Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in week 39, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Shimadzu, Thermo Fisher Scientific, and Metrohm!<h4>1. Thermo Fisher Scientific: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002821_tea_icap_ms_icap_tqe_industrial_an002821_em_en_b60acdccc6.pdf">Analysis of process water from hydrogen fuel cells using triple quadrupole inductively coupled plasma mass spectrometry (ICP-MS)</a></h4><ul><li>Application</li></ul>GoalTo demonstrate the analysis of process water from hydrogen fuel cells for inorganic trace contaminants with high sensitivity and accuracy using triple quadrupole ICP-MS.IntroductionThe reduction of CO2 emissions is a major task for societies globally as the rise of CO2 in the atmosphere plays an enormous role in global warming. The automotive industry mainly focuses on the transition from petrol-fueled to electric vehicles (EVs) to reduce emissions; however, the generation of energy and energy-intensive industrial processes are also important sources of emissions. Here, other ways of reducing CO2 emissions might be feasible, and in the center of current debate stands the use of (ideally green) hydrogen and its combustion in hydrogen fuel cells. Hydrogen fuel cells are one of the key technological developments as there is no emission other than water. In addition, hydrogen can be created using renewable energies and can be transported with low effort due to its low density of only 70.85 g·L-1 when liquified.A typical hydrogen fuel cell consists of two electrodes (anode and cathode) and a polymeric electrolyte membrane (PEM) as shown in Figure 1. Typically, the electrode is made from fluorinated polymers to allow for chemical and mechanical stability and coated with a catalyst. Platinum is the catalyst material offering the highest efficiency; however, it is expensive. To reduce the production cost, improving the platinum coating technology and monitoring potential degradation by means of metal release into the water produced in the process are important. Due to the use of material blends, different trace metals as well as other non-metal contaminants must be monitored.In general, inductively coupled plasma mass spectrometry (ICP-MS) is the preferred analytical technique for the analysis of metals and related contaminants down to sub ng·L-1 levels. However, non-metals such as phosphorous or sulfur are challenging to analyze using ICP-MS due to a combination of their usually elevated ionization potentials and significant spectral interferences. Current hydrogen fuel cell technology uses mineral acids, like sulfuric acid, as electrolytes with a platinum catalyst on the electrodes (PAFC). Thus, it is important to monitor the concentrations of these elements at low concentrations. Oxygen- and nitrogen-based polyatomic interferences are usually of greatest concern for these analytes, but other polyatomic interference, like 31P1H+, may lead to false positive results and must be removed.Another challenge is the analysis of fluorine, which is also a key analyte for monitoring degradation of the PEM. Fluorine has the third highest first ionization potential of any element in the periodic table (behind neon and helium). In addition, its only naturally occurring isotope, 19F, falls into a severely interfered mass range, mainly due to the interferences generated by naturally abundant ions such as H3O+ and peak tailing of H2O+. To overcome these challenges, fluorine can be measured indirectly after mixing the sample with a solution containing barium. This results in the formation of 138Ba19F+ in the plasma, allowing the fluorine concentration to be measured interference free via m/z 157. Because of the required setup, the analysis of fluorine has to be conducted in a separate measurement and cannot be combined with the analysis of the other contaminants.In this study, a Thermo Scientific™ iCAP™ TQe ICP-MS was used for the analysis. Use of triple quadrupole technology offered superior interference removal and facilitated the analysis of important contaminants, including fluorine, at ultra-trace levels in the water produced by hydrogen fuel cells<h4>2. Metrohm: <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AN_RS_044_download_a7cb58965c.pdf">Optimize raw material identification and verification (RMID) with MIRA P</a></h4><ul><li>Application</li></ul>Validation model transfer increases productivityUsing a verification model on multiple instruments expands a manufacturer’s raw material identification/ verification (RMID) capabilities by speeding up incoming inspection, imparting flexibility to an operation, or avoiding downtime.In a scenario where several operators use multiple MIRA P systems at different locations, the ability of any operator to use any MIRA P to validate a new shipment streamlines operations and allows that shipment to be quickly released to production. In most cases, a well-designed model with inherent sample variability can be built on one MIRA P and transferred to another. In some cases, variance must be added to a training set with a few additional samples. This Application Note describes how a model transfers from one MIRA P to another in order to scale MIRA P usage across an entire operation.INTRODUCTIONModel building (including training and validation set samples, operating procedure (OP) settings, and necessary variance) has already been well-established for RMID with a unique MIRA P [1,2].In summary, MIRA Cal P generates PCA-based (principal component analysis) models using Training Set data and Operating Set parameters to verify target substances. Ideally, a model can be created on one instrument («MIRA P 1»), downloaded onto a second instrument («MIRA P 2»), then validated on the second unit and used directly.The model must be expanded if the initial transfer does not produce satisfactory p-values or does not pass validation. This involves introducing variance in the model and/or optimizing model parameters and/or ensuring consistent usage by each operator of the instrument.CONCLUSIONThe benefits of using multiple MIRA P devices for raw material verification include smoother operations and faster turnaround of products. This Application Note is intended to guide users through model transfer and enable the deployment of multiple MIRA P instruments. From tips for the simplest transfer to tools for more challenging tasks, we want you to be confident in taking your inspection with MIRA P to the next level. This flowchart is a quick reference for the basic flow of operations during MIRA P to MIRA P transfer.<h4>3. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ab_fentanyl_resolve_raman_5994_7699en_agilent_22a55edc96.pdf">Fentanyl Detection Using an Agilent Resolve Handheld Raman Analyzer</a></h4><ul><li>Application</li></ul>Safe identification of novel illicit opioidsFentanyl and fentanyl analogs are highly potent synthetic opioids that were developed in the 1950s as analgesics. These drugs are approved for clinical and veterinary use due to their rapid onset, potency (10 to 10,000 fold higher potency than morphine), and variety of administration methods.1 However, these highly potent substances are increasingly found on the illicit drug market in North America2, where they have contributed significantly to the "opioid crisis" and to a high number of overdose-related deaths. Illicit fentanyls are available as powders, tablets, liquids, or skin patches, and have been found with other psychoactive substances, including heroin, cocaine, and methamphetamine.3 All these material types present a high risk both in their pure form and after they have been prepared and packaged for sale.The Agilent Resolve handheld Raman analyzer uses spatially offset Raman spectroscopy (SORS) technology to identify hazardous materials, explosives, and narcotics concealed behind single and multiple barriers. These barriers can include colored and opaque plastics, glass, paper, cardboard, wrapping, and fabrics. The combination of SORS, high data quality, low fluorescence interference, and a spectral library that is continuously updated with new psychoactive substances makes the Resolve a powerful tool in the detection and identification of controlled substances. As of library version 41, over 70 different fentanyls can be identified using Resolve.<h4>4. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00666_en_64f8e5df48/an_01-00666-en.pdf">Evaluation of TOC of Sulfuric Acid using Wet Oxidation TOC Analyzer</a></h4><ul><li>Application</li></ul>User Benefits<ul><li>It is feasible to quantify low TOC content in 10 % sulfuric acid solution and thereby manage organic contamination within sulfuric acid solutions.</li><li>By using the auto-sampler, multiple samples can be automatically measured.</li></ul>IntroductionSulfuric acid is one of the chemicals used in the semiconductor industry for precision cleaning of surfaces such as wafers. When the cleaning solution is contaminated with organic impurities, it may not only affect the objects being cleaned but also the manufacturing process itself. Therefore, stringent quality control is imperative for the sulfuric acid utilized in the cleaning process.Organic impurities in sulfuric acid can be evaluated by measuring total organic carbon (TOC). The wet oxidation TOC analyzer, which is capable of high-sensitivity TOC measurement, is effective for managing trace organic substances required by the increasing complexity of integrated circuits. This article introduces an example of TOC measurement conducted with the Shimadzu wet oxidation total organic carbon analyzer TOC-V on a 10 % sulfuric acid solution.ConclusionThe capability to measure low-concentration TOC in 10 % sulfuric acid solution by using the wet oxidation total organic carbon analyzer TOC-V is confirmed. When high-purity sulfuric acid is required, as in industries like semiconductor manufacturing, the use of the wet oxidation TOC-V analyzer can facilitate the management of organic impurities in sulfuric acid, offering the potential for its utilization in quality assessment. Additionally, the use of an autosampler enables the automated measurement of multiple samples, contributing to improved analytical efficiency.Furthermore, <a target="_blank" rel="noopener noreferrer" href="https://www.shimadzu.com/an/sites/shimadzu.com.an/files/pim/pim_document_file/applications/application_note/21897/an_01-00535-en.pdf">application news 01-00535</a> introduces the combustion catalytic oxidation TOC-L analyzer, which is used to measure TOC in approximately 1 % sulfuric acid solution.

News from LabRulezICPMS Library - Week 38, 2024

In the week from September 30, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4></blockquote><blockquote>👉 Search and filter in the largest global database with over 3 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1.&nbsp;Agilent Technologies: Alcoholic Beverages Virtual Symposium: Beer</h5><ul><li>Tu, 1.10.2024 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4262">Registration</a></li></ul>How you can assure safety, authenticity, and quality of alcoholic beverages.<h5>2.&nbsp;C&amp;EN/Metrohm: In-field Identification of Low-Quality Medicines using Handheld Raman</h5><ul><li>Th, 3.10.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4317">Registration</a></li></ul>The global pharmaceutical market's growth has led to an alarming increase in substandard and falsified (SF) medicines, posing significant risks to public health.<h5>3.&nbsp;Waters Corporation: ICYMI (In Case You Missed It) - Empower Hot Topics from [inform] 2024</h5><ul><li>Th, 3.10.2024 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4302">Registration</a></li></ul>Best practices and essential tools for reviewing data and audit trails in Empower.

Webinars LabRulezGCMS Week 40/2024

In the week of September 30, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4></blockquote><blockquote>👉 Search and filter in the largest global database with over 3 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Quantitative metabolomics with validated standard protocols on high-resolution mass spectrometers</h5><ul><li>Mo, 30.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4297">Registration</a></li></ul>This webcast will describe how use of this targeted quantitative approach has now been validated for the Thermo Scientific Orbitrap Exploris family of mass spectrometers.<h5>2.&nbsp;SelectScience/Quantum-Si: Integrating top-down mass spectrometry and single-molecule sequencing for proteoform analysis</h5><ul><li>Mo, 30.9.2024 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4232">Registration</a></li></ul>Learn how TD-MS and Next-Generation Protein Sequencing can be used as complementary platforms for protein analysis.<h5>3.&nbsp;Agilent Technologies: LC Instrument Hardware</h5><ul><li>Tu, 1.10.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4258">Registration</a></li></ul>This webinar will give an overview of the different LC modules and how they work.<h5>4. Technology Networks/SCIEX: Bridging Exposomics and Metabolomics in a Single LC-MS Run</h5><ul><li>Tu, 1.10.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4236">Registration</a></li></ul>How a new method with sequential acquisition of targeted and untargeted data can be used to analyze the exposome and the metabolome in a single LC-MS run.<h5>5. Waters Corporation: Analytical Method Development</h5><ul><li>We, 2.10.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/3812">Registration</a></li></ul>The fifth episode will expleain how to select analytical column kit and the critical parameters for your method.<h5>6. Technology Networks/Bruker: Moving Towards the Next Generation of Food Allergen Analysis</h5><ul><li>We, 2.10.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4299">Registration</a></li></ul>How HPLC-HRMS can detect a wide range of allergens in a single run, reducing the time and effort involved in food analysis.<h5>7. Agilent Technologies: Mastering Chromatographic Adjustments: A Guide to USP Chapter 621</h5><ul><li>Th, 3.10.2024 05:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4324">Registration</a></li></ul>To be successful in implementing USP Chapter 621, we show you the practicality of using Agilent recommended LC supplies and explore how they can enhance laboratory efficiency.<h5>8. Evosep Biosystems: Tracking early signs of infectious disease with Evosep One to improve patient outcomes</h5><ul><li>Th, 3.10.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4318">Registration</a></li></ul>Learn how Evosep One’s robustness, sensitivity, and efficiency are helping laboratories and clinicians stay ahead of disease progression.<h5>9. Waters Corporation: Automated Sample Prep Prior to LC-MS Studies of Monoclonal Antibodies</h5><ul><li>Th, 3.10.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4301">Registration</a></li></ul>How you can leverage the Andrew+ Pipetting Robot to automate sample preparation prior to LC-MS studies of monoclonal antibodies.<h5>10. MAC-MOD ANALYTICAL/Avantor: Understanding Chromatographic Selectivity</h5><ul><li>Th, 3.10.2024 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4329">Registration</a></li></ul>We review the importance of chromatographic selectivity in RPLC from a theoretical and practical perspective and how this relates to analyte resolution for method development.<h5>11. Waters Corporation: ICYMI (In Case You Missed It) - Empower Hot Topics from [inform] 2024</h5><ul><li>Th, 3.10.2024 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4302">Registration</a></li></ul>Best practices and essential tools for reviewing data and audit trails in Empower.<h5>12. Agilent Technologies: Nitrosamines &amp; NDSRI's: Workflow readiness for Nitrosamines and NDSRI’s.</h5><ul><li>Fr, 4.10.2024 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4291">Registration</a></li></ul>NDSRI webinar series is a comprehensive three-part webinar series designed to provide valuable insights into the evolving landscape of analytical methods and regulatory requirements.

Webinars LabRulezLCMS Week 40/2024

In the week from September 30, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4></blockquote><blockquote>👉 Search and filter in the largest global database with over 3 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Anton Paar: Quality Control with the Abbemat in the Chemical Industry</h5><ul><li>Mo, 30.9.2024 19:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4322">Registration</a></li></ul>We invite you to join us for a webinar aimed at the chemical industry as our specialist, Rene, demonstrates how the Anton Paar Abbemat can improve the quality control process.<h5>2. Thermo Fisher Scientific: Ignite Your ICP-MS Workflow for Enhanced Efficiency and Productivity</h5><ul><li>Tu, 1.10.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4298">Registration</a></li></ul>How to streamline your ICP-MS workflows and enhance your productivity and elemental research using the latest ICP-MS technology.<h5>3. PerkinElmer: Technology Critical Element Extraction: Transforming E-Waste into Environmental and Industrial Opportunities</h5><ul><li>Tu, 1.10.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4316">Registration</a></li></ul>Identifying and quantifying TCEs (Technology Critical Elements) found in electronic waste.<h5>4. Anton Paar: Nano- and Micromechanical Characterization of Lithium-Ion Battery Electrodes: Adhesion and Hardness</h5><ul><li>We, 2.10.2024 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4323">Registration</a></li></ul>In this webinar we will present an application of the scratch test method using a wedge blade indenter for determination of adhesion of the electrode active layer.<h5>5. Separation Science/Agilent Technologies: Enhancing Lithium-Ion Battery Production: Automated and Sustainable Elemental Analysis in Mining and Manufacturing using ICP-OES</h5><ul><li>Th, 3.10.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4300">Registration</a></li></ul>Sustainable extraction of lithium, a crucial component in the lithium-ion battery supply chain.<h5>6. C&amp;EN/Metrohm: In-field Identification of Low-Quality Medicines using Handheld Raman</h5><ul><li>Th, 3.10.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4317">Registration</a></li></ul>The global pharmaceutical market's growth has led to an alarming increase in substandard and falsified (SF) medicines, posing significant risks to public health.<h5>7. Thermo Fisher Scientific: Maintaining Productivity using Thermo Scientific Qtegra ISDS Hawk Maintenance and Consumables Assistant</h5><ul><li>Fr, 4.10.2024 13:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4195">Registration</a></li></ul>Learn how to maintain productivity and avoid unplanned downtime with Thermo ScientificTM HawkTM Consumables and Maintenance Assistant.

Webinars LabRulezICPMS Week 40/2024

GC×GC-TOFMS Analysis of Fecal Metabolome Stabilized Using an At-Home Stool Collection Device

Fast and efficient size exclusion chromatography of adeno associated viral vectors with 2.5 micrometer particle low adsorption columns

Blending Samples to Increase Accuracy and Precision of 1H NMR Urine Metabolomics

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 23rd September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Shimadzu, Thermo Fisher Scientific, and a presentation by LECO!<h4>1. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_09_SSK_019_en_5e1bde719c.pdf">Analysis of Epichlorohydrin in Water using HS- GC/MS</a></h4><ul><li>Application</li></ul>User Benefits<ul><li>Water samples can be analyzed with a simple preparation.</li><li>Using a headspace autosampler, the analysis of epichlorohydrin in water quality can be performed conveniently.</li></ul>IntroductionEpichlorohydrin (ECH) is primarily used in the production of various resins (epoxy, ion exchange, etc.) and synthetic glycerin. Additionally, it is used as a stabilizer for carbon containing products in surfactants, plasticizers, dyes, and pharmaceuticals1). Some studies have demonstrated that damage to the nasal passages, respiratory tract and kidneys occurred in rodents exposed to epichlorohydrin. It has been observed that exposure to ECH induced a high nasal cancer response in rats, therefore, the United States Environmental Protection Agency (EPA) has classified epichlorohydrin as a “probable” human carcinogen (Group B2).According Water Pollutants of Water Environment Conservation Act, the permissible discharge limits of ECH in water were 0.03 to 0.3 mg /L by the classified area. The test method for ECH analysis in water is "Epichlorohydrin-Solvent Extraction/Gas Chromatography-Mass Spectrometry (ES 04608.1)" as the official test method of water pollution.2)The ES 04608.1 was used to extraction method with a large volume of solvent, it caused high consumption of solvent and long time of preparation. To solve these disadvantages, analysis of ECH in water in this application was performed using HS-20 NX headspace sampler without sample pretreatment.This application demonstrates the validation of a method for analysis of ECH in water samples using HS-GC/MS (Fig. 1) to meet the demanded levels of ES 04608.1 in Korea.ConclusionsThis Application news demonstrated the use of a Shimadzu GCMS-QP2020 NX coupled HS-20 NX for measurement of ECH in water. The proposed analytical method was with good validation parameters, such as linearity, MDL, LOQ, accuracy and precision which was satisfied the criteria of standard method (ES 04608.1) in Korea.<h4>2. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_ethylene_oxide_2_chloroethanol_8890_7010_gcms_5994_7720en_agilent_337dc4394d.pdf">Estimation of Ethylene Oxide and 2-Chloroethanol in Spices and Oilseeds Using QuEChERS Extraction and GC/MS/MS</a></h4><ul><li>Application</li></ul>AbstractThis application note demonstrates the use of an Agilent 8890 GC system coupled with an Agilent 7010 GC/MS triple quadrupole mass spectrometry system to detect and quantify ethylene oxide (EtO) and 2-chloroethanol (2-CE) simultaneously in foodstuffs such as flaxseed, cumin powder, and red chili powder. Sample preparation was done using QuEChERS extraction and a dispersive cleanup process followed by injection into GC/MS/MS through liquid injection. A limit of quantification (LOQ) of 10 ppb for both compounds was achieved in matrix. Average recoveries ranged from 75 to 86% for both compounds.IntroductionEtO is used to sterilize foods to eliminate insects and bacteria, such as salmonella. Ethylene chlorohydrin, or 2-CE, is a derivative produced by the reaction of EtO with chlorine ions present in foodstuff. Use of EtO is banned in the European Union (EU) due to its carcinogenic and toxic properties.Previously, methods for analysis of EtO (EtO and 2-CE) have been developed that include acidic conversion of EtO to 2-CE. These methods are time-consuming, labor-intensive, and require large quantities of harmful solvents. Due to the volatile nature of EtO, sample preparation is crucial. In December 2020, the EU Reference Laboratories (EURL) for Residues of Pesticides recommended a single-residue method for the analysis of EtO and 2-CE in sesame seeds using QuEChERS extraction followed by GC/MS/MS analysis. The method adopted in this work demonstrates the use of an automated liquid sampler for sample introduction to the 8890 GC system coupled with a 7010 GC/MS triple quadrupole mass spectrometry system.ConclusionAn accurate and rugged method was developed which meets the requirements of the EURL for a single-residue method that uses QuEChERS extraction followed by GC/MS/MS analysis for the analysis of EtO and 2-CE in flaxseed, cumin powder, and red chili powder. The LOQ of the method was demonstrated at 10 ng/g for all the tested matrices. Repeatable results are found for 6 successive replicates of matrix-based standards at 10 ng/g concentration levels for EtO and 2-CE. Excellent recoveries were obtained for both EtO and 2-CE in all tested matrices at 20 and 50 ng/g spiked concentration levels. Thus, this study demonstrates the usefulness of the developed method for the routine analysis of food samples for EtO and 2-CE at trace levels.<h4>3. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/An_advanced_integrated_GC_MS_MS_and_LC_MS_MS_workflow_for_the_comprehensive_analysis_of_pesticide_residues_in_food_a5878f2c6b.pdf">An advanced integrated GC-MS/MS and LC-MS/MS workflow for the comprehensive analysis of pesticide residues in food</a></h4><ul><li>Application</li></ul>GoalAnalysis of proficiency test (PT) samples to demonstrate the benefits of combining GC-MS/MS and LC-MS/MS with the innovative Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) for improving laboratory efficiency in the analysis of multi-class pesticide residues in food.Keywords: Pesticide residues analysis, comprehensive pesticides workflows, QuEChERS, LC-MS/MS, GC-MS/MS, Chromeleon CDS, cross-confirmation, targeted quantitation, automated data review.BackgroundAccording to the World Health Organization, more than one thousand different pesticides are used to protect crops from pests to increase crop yields and to minimize deterioration of agricultural products during post-harvest storage and transportation. However, inappropriate use of pesticides can result in contamination of the food supply, making it essential to define and monitor pesticide residue targets to protect consumer health, support trade, and establish food regulatory control.1Consequently, laboratories are tasked to develop methods to detect, correctly identify, and quantitate hundreds of different pesticides and their transformation products in hundreds of different sample matrices, in compliance with Maximum Residue Levels (MRLs) set by regulatory bodies.Data analysis of pesticide residues in food typically requires numerous performance checks including retention time, ion ratios, calibration curves, recovery, and precision. Data review of thousands of data values in a single chromatographic run and checking compliance against quality control criteria such as the EC SANTE guidelines2 are some of the most time-consuming tasks in pesticides analysis.Therefore, it is essential that workflows cover a broad pesticides scope, are sensitive and robust, and are as productive and efficient as possible to achieve compliance with regulations while meeting business goals such as return on investment (ROI), sample turnaround times, and cost-per-sample targets.An innovative approachIn response to this challenge, new pre-configured “out of the box” pesticide workflows based on the latest Thermo Scientific™ GC-MS/MS and LC-MS/MS instruments and Chromeleon CDS 3 have been specifically designed for multi-class pesticides analysis.These solutions include the hardware, software, built-in instrument acquisition methods, and customizable data processing methods including view settings and report templates, along with details of sample extraction and consumables for fast implementation.This new approach, which enables the detection, identification, and quantitation of up to 700 pesticides by GC-MS/MS and LC-MS/MS, combines results in a unique software user interface to confirm the identity of residues quickly and accurately, especially those amenable by both techniques.This automated cross-confirmation increases confidence in the data by minimizing the risk of false positive and false negative results while increasing productivity by reducing the need for repeat sample injections when either the LC-MS/MS or GC-MS/MS analysis is subject to interference. This is especially the case for more difficult samples that contain high amounts of matrix co-extractives.Proof statementLaboratories are often required to undertake blind analysis of PT samples containing an unknown number of unspecified pesticides. Assessing PT samples is an independent and more realistic test of the laboratory’s methods and procedures.In this application brief, the analysis of PT samples was undertaken to evaluate the analytical performance of the new integrated GC-MS/MS and LC-MS/MS pesticides workflow and to illustrate the benefits of the new software features.<h4>4. LECO: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_12_Characterization_and_Quantitative_Hydrocarbon_Group_Type_Analysis_of_Plastic_Derived_Pyrolysis_Oils_by_G_Cx_GC_TOFMS_FID_0a253a5d5e/O-12-Characterization-and-Quantitative-Hydrocarbon-Group-Type-Analysis-of-Plastic-Derived-Pyrolysis-Oils-by-GCxGC-TOFMS-FID.pdf">Characterization and Quantitative Hydrocarbon Group-Type Analysis of Plastic-Derived Pyrolysis Oils by GCxGC-TOFMS/FID</a></h4><ul><li>Presentation / <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/companies/218">MDCW</a></li></ul>Outline<ul><li>Pyrolysis Oils Characterization Workflow</li><li>Plastic-Derived Pyrolysis Oil Samples</li><li>Choosing a GCxGC system</li><li>Benefits of the Pegasus BT 4D MS</li><li>Benefits of the Paradigm Shift System</li><li>Choosing a GCxGC column set…</li><li>Mapping out the GCxGC Space</li><li>Group-Type Analysis of Pyrolysis Oils</li><li>ChromaTOF TILE</li><li>Areas of Interest + PCA</li><li>Comparing Trends of Multiple Features</li><li>Benefits of the Pegasus HRT+ 4D</li><li>Benefits of the Multi-Mode Source (MMS)</li><li>Pegasus HRT+ 4D Data Processing Workflows</li><li>High-Resolution, Accurate Mass Data</li><li>Mass Defect: Nitrogen-Containing Species</li><li>Mass Defect: Sulfur-Containing Species</li><li>Leveraging High Resolution Mass Accuracy</li><li>Conclusion</li></ul>

News from LabRulezGCMS Library - Week 39, 2024

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 16th September 2024? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Shimadzu, Thermo Fisher Scientific, Waters Corporation, and Metrohm!<h4>1. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00744_en_8f5d3dd3af.pdf">Analysis of Pesticides Residue in Brown Rice by LCMS-8050RX - Comparison of On-Line Purification vs QuEChERS Methods</a></h4><ul><li>Application</li></ul>User Benefits<ul><li>Enables quick and simple sample preparation by combining the QuEChERS extraction process with an on-line purification column.</li><li>LCMS-8050RX enables analysis with good recovery rates and reproducibility.</li></ul>IntroductionWith the increase in the number of regulated pesticides, more effective methods for simultaneous analysis of residual pesticides in food are required.The QuEChERS method, which is widely used for pesticide residue analysis, is a pretreatment method that consists of an extraction step with acetonitrile and salts or a buffer and a purification step with dispersive solid-phase extraction (dSPE). The method can efficiently extract and purify pesticides without special equipment, but there are problems with operator-dependent data variability and the long time required for the process.Revive in-line sample preparation (ILSP) columns1) (RESTEK Co.) are pretreatment columns that can be incorporated into the LC flow path for on-line cleanup of matrix-derived components. It makes the sample preparation process quicker and simpler, and it can be expected to reduce plastic consumable waste and costs associated with pretreatment.This article describes the results of comparing the purification efficiency of a Revive ILSP column versus a dSPE using an LCMS-8050RX.ConclusionSimultaneous analysis of pesticides was performed using an LCMS-8050RX system. The combination of the QuEChERS method and Revive ILSP columns enabled the pretreatment process to be accelerated and simplified. On-line purification with a Revive ILSP column showed comparable recovery and reproducibility results to dSPE purification and demonstrated the ability to remove contaminants that remain with dSPE purification. Therefore, on-line purification with a Revise ILSP column could be used as a quick and simple alternative to dSPE for the QuEChERS method.<h4>2. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_iohexol_compendial_method_1260_infinity_iii_assist_5994_7571en_agilent_1618701b03.pdf">Analyzing Iohexol by Compendial Method Produces Excellent Precision with Shallow Gradients Using an Agilent 1260 Infinity III LC</a></h4><ul><li>Application</li></ul>AbstractCompendial methods of pharmacopoeias are the primary guidance for the analysis of pharmaceuticals. Some of these methods require conditions such as shallow gradients that are challenging for the applied liquid chromatography (LC) hardware. The Agilent 1260 Infinity III LC was designed with these requirements in mind and delivers highly precise retention times even under demanding conditions. This application note demonstrates the performance for the compendial analysis of iohexol. The method is further optimized using the same system to reduce analysis time and solvent consumption to work more efficiently and sustainably while maintaining system suitability requirements of the compendial method.IntroductionCompendial methods found in different pharmacopoeias provide validated analytical procedures for many pharmaceuticals. These compendial methods are widely used, e.g., for quality control and impurity tests in the pharmaceutical production workflow. When introduced in a new laboratory or applied to new hardware for the first time, each method needs to be verified under "actual conditions of use".1 To verify a method, pharmacopoeias usually describe system suitability parameters that need to be met, e.g., minimum resolution between two analytes. For a reliable determination of these parameters, LC hardware needs to deliver precise and reproducible results.An example for a compendial method is the analysis of iohexol and its related substances.2 Iohexol (Figure 1) is used as an X-ray contrast agent.3 The polar nature of the molecule causes poor retention of the main compound and its impurities on reversed-phase stationary phases. For this reason, the separation method employs a long, shallow gradient starting at highly aqueous conditions, which is demanding for any HPLC system.This application note demonstrates the analysis of iohexol and two known impurities, applying the method described in the European Pharmacopoeia (Ph. Eur.) to a quaternary LC system. The compendial method will then be adjusted to UHPLC conditions to minimize solvent consumption and time spent per analysis. System suitability parameters, such as resolution and retention time stability, will be monitored and reported to evaluate the quality of both methods.ConclusionA compendial method using a shallow binary gradient was applied to separate iohexol and two impurities. Ph. Eur. system suitability parameters were passed, with retention time RSDs ≤ 0.083% (N = 8). The original 75-minute method was optimized and transferred to UHPLC conditions within the boundaries dictated by the harmonized chapter 621 of the USP4 and 2.2.46 of the Ph. Eur.5 The optimized method maintained the resolution achieved with the original method, improved RT RSDs to ≤ 0.044%, and reduced analysis time and solvent consumption by 66 and 71%, respectively. These numbers demonstrate that the Agilent 1260 Infinity III LC delivers highly reproducible results, even under challenging shallow gradient conditions of compendial methods, and at the same time offers the flexibility to optimize these methods to save time and operate more sustainably.<h4>3. Waters Corporation: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008494_en_f6481968d4.pdf">Repeatability and Reproducibility of the Oasis™ GCB/WAX for PFAS Analysis Cartridges in Soil/Solid Samples for EPA Method 1633</a></h4><ul><li>Application</li></ul>AbstractIn January 2024, EPA Method 1633 was finalized. EPA Method 1633 is the first method to incorporate the determination of 40 PFAS compounds across many challenging environmental sample matrices outside of drinking water including non-potable waters (ground water, surface water, and wastewater) as well as soil, biosolids, and tissue by LC-MS/MS analysis. EPA Method 1633 requires use of both weak anion exchange (WAX) solid phase extraction with graphitized carbon black (GCB) cleanup and is a performance-based method allowing for modifications as long as acceptance criteria for recoveries and %RSDs are met.This application note highlights the extraction of soil samples in EPA Method 1633 using the Oasis GCB/WAX for PFAS Analysis, a dual-phase solid-phase extraction cartridge. The results meet the method's acceptance criteria and demonstrate the reproducibility of the cartridges.Benefits<ul><li>Oasis GCB/WAX for PFAS Analysis, a dual-phase cartridge is reproducible and repeatable for EPA Method 1633 soil samples in inter-batch assays</li><li>Reduction of manual steps, overall sample preparation time by use of the dual-phase SPE cartridge</li><li>Acceptance criteria for recoveries and %RSDs are met for EPA Method 1633 for soil samples</li></ul>IntroductionWith EPA Method 1633 finalized, this introduces the first comprehensive US EPA method focused outside of drinking water for PFAS determination.1 As the method incorporates a wide variety of matrices including ground water, surface water, wastewater, soil, biosolids, and tissue, their sample preparation to ensure reproducibility, sensitivity, and robustness is critical. In EPA Method 1633, the sample preparation incorporates two sorbents, GCB and WAX.For soil sample analysis, the GCB is packed on top of the WAX sorbent to replicate the EPA Method 1633 where the GCB is used to clean the sample prior to WAX SPE. However, the method is performance-based and gives requirements for establishing quivalency.1 Oasis GCB/WAX for PFAS Analysis cartridges can alternatively be used and have been tested and shown to meet the acceptance criteria for multiple non-potable water sources as described previously.2 Oasis GCB/WAX is a dual-phase, or bilayer cartridge which combines both sorbents into a single device benefitting the user by removing total manual steps in the sample preparation workflow and reducing time by up to 20% compared to use of loose GCB and a WAX cartridge. Additionally, Oasis GCB/WAX for PFAS Analysis undergoes a QC-batch release test for common PFAS to ensure cleanliness during the SPE process reducing the risk of false positives.This application note uses Oasis GCB/WAX for PFAS Analysis on soil samples showing that the acceptance criteria for EPA Method 1633 is met across three separate product lots of GCB/WAX with six replicates within each lot. This demonstrates not only robustness of the SPE product in EPA 1633 workflows, but and the repeatability and reproducibility inter-batch of GCB/WAX cartridges ensures confidence in out-of-the-box performance of the cartridges for use with complex matrices, like those in EPA Method 1633.ConclusionThis study demonstrates the reproducibility of the dual-phase Oasis GCB/WAX for PFAS Analysis cartridges for determination of 40 PFAS and standards using the ACQUITY UPLC I-Class System and Xevo TQ-XS mass spectrometer. The cartridges are suitable for PFAS analysis in accordance with EPA 1633 guidelines for recovery and % RSD. The GCB/WAX cartridges show excellent repeatability across multiple replicates across soil samples. The data demonstrates Oasis GCB/WAX for PFAS Analysis cartridges are ideally suited for PFAS analysis from complex matrices, such as soils and solid samples like those described in EPA Method 1633. Out of the box performance is expected lot to lot and within lot for SPE when using Oasis GCB/WAX for PFAS Analysis.<h4>4. Metrohm: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_bat_014_download_6c810739bf.pdf">Constant current constant voltage (CCCV) cycling with INTELLO</a></h4><ul><li>Application</li></ul>Intuitive battery analysis solutions from Metrohm AutolabCharge/discharge cycling, or cycle testing, is perhaps one of the most fundamental techniques in battery research. This technique involves repeatedly charging and discharging a battery under controlled conditions in order to simulate real-world usage. From this, one can gather a wealth of data about the battery itself and the material inside.Among the most important parameters are the actual (experimental) capacity, the coulombic efficiency, and the rate capability. Important insight into the underlying chemistry and potential failure mechanisms can also be obtained from analysis of the curves from cycle testing batteries.This Application Note introduces the cycling tools which energy researchers can use in INTELLO, as well as the steps to obtain the recommended plots.CONCLUSIONSWithin the battery cycling environment of INTELLO, batteries of different geometries and sizes can undergo cycle testing. Cycling procedures can be made quickly and conveniently in INTELLO, and the plots needed to understand the battery chemistry and behavior can be produced and analyzed with ease.<h4>5. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003273_lsms_microflow_lcms_pesticides_garlic_an003273_na_en_5a24830d5d.pdf">Practical application of microflow LC-MS to multiresidue pesticides analysis in garlic extracts</a></h4><ul><li>Application</li></ul>Application benefits<ul><li>The Thermo Scientific™ Vanquish Neo™ UHPLC system delivers maximum performance 24/7 for reproducible nano-, capillary-, and microflow LC-MS applications and is designed for both novice and expert users.</li><li>Microflow LC-MS for pesticide residues analysis in food offers greatly reduced solvent consumption compared to standard flow systems that are considered the “gold standard” in food control laboratories.</li><li>Microflow with the Vanquish Neo UHPLC system provides enhanced sensitivity when using narrow bore columns (0.3–1.0 mm inner diameter (i.d.)) without sacrificing throughput, and at the same time, maintaining robust operation with food extracts prepared using the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) sample preparation method.</li></ul>Keywords: Orbitrap Exploris 120 mass spectrometer, Vanquish Neo UHPLC system, pesticides, garlic extract, microflow, QuEChERS, LC-MSGoalTo demonstrate the benefits of using microflow LC-MS for quantitative assays—greatly reduced solvent consumption, little to no solvent waste production, and fast (~12 min) sample-to-sample cycle times.Conclusion<ul><li>The developed microflow LC-MS method was shown to save mobile phase, thus reducing waste with significant cost savings benefit. For example, for every 100 injections, it was calculated that the method consumed only 37 mL of mobile phase A and 30 mL of mobile phase B.</li><li>The cycle time from injection-to-injection was only 12 minutes, and therefore competitive with standard flow systems to maintain the high throughput required in high production labs.</li><li>The observed robust area response and retention times demonstrate that the Vanquish Neo UHPLC system has a superior pumping system with low dead volume, overcoming the traditional roadblocks associated with transitioning from standard flow to microflow.</li><li>The Orbitrap Exploris 120 mass spectrometer offers high resolution, low ppm mass accuracy, and the ability to acquire full scan data for retrospective analysis. Sensitivity gains in microflow LC-MS enable use of HRAM (high resolution accurate mass), and the method can be easily transferred to Themo Scientific triple quadrupole MS platforms.</li><li>The Vanquish Neo UHPLC system can also be operated in a ‘trap-and-elute’ mode, and it is currently being applied to pesticide residue analysis. This is ongoing research and will be explored in further studies.</li></ul>

News from LabRulezLCMS Library - Week 39, 2024

News from LabRulezICPMS Library - Week 39, 2024

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LECO Separation Science Workshop

Thermo Fisher Scientific at SOFT/TIAFT 2026

Bruker at SOFT-TIAFT 2026

Automatic ICP-OES Analysis of Lubricating Oils Using SPECTRO GENESIS DSOI and ACAROS Automation

Detection and Identification of Microplastics in Water and Other Matrices Using the Agilent Laser Infrared Spectroscopy Microscope

Unlocking New Analytical Possibilities with Waters APGC Solutions