<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring to you applications by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, and <strong>Thermo Fisher Scientific</strong> and poster by <strong>LECO</strong> from ACS meeting!</p><h4><strong>1. Thermo Fisher Scientific: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002952_gc_ms_isq_environmental_an002952_na_en_9738609742.pdf"><strong>Adhering to U.S. EPA Method 524.2 for the analysis of volatile organic compounds in drinking water</strong></a></h4><ul><li>application</li></ul><p><strong>Goal: </strong>Demonstration of a routine analytical method that meets the requirements outlined in U.S. EPA 524.2 for the quantitation of volatile organic compounds (VOCs) in drinking water, using the Teledyne LABS Tekmar Lumin Purge and Trap (P&amp;T) concentrator paired with the AQUATek LVA autosampler system along with a Thermo Scientific™ ISQ™ 7610 MS system coupled with a Thermo Scientific™ TRACE™ 1610 gas chromatograph (GC) and Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS). Method linearity, method detection limit (MDL), precision, and accuracy were assessed to evaluate method performance.</p><p><strong>Introduction:</strong> Analytical testing labs play a crucial role in monitoring surface, ground, and drinking water for volatile organic compounds (VOCs). Common by-products in the processing of household and industrial products, VOCs can contaminate water sources, potentially harming the environment and public health. To safeguard against this, labs use the U.S. EPA Method 524.21 to test water for the presence of VOCs, including four trihalomethane disinfection by-products. This procedure utilizes Purge and Trap (P&amp;T) procedures to remove VOCs with high volatility and low water solubility from water samples, followed by gas chromatography-mass spectrometry (GC-MS).</p><p><strong>Conclusion:</strong> The TRACE 1610 GC, the ISQ 7610 system, and the Tekmar Lumin P&amp;T with the AQUATek LVA autosampler system together offer benefits for executing U.S. EPA Method 524.2. The Tekmar Lumin P&amp;T concentrator enhances sample throughput through efficient trap cooling and moisture control, thus reducing peak interference and extending GC column life. The ISQ 7610 system’s VPI and ExtractaBrite ion source allow ionization source and analytical column replacement without venting the instrument, ensuring minimal downtime, and the XLXR™ detector offers extended linear dynamic range. The collective technology addresses routine VOC analysis challenges, ensuring robust sensitivity, maximized output, and consistent method compliance. The ISQ 7610 system equipped with the VPI coupled with the Tekmar Lumin P&amp;T and the AQUATek LVA autosampler exceeds all the requirements outlined in U.S. EPA Method 524.2 for analysis of VOCs in drinking water:</p><ul><li>Excellent linearity for all compounds was demonstrated with the %RSD of the calibration response factors passing all method requirements.</li><li>MDL and precision for seven 0.5 ppb standards showed no interference from excessive water and produced very reproducible results. The average MDL result for all 83 target compounds was 0.06 ppb with a precision of 4.06%.</li><li>The precision for n=31 samples over 189 injections displayed &lt;30% RSD accuracy for all compounds as the method requires. The average precision for all 83 target compounds and 2 surrogates gave a %RSD of 6.43% with an accuracy of 98% recovering the compounds. Individually, 4-bromofluorobenzene and 1,2-dichlorobenzene-d4 had a 7.68% RSD with an accuracy of 98% and 4.95% RSD and an accuracy of 95%, respectively, over 189 injections and almost four days of uninterrupted analysis.</li></ul><h4><strong>2. Shimadzu: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00706_en_f95bd4b605.pdf"><strong>Analysis of Denatured Fuel Ethanol with Brevis GC-2050 Using ASTM D5501</strong></a></h4><ul><li>application</li></ul><p><strong>User Benefits</strong></p><ul><li>The compact design of the Brevis GC-2050 enables space-saving in the laboratory.</li><li>As an alternative gas for helium, hydrogen can be used as the carrier gas.</li><li>&nbsp;Analysis of ethanol and methanol in fuels based on ASTM D5501 is possible.</li></ul><p><strong>Introduction</strong></p><p>Bioethanol has attracted attention as a form of renewable energy which can be obtained from biomasssuch as corn and sugar cane. ASTM D5501 provides a test method for determination of the concentrations of ethanol and methanol in fuels for concentrations of ethanol from 20 to 100 wt% and concentrations of methanol from 0.01 to 0.6 wt%.</p><p>In this Application News article, measurements of the purity of ethanol containing gasoline as a denaturant as specified in ASTM D5501 were carried out with a Brevis GC-2050 gas chromatograph, using helium and hydrogen asthe carrier gases.</p><p><strong>Conclusion</strong></p><p>Ethanol purity tests were carried out as provided in ASTM D5501 using a Brevis GC-2050 gas chromatograph. The splitter linearity test showed no inlet discrimination so that accurate qualitative analysis could be made for denatured fuel ethanol with the wide boiling range components regardless of whether helium or hydrogen was used as the carrier gas.</p><h4><strong>3. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_aldehydes_beer_pal3_autosampler_5977c_gc_msd_5994_7633en_agilent_1fe3b8541c.pdf"><strong>Analysis of Aldehydes in Beer by Agilent PAL3 Autosampler and 5977C GC/MSD</strong></a></h4><ul><li>application</li></ul><p><strong>Abstract</strong></p><p>This application note describes a method for quantitation of four aldehydes (hexanal, furfural, phenylacetaldehyde, and trans-2-nonenal) responsible for off-flavors in beer using an Agilent 8890/5977C GC/MSD with an Agilent PAL3 (SPME) autosampler. The method used fully automated, solvent-free extraction and on-fiber derivatization. The aldehyde compounds were derivatized with the derivatization agent O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) using the on-fiber derivatization procedure. The derivatization agent was first adsorbed onto an Agilent 65 µm PDMS/DVB fiber. Next, the fiber was inserted into a 20 mL headspace vial containing a 2 mL beer sample with agitation at 60 °C for 30 minutes. Both extraction and derivatization procedures were automatically performed using the PAL3 autosampler. The method demonstrated excellent sensitivity, with detection limits of 0.0009 µg/L for hexanal, 0.52 µg/L for furfural, 0.015 µg/L for phenylacetaldehyde, and 0.003 µg/L for trans-2-nonenal. The limits of the quantification for the four compounds were 0.003, 1.72, 0.05, and 0.01&nbsp;µg/L, respectively. The four aldehydes were successfully quantified in four beer samples purchased from a supermarket. Good repeatability was demonstrated with RSD &lt; 4.9% based on three replicate injections of the four beer samples for all four&nbsp;aldehydes.</p><p><strong>Conclusion</strong></p><p>This application note describes the quantitative analysis of four aldehydes (hexanal, furfural, phenylacetaldehyde, and trans-2-nonenal) responsible for off-flavors in beer using an Agilent 8890/5977C GC/MSD with a PAL3 (SPME) autosampler. This method offers the advantages of full automation, rapid analysis, solvent-free extraction, and on-fiber derivatization. With this automated solution, excellent sensitivity was demonstrated for the detection of hexanal (0.0009 μg/L), furfural (0.52 μg/L), phenylacetaldehyde (0.015&nbsp;μg/L), and trans-2-nonenal (0.003 μg/L). Four different brands of beer were analyzed, with hexanal detected in the range of 0.45 to 1.56 μg/L, furfural in the range of 6.62&nbsp;to 50.37 μg/L, phenylacetaldehyde in the range of 6.64 to 10.51&nbsp;μg/L, and trans-2-nonenal in the range of 0.031 to 0.062&nbsp;μg/L. Good repeatability was demonstrated with RSD&nbsp;&lt;&nbsp;4.9% based on three replicate injections of the four beer samples for all four aldehydes.</p><h4><strong>4. LECO: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/hf_acs21_lpss_284_c35134b9cd.pdf"><strong>Combining GC with MS and Olfactory Detection for a Variety of Food, Flavor, and Fragrance Analyses</strong></a></h4><ul><li>Poster / <strong>ACS</strong></li></ul><p><strong>INTRODUCTION</strong></p><p>Gas chromatography (GC) coupled with mass spectrometry (MS) is an important tool for the characterization of a wide range of food, flavor, and fragrance samples. The components most likely to contribute to the aroma of a sample tend to be volatile and semi-volatile analytes, and GC-MS is well-suited for this type of analysis. Complex samples are effectively separated into the individual analyte components with GC. Time-of-Flight (TOF) MS detection provides important information towards the identification of these potentially important components of the sample with full m/z range data that can be library searched and that is also optimal for deconvolution algorithms. The incorporation of olfactory (O) detection with this data is particularly helpful for connecting the identified features with their contributions to the overall aroma or flavor. This type of sensory directed analysis highlights regions of interest and leads to specific analytes of interest for a focused review of the data. This combination of tools can separate and identify analytes and then determine those that are most important for contributing to the sensory characteristics of the sample. A variety of samples were analyzed with this combination of tools, and the benefits of using the information together are highlighted.</p><p><strong>CONCLUSIONS</strong></p><p>In this work, the combination of a GC separation with MS and O for detection provided a powerful and efficient analytical platform to isolate individual analytes, identify those isolated analytes, and connect them to their sensory impacts. The olfactory data allowed for sensory directed analysis. In each case, the GC separation and full m/z range TOFMS data were crucial for determining the identification of the feature responsible for the characteristic aroma. This collection of tools was demonstrated for the characterization of the most aroma impacting components of a nutmeg essential oil, the distinction of sensory differences in cilantro, and the determination of an off-odor in beer.</p>

News from LabRulezGCMS Library - Week 37, 2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in week 37, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring to you applications and other documents by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, <strong>Thermo Fisher Scientific</strong>, and<strong> Metrohm</strong>!</p><h4><strong>1. Thermo Fisher Scientific: </strong><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/XX_72201_ICP_MS_5_Questions_Infographic_XX_72201_EN_de14a23b16.pdf"><strong>How to Choose Your ICP-MS Solution. 5 Questions about ICP-MS</strong></a></h4><ul><li>other</li></ul><p><strong>5 Questions about ICP-MS</strong></p><ol><li>When is trace elemental quantification important?</li><li>What advanced applications are possible with ICP-MS?</li><li>Wha are high precision isotope ratios important?</li><li>How is interference removal achieved in ICP-MS</li><li>What are the typical detection limits of ICP-MS system?</li></ol><h4><strong>2. Shimadzu: </strong><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00512_en_ca79400760.pdf"><strong>Analysis of Stain-like Deposits on the Surface of Metal Machined Parts for the Transportation Industry Using the AIRsight Infrared/Raman Microscope</strong></a></h4><ul><li>application</li></ul><p><strong>User Benefits</strong></p><ul><li>AIRsight makes it easy to quickly switch between infrared and Raman measurements without moving the target.</li><li>Materials up to 40 mm thick can be measured directly and non-destructively.</li><li>Raman spectroscopy is ideal for measuring micron-scale areas and rough surfaces.</li></ul><p><strong>Introduction</strong></p><p>When manufacturing metal machined parts, anti-rust oil or cleaning fluid from machine tools may remain on metal parts, potentially leading to stain-like deposits. These stains can cause issues, such as reacting with lubricating oil or causing poor plating adhesion. This Application News presents a case study of measuring stainlike deposits found on the surface of metal machined partsfor the transportation industry using the infrared-Raman microscope AIRsight.</p><p><strong>Conclusion</strong></p><p>The analysis of stain-like deposits discovered on the surface of metal machined parts for the transportation industry using AIRsight was introduced. Raman spectroscopy allowed the qualitative identification of the stain components, which was difficult with infrared spectroscopy due to the surface's unevenness. AIRsight is very useful for the qualitative analysis of unknown samples by allowing rapid switching and measurement of both infrared and Raman spectroscopy without moving the sample. Additionally, it can measure thick samples like metal machined parts non-destructively.</p><h4><strong>3. Agilent Technologies: </strong><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_mea_triazine_analysis_5994_7579en_agilent_1a14b8d0a5.pdf"><strong>Quantitative Analysis of MEA-Triazine Hydrogen Sulfide Scavengers Through Innovative Transmission FTIR Spectroscopy</strong></a></h4><ul><li>application</li></ul><h5><strong>The Agilent Cary 630 FTIR spectrometer with DialPath module: transmission FTIR with variable path lengths</strong></h5><p><strong>Abstract</strong></p><p>A common contaminant in oil and gas extraction is hydrogen sulfide (H<sub>2</sub>S). Monoethanolamine-triazine (MEA-triazine) is one of the most used scavengers for H<sup>2</sup>S. Industrially, there are many challenges in measuring MEA-triazine concentration in aqueous solutions. This application note aims to develop a mid-infrared (mid-IR) method using an Agilent DialPath transmission module to measure the concentration of MEA-triazine in aqueous solutions. The analytical method described meets the requirements for quantifying MEA-triazine with different solvents, providing time savings, ease of use, and reduced susceptibility to pipetting errors due to viscosity.</p><p><strong>Conclusion</strong></p><p>The Agilent Cary 630 FTIR spectrometer with DialPath module proves to be a highly effective, accurate, and user-friendly method for the quantitative analysis of MEA-triazine in aqueous solutions. The technique's excellent linearity and robustness against additives such as MeOH and IPA highlight its reliability. The DialPath module's innovative design simplifies the measurement process, enhances sample throughput, and reduces common issues such as leaks and air bubbles. This method offers a significant improvement over traditional analytical techniques, providing a practical solution for both field and laboratory measurements in the oil and gas industry.</p><h4><strong>4. Metrohm: </strong><style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_122_download_da32ea61a1.pdf"><strong>Quantification of water in lactose with the OMNIS NIRS Analyzer</strong></a></h4><ul><li>application</li></ul><h5><strong>Fast, non-destructive determination of water with NIRS</strong></h5><p>Lactose is an important pharmaceutical product. Approximately 60% to 70% of pharmaceutical dosage forms contain lactose [1], and it is one of the largest pharmaceutical excipients by volume. Lactose can be used as a bulk filler for pharmaceutical tablets, as a binder to provide more strength to a dosage form, and it can also be added to facilitate the flow of a formulation during the production process. Moisture in lactose is undesirable at high levels as it causes the material to become sticky and bind to itself, forming hard clusters that may be difficult to break apart. USP specifies the water content range in lactose monohydrate from 4.5 % to 5.5 % [2]. The analysis of water in lactose is usually done with time-consuming methods. Near-infrared spectroscopy (NIRS) is a faster alternative. This Application Note shows the determination of water content in lactose with NIRS.</p><p><strong>CONCLUSION</strong></p><p>This Application Note demonstrates the feasibility to determine water content in lactose quickly and easily. NIR spectroscopy offers users a fast, cost-effective, and highly accurate alternative to other standard testing methods. Additionally, NIRS analysis is nondestructive, completely reagent-free, and gives results in only a few seconds.</p>

News from LabRulezICPMS Library - Week 37, 2024

Comprehensive methodology for semi-volatile organic compound determination in ambient air with emphasis on polycyclic aromatic hydrocarbons analysis by GC–MS/MS

<p><strong>In the week from September 23, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1.&nbsp;Mettler-Toledo: Automated Data Management for LC/GC Workflows</strong></h5><ul><li>Mo, 23.9.2024 10:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4226">Registration</a></li></ul><p>How can you support digitalized and scalable sample preparation processes for better chromatography results.</p><h5><strong>2. Agilent Technologies: PFAS in Food Supply Chains: Regulations and Analytical Approaches: in association with AOAC India Section</strong></h5><ul><li>Tu, 24.9.2024 08:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4281">Registration</a></li></ul><p>PFAS characteristics and the challenges they present to food safety.</p><h5><strong>3. Waters Corporation: Chromatography - APGC</strong></h5><ul><li>Tu, 24.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4307">Registration</a></li></ul><p>Discover the advantages of GC coupled to MS under atmospheric pressure (Atmospheric Pressure GC/ APGC) as a powerful alternative to electron ionization (EI) for GC-MS.</p><h5><strong>4. Agilent Technologies: Alcoholic Beverages Virtual Symposium: Wine</strong></h5><ul><li>Tu, 24.9.2024 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4259">Registration</a></li></ul><p>How you can assure safety, authenticity, and quality of alcoholic beverages.</p><h5><strong>5. Waters Corporation: General Sample Preparation</strong></h5><ul><li>We, 25.9.2024 09:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4308">Registration</a></li></ul><p>Join us in exploring SPE key parameters and best practices for implementing successful SPE methods.</p><h5><strong>6. Waters Corporation: Automated Sample Preparation</strong></h5><ul><li>We, 25.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4309">Registration</a></li></ul><p>The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders.</p><h5><strong>7. Agilent Technologies: Sample Cleanup: Method Development for Solid Phase Extraction and Beyond</strong></h5><ul><li>We, 25.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3917">Registration</a></li></ul><p>We’ll discuss tips for selecting, developing, and implementing SPE methods. We’ll also discuss newly developed targeted filtration options and their benefits.</p><h5><strong>8. LECO: Non-Targeted Screening in Sustainable Fuels: Exploring Method Development and Fuel Quality Assessment Using GCxGC-MS and Hyphenated Techniques</strong></h5><ul><li>Th, 26.9.2024 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4296">Registration</a></li></ul><p>Embark on a journey of discovery in chemical analysis, with each instalments of our monthly webinar series delivering fresh perspectives and invaluable insights.</p>

Webinars LabRulezGCMS Week 39/2024

<p><strong>In the week from September 23, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Metrohm: Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS</strong></h5><ul><li>Tu, 24.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4280">Registration</a></li></ul><p>Key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS.</p><h5><strong>2. Agilent Technologies: Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity</strong></h5><ul><li>We, 25.9.2024 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4295">Registration</a></li></ul><p>Join the webinar to discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.</p><h5><strong>3. Bruker: From Biological Exploration to Clinical Translation: Lipoproteins in Inflammation Response</strong></h5><ul><li>We, 25.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4228">Registration</a></li></ul><p>How our translational achievements in NMR technology are poised to revolutionize clinical research settings.</p><h5><strong>4. Mettler-Toledo: Thermal Analysis of Inorganic Materials</strong></h5><ul><li>Th, 26.9.2024 08:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/3918">Registration</a></li></ul><p>Discover Key Techniques for Characterizing This Diverse Group of Materials.</p><h5><strong>5. Bruker: Hypoxia assessment using simultaneous multiparametric PET/MRI</strong></h5><ul><li>Th, 26.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4230">Registration</a></li></ul><p>Simultaneous PET/MRI methods and challenges in the characterization of hypoxia-induced physiological differences between breast cancer subtypes.</p>

Webinars LabRulezICPMS Week 39/2024

Advancing Fundamental Understanding of Retention Interactions in Supercritical Fluid Chromatography Using Artificial Neural Networks: Polar Stationary Phases with –OH Moieties

<p><strong>In the week of September 23, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4></blockquote><blockquote><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Mettler-Toledo: Automated Data Management for LC/GC Workflows</strong></h5><ul><li>Mo, 23.9.2024 10:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4226">Registration</a></li></ul><p>How can you support digitalized and scalable sample preparation processes for better chromatography results.</p><h5><strong>2. &nbsp;Agilent Technologies: PFAS in Food Supply Chains: Regulations and Analytical Approaches: in association with AOAC India Section</strong></h5><ul><li>Tu, 24.9.2024 08:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4281">Registration</a></li></ul><p>PFAS characteristics and the challenges they present to food safety.</p><h5><strong>3. Waters Corporation: Chromatography - UPLC</strong></h5><ul><li>Tu, 24.9.2024 09:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4304">Registration</a></li></ul><p>An overview of the Waters reference material available to customer to help plan the best columns and chromatographic conditions for their LC-MS methods.</p><h5><strong>4. Waters Corporation: Tandem Quadrupole MS and MS-Method Development</strong></h5><ul><li>Tu, 24.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4305">Registration</a></li></ul><p>In this episode it’s all about the tandem quadrupole mass specs and the setup of MS-methods.</p><h5><strong>5. &nbsp;Agilent Technologies: Stationary Phases in HPLC - Part II</strong></h5><ul><li>Tu, 24.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4257">Registration</a></li></ul><p>We look at other separation modes: IEX, SEC, ligand exchange and HILIC and what we think they are best suited for.</p><h5><strong>6. Phenomenex: Advanced strategies in LC/MS/MS for the clean-up and the analysis of per- and polyfluoroalkyl substances (PFAS) in various matrices</strong></h5><ul><li>Tu, 24.9.2024 12:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4314">Registration</a></li></ul><p>Extremely sensitive and robust LC-MS/MS and sample preparation solutions, with methods and software which are ready to implement.</p><h5><strong>7. Waters Corporation: Introduction Non-target Screening (NTS)</strong></h5><ul><li>Tu, 24.9.2024 13:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4306">Registration</a></li></ul><p>We’ll discuss a holistic approach and introduce high-resolution mass spectrometry methods for both Suspect and NTS screening.</p><h5><strong>8. Waters Corporation: Software and Instruments for NTS</strong></h5><ul><li>Tu, 24.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4311">Registration</a></li></ul><p>This session will focus on presenting in detail the data evaluation of HRMS-Screening experiments.</p><h5><strong>9. Waters Corporation: Chromatography - APGC</strong></h5><ul><li>Tu, 24.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4307">Registration</a></li></ul><p>Discover the advantages of GC coupled to MS under atmospheric pressure (Atmospheric Pressure GC/ APGC) as a powerful alternative to electron ionization (EI) for GC-MS.</p><h5><strong>10. Technology Networks/Agilent Technologies: Biopharma Innovations Summit Day 1</strong></h5><ul><li>Tu, 24.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4227">Registration</a></li></ul><p>Learn more about our cell analysis and genomics expertise and the tools we provide to drive IVT mRNA development.</p><h5><strong>11. SelectScience/CAMAG: Development of an HPTLC method for evaluating vegetable oil adulteration</strong></h5><ul><li>Tu, 24.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4315">Registration</a></li></ul><p>How HPTLC can enhance the reliability and efficiency of your edible oil quality assessments.</p><h5><strong>12. SCIEX: SCIEX summit Day one: Innovation and data insights</strong></h5><ul><li>Tu, 24.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4292">Registration</a></li></ul><p>Join us to discuss the importance of LC-MS in fields like food and environmental testing, pharmaceutical and biopharmaceutical discovery and development and biomedical and omics research.</p><h5><strong>13. Metrohm/Agilent Technologies: Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS</strong></h5><ul><li>Tu, 24.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4280">Registration</a></li></ul><p>Key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS.</p><h5><strong>14. Waters Corporation: HPLC Troubleshooting: A System Monitoring Approach</strong></h5><ul><li>Tu, 24.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4279">Registration</a></li></ul><p>Troubleshooting HPLC systems and chromatographic issues using a structured workflow.</p><h5><strong>15. Waters Corporation: General Sample Preparation</strong></h5><ul><li>We, 25.9.2024 09:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4308">Registration</a></li></ul><p>Join us in exploring SPE key parameters and best practices for implementing successful SPE methods.</p><h5><strong>16. &nbsp;Waters Corporation: Automated Sample Preparation</strong></h5><ul><li>We, 25.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4309">Registration</a></li></ul><p>The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders.</p><h5><strong>17. Agilent Technologies: Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity</strong></h5><ul><li>We, 25.9.2024 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4295">Registration</a></li></ul><p>Join the webinar to discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.</p><h5><strong>18. Waters Corporation: Quantification for Targeted Analysis</strong></h5><ul><li>We, 25.9.2024 13:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4310">Registration</a></li></ul><p>The MS Quan application’s main workflows and overarching features are introduced and illustrated with a PFAS analysis dataset.</p><h5><strong>19. Technology Networks/Agilent Technologies: Biopharma Innovations Summit Day 2</strong></h5><ul><li>We, 25.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4246">Registration</a></li></ul><p>Learn more about our cell analysis and genomics expertise and the tools we provide to drive IVT mRNA development.</p><h5><strong>20. SCIEX: SCIEX summit Day two: Characterization and discovery</strong></h5><ul><li>We, 25.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4293">Registration</a></li></ul><p>Join us to discuss the importance of LC-MS in fields like food and environmental testing, pharmaceutical and biopharmaceutical discovery and development and biomedical and omics research.</p><h5><strong>21. Separation Science/Agilent Technologies: Streamlining N-Glycan Analysis: A Complete Workflow from Agilent</strong></h5><ul><li>We, 25.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4282">Registration</a></li></ul><p>Learn about the latest N-Glycan sample preparation techniques.</p><h5><strong>22. &nbsp;Agilent Technologies: Sample Cleanup: Method Development for Solid Phase Extraction and Beyond</strong></h5><ul><li>We, 25.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/3917">Registration</a></li></ul><p>We’ll discuss tips for selecting, developing, and implementing SPE methods. We’ll also discuss newly developed targeted filtration options and their benefits.</p><h5><strong>23. Waters Corporation: PFAS in Food</strong></h5><ul><li>Th, 26.9.2024 09:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4312">Registration</a></li></ul><p>We will discuss the successful method implementation from sample preparation to final report and hear real-life experiences.</p><h5><strong>24. Waters Corporation: PFAS Analysis in Drinking, Ground, and Surface Water</strong></h5><ul><li>Th, 26.9.2024 13:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4313">Registration</a></li></ul><p>We will give insights how the analysis of PFAS in environmental samples works in routine testing labs.</p><h5><strong>25. &nbsp;Agilent Technologies: Back to the Lab with Your Fragment Analyzer and Femto Pulse</strong></h5><ul><li>Th, 26.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4177">Registration</a></li></ul><p>Top tips for achieving high-quality analysis with the Fragment Analyzer and Femto Pulse systems.</p><h5><strong>26. SCIEX: SCIEX summit Day three: Quantitation and screening</strong></h5><ul><li>Th, 26.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4294">Registration</a></li></ul><p>Join us to discuss the importance of LC-MS in fields like food and environmental testing, pharmaceutical and biopharmaceutical discovery and development and biomedical and omics research.</p><h5><strong>27. Thermo Fisher Scientific: Integrating charged aerosol detection in chromatographic workflows</strong></h5><ul><li>Th, 26.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4231">Registration</a></li></ul><p>We will share insights into Professor James Grinias laboratory’s pioneering work with charged aerosol detection (CAD).</p><h5><strong>28. Agilent Technologies: Nitrosamines &amp; NDSRI's: Analytical method development trends and challenges in Nitrosamines and NDSRI's.</strong></h5><ul><li>Fr, 27.9.2024 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4290">Registration</a></li></ul><p>NDSRI webinar series is a comprehensive three-part webinar series designed to provide valuable insights into the evolving landscape of analytical methods and regulatory requirements.</p>

Webinars LabRulezLCMS Week 39/2024

Direct detection of beer photodegradation in commercial bottles and introduction of a new Light-Struck Flavour Susceptibility Index

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 16th September 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring to you applications, technical notes, posters, and other documents by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, <strong>Thermo Fisher Scientific,</strong> <strong>Waters Corporation</strong>,<strong> Metrohm</strong>, and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/313"><strong>Galochrom</strong></a>!</p><h4><strong>1. Galochrom: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Chiral_ION_QN_and_Chiral_ION_QD_Brochure_10c44e1448.pdf"><strong>Galochrom Chiral ION-QN &amp; Chiral ION-QD</strong></a></h4><ul><li>Brochure</li></ul><h5><strong>Weak Anion-Exchanger (WAX) stationary phases for reliable chiral separation of acidic compounds</strong></h5><p><strong>Transform Your Chiral Analysis</strong></p><p>Weak Anion-Exchanger (WAX) stationary phases for reliable chiral separation of acidic compounds One of the main challenges of today’s liquid chromatography is chiral separation of ionised and ionisable analytes, e.g., organic acids, amino acids, N-protected amino acids, amino acid mimics, etc. The most efficient approach to purify and resolve such troublesome racemates utilises ion exchange-type stationary phases that facilitate strong interactions between the chiral selector and the analyte.</p><p>Galochrom introduces its own generic series of weak anion-exchangers, based on tert-butyl-carbamoylated Cinchona alkaloids quinine (QN) and quinidine (QD). These chiral phases have demonstrated excellent selectivity and improved peak resolution, resulting in highly accurate and replicable analyses. Our innovative manufacturing and strict quality control ensure that these generic columns not only outperform commercial alternatives, but also meet your technical requirements.</p><p><strong>Chiral </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1241"><strong>ION-QN</strong></a><strong> &amp; Chiral </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1240"><strong>ION-QD</strong></a><strong> represent the most efficient approach to purify and resolve even the most challenging mixtures.</strong></p><h5><strong>Applications</strong></h5><p>Chiral ION-QN &amp; Chiral ION-QD are ideal for enantioseparations of:</p><ul><li><strong>N-protected amino acids</strong></li><li><strong>Aminophosphonic &amp; Aminosulfonic acids</strong></li><li><strong>Lactic &amp; Thiolactic acids</strong></li><li><strong>Clenbuterol &amp; Thyroxine</strong></li></ul><h4><strong>2. Metrohm: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_eis_004_download_4e13c9c1a9.pdf"><strong>Electrochemical Impedance Spectroscopy - Equivalent circuit models</strong></a></h4><ul><li>Technical note</li></ul><h5><strong>Electrochemical Impedance Spectroscopy</strong></h5><p><strong>Part 4 – Equivalent circuit models</strong></p><p>The circuit elements which are described in Application Note AN-EIS-003 can be combined in series and in parallel to build equivalent circuit models which can then be used to model the various phenomena occurring at the electrochemical interface.</p><p>This seven-part series introduces EIS and covers basic theory, experimental setups, common equivalent circuits used for fitting data, and tips for improving the quality of the measured data and fitting. This Application Note (part 4) provides example equivalent circuit models produced from the elements discussed in part 3. These models are among the most commonly encountered within electrochemistry research. The associated Nyquist plot is also shown for each model discussed.</p><p><strong>CONCLUSIONS</strong></p><p>This Application Note shows how electrical elements can be arranged in order to build both simple and more complex equivalent circuits that can be used for fitting EIS data. The resulting Nyquist plots for all the equivalent circuits are shown as well.</p><h4><strong>3. Thermo Fisher Scientific: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/wp_002641_ic_dionex_inuvion_ionic_small_polar_compounds_wp002641_na_en_9c0213a96b.pdf"><strong>Developing an ion chromatography system</strong></a></h4><ul><li>Technical note</li></ul><p><strong>Introduction</strong></p><p>Ion chromatography (IC) has become essential for analyzing ionic and small polar compounds. It has been applied in many areas, ranging from the analysis of drinking water, food and beverages, and cooling water to lithium-ion battery research, process quality assurance, and the presence of corrosives in liquified petroleum gas.</p><p>IC can trace its origins to work done at what would become Dionex Corporation in the mid-1970s with the introduction of the first ion chromatograph in 1975, the Dionex™ Model 10 IC system. This system had the essential elements of an IC system: a pump, separating column, eluent suppressor, conductivity detector, and data recorder (Figure 1).</p><p>This basic system provided adequate data, but several factors restricted sample throughput and required a considerable investment in labor and significant expertise to maintain. Column capacity and packed bed suppressor capacity were limited, and the instrument configuration was inflexible, constraining the type of samples that could be analyzed. Offline suppressor column regeneration was needed, the pressure tolerance was low, and the background conductivity was comparatively high. Furthermore, manual peak integration was required, eluent usage was significant, and there was substantial run-to-run variability. Since the Dionex Model 10 IC system, many innovations have been developed and incorporated into new systems to address these deficiencies. Additional advancements have enhanced robustness, reliability, user-friendliness, functional flexibility, and integrated data analysis. Ideally, an ion chromatograph will meet current customer demands while being adaptable to address potential future analytical needs.</p><p><strong>Conclusion</strong></p><p>The progression from the Dionex Model 10 IC system to the sophisticated Dionex Inuvion IC system highlights the significant advancements that have been made in the field of IC. These advancements have not only addressed previous limitations but also introduced new features and capabilities that significantly enhance the performance, reliability, and user-friendliness of IC systems. As a result, the Dionex Inuvion IC system represents the current pinnacle in the ongoing development of IC technology, setting a new standard for what can be achieved in the analysis of ionic and small polar compounds.</p><p>The Dionex Inuvion IC system is the result of state-of-the-art techniques and processes used to manufacture, design, and optimize essential hardware components such as pumps, instrument electronics, range-free detectors, and conductivity cells. This integration of advanced technology has resulted in a system that is not only reliable and robust but also flexible and user-friendly.</p><p>As we look to the future, the field of ion chromatography will continue to evolve with new challenges and opportunities on the horizon. The Dionex Inuvion IC system is well-positioned to meet these challenges, providing laboratories with a reliable and efficient solution for their analytical needs. In conclusion, the Dionex Inuvion IC system represents a significant achievement in ion chromatography, solidifying Thermo Fisher Scientific's position as a leader in the industry.</p><h4><strong>4. Waters Corporation: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/2024_asms_alelyunas_cellculturemediabioprocessing_27380a2953.pdf"><strong>A High Throughput LC-MS Method for Cell Culture Media Nutrient and Metabolite Analysis Supporting Upstream Bioprocessing</strong></a></h4><ul><li>poster / <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/296"><strong>ASMS</strong></a></li></ul><p><strong>INTRODUCTION</strong></p><p>A 9-minute rapid and direct liquid chromatography and mass spectrometry (LC-MS) analysis method for cell culture media (CCM) nutrients and metabolites covering 220+ compounds is described. The method is based on reversed phase chromatography where amino acids are directly detected without derivatization. This rapid method reduces turn-around time for monitoring and decision making using previously established user-friendly data review workflows and access to multivariate data analytics (MVDA). The method has been applied for the qualitative and quantitative determination of cell culture media nutrient and metabolite analysis in commercial cell culture media and spent media from process optimization in cNISTmAb production using NISTCHO cells. Monitoring of glucose directly from media using this method was also investigated and described.</p><p><strong>CONCLUSION</strong></p><ul><li>A rapid throughput method based on 9 min data acquisition is described for cell culture media nutrient and metabolite monitoring.</li><li>The method uses less than 10 μL of spent media sample and has coverage of 220 compounds.</li><li>Comparison with the previous 20 min method suggests the same high-quality data and method robustness, even when the analysis time is shortened by 50%.</li><li>Combination of the rapid throughput method with Waters bioprocess walk-up solution<sup>2</sup> can enable analytical scientist and bioprocess engineers to obtain high quality data easily and routinely for upstream bioprocess optimization.</li></ul><h4><strong>5. Shimadzu: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00767_en_135939ebe6.pdf"><strong>Automatic Optimization of Gradient Conditions by AI Algorithm for Impurity Analysis</strong></a></h4><ul><li>Application</li></ul><p><strong>User Benefits</strong></p><ul><li>The AI algorithm of LabSolutions MD can automatically optimize gradient conditions to greatly reduce labor of LC method<br>development.</li><li>Anyone can optimize gradient conditions, regardless of their experience in chromatography.</li><li>Gradient conditions that meet the resolution criteria for specified peaks are automatically searched (e.g., principal component and its related impurities).</li></ul><p><strong>Introduction</strong></p><p>In the typical LC method development, the process begins with “preparation” which includes mobile phase preparation, column installation, and creation of analysis schedules, then the analysis is started. After that, the acquired data is analyzed and “preparation” for the subsequent analysis is carried out, followed by starting the next analysis again. The method development progresses by repeating these processes, but in addition to the significant time required to repeatedly create analysis schedules, expertise in chromatography is necessary to explore optimal conditions based on data analysis. In other words, typical method development requires “human intervention”. Therefore, eliminating human involvement and automating such method development processes would be desirable to improve labor efficiency. This article introduces an example of automatic optimization of gradient conditions to separate montelukast (a small molecule drug) and its related impurities using LabSolutions MD (<a target="_blank" rel="noopener noreferrer" href="https://www.shimadzu.com/an/sites/shimadzu.com.an/files/pim/pim_document_file/technical/technical_reports/22105/c190-e309.pdf">Technical Report C190-E309</a>), a dedicated software for supporting method development.</p><p><strong>Conclusion</strong></p><p>Automatic optimization of gradient conditions using AI algorithm of LabSolutions MD was applied to montelukast and its related impurity. As a result, gradient conditions that met the criteria (“resolution for montelukast and related impurity &gt; 3.0” and “elution time of the last peak &lt; 15 minutes”) were successfully explored. This result indicates that significant labor saving in method development can be expected by LabSolutions MD. This article introduces an automatic optimization of gradient conditions in method development while LabSolutions MD also supports a series of workflow of method development, including the screening phase and robustness evaluation phase. For details, please refer to the Technical Report “<a target="_blank" rel="noopener noreferrer" href="https://www.shimadzu.com/an/sites/shimadzu.com.an/files/pim/pim_document_file/technical/technical_reports/14629/c190-e284.pdf">Efficient Method Development Based on Analytical Quality by Design with LabSolutions MD Software (C190-E284)</a>”.</p><h4><strong>6. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_polar_nitrosamines_1260_infinity_ii_multisampler_5994_7589en_agilent_22cb1563ee.pdf"><strong>Improved LC/MS Performance to Determine Polar Nitrosamines Using the Agilent 1260 Infinity II Hybrid Multisampler</strong></a></h4><ul><li>Application</li></ul><p><strong>Abstract</strong></p><p>This application note demonstrates the use of the Agilent 1260 Infinity II Hybrid Multisampler for the analysis of polar nitrosamines injected from organic solvents of high elution strength. The 1260 Infinity II Hybrid Multisampler is used under optimized feed speed conditions to trap and enrich the polar nitrosamines on the column. This avoids breakthrough and provides better peak shapes with more reliable quantification and improved detection limits.</p><p><strong>Introduction</strong></p><p>With the chemical synthesis of active pharmaceutical ingredients (APIs), impurities occur during chemical reactions. Genotoxic impurities (GTIs) are especially important because of their carcinogenic potential. To control the amount of GTIs, the U.S. Food and Drug Administration and the European Medicine Agency released guidelines for the maximum intake of GTIs with the daily dose of a drug depending upon the duration of application. According to these guidelines, the exposure to an individual genotoxic impurity must be below 1.5 μg/day for an application time longer than ten years.<sup>1</sup> In 2018, the drug Diovan was withdrawn from the market due to an increased amount of the nitrosamine impurity N-nitrosodimethylamine (NDMA) in the included API valsartan.<sup>2,3</sup> This application note describes the results achieved by the Agilent 1260 Infinity II hybrid injector for the analysis of nitrosamines injected from high organic solvents. The peak performance, like area precision, linearity, and sensitivity, will be discussed.</p><p><strong>Conclusion</strong></p><p>This application note describes the comparative measurement of nitrosamines using the Agilent 1260 Infinity II Hybrid Multisampler in feed injection mode and classical flow through injection mode. With the application of an optimized feed injection method, highly polar nitrosamines in a solvent of high eluting strength can be separated with good peak shapes. With classical flow through injection, massive peak broadening or even breakthrough were observed. Peak area RSD and LOQs are typically lower by a factor of 3 to 5 with feed injection.</p>

News from LabRulezLCMS Library - Week 38, 2024

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 16th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring to you applications and other documents by <strong>Agilent Technologies</strong>, <strong>Shimadzu</strong>, <strong>Thermo Fisher Scientific,</strong> and <strong>LECO</strong>!</p><h4><strong>1. Shimadzu: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c146_e452_c8a53d60a2.pdf"><strong>Database for GC-MS(/MS) Aroma Analysis - Smart Aroma Database</strong></a></h4><ul><li>Brochure</li></ul><p><strong>Provides Efficient and Accurate Aroma Analysis Using GC-MS(/MS)</strong></p><p>Information on more than 500 compounds that contribute to aroma is registered in Smart Aroma Database™, enabling the objective evaluation and analysis of aroma compounds using GC-MS(/MS).</p><p>1. Automatically Detects Aroma Compounds from Scan Measurements with High Accuracy</p><p>2. Easily Narrows Down the Compounds that Contribute to the Aroma</p><p>3. Enables High-Sensitivity Target Analysis Using MRM and SIM</p><p>4. Supports a Variety of Systems</p><h4><strong>2. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/br_5q_gc_column_campaign_5994_7596en_agilent_baca38e505.pdf"><strong>Agilent J&amp;W DB-5Q and HP-5Q GC columns</strong></a></h4><ul><li>Brochure</li></ul><h5><strong>Get the Most from Your MS</strong></h5><p><strong>As mass spectrometry continues to push the boundaries of sensitivity and speed, you need a column that can do the same</strong></p><ul><li>Agilent J&amp;W 5Q GC columns are designed to ensure optimal analyte delivery to your quadrupoles. They combine industry-leading ultra inert performance with ultra low-bleed technology, setting a new standard for GC/MS column reliability and productivity.</li><li>Ultra low-bleed performance enhances data accuracy with high spectral fidelity and stable baseline integration.</li><li>Ultra inert performance increases sensitivity for active, trace-level analytes and provides balanced deactivation for multiclass analyte panels.</li><li>Ultrafast conditioning and outstanding column durability improve uptime by minimizing the frequency of column changes.</li><li>Identical selectivity to current 5ms columns simplifies adaptation to existing retention time libraries and retention time locking.</li><li>Compatibility with any GC/MS system ensures a seamless fit for all Agilent GC platforms. Agilent J&amp;W 5Q GC columns are available in high-efficiency, hydrogen-compatible, and backflushing dimensions.</li></ul><h4><strong>3. Thermo Fisher Scientific: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AN_002784_Improvements_for_the_analysis_of_volatile_VOC_and_very_volatile_VVOC_organic_compounds_using_In_Tube_Extraction_Dynamic_Headspace_ITEX_DHS_and_cryogen_free_refocusing_4_bd362df5a5.pdf"><strong>Improvements for the analysis of volatile (VOC) and very volatile (VVOC) organic compounds using In-Tube Extraction-Dynamic Headspace (ITEX-DHS) and cryogen-free refocusing</strong></a></h4><ul><li>Application</li></ul><p><strong>Goal</strong></p><p>To demonstrate how the technological development of dynamic headspace extraction/enrichment techniques, such as ITEX-DHS (In-Tube Extraction-Dynamic Headspace) coupled to a cryogen-free refocusing in the PTV injector, enables the achievement of lower detection limits for volatile and very volatile organic compounds.</p><p><strong>Introduction</strong></p><p>Volatile organic compounds (VOCs) are a group of organic chemicals with low vapor pressure that can easily evaporate into the air, even at room temperature. These compounds can originate from various sources, including industrial processes, vehicle emissions, and natural sources. While VOCs are often associated with air pollution, they can also contaminate water, thus posing potential risks to human health and the environment.<sup>1</sup> VOCs can enter water through direct discharges, atmospheric deposition, or runoff from contaminated areas. Common VOCs found in water include benzene, toluene, ethylbenzene, and xylene (BTEX), as well as chlorinated compounds such as trichloroethylene (TCE) and tetrachloroethylene (PCE). These compounds can cause adverse health effects, ranging from short-term irritation to long-term chronic conditions, depending on the concentration and duration of exposure.</p><p>Regulatory authorities all over the world have established limits to control the maximum amount of VOCs in drinking water, groundwater, or surface water (e.g., Safe Drinking Water Act (SDWA) in the USA or the European Directive 2008/105/EC).<sup>2,3</sup> Therefore, monitoring and analyzing VOCs in water play crucial roles in identifying and addressing potential contamination issues, guiding remediation efforts, and ensuring compliance with water quality regulations.<sup>4</sup></p><p>Common methods to analyze VOCs in water include headspace, purge and trap, solid-phase microextraction, and liquid-liquid<br>extraction as possible sample preparation techniques employed to extract and concentrate VOCs before GC-MS analysis. As technology advances, continuous improvements in analytical methods and instrumentation contribute to more accurate and efficient VOC analysis, enhancing the ability to safeguard water resources and public health.</p><p>When dealing with drinking water testing, the limits of detection are particularly challenging, requiring an efficient enrichment before GC-MS analysis.</p><p>In-Tube Extraction-Dynamic Headspace (ITEX-DHS) is a sample preparation technique for the extraction and preconcentration of volatile compounds from different matrices, such as water, soil, or biological samples. One of the key advantages of ITEX-DHS is its high sensitivity and selectivity for volatile compounds. It allows for the extraction of low concentrated analytes from complex matrices while minimizing interference from non-volatile matrix components. Additionally, the technique offers an automated and efficient sampling process through a robotic autosampler, making it suitable for unattended and time-sensitive analyses.</p><p>ITEX-DHS has found applications in various fields, including environmental monitoring, food analysis, and forensic science. Its versatility makes it particularly valuable in situations where trace-level analysis of volatile compounds is crucial. An example of the use of ITEX-DHS for the detection of odorants in water at ng/L level is reported in a previous application note.<sup>5</sup></p><p>In this study, the performance of the ITEX-DHS sampling technique has been evaluated for trace level detection of volatile and very volatile compounds (VVOCs) in water, in combination with peak refocusing into a Programmed Temperature Vaporizer (PTV) injector, to enhance peak shape and signal-to-noise ratio.</p><h4><strong>4. LECO: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/PEGBTX_EXPAND_YOUR_PFAS_ANALYSIS_203_821_689_d24746e8bb.pdf"><strong>Expand Your PFAS Analysis - Screen for Targets and Identify Unknowns Simultaneously</strong></a></h4><ul><li>Application</li></ul><p><strong>Key Words:</strong> PFAS, GC-MS, HR-MS, TOFMS, Environmental Analysis, Pollutants, Emerging Substances, Non-target, NTS, Screening</p><p><strong>Background and Description</strong></p><p>Research into the prevalence of er- and polyfluoroalkyl substances (PFAS)—also known as “forever chemicals” due to theirp high stability in our environment and food chain continues to grow. At the same time, regulatory control of these species in our water and food supplies continues to gain momentum. However, analysis of PFAS in complex environmental samples can be challenging due to the enormous number and variety of PFAS chemicals. New analytical methods must be developed to monitor PFAS in the environment.</p><p>This application focuses on the rapidly expanding area of PFAS analysis and highlights how screening for known PFASnote targets, as well as discovering and identifying unknown PFAS chemicals, can be performed using high-performance GC-TOFMS. New libraries are being developed to facilitate the screening of these pollutants in samples.</p><p><strong>Conclusion</strong></p><p>Meeting the growing environmental research and regulatory needs for PFAS analysis requires the use of powerful technologies to screen for known targets and to detect and identify unknown PFAS candidates. Here, sub-nominal mass GC-TOFMS, allowed simultaneous, full mass range, highly sensitive target, and NTS screening for PFAS in Anti-Fog/Demisting products, detecting a variety of both known PFAS and unknown PFAS candidates. The use of accurate mass GC-HR-TOFMS technology with EI and CI capabilities facilitated strong tentative identifications of the unknowns to be a class of fluorotelomer ethoxylates (FTEOs). This approach, together with the results obtained, suggests these technologies are an ideal choice for screening and identification of volatile and semi-volatile PFAS, in an array of sample types in complex matrices.</p>

News from LabRulezGCMS Library - Week 38, 2024

Article

Product

Events

Webinars

Application

Academy

Video

Poster

Scientists

Plastics

Environment

Food

Water

Health

Presentation

Scientific article

Interview

Toxicology

Popularization

Science and research

Software

Covid-19

Career

Laboratories

Various

PFAS 

Zaměření

Type of News

Focus

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

LECO Separation Science Workshop

Thermo Fisher Scientific at SOFT/TIAFT 2026

Bruker at SOFT-TIAFT 2026

Automatic ICP-OES Analysis of Lubricating Oils Using SPECTRO GENESIS DSOI and ACAROS Automation

Detection and Identification of Microplastics in Water and Other Matrices Using the Agilent Laser Infrared Spectroscopy Microscope

Unlocking New Analytical Possibilities with Waters APGC Solutions