Synthesis and absolute configuration of cyclic synthetic cathinones derived from α-tetralone

<p><strong>In the week from February 3, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Agilent Technologies: Peak Perfection: A Guide to GC troubleshooting</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4514">Registration</a></div></li></ul></div><p>We will discuss some of the most common chromatographic issues that you experience with Gas Chromatography and take a logical approach to finding the root cause and correcting the problem.</p></div><h5><strong>2. GERSTEL: Determination of mineral oil residues HPLC-GC analysis of MOSH &amp; MOAH</strong></h5><div><div><ul><li><div>We, 5.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4639">Registration</a></div></li></ul></div><p>Experience the LC-GC-FID analysis for MOSH/MOAH in our informative webinar! We will introduce you to the key features of the GERSTEL LC-GC-FID system and show you how it simplifies your daily work.</p></div><h5><strong>3. DataApex: Clarity 10 Webinar</strong></h5><div><div><ul><li><div>Th, 6.2.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4696">Registration</a></div></li></ul></div><p>Discover the new Dual Chromatogram Mode for dual tower samplers, enhanced User Account settings, updated control modules, Extensions' improvements, and more.</p></div><h5><strong>4. Anton Paar: Data Integrity - the Anton Paar way</strong></h5><div><div><ul><li><div>Th, 6.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4551">Registration</a></div></li></ul></div><p>Data integrity has now been extended from the device to the AP Connect Pharma edition. This software allows you to store, verify, and validate your data easily in your own SQL database.</p></div><h5><strong>5. Technology Networks: Toward More Sustainable Labs: The Impact of Gas Supply</strong></h5><div><div><ul><li><div>Th, 6.2.2025 15:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4690">Registration</a></div></li></ul></div><p>This webinar will discuss the improvements you could make to your lab’s sustainability goals with the introduction of on-site gas generation.</p></div><h5><strong>6. Agilent Technologies: Eliminate errors with automation and stress-free sample tracking</strong></h5><div><div><ul><li><div>Th, 6.2.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4571">Registration</a></div></li></ul></div><p>Join us to hear about a new technology, linking samples and software for unprecedented control, to give you confidence in your laboratory workflow.</p></div>

Webinars LabRulezGCMS Week 6/2025

<p><strong>In the week of February 3, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over&nbsp;</p><p><strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Shimadzu Corporation: Analyzing Consumer Products for PFAS: New Method Development</strong></h5><div><div><ul><li><div>Mo, 3.2.2025 20:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4466">Registration</a></div></li></ul></div><p>Learn how to test nonvolatile and semi-volatile PFAS compounds in consumer products by LC-MS/MS as outlined in a method being standardized by ASTM.</p></div><h5><strong>2.&nbsp;Thermo Fisher Scientific: Methods for plasma proteomics at large scale and high-throughput</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4693">Registration</a></div></li></ul></div><p>The presentation highlights the integration of advanced proteomics technologies, particularly mass spectrometry, into clinical research and diagnostics.</p></div><h5><strong>3.&nbsp;GERSTEL: Determination of mineral oil residues HPLC-GC analysis of MOSH &amp; MOAH</strong></h5><div><div><ul><li><div>We, 5.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4639">Registration</a></div></li></ul></div><p>Experience the LC-GC-FID analysis for MOSH/MOAH in our informative webinar! We will introduce you to the key features of the GERSTEL LC-GC-FID system and show you how it simplifies your daily work.</p></div><h5><strong>4.&nbsp;DataApex: Clarity 10 Webinar</strong></h5><div><div><ul><li><div>Th, 6.2.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4696">Registration</a></div></li></ul></div><p>Discover the new Dual Chromatogram Mode for dual tower samplers, enhanced User Account settings, updated control modules, Extensions' improvements, and more.</p></div><h5><strong>5.&nbsp;Thermo Fisher Scientific: Navigating proteomics techniques for molecular profiling of clinical cancer cohorts</strong></h5><div><div><ul><li><div>Th, 6.2.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4694">Registration</a></div></li></ul></div><p>The presentation explores the integration of proteomics into clinical practice, particularly in cancer research and emphasizes the use of mass spectrometry-based proteomics.</p></div><h5><strong>6.&nbsp;Technology Networks/Peak Scientific: Toward More Sustainable Labs: The Impact of Gas Supply</strong></h5><div><div><ul><li><div>Th, 6.2.2025 15:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4690">Registration</a></div></li></ul></div><p>This webinar will discuss the improvements you could make to your lab’s sustainability goals with the introduction of on-site gas generation.</p></div><h5><strong>7.&nbsp;Agilent Technologies: Eliminate errors with automation and stress-free sample tracking</strong></h5><div><div><ul><li><div>Th, 6.2.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4571">Registration</a></div></li></ul></div><p>Join us to hear about a new technology, linking samples and software for unprecedented control, to give you confidence in your laboratory workflow.</p></div>

Webinars LabRulezLCMS Week 6/2025

<p><strong>In the week from February 3, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Mettler-Toledo: Improve Dairy Processing</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4655">Registration</a></div></li></ul></div><p>The impact of pH on dairy production, issues with lab pH measurement, the value of continuous pH data and how the latest pH measurement systems can improve dairy processing.</p></div><h5><strong>2.&nbsp;Anton Paar: Optimizing Animal Feed Production: Mixing, Extrusion, Texture, and Tribology</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 18:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4452">Registration</a></div></li></ul></div><p>This webinar will introduce both single and twin-screw extrusion techniques for lab-scale animal food production.</p></div><h5><strong>3.&nbsp;Agilent Technologies: Learn Why Atomic Absorption, MicroWave, and ICP Plasma Spectroscopy are the Perfect Tools for Both a Teaching and Research Environment</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 19:00 (CET)</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/3158">Registration</a></div></li></ul></div><p>We will discuss each of the above techniques and outline the advantages and challenges of each.</p></div><h5><strong>4.&nbsp;Anton Paar: Scratch Measurement Optimization</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 20:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4450">Registration</a></div></li></ul></div><p>Explore how to fine-tune scratch test parameters for your specific needs.</p></div><h5><strong>5.&nbsp;Agilent Technologies: Atomic Spectroscopy</strong></h5><div><div><ul><li><div>Th, 6.2.2025 04:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4672">Registration</a></div></li></ul></div><p>In order to increase the effectiveness and productivity of elemental analysis in food and environmental samples, in this first session we will exchange tips and the newest Agilent technology available.</p></div><h5><strong>6.&nbsp;Anton Paar: Data Integrity - the Anton Paar way</strong></h5><div><div><ul><li><div>Th, 6.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4551">Registration</a></div></li></ul></div><p>Data integrity has now been extended from the device to the AP Connect Pharma edition. This software allows you to store, verify, and validate your data easily in your own SQL database.</p></div><h5><strong>7.&nbsp;Separation Science/Agilent Technologies: Improving Efficiency with Challenging ICP-OES Applications Utilizing a Robust Sample Introduction System</strong></h5><div><div><ul><li><div>Th, 6.2.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4684">Registration</a></div></li></ul></div><p>In this webinar, we'll provide an overview of some new sample introduction components that remove pain points around running challenging sample matrices by ICP-OES efficiently.</p></div>

Webinars LabRulezICPMS Week 6/2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 3rd February 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you applications and other documents by <strong>Shimadzu, Agilent Technologies </strong>and <strong>Thermo Fisher Scientific</strong>!</p><h4><strong>1. Analysis of Essential Oils Using Comprehensive Two-Dimensional Gas Chromatography (GC × GC) and High-Resolution Mass Spectrometer</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_essential_oil_analysis_gcxgc_5994_8029en_agilent_7f4357b3cd.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The analysis of complex samples such as essential oils can benefit substantially from comprehensive two-dimensional gas chromatography (GC × GC), which provides a high degree of chromatographic separation due to the second dimension. Combining GC × GC with high-resolution accurate mass measurement increases the number of identifiable components and enhances confidence in the results.</p><p>The focus of this study was to establish a workflow for the analysis of essential oils using GC × GC with a reverse flow modulator (RFM) combined with a high-resolution quadrupole time-of-flight (GC/Q-TOF) mass spectrometer.</p><h5><strong>Experimental</strong></h5><p>The samples were separated on an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890 GC</strong></a> using a GC × GC configuration with an RFM and analyzed using a high-resolution accurate mass <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7250"><strong>Agilent 7250 GC/Q-TOF MS</strong></a> as well as an FID. A "normal" column set, combining a nonpolar primary column and a polar secondary column, was used. This set consisted of a 20 m × 0.1 mm, 0.1 μm Agilent DB-1ms column (100% dimethylpolysiloxane) and a 5 m × 0.25 mm, 0.15 μm Agilent DB-17ms column (equivalent to (50%-phenyl)-methylpolysiloxane).</p><p>To decrease flow to the MS, and to add an FID to the configuration as a second detector, the column flow must be split at the end of the secondary column by connecting it to a splitter. Two splitter types, purged and unpurged, have been explored to highlight the benefits and limitations of each configuration. In the case of a purged splitter, the column flow mixes with the makeup flow before splitting between the two detectors. In contrast, an unpurged splitter does not use makeup flow when splitting the column effluent between the two restrictors connected to the two detectors. A second FID (monitor, or vent) channel was added for method optimization and troubleshooting.</p><h5><strong>Conclusion</strong></h5><p>In this application note, a method for the analysis of essential oils using several comprehensive GC × GC configurations with a reverse flow modulator (RFM) and a high-resolution Agilent 7250 GC/Q-TOF system was developed. Method optimization was performed using a diesel sample. Essential oil components, separated by GC × GC, were reliably identified using the Unknowns Analysis tool. Agilent Mass Profiler Professional (MPP) software successfully determined the differences in chemical composition between the essential oils.</p><h4><strong>2.&nbsp;Utilizing hydrogen carrier gas for sensitive analysis of pesticides in food using gas chromatography mass spectrometry</strong></h4><ul><li>Poster / ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf"><strong>Full PDF for download</strong></a></li></ul><p><strong>Purpose:</strong> To demonstrate the performance of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=3&amp;search=HeSaver"><strong>Thermo Scientifc HeSaver-H2Safer kit </strong></a>for iConnect split-splitless (SSL) injection module for trace analysis of pesticides using H2 as a carrier gas as a safe and sustainable solution for laboratory operations.</p><p><strong>Methods: </strong>In this study, hydrogen was used as a carrier gas for <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=15&amp;mainauthorItems=3"><strong>GC-MS/MS analysis</strong></a> of trace levels of pesticides in food. The GC was fitted with a new hydrogen safer split/splitless injector, with chromatographic separation performed on a TG-5 SIL MS(30 m × 0.25 mm, 0.25 μm) capillary GC column. The chromatographic conditions applied ensured critical pair separation was achieved. The GC-MS/MS system was equipped with an advanced electron ionization (AEI) source to increase sensitivity for analyte detection. Quantification and assessment of critical regulatory requirements, such as linearity and sensitivity, were performed in a single software.</p><h5><strong>Conclusions</strong></h5><ul><li>The use of the HeSaver-H2Safer technology allows for a safe and compliant use of hydrogen as an alternative carrier gas in GC/GC-MS applications without the need to install a hydrogen sensor and removes any risk of unwanted reactions with the sample in the hot SSL injector.</li><li>When used with hydrogen, the limited carrier gas consumption offered by the HeSaver-H2Safer mode permits a very controlled system demand for hydrogen, making this solution ideal for laboratories working with hydrogen generators.</li><li>Migrating the GC-MS/MS method from helium to hydrogen requires an adaptation of method parameters to address (i.e., retention time shift and different fragmentation patterns).</li><li>97% of pesticides in baby food and 98% in honey showed a linear response in the concentration range 0.005–0.500 mg/kg and the relative standard deviation for N=5 repeats of each sample type at 0.01 mg/kg was equal or lower than 10% for 98% of the evaluated compounds.</li></ul><h4><strong>3.&nbsp;Analysis of VOC and SVOC Emissions from Automotive Interior Materials Using GCMS-QP2050 in Accordance with ISO 12219-11</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00845_en_9771953555.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=QP2050"><strong>GCMS-QP2050</strong></a> features a new interface that enables good peak shape and sensitivity even when analyzing compounds with high boiling points.</li><li>When used with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=TD-30R"><strong>TD-30R</strong></a> thermal desorption system, it can analyze compounds in accordance with ISO 12219-11.</li><li>The TVOC Calculation Tool can calculate in a simple manner quantitative emissions (toluene and hexadecane equivalents) in accordance with ISO 12219-11.</li></ul><h5><strong>Introduction</strong></h5><p>In recent years, measures to reduce the use of organic compounds in automotive interiors have progressed, the ISO 12219-11 standard is being developed for the analysis of volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) that are emitted from automotive interior materials. The ISO 12219-11 analytical procedure involves filling a thermal desorption (TD) glass tube with a sample of materials, heating the tube using TD, and loading the VOCs (up to C25) and SVOCs (C14 to C32) that were emitted from the sample into a GC-MS system for analysis. Although this standardized procedure enables simple and quick analysis of VOC and SVOC emissions from these materials, contamination of the MS system caused by the simultaneous loading of compounds with high boiling points is a problem.</p><p>As shown in Fig. 1, the GCMS-QP2050 is equipped with a new contamination-resistant ion optical system that effectively minimizes contamination of the MS. Featuring a new interface (Fig. 2) that enables good peak shape and sensitivity even for compounds that are typically prone to adsorption, it is optimally suited to analyzing SVOCs, including those with high boiling points.</p><p>TD-30R and GCMS-QP2020 NX will be listed as examples for suitable test equipment on ISO 12219-11. This Application News describes analyzing VOC and SVOC emissions from the materials of vehicle interiors in compliance with ISO 12219-11 using the GCMS-QP2050 together with the NexisTM GC-2030 and the TD-30R thermal desorption system.</p><h5><strong>Conclusion</strong></h5><p>Using the new GCMS-QP2050, it was possible to consistently analyze SVOCs and other compounds with high boiling points. By combining this system with the TD-30R thermal desorption system and the TVOC Calculation Tool, even inexperienced users can rapidly analyze automotive interior materials and quantify emissions (i.e., calculate toluene and hexadecane equivalents) in compliance with ISO 12219-11.</p>

News from LabRulezGCMS Library - Week 6, 2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 3rd February 2025? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you tech. note by <strong>Agilent Technologies, </strong>applications by <strong>Shimadzu, Thermo Fisher Scientific, Metrohm,</strong> and Poster by <strong>Waters Corporation</strong>!</p><h4><strong>1. Simultaneous Determination of Five Genotoxic Aryl Sulfonate Impurities in Pharmaceuticals by LCMS-2050</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_03_lcms_053_en_befdf50f8c.pdf">Full PDF for download</a></li></ul><h5><strong>User Benefit</strong></h5><ul><li>A novel method for determining the content of five genotoxic aromatic sulfonate impurities in drugs was established by using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=2050"><strong>LCMS-2050 single quadrupole mass spectrometer</strong></a>.</li><li>The pretreatment of this method was simple, and it had a wide linear range and a high accuracy rate.</li></ul><h5><strong>Introduction</strong></h5><p>Genotoxic impurities (GTIs) refer to substances that directly or indirectly damage cellular DNA, generating gene mutations or in vivo mutagenesis. GITs may can cause damage to human genetic material at extremely low concentrations, which in turn leads to gene mutations and promotes the occurrence of tumors. Because of the potential risks of GITs, it is essential to monitor any potentially existing genotoxic impurities in active pharmaceutical ingredients or medicinal products.</p><p>In the pharmaceutical industry, when drug active ingredients exist in the forms of alkyl sulfonates, benzenesulfonates, p-toluenesulfonates, and hydroxyethyl sulfonates or sulfonic acid reagents are utilized in the drug synthesis process, sulfonate esters are regarded as potential GTIs. GTIs of sulfonate esters can be classified as alkyl sulfonate esters and aryl sulfonate esters based on different substituents.</p><p>Previously, relevant literature has reported quantitative detection methods for some GTIs of sulfonate esters, such as GC-MS, GC-FID, LC-MS/MS, and complex derivatization treatment of samples might be necessary. In this study, LC-MS was mainly utilized for the quantitative analysis of five GTIs of aryl sulfonate esters. This method features simple pretreatment and high accuracy, which can offer a reference for the detection of genotoxic impurities of aryl sulfonate esters in drugs.</p><h5><strong>Conclusion</strong></h5><p>A novel method for determining the content of five genotoxic impurity aryl sulfonates in drugs was established by using the LCMS-2050. Within the concentration range of 5 - 500 μg/L, the correlation coefficients of the five genotoxic impurity aryl sulfonates were all greater than 0.994. When a mixed standard solution of three concentrations was added to the drugs, the recovery rates of each component ranged from 110.5% to 115.3%. This method features simple pretreatment, excellent specificity and high sensitivity, and can provide a reference for the determination of the content of five genotoxic impurities aryl sulfonates in drugs.</p><h4><strong>2.&nbsp;Method Transfer from an Agilent 1100 Series Quaternary LC to an Agilent 1260 Infinity III LC</strong></h4><ul><li>Technical Overview</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_method_transfer_equivalency_1100_series_1260_infinity_iii_5994_8031en_agilent_1_b429e7bd87.pdf">Full PDF for download</a></li></ul><p><strong>Proof of equivalency for the transfer of conventional LC methods</strong></p><p>Method transfer from legacy equipment to new instruments, such as the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1260+Infinity+III"><strong>Agilent 1260 Infinity III LC</strong></a>, is an important topic for all laboratories throughout different industries. Seamless method transfer ensures that the same methods can still be used, which ensures business continuity and reduced regulatory and financial risks.</p><p>This technical overview demonstrates method transfer from an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1100"><strong>Agilent 1100 Series Quaternary LC</strong></a> to an Agilent 1260 Infinity III LC for conventional LC methods covering diverse gradient conditions. Equivalent results are obtained, which proves that seamless method transfer can be expected for typical, robust, conventional LC methods. In terms of retention time precision, the 1260 Infinity III LC outperforms the 1100 LC, leading to higher trust in the data.</p><h5><strong>Introduction</strong></h5><p>Method transfer is an important topic for all laboratories throughout different industries, where HPLC methods are transferred between departments and locations as well as between different LC instruments.<sup>1</sup> For validated methods in the pharmaceutical industry, method transferability is compulsory.</p><p>Method transfer, or the transfer of analytical procedures from one laboratory to another in the pharmaceutical industry requires a documented process that requires comparative testing.<sup>2</sup> One example for instrument-to-instrument method transfer is the transfer of conventional LC methods from legacy equipment to new instruments such as a 1260 Infinity III LC.</p><p>This technical overview demonstrates method transfer from a 1100 Series Quaternary LC to a 1260 Infinity III LC for conventional LC methods. Several methods were chosen that cover diverse gradient conditions including challenging conditions such as a shallow gradient and a gradient starting at a composition extreme. This should prove that equivalent results are obtained when transferring methods from a broad application space of conventional LC methods from the 1100 Series Quaternary LC to the 1260 Infinity III LC.</p><p><strong>Conclusion</strong></p><p>The transfer of conventional LC methods covering diverse gradient conditions from an Agilent 1100 Series Quaternary LC to an Agilent 1260 Infinity III LC leads to equivalent results, thereby proving that seamless method transfer can be expected for typical, robust, conventional LC methods. In terms of retention time precision, the 1260 Infinity III LC outperforms the 1100 LC, leading to a higher trust in the data.</p><h4><strong>3.&nbsp;Development of Separation Methods for GLP-1 Synthetic Peptides Utilizing a Systematic Protocol and MaxPeak High Performance Surface Technology</strong></h4><ul><li>Poster / HPLC Symposium</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/2024_hplc_bengtson_glp1_synthetic_peptides_7d92bb96e7.pdf">Full PDF for download</a></li></ul><p>Peptides offer higher specificity than small molecules, and low immunogenicity which makes them excellent candidates for new medications. Specifically synthetic peptides produced through solid phase peptide synthesis allow for more control with more predictable impurities with a relatively low manufacturing cost.</p><p>An excellent example of upcoming synthetic peptide drugs is Glucagon-Like Peptide-1 Agonists (GLP-1s) which are prescribed for the treatment and management of obesity and type-II diabetes1. Recently, GLP-1 drugs such as semaglutide, have boomed in popularity as a weight management treatment after success in clinical trials.2 Given the prevalence of GLP-1s, it is important that the quality control for this class of pharmaceuticals is supported by versatile, sensitive, and reproducible chromatography methods.</p><p>Here we address these needs and developed a single HLPC-UV/MS method for the analysis of a variety of GLP-1s. The experiment was based around a systematic protocol which was key in helping to identify high-risk factors and to shorten the method development time. Beyond this <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=5&amp;search=MaxPeak+HPS"><strong>MaxPeak high performance (HPS)</strong></a> technology was used to improve chromatographic performance.</p><h5><strong>Conslusion</strong></h5><p>The thoughought assessment of the risk before conduction the development of a separation method allowed for the ccreation of a more quality method while reducing time. Asessing the high risk variables showed ther benefit in MaxPeak HPS technology when working with these compounds. MaxPeak HPS technology</p><h4><strong>4.&nbsp;Quantifying impurities in cationic lipids raw materials with the inverse gradient method using LC-CAD-MS</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003384_pb_cationic_lipids_isq_lc_cad_ms_an003384_na_en_d3a34737de.pdf">Full PDF for download</a></li></ul><h5><strong>Application benefits</strong></h5><ul><li>Enable the quantification of impurities even in the absence of specific reference standards</li><li>Use a single quadrupole mass spectrometer to match impurities based on their retention time and molecular masses</li><li>Use an inverse gradient with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=Charged+Aerosol+CAD"><strong>Charged Aerosol Detector (CAD)</strong></a> to enable accurate surrogate quantitation when there is large difference in retention times between the lipid standard and its impurities, even in the absence of impurity standards</li><li>Confirm the unit mass of both the lipid standard and its associated impurities using the correlation of CAD and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=ISQ"><strong>ISQ channels</strong></a></li></ul><h5><strong>Goal</strong></h5><ul><li>Provide instructions, methodologies, and recommended techniques to improve quantification of impurities in cationic lipid components</li><li>Use the Thermo Scientific™ Vanquish™ Flex Inverse Gradient UHPLC System coupled to a Thermo Scientific™ Vanquish™ Charged Aerosol Detetor to provide more accurate estimated quantitation of cationic lipid impurities without the need for reference standards</li></ul><h5><strong>Conclusion</strong></h5><p>In this study, we have developed an inverse gradient quantification method for cationic lipids impurity analysis when impurity reference standards are not available. For further identification of lipid impurities, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002455_bt_lc_cad_hram_ms_lipid_nanoparticle_an002455_na_en_2c6a86ecac/an-002455-bt-lc-cad-hram-ms-lipid-nanoparticle-an002455-na-en.pdf"><strong>Application Note 002455</strong></a> can be referenced.</p><ul><li>The impurity amount can be automatically estimated using another peak or peak group within the same run for this surrogate quantitation in Chromeleon CDS.</li><li>Both inverse gradient configuration and method can be automatically generated via the wizard.</li><li>When there is a significant difference in retention times between the lipid standard and its impurities, using an inverse gradient provides more accurate estimated quantitation than a conventional gradient method.</li><li>The use of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=ISQ"><strong>ISQ EM MS</strong></a> in conjunction with CAD allowed for confirmation of the m/z of the lipid raw material as well as determination of the m/z for the unknown impurities.</li></ul><h4><strong>5.&nbsp;Using a portable standalone system for easy fermentation monitoring</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_ec_035_download_f48491e484.pdf">Full PDF for download</a></li></ul><p><strong>In-situ measurements of lactic acid in beer using screen-printed electrodes (SPEs)</strong></p><p>Lactic acid (2-hydroxypropanoic acid) is primarily found in sour dairy products. In beer, the presence of lactic acid contributes to its acidity and lactic aromas, and usually appears as the result of fermentation with lactic acid bacteria. These bacteria may be purposely introduced to the wort, or they can also appear as a result of an infection.</p><p>Although lactic acid is essential in beer up to a certain amount, in excess it is considered a defect. Its perception threshold is 0.0044 mol/L. However, in some lambic-type beers, the lactic acid concentration can reach levels higher than 0.0333 mol/L.</p><p>In this Application Note, an enzymatic sensor based on a screen-printed electrode is used to measure lactic acid in commercial beers as a proof of concept for its potential application during fermentation monitoring.</p><p><strong>Conclusion</strong></p><p>In this study, an electrochemical biosensor for the detection of lactic acid in beer is proposed. The sample with the electrochemical method proposed only needs to be diluted 1:10 with a solution of 0.1 mol/L Tris-NO<sub>3</sub> at pH 7.2. Using a simple amperometric assay, it is possible in 75 s to measure the amount of lactic acid in a beer sample without any pretreatment. Measurements obtained are similar to those taken with a traditional L-Lactate Assay kit and non-portable optical devices</p>

News from LabRulezLCMS Library - Week 6, 2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 3rd February 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you applications by <strong>Shimadzu, Agilent Technologies </strong>and<strong> Thermo Fisher Scientific!</strong></p><h4><strong>1. Shimadzu: Simultaneous TG/DTA - DTG-60 Series</strong></h4><ul><li>Product note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c161_e005_0b449915ae.pdf">Full PDF for download</a></li></ul><p>This instrument varies the sample temperature in accordance with a program, and simultaneously measures the change in mass of the sample (TG) and the temperature difference between the sample and a standard substance (DTA).</p><ul><li>High-Sensitivity and High-Accuracy Measurement</li><li>Supports Various Types of Measurement</li><li>Automated Functions Increase Throughput</li><li>Complies with Analysis Laboratory Regulations</li><li>Compact Design</li></ul><h4><strong>2.&nbsp;Agilent Technologies: Capabilities and Operation of the Advanced Dilution System 2</strong></h4><ul><li>Technical Overview</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_ads_2_icp_5994_7211en_agilent_631a8d1650.pdf">Full PDF for download</a></li></ul><p><strong>Automate calibration and sample dilution for Agilent ICP-OES and ICP-MS instruments</strong></p><p>Now, more than ever, laboratories worldwide are facing increasing challenges to perform more analyses with fewer resources, prompting a re-evaluation of many analytical practices. Automation of certain tasks can help lab managers to streamline workflows and optimize resource utilization. To increase the efficiency of labs equipped with Agilent ICP-OES or ICP-MS instrumentation, Agilent has developed the Advanced Dilution System 2 (ADS 2)—a fully integrated inline autodilution system designed for routine, high throughput applications. The ADS 2 can automatically dilute stock standards and samples up to 400 times, making it ideal for the auto-preparation of calibration standards and samples, or dilution of overrange samples. The ADS 2 effectively reduces the number of manual tasks that operators have to perform when preparing a quantitative method for ICP-OES or ICP-MS, allowing more time to work on other tasks.</p><p>The two-syringe ADS 2 is available for the Agilent 5800 and 5900 ICP-OES* and Agilent 7850, 7900, and 8900 ICP-MS*. The ADS 2 and Advanced Valve System (AVS)** work seamlessly together under software control to maximize sample throughput, increase sample turn-around-time, and reduce cost-per-sample. The integrated design of the ADS 2 and AVS avoids adding excess time when not performing a dilution, addressing a common drawback of other dilution systems. The design also ensures that the system remains readily available to provide inline sample dilution whenever needed. If a reactive dilution of a sample is required, the intelligent software conveniently presents the results for the diluted sample at the end of each worksheet run, while retaining full access to all data.</p><h4><strong>3.&nbsp;Thermo Fisher Scientific: Thermo Scientific iCAP MX Series ICP-MS - Fully automatic start up and performance verification</strong></h4><ul><li>Product spotlight</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/sl_002910_tea_qtegra_isds_software_get_ready_sl002910_em_en_9e1bfd41ac.pdf">Full PDF for download</a></li></ul><p>The Thermo Scientific™ iCAP™ MX Series ICP-MS instruments provide sensitive, accurate, and robust analysis of a wide variety of sample matrices. Designed with ease of use and intelligent solutions to time-consuming steps in the daily laboratory in mind, the Get Ready process allows for automatic and unattended instrument initialization and performance verification.</p><p>Inductively coupled plasma-mass spectrometry (ICP-MS) is a powerful technology for trace and ultra-trace determination of elemental impurities in various markets, including environmental and food safety testing, industrial applications, clinical analysis, and research. In recent years, ICP-MS has become not only more sensitive to improve detection of lower concentrations, but also more robust to replace analyses previously run on ICP-optical emission spectroscopy (ICP-OES) instruments.</p><p>Another emerging trend is an increase in automation of labor-intensive and time-consuming steps in sample preparation and analysis. With increased demands on flexibility, both from clients demanding results with short turnover time as well as laboratory personnel looking for more flexible work arrangements, automated and timed start of the analytical system is an area to improve on efficiency and productivity in the laboratory.</p>

News from LabRulezICPMS Library - Week 6, 2025

<p><strong>In the week from February 10, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Merck: Webinar Series &amp; Expert Roundtable (Day 1)</strong></h5><ul><li>Monday, February 10, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4647">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 1) - Navigating Quality Grades Part 1: Inorganics and Solvents for Classical Analysis and Research and Part 2: Solvents and Reagents for Chromatography Applications</p><h5><strong>2. Merck: Webinar Series &amp; Expert Roundtable (Day 2)</strong></h5><ul><li>Tuesday, February 11, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4646">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 2) - Part 1: Dihydropinene, γ-Valerolactone, and Dimethyl Isosorbide: Solvents for Organic Synthesis and Part 2: Enhance Your PFAS Testing</p><h5><strong>3. Mettler-Toledo: Laboratory Balance Cleaning</strong></h5><ul><li>Tuesday, February 11, 2025, 10:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4654">Registration</a></li></ul><p>Join our free live webinar to find out more about the benefits of and solutions for cleaning your balance.</p><h5><strong>4. Merck: Webinar Series &amp; Expert Roundtable (Day 3)</strong></h5><ul><li>Wednesday, February 12, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4648">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 3) - Part 1: Optimize Your Karl Fischer Titration and Part 2: Beyond Safety Standards – Best Practices for Safe Handling of Hazardous Chemicals</p><h5><strong>5. GERSTEL: Efficiency boost through automation MOSH/MOAH</strong></h5><ul><li>Wednesday, February 12, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4640">Registration</a></li></ul><p>In this webinar we will show you the different sample preparation methods for MOSH &amp; MOAH analyses and their automation with the GERSTEL MultiPurpose Sampler.</p><h5><strong>6. C&amp;EN/Metrohm: From Challenges to Solutions: Revolutionizing Moisture Analysis with NIR and Titration</strong></h5><ul><li>Wednesday, February 12, 2025, 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4731">Registration</a></li></ul><p>Join industry experts as they explore modern approaches to moisture analysis in chemical, polymer, and petrochemical environments.</p><h5><strong>7. Merck: Webinar Series &amp; Expert Roundtable (Day 4)</strong></h5><ul><li>Thursday, February 13, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4649">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 4) - Part 1: Greener Solvents - Making Big Moves for More Sustainability in the Lab! and Part 2: Tips and Tricks for LC-MS Troubleshooting.</p><h5><strong>8. Thermo Fisher Scientific: Detecting PFAS in drinking water for regulations in Europe</strong></h5><ul><li>Thursday, February 13, 2025, 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4740">Registration</a></li></ul><p>Discover a comprehensive solution for PFAS analysis, from sample preparation to reporting, tailored to meet European regulatory standards.</p><h5><strong>9. Agilent Technologies: New Improvements to MP Workflow</strong></h5><ul><li>Thursday, February 13, 2025, 20:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4552">Registration</a></li></ul><p>Improvements to Microplastics workflow will be demonstrated.</p><h5><strong>10. Merck: Webinar Series &amp; Expert Roundtable (Day 5)</strong></h5><ul><li>Friday, February 14, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4650">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 5) - Roundtable Expert Discussion.</p>

Webinars LabRulezGCMS Week 7/2025

<p><strong>In the week of February 10, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over&nbsp;</p><p><strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Merck: Webinar Series &amp; Expert Roundtable (Day 1)</strong></h5><ul><li>Monday, February 10, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4647">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 1) - Navigating Quality Grades Part 1: Inorganics and Solvents for Classical Analysis and Research and Part 2: Solvents and Reagents for Chromatography Applications</p><h5><strong>2. Merck: Webinar Series &amp; Expert Roundtable (Day 2)</strong></h5><ul><li>Tuesday, February 11, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4646">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 2) - Part 1: Dihydropinene, γ-Valerolactone, and Dimethyl Isosorbide: Solvents for Organic Synthesis and Part 2: Enhance Your PFAS Testing</p><h5><strong>3. Mettler-Toledo: Laboratory Balance Cleaning</strong></h5><ul><li>Tuesday, February 11, 2025, 10:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4654">Registration</a></li></ul><p>Join our free live webinar to find out more about the benefits of and solutions for cleaning your balance.</p><h5><strong>4. Thermo Fisher Scientific: Innovations in Protein Characterization</strong></h5><ul><li>Tuesday, February 11, 2025, 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4730">Registration</a></li></ul><p>This live webinar will be an excellent opportunity to boost your R&amp;D capabilities and strengthen your QC analytical methods for the characterization of biotherapeutics and gene therapies.</p><h5><strong>5. Agilent Technologies: Size Exclusion Chromatography of Biomolecules: Column Selection and Method Optimization</strong></h5><ul><li>Tuesday, February 11, 2025, 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4520">Registration</a></li></ul><p>We will outline basic theory, principles, and practical guidelines on column selection for SEC method development.</p><h5><strong>6. Merck: Webinar Series &amp; Expert Roundtable (Day 3)</strong></h5><ul><li>Wednesday, February 12, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4648">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 3) - Part 1: Optimize Your Karl Fischer Titration and Part 2: Beyond Safety Standards – Best Practices for Safe Handling of Hazardous Chemicals</p><h5><strong>7. GERSTEL: Efficiency Boost Through Automation MOSH/MOAH</strong></h5><ul><li>Wednesday, February 12, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4640">Registration</a></li></ul><p>In this webinar we will show you the different sample preparation methods for MOSH &amp; MOAH analyses and their automation with the GERSTEL MultiPurpose Sampler.</p><h5><strong>8. Thermo Fisher Scientific: From Biomarker Discovery to Targeted Assays with Stellar MS</strong></h5><ul><li>Wednesday, February 12, 2025, 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4695">Registration</a></li></ul><p>The presentation delves into the latest advancements in mass spectrometry-based proteomics, focusing on its application in clinical settings.</p><h5><strong>9. Agilent Technologies: Rapid and Sensitive Determination of Haloacetic Acids and Acrylamide in Drinking Water Using LC-Triple Quadrupole Mass Spectrometry</strong></h5><ul><li>Wednesday, February 12, 2025, 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4709">Registration</a></li></ul><p>How the Agilent LC-Triple Quadrupole mass spectrometers are utilized for the rapid and sensitive determination of haloacetic acids and acrylamide in drinking water.</p><h5><strong>10. C&amp;EN/Merck: From Challenges to Solutions: Revolutionizing Moisture Analysis with NIR and Titration</strong></h5><div><div><ul><li>Wednesday, February 12, 2025, 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4731">Registration</a></li></ul></div><p>Join industry experts as they explore modern approaches to moisture analysis in chemical, polymer, and petrochemical environments.</p><h5><strong>11. Waters Corporation: Unlocking the Mysteries of Liquid Chromatography : Fundamentals of Chemistry</strong></h5><div><div><ul><li>Wednesday, February 12, 2025, 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4751">Registration</a></li></ul></div><p>This session promises to provide valuable insights and practical tips to enhance your understanding of liquid chromatography.</p></div></div><h5><strong>12. Merck: Webinar Series &amp; Expert Roundtable (Day 4)</strong></h5><ul><li>Thursday, February 13, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4649">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 4) - Part 1: Greener Solvents - Making Big Moves for More Sustainability in the Lab! and Part 2: Tips and Tricks for LC-MS Troubleshooting.</p><h5><strong>13. Thermo Fisher Scientific: Detecting PFAS in Drinking Water for Regulations in Europe</strong></h5><ul><li>Thursday, February 13, 2025, 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4740">Registration</a></li></ul><p>Discover a comprehensive solution for PFAS analysis, from sample preparation to reporting, tailored to meet European regulatory standards.</p><h5><strong>14. Thermo Fisher Scientific: Tandem Micro-Flow LC-MS Proteome Analysis of Urine and Plasma to Unravel Disease ​Mechanisms and Biomarker Discovery</strong></h5><ul><li>Thursday, February 13, 2025, 11:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4704">Registration</a></li></ul><p>The presentation focuses on advancements in proteomics and metabolomics, emphasizing robust, large-scale, and high-throughput analysis.</p><h5><strong>15. Waters Corporation: Dominate Your LC-MS/MS Data, Maximize Efficiency and Bolster Regulatory Compliance with waters_connect for Quantitation 3.0</strong></h5><ul><li>Thursday, February 13, 2025, 15:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4660">Registration</a></li></ul><p>Join us for an exclusive webinar to discover how groundbreaking software is transforming LC-MS/MS workflows, delivering faster, more accurate quantitation, and future-proofing your laboratory operations.</p><h5><strong>16. Merck: Webinar Series &amp; Expert Roundtable (Day 5)</strong></h5><ul><li>Friday, February 14, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4650">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 5) - Roundtable Expert Discussion.</p>

Webinars LabRulezLCMS Week 7/2025

<p><strong>In the week from February 10, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Merck: Webinar Series &amp; Expert Roundtable (Day 1)</strong></h5><ul><li>Monday, February 10, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4647">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 1) - Navigating Quality Grades Part 1: Inorganics and Solvents for Classical Analysis and Research and Part 2: Solvents and Reagents for Chromatography Applications</p><h5><strong>2. Merck: Webinar Series &amp; Expert Roundtable (Day 2)</strong></h5><ul><li>Tuesday, February 11, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4646">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 2) - Part 1: Dihydropinene, γ-Valerolactone, and Dimethyl Isosorbide: Solvents for Organic Synthesis and Part 2: Enhance Your PFAS Testing</p><h5><strong>3. Mettler-Toledo: Laboratory Balance Cleaning</strong></h5><ul><li>Tuesday, February 11, 2025, 10:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4654">Registration</a></li></ul><p>Join our free live webinar to find out more about the benefits of and solutions for cleaning your balance.</p><h5><strong>4. Thermo Fisher Scientific: Increasing Matrix Robustness using Intelligent Matrix Handling (IMH) with Thermo Scientific iCAP MX Series ICP-MS</strong></h5><ul><li>Tuesday, February 11, 2025, 13:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4698">Registration</a></li></ul><p>Join this virtual demonstration of the Thermo Scientific iCAP MX Series ICP-MS to learn how Qtegra ISDS Intelligent Matrix Handling reduces sample-to-sample carryover and maintenance of your instrument.</p><h5><strong>5. Agilent Technologies: From Single Cell and Nanoparticle Analysis to Laser Ablation and Beyond: Advanced ICP-MS Research Applications</strong></h5><ul><li>Tuesday, February 11, 2025, 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/3159">Registration</a></li></ul><p>Explore nanoparticle, single cell, speciation, laser ablation, and other hyphenated ICP-MS applications that can advance your research.</p><h5><strong>6. Merck: Webinar Series &amp; Expert Roundtable (Day 3)</strong></h5><ul><li>Wednesday, February 12, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4648">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 3) - Part 1: Optimize Your Karl Fischer Titration and Part 2: Beyond Safety Standards – Best Practices for Safe Handling of Hazardous Chemicals</p><h5><strong>7. C&amp;EN/Merck: From Challenges to Solutions: Revolutionizing Moisture Analysis with NIR and Titration</strong></h5><ul><li>Wednesday, February 12, 2025, 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4731">Registration</a></li></ul><p>Join industry experts as they explore modern approaches to moisture analysis in chemical, polymer, and petrochemical environments.</p><h5><strong>8. Merck: Webinar Series &amp; Expert Roundtable (Day 4)</strong></h5><ul><li>Thursday, February 13, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4649">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 4) - Part 1: Greener Solvents - Making Big Moves for More Sustainability in the Lab! and Part 2: Tips and Tricks for LC-MS Troubleshooting.</p><h5><strong>9. LECO: Kjeldahl vs Dumas - How Do You Determine Protein?</strong></h5><ul><li>Thursday, February 13, 2025, 16:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4685">Registration</a></li></ul><p>Join us for this 30-minute webinar where Michael Jakob, LECO European Product Manager, discusses how LECO’s protein analyzers streamline the Dumas method for protein determination. The webinar also features an online demonstration of running a sample on the FP828 in our Berlin lab.</p><h5><strong>10. Agilent Technologies: New Improvements to MP Workflow</strong></h5><ul><li>Thursday, February 13, 2025, 20:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4552">Registration</a></li></ul><p>Improvements to Microplastics workflow will be demonstrated.</p><h5><strong>11. Merck: Webinar Series &amp; Expert Roundtable (Day 5)</strong></h5><ul><li>Friday, February 14, 2025, 10:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4650">Registration</a></li></ul><p>Webinar Series &amp; Expert Roundtable (Day 5) - Roundtable Expert Discussion.</p>

Webinars LabRulezICPMS Week 7/2025

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

LECO Separation Science Workshop

Thermo Fisher Scientific at SOFT/TIAFT 2026

Bruker at SOFT-TIAFT 2026

The Next Frontier in Nitrosamines Testing: Detection and Risk Assessment in Packaging and IV Infusion Bags

From Cleared Tissue to Quantitative 3D Insights: Integrated Bruker and Translucence Biosystems Workflows for Whole-Organ Imaging

Membrane Technologies for Water and Food Sustainability