclusions has therefore become essential to the production of modern steels as demanded by today’s markets.</p><p>The Thermo Scientific ARL iSpark Plus is a high-end metal analyzer that allows precise and accurate elemental analysis of steel. It also enables ultra-fast analysis of non-metallic inclusions, enabling a steel plant to control steel quality and production process even more effectively, and considerably reduce the costs associated with unwanted inclusions.</p><p>The Basic Inclusion Analysis Spark-DAT (Spark Data Analysis and Treatment) option is the entry-level method for standard inclusion analysis in low alloy steel. It reports the amounts of some of the most common types of non-metallic inclusions together with the elemental concentrations, helping steel plants to guarantee the quality and the properties of the steel product, as well as the smooth running of the production process.</p><p>Principles and details on Spark-DAT inclusion analysis can be found in the application note of the Standard Inclusion Analysis (AN41219).</p><h4><strong>4. </strong><style type="text/css"></style><style type="text/css"></style><style type="text/css"></style><strong>Metrohm: </strong><style type="text/css"></style><style type="text/css"></style><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_118_download_7c2174fc54.pdf"><strong>Quantification of cotton content in textiles by near-infrared spectroscopy</strong></a></h4><ul><li>Application</li></ul><p><strong>Fast, non-destructive determination of cotton with NIRS</strong></p><p>Cotton and polyester are two of the most popular fabrics for creating garments. Polyester is a synthetic material produced from petrochemical products, and cotton is a natural and sustainable fiber harvested from cottonseeds. Polyester is the best choice for water-resistant, durable apparel, while cotton is better suited for breathable, cool summer clothing. Textile products must be labeled according to their fiber composition. The procedures for the determination of fiber composition include mechanical, chemical, and microscopic methods—all of which are time consuming. In contrast, nearinfrared spectroscopy (NIRS) is a fast and chemicalfree alternative. This Application Note shows how NIR spectroscopy can be used to determine the cotton content in textile products within 30 seconds.</p><p><strong>CONCLUSION</strong></p><p>&nbsp;This Application Note demonstrates the feasibility of NIR spectroscopy to determine the cotton percentage in textile blends quickly and easily. Vis-NIR spectroscopy offers users a fast, cost-effective, and highly accurate alternative to other standard testing methods.</p><p>Additionally, NIRS analysis is non-destructive, completely reagent-free, and gives results in only 30 seconds.</p>

News from LabRulezICPMS - Library Week 35, 2024

<p><strong>In the next two weeks from September 9, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Phenomenex: Solid Phase Extraction Method Development</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 10.9.2024 11:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4182">Registration</a></div></li></ul></div><p>Understand how to develop SPE methods from start to finish. Learn when and how to optimize SPE methods, and discover new tips and tricks to make SPE method development easier.</p></div><h5><strong>2. Agilent Technologies: Comprehensive Quality Control Testing of Biofuels to Ensure a Greener, more Sustainable Future</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 10:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4204">Registration</a></div></li></ul></div><p>Learn about the latest laboratory testing techniques that are used to ensure the quality, efficiency, and sustainability of modern biofuels.</p></div><h5><strong>3. Separation Science/Markes International: Advanced GC–MS Techniques in Polymer Chemistry</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 11:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4185">Registration</a></div></li></ul></div><p>Discover the latest trends and technologies in sampling and analysis of material emissions in the polymer industry.</p></div><h5><strong>4. Thermo Fisher Scientific: Discover the next generation of raw material ID testing for QA/QC</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 16:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4253">Registration</a></div></li></ul></div><p>Learn about the&nbsp;new features available in the TruScan G3 for pharmaceutical and biotechnology manufacturing QA/QC.</p></div><h5><strong>5. Agilent Technologies: Tips, Tricks, and Troubleshooting for Successful Headspace Analysis in GC</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 17:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3915">Registration</a></div></li></ul></div><p>We go over the basics of headspace and how you can implement it successfully in the lab.</p></div><h5><strong>6. SGS: Clearing the Air: Understanding Airborne PFAS Exposure</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 19:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4219">Registration</a></div></li></ul></div><p>US EPA methods OTM45 and OTM-50, vapor intrusion, landfill gas monitoring, and the future of personal and occupational exposure monitoring.</p></div><h5><strong>7. Agilent Technologies: Alcoholic Beverages Virtual Symposium: Spirits</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 17.9.2024 20:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4256">Registration</a></div></li></ul></div><p>How you can assure safety, authenticity, and quality of alcoholic beverages.</p><div class="sc-c459d889-0 fAWHTe"><strong>8. SelectScience: Master GC-MS analysis of volatile and semivolatile organic compounds</strong></div></div><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Th, 19.9.2024 17:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4223">Registration</a></div></li></ul></div><p>How to boost throughput with the use of an enhanced tuning algorithm, faster data acquisition, and other novel GC-MS designs.</p></div>

Webinars LabRulezGCMS Week 37-38/2024

<p><strong>In the week of September 9, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Agilent Technologies: Liquid Chromatography Fundamentals</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4254">Registration</a></li></ul></div><p>We start the LC Beginner webinar series with an overview of basic terms relevant to liquid chromatography.</p></div><h5><strong>2. Phenomenex: Solid Phase Extraction Method Development</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4182">Registration</a></li></ul></div><p>Understand how to develop SPE methods from start to finish. Learn when and how to optimize SPE methods, and discover new tips and tricks to make SPE method development easier.</p></div><h5><strong>3. Waters Corporation: Basics of Liquid Chromatography</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/3811">Registration</a></li></ul></div><p>The fourth episode will introduce you to LC system components: pumps, injectors, and detectors.</p></div><h5><strong>4. Waters Corporation: Fundamentals of HPLC Separations for Small Molecule Analyses</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4247">Registration</a></li></ul></div><p>This webinar will introduce liquid chromatography and provide a comprehensive overview of an HPLC system.</p></div><h5><strong>5. Waters Corporation: Advancements in Targeted Quantitation of PFAS</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4248">Registration</a></li></ul></div><p>Learn how technologies are transforming PFAS analysis, helping laboratories meet the growing demand for more efficient and accurate testing.</p></div><h5><strong>6. C&amp;EN/Repligen: Maximize Downstream Control and Efficiency with In-line Concentration Measurement</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4243">Registration</a></li></ul></div><p>In this webinar we will discuss how the FlowVPX System can be integrated in-line, at different steps in a downstream process.</p></div><h5><strong>7. Metrohm: Real-World Titration Optimization: Advanced Techniques for Improved Results</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4244">Registration</a></li></ul></div><p>We will share success stories of titration methodology optimization and demonstrate how automated systems can systematically reduce human error, and enhance the accuracy and reproducibility of results.</p></div><h5><strong>8. Phenomenex: LC Chiral Theory and Method Development</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Tu, 10.9.2024 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4203">Registration</a></li></ul></div><p>Learn what chiral compounds are and how they are separated using LC and what a chiral stationary phase (CSP) is and the different types there are.</p></div><h5><strong>9. Bruker: Taking 4D-Proteomics™ to the routinely exceptional with the timsTOF Ultra 2</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>We, 11.9.2024 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4234">Registration</a></li></ul></div><p>Through real-life examples how sensitive and versatile the timsTOF Ultra 2 can be.</p></div><h5><strong>10. SCIEX: Analysis of ultra short-chain PFCAs to better understand environmental sources and fate</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>We, 11.9.2024 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/3870">Registration</a></li></ul></div><p>Stay on the leading edge of all things PFAS with this enlightening monthly webinar series on testing workflows and cutting-edge technology that will demystify these “forever chemicals”.</p></div><h5><strong>11. Waters Corporation: Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Th, 12.9.2024 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4250">Registration</a></li></ul></div><p>Discuss some of the most popular and exciting peer-reviewed publications in a friendly and open forum.</p></div><h5><strong>12. Technology Networks/SCIEX: Transforming Viral Vector Manufacturing With Capillary Electrophoresis</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Th, 12.9.2024 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4214">Registration</a></li></ul></div><p>In this webinar, our expert speakers will explore the different ways that CE is advancing biopharmaceutical development.</p></div><h5><strong>13. Waters Corporation: Innovative Approaches in HRMS and Software for PFAS Analysis</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li>Th, 12.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4249">Registration</a></li></ul></div><p>Learn how these cutting-edge approaches are revolutionizing PFAS detection and analysis, offering more accurate and efficient solutions for environmental monitoring and public health protection.</p></div>

Webinars LabRulezLCMS Week 37/2024

<p><strong>In the week from September 9, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. C&amp;EN/Repligen: Maximize Downstream Control and Efficiency with In-line Concentration Measurement</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Tu, 10.9.2024 17:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4243">Registration</a></div></li></ul><p>In this webinar we will discuss how the FlowVPX System can be integrated in-line, at different steps in a downstream process.</p></div></div><h5><strong>2. Bruker: XRF Unveiled: Mastering the Art of Sample Preparation</strong></h5><div class="sc-eecb5a47-15 uisAy"><div class="sc-eecb5a47-5 fnfCwD"><ul><li><div class="sc-eecb5a47-16 iJCuZC">Th, 12.9.2024 09:00 CEST</div></li><li><div class="sc-eecb5a47-16 iJCuZC"><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4211">Registration</a></div></li></ul><p>In our lab sessions, we will show valuable tips and tricks for various applications and materials. Our experts will answer your questions during our Q&amp;A session.</p></div></div>

Webinars LabRulezICPMS Week 37/2024

Quantitative determination of olefins in pyrolysis oils from waste plastics and tires using selective adsorption by Ag–SiO2 followed by GC×GC-FID

An FDA-Validated, Self-Cleaning Liquid Chromatography–Mass Spectrometry System for Determining Small-Molecule Drugs and Metabolites in Organoid/Organ-on-Chip Medium

Single-protein optical holography

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Covid-19

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LabRulez

LECO Separation Science Workshop

Thermo Fisher Scientific at SOFT/TIAFT 2026

Bruker at SOFT-TIAFT 2026

Automatic ICP-OES Analysis of Lubricating Oils Using SPECTRO GENESIS DSOI and ACAROS Automation

Detection and Identification of Microplastics in Water and Other Matrices Using the Agilent Laser Infrared Spectroscopy Microscope

Unlocking New Analytical Possibilities with Waters APGC Solutions