<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 24th February 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies,&nbsp;Bruker, Metrohm, Shimadzu </strong>and<strong> Thermo Fisher Scientific!</strong></p><h4><strong>1. Agilent Technologies: Sustainable Lithium-Ion Battery Recycling: Recovery of Metals in Green Solvents by ICP-OES</strong></h4><h5><strong>Fast analysis of deep eutectic solvents using Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=1&amp;search=5800+VDV"><strong>5800 VDV</strong></a><strong> ICP-OES with switching valve</strong></h5><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_green_solvent_battery_recycling_5800_icp_oes_5994_8017en_agilent_d95e03655d.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Currently, two primary industrial processes are used for recycling spent LIBs: pyrometallurgy and hydrometallurgy. Pyrometallurgy involves the high-temperature extraction of metals, which is energy demanding and yields relatively poor-quality output.<sup>3</sup> Hydrometallurgy requires the use of numerous extractants and a longer process but achieves better metal recoveries than pyrometallurgy.<sup>3</sup> However, the hydrometallurgical process produces large quantities of acidic and alkaline wastewater, which can threaten the environment if not properly managed.<sup>3</sup></p><p>Deep eutectic solvents (DESs) are an emerging class of green solvents that offer a novel solution for LIB recycling. Made from mixtures of biodegradable components, DESs are easy to prepare, inexpensive, nontoxic, and reusable.<sup>4</sup> Scientists are actively investigating how the unique properties of DESs can be used to efficiently leach critical metals from spent LIBs.<sup>4</sup> To verify the effectiveness of DESs in terms of metal-recovery rates, researchers often use a multi-element analytical technique such as inductively coupled plasma optical emission spectroscopy (ICP-OES). However, analyzing leached metals in DESs by ICP-OES is not without its challenges. The high Total Dissolved Solids (TDS) matrix samples can cause wear on the sample introductory system, potentially introducing errors in the results. There is also a need for a wide Linear Dynamic Range (LDR), as the elemental profile of end-of-life LIBs can vary greatly.</p><p>The Agilent 5800 Vertical Dual View (VDV) ICP-OES is widely used to determine metals and other elements in LIB battery materials.<sup>5</sup> Designed for robustness and stability, the 5800 enables the fast, simultaneous measurement of over 70 elements in many sample types. The wide LDR of the instrument’s Vista Chip III detector enables a range of elements to be analyzed in the same sample, avoiding the need to perform multiple dilutions.<sup>6</sup> This field-proven instrument uses advanced tools and accessories to support the development of new methods, making it ideal for LIB recycling initiatives, such as facilitating the recovery of valuable metals using DESs.&nbsp;</p><p>In this application, the 5800 VDV ICP-OES was used to determine eight representative elements of spent LIBs spiked in a choline chloride and urea (ChCl:Urea) DES solution. The analytes aluminum (Al), Co, copper (Cu), iron (Fe), Li, manganese (Mn), Ni, and phosphorus (P) were selected based on their presence in various types of cathode active materials (CAMs).&nbsp;</p><h4><strong>Conclusion</strong></h4><p>The Agilent 5800 VDV ICP-OES with the integrated AVS 7 switching valve effectively determined valuable LIB-related elements in DES. Leaching metals from end-of-life LIBs using DESs offers a more sustainable alternative to traditional metallurgical processes for battery recycling. Under the control of Agilent ICP Expert Pro software, the 5800 enabled the fast, robust, and accurate analysis of eight representative elements of LIBs in a spiked ChCl:Urea DES solution. The following hardware and software tools were used to ensure the quality of the quantitative data:</p><ul><li>IntelliQuant Screening streamlined method development by recommending optimal calibration ranges and interference-free wavelengths for all analytes, ensuring accurate analysis of analytes in DESs.</li><li>The AVS 7 improved sample throughput requiring only 41 s per sample compared to 90 s without the AVS. It also minimized costs by lowering argon consumption to 9.8 L per sample and less frequent cleaning of consumables such as the torch and nebulizer.</li><li>FBC automatically corrected the background structures for Al, Co, Cu, Fe, Mn, Ni, and P and FACT deconvoluted the Li peak from more complex background spectra.&nbsp;</li></ul><p>The accuracy of the 5800 ICP-OES method was confirmed by recoveries of all analytes spiked at high and low levels in DES, with results within 100 ±10%. Excellent long-term stability was demonstrated when 645 solutions were analyzed over seven hours. Recoveries of the QCs and spiked DES samples were within ±10% of the expected values. Good precision was achieved for the spiked DES sample measurements, with RSDs ≤2.2% for all elements. The performance of the 5800 VDV ICP-OES with AVS 7 demonstrates its suitability for the fast, quantitative analysis of critical LIB-related elements such as Co, Mn, and Li in complex matrices like ChCl:Urea DES.</p><h4><strong>2. Bruker: Analysis of Pet Food with FT-NIR Spectroscopy</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AN_N308_Petfood_EN_a5a1ea8cdd.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Pets are today an important part of peoples lives. Therefore consumers trust in brands which guarantee the best quality for their individual animal, since pets of different breed, size and age often need a special nutrient profile in their diet. Pet food producers have to provide a vast amount of different products, produced at an acceptable cost.&nbsp;</p><h5><strong>From raw materials to finished pet food</strong></h5><p>The biggest challenge in pet food production is to keep track of the different recipes depending on the availability of the expensive raw materials. Depending on origin and season, they often show huge batch-to-batch variability; nevertheless, feeding the least cost formulation programs with valid compositional data is essential and a fast and accurate analysis, providing results in seconds can help keeping track of the production process.</p><p>Near infrared spectroscopy is used in agriculture for many decades for the analysis of main constituents like moisture, fat and protein. It is fast and safe, since it requires little to no sample preparation, nor hazardous chemicals or gases. This makes a quick test of the incoming raw material using FT-NIR available even to production staff, before processing the materials and also allows a fast way of testing the final material before packaging.</p><h5><strong>Easy sampling and measurement</strong></h5><p>Solid samples like like raw materials and finished pet food are filled in cups with a quartz glass bottom, placed on the integrating sphere of the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=10&amp;search=MPA+II"><strong>MPA II</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=10&amp;search=TANGO-R"><strong>TANGO-R</strong></a> spectrometer and measured from below. This way, the product has an even surface and for highly reproducible results, it is rotated during the measurement. Liquid samples like oils and fats are are simply filled in 8mm glass vials and are measured in the sample compartment of the MPA II or TANGO-T.</p><h4><strong>3. Metrohm: Polyethylene content determination in polypropylene pellets by NIRS</strong></h4><h5><strong>Rapid analysis of recycled polyolefins</strong></h5><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_124_download_db3dcba358.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Next to polyethylene (PE), polypropylene (PP) is the most widely used plastic worldwide. Recycling these polyolefins is problematic, since it is challenging to separate polyethylene from polypropylene using sink float separation. Increasing PE content in PP leads to a poor interfacial bond strength which could negatively impact the mechanical properties of the final molded product.</p><p>An efficient method to determine the polyolefin composition based on near-infrared spectroscopy (NIRS) analysis is presented in this Application Note. The main advantage is the short time to result. Compared to the time-consuming standard method (i.e., Differential Scanning Calorimetry or DSC), the analysis of polyethylene content in polypropylene using near-infrared spectroscopy is performed in just seconds.</p><h4><strong>Experimental equipment</strong></h4><p>Different polymer blends (n = 54) with varying polyethylene content from 0.5–35% were produced in a compounder. The polyethylene content was determined by weighing before the polymer blends were produced. All measurements on the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=56&amp;search=OMNIS+NIR"><strong>OMNIS NIR</strong></a> Analyzer Solid (Figure 1) were performed in rotation using a large sample cup to average the subsample spectra. This sample setup reduces the influence of the particle size distribution of the polymer particles.</p><h4><strong>Conclusion</strong></h4><p>This Application Note shows the feasibility of NIR spectroscopy for the analysis of polyolefins. Detecting PE concentrations below 5% with the standard Differential Scanning Calorimetry (DSC) method can be challenging and time consuming. Compared to DSC measurements (Table 2), near-infrared analysis saves significant time: one sample measurement is performed in a couple of seconds. Next to PE content, physical parameters like density can also be determined with NIRS.&nbsp;</p><h4><strong>4. Shimadzu: Three-Point Bending Fatigue Tests of Carbon Fiber Reinforced Plastic Using the </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=3&amp;search=SEM+Servopulser"><strong>SEM Servopulser</strong></a></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00793_en_a50aabfd66.pdf"><strong>Full PDF for download</strong></a></li></ul><p><strong>User Benefits:</strong></p><ul><li>The SEM Servopulser can perform three-point bending fatigue tests of carbon fiber reinforced plastic.</li><li>The SEM Servopulser can also be used to observe fatigue cracks.</li><li>High-accuracy dynamic control can be achieved with the Servo Controller 4830</li></ul><p>Carbon fiber reinforced plastic (CFRP) has high specific strength and stiffness and is widely used in various industrial fields, including transport vehicles. In order to ascertain its long-term reliability and durability as a structural material, it is necessary to evaluate it for fatigue, one of the main causes of structural failure. However, since CFRP is composed of two types of materials, carbon fibers and matrix resin, it exhibits complex behaviors in failure, such as matrix cracking, inter-layer delamination,and fiber rupture.</p><p>This article describes bending fatigue tests that used the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=3&amp;search=Servopulser+EHF-L"><strong>Servopulser EHF-L</strong></a> tabletop dynamic and fatigue testing system. The extension of cracks during the fatigue tests was observed using the SEM Servopulser, a high-temperature fatigue testing machine with a scanning electron microscope.</p><h4><strong>Conclusion</strong></h4><p>Bending fatigue tests were performed on CFRP using a fatigue testing system, and the resulting S-N curve was compiled. Then the conditions were set on the SEM Servopulser based on the SN curve obtained, and damage to the test specimen was observed during the test. By changing the magnification on the SEM, it was possible to observe the damage location on the test specimen in detail. As the test progressed, it was possible to clearly observe how the damage progressed. In this way, the SEM Servopulser demonstrated it can assist in evaluating the fatigue properties of composite materials,such as CFRP.&nbsp;</p><h4><strong>5. Thermo Fisher Scientific: Measurement of traces of heavy metals in cosmetic raw materials and finished products according to ISO/DIS 21392:2021 using triple quadrupole ICP-MS</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AN_003602_Measurement_of_traces_of_heavy_metals_in_cosmetic_raw_materials_and_finished_products_according_to_ISO_DIS_21392_2021_using_triple_quadrupole_ICP_MS_c71fff2bcc.pdf"><strong>Full PDF for download</strong></a></li></ul><p>This application note highlights a complete and comprehensive workflow for the analysis of heavy metals in different types of cosmetic products, including raw materials, and will demonstrate the need to use triple quadrupole ICP-MS technology to achieve complete interference removal. As described in ISO/DIS 21392:2021, the samples were prepared using a microwave system prior to analysis.</p><h4><strong>Experimental</strong></h4><p>A Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=2&amp;search=iCAP%E2%84%A2+MTX+"><strong>iCAP™ MTX </strong></a>ICP-MS and a Thermo Scientific™<a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=2&amp;search=+iSC-65"><strong> iSC-65</strong></a> autosampler were used for analysis. The ICP-MS was operated using the parameters highlighted in Table 1. Due to the great variability of total dissolved solids (TDS) used in cosmetic matrices, the instrument was operated using Argon Gas Dilution (AGD). Thus, all calibration standards and samples were automatically diluted approximately five times to ensure analytical robustness for all sample types, such as raw materials and finished products. Due to the potential presence of interferences, the iCAP MTX ICP-MS was operated in collision (SQ-KED) and reaction (TQ-O2) modes to remove polyatomic and isobaric interferences, and to reach the best quantification limits for critical elements.</p><h4><strong>Conclusion</strong></h4><p>As the demand for cosmetic products continues to grow worldwide, the testing of raw materials and finished cosmetic products becomes a key activity to ensure consumer safety with respect to exposure to potentially toxic heavy metals. Maintaining stringent safety standards remains a priority to protect consumer health and uphold the reputation of the industry. The proposed method provides a powerful and reliable option for both manufacturers as well as testing laboratories to obtain high quality data in combination with the often-required productivity. It ensures regulatory compliance with ISO/DIS 21392:2021, but also provides valuable insights as also other elements, currently not under regulation, can be determined free from interferences and potential biases.</p><p><strong>Some key advantages are summarized below:</strong></p><ul><li>The automated sample preparation with the combination of the EasyFILL Acid Delivery and the ultraWAVE SRC microwave system ensures an efficient and reproducible method for the acid digestion of the cosmetic samples.</li><li>EasyAGD delivers a constant and automatic 5-times dilution for all samples, which allows laboratories to analyze finished products as well as raw materials in the same batch with excellent robustness.</li><li>The use of the iCAP MTX ICP-MS allows the leveraging of oxygen as a reactive gas in TQ-O2 mode to overcome critical interferences and to obtain the lower quantification limits required by the regulation for highly toxic heavy metals.</li><li>The presence of high concentrations of tungsten, tin, and zirconium in certain raw materials can create isobaric and polyatomic interferences on toxic heavy metals such as mercury and cadmium. The use of TQ-O2 mode guarantees excellent method accuracy for all sample types.</li><li>Workflows can be further streamlined using innovative features such as the Get Ready process for automatic and scheduled plasma start. The Thermo Scientific™ Hawk™ Consumables and Maintenance Assistant within Qtegra ISDS Software allows contract testing laboratories to ensure all maintenance activities are accomplished before unexpected downtime of the system impacts laboratory productivity.</li></ul>

News from LabRulezICPMS Library - Week 9, 2025

News from LabRulezLCMS Library - Week 9, 2025

Ionic liquid coating for stir bar sorptive extraction and its application for extraction and nontargeted screening analysis via TD-GC–Orbitrap-HRMS of pollutants in river water

Solving the retention time repeatability problem of hydrophilic interaction liquid chromatography

ICP-MS triple quadrupole as analytical technique for the characterization of metal contamination processes in commercial flours for food safety

<p><strong>In the week from March 3, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="64" data-end="165">1. Agilent Technologies: </strong><strong>Application of GC/MS for the Analysis of Poly-Aromatic Hydrocarbons (PAHs) and Pesticides in Drinking Water According to the Directive EU 2020/2184</strong></h5><div><div><ul><li><div>We, 5.3.2025 14:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4712">Registration</a></div></li></ul></div><p>The main analytical techniques for the analysis of PAHs and pesticides in GC/MS in drinking water, with particular attention to the Solid Phase Micro-Extraction (SPME) technique.</p></div>

Webinars LabRulezGCMS Week 10/2025

<p><strong>In the week of March 3, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over&nbsp;</p><p><strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5 data-start="90" data-end="254"><strong data-start="96" data-end="254">1. Waters Corporation: Enhancing Bioprocess Development through Spent Media Analysis by LC-MS: Automated and Rapid Workflow with Data Connectivity via JMP</strong></h5><ul data-start="256" data-end="350"><li data-start="256" data-end="293">Wednesday, March 5, 2025, 11:00 CET</li><li data-start="294" data-end="350"><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4720">Registration</a></li></ul><p data-start="352" data-end="433"><span>The new Bioprocessing Monitor App enables routine monitoring of protein titer, spent media metabolites, and protein quality from a single LC-MS experiment.</span>​</p><h5 data-start="435" data-end="523"><strong data-start="441" data-end="523">2. Agilent Technologies: Navigating the Challenges of Released Glycan Analysis</strong></h5><ul data-start="525" data-end="619"><li data-start="525" data-end="562">Wednesday, March 5, 2025, 15:30 CET</li><li data-start="563" data-end="619"><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4759">Registration</a></li></ul><p data-start="621" data-end="702"><span>Join a panel of Agilent experts in the field of glycobiology to help you make the right choices and overcome common troubleshooting hurdles.</span></p><h5 data-start="704" data-end="809"><strong data-start="710" data-end="809">3. Waters Corporation: Unlocking the Mysteries of Liquid Chromatography: Monitoring Your Method</strong></h5><ul data-start="811" data-end="905"><li data-start="811" data-end="848">Wednesday, March 5, 2025, 19:00 CET</li><li data-start="849" data-end="905"><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4757">Registration</a></li></ul><p data-start="907" data-end="988"><span>Explore best practices, including using reference standards and control charts to ensure accuracy and consistency in liquid chromatography methods.</span></p><h5 data-start="990" data-end="1148"><strong data-start="996" data-end="1148">4. Thermo Fisher Scientific: Biomarker Breakdown: Combatting Global Fungal Virulence, Diagnostics, and Resistance with Dr. Jennifer Geddes-McAlister</strong></h5><ul data-start="1150" data-end="1243"><li data-start="1150" data-end="1186">Thursday, March 6, 2025, 17:00 CET</li><li data-start="1187" data-end="1243"><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4791">Registration</a></li></ul><p data-start="1245" data-end="1326"><span>Join Dr. Jennifer Geddes-McAlister as she delves into her pioneering research, sharing invaluable lessons learned in combating global fungal virulence, diagnostics, and resistance.</span></p>

Webinars LabRulezLCMS Week 10/2025

<p><strong>In the week from March 3, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong data-start="2559" data-end="2651">1. Anton Paar: Battery Materials</strong></h5><ul data-start="2653" data-end="2689"><li data-start="2653" data-end="2676">Tu, 4.3.2025 19:00 CET</li><li data-start="2677" data-end="2689"><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4453">Registration</a></li></ul><p data-start="2691" data-end="2792">This webinar highlights the critical role of mechanical property testing in evaluating the performance and reliability of battery materials.</p><h5><strong data-start="2559" data-end="2651">2. Agilent Technologies: Lithium-Ion Battery Industry Chain: Quality Control Insights from Elemental Analysis of High TDS Raw Materials and More by ICP-OES</strong></h5><ul data-start="2653" data-end="2689"><li data-start="2653" data-end="2676">Tu, 4.3.2025 21:30 (CET)</li><li data-start="2677" data-end="2689"><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/2441">Registration</a></li></ul><p>During this talk, a review of data collected from ICP-OES on various battery materials will be discussed with special emphasis on high TDS samples.</p>

Webinars LabRulezICPMS Week 10/2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 3rd March 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you poster by <strong>Agilent Technologies </strong>and application notes by<strong> Knauer, Shimadzu </strong>and <strong>Thermo Fisher Scientific</strong>!</p><h4><strong>1. Agilent Technologies: GC/MS Approach for Analysis of</strong><br><strong>Extractables and Leachables (E&amp;L) in Complex Matrices Using Spectral Deconvolution and Retention Indices</strong></h4><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_7250_5977c_extractable_leachable_asms_2024_mp208_en_agilent_71b19d3b16.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Modern drug delivery systems are meant to protect a drug from environmental contamination, but they may also be a source of contamination. It is necessary to identify those compounds that can extract, leach, or migrate from the package or device. Extractables and leachables analysis presents a challenge for GC/MS because of the complexity of the various sample matrices and a diverse range of compounds to be identified. This study demonstrates how unit resolution GC/MS workflow is employed for identifying GC-amenable E&amp;L compounds by leveraging spectral deconvolution in combination with retention index-based time filtering. An addition of the accurate mass high-resolution GC/Q-TOF into the workflow provided extra confidence in compound identification, sensitivity and capability of structural elucidation.&nbsp;</p><p>Operating in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=OpenLab+ECM"><strong>OpenLab Electronic Content Management </strong></a>(ECM) XT configuration enabled tools that help facilitate compliance with various national and EU electronic record regulations, including audit trails, and remote data storage.</p><h5><strong>Experimental</strong></h5><p>Rubber syringe gaskets were extracted using tetrahydrofuran (THF) solvent at room temperature for six months. An aliquot of the extracts was analyzed using both <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=GC%2FMSD"><strong>GC/MSD</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=GC%2Fq-TOF"><strong>GC/Q-TOF</strong></a> systems. The acquisition software operated under a unified compliance environment. The instrumental parameters are shown in Table 1. The chromatographic deconvolution and library search were performed in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=MassHunter"><strong>MassHunter</strong></a> Unknowns Analysis 12.1. The NIST23 library was used to perform initial compound identification. Structural elucidation was performed using Molecular Structure Correlator (MSC) software 8.2.&nbsp;</p><p>Retention time locking was used to achieve the same retention times between multiple GC/MSD and GC/Q-TOF systems allowing for using both retention index and retention time matching.</p><h5><strong>Conclusions</strong></h5><ul><li>The optimized GC/MSD and GC/Q-TOF approach for analysis of extractables and leachables allowed for identifying over 150 compounds in a complex E&amp;L extract&nbsp;</li><li>High-resolution GC/MS enabled identification of over 60 additional components with increased confidence and structure elucidation of the unknowns&nbsp;</li><li>The novel ultra low bleed Agilent <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=1&amp;search=J%26W+DB-5Q"><strong>J&amp;W DB-5Q</strong></a> GC column resulted in significant decrease in background, that could potentially yield higher number of identifications of late eluting compounds.</li></ul><h4><strong>2. Knauer: GPC cleanup method for soil samples before PAHs analysis</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/VEV_0082_GPC_Cleanup_of_soil_samples_FINAL_web_5260b86091.pdf"><strong>Full PDF for download</strong></a></li></ul><p>GPC (Gel Permeation Chromatography) is a size-exclusion clean-up procedure that readily separates high molecular weight interferents from sample extracts using organic solvents and a porous hydrophobic gel (primarily a crosslinked divinylbenzene-styrene copolymer) [1]. It is possible to distinguish between different types of Bio-Beads resin based on the type of cross-linkage. In this application Bio-Beads S-X3 with 200–400 mesh was used according to EPA method 3640 [1]. GPC clean-up can be used extensively in numerous environmental analysis especially for preparing sample extracts prior to semivolatile compounds determination, such as pesticide, and PAHs analysis by GC/MS or HPLC-UV-DAD. Sample cleanup is particularly important for analytical separations such as GC, HPLC, and electrophoresis because high-boiling materials can cause a variety of problems in analytical systems, like analyte adsorption in the injection port or in front of a GC or LC column [2]. GPC cleanup protects GC and HPLC columns, reduces analytical maintenance costs, improves accuracy, and allows lower detection limits.</p><h5><strong>Materials and Methods</strong></h5><p>Extraction of Polycyclic Aromatic Hydrocarbons was carried out using Accelerated Solvent Extraction (ASE), according to the 3545A EPA method [3]. Bio-Beads S-X are supplied dry and must be swollen prior to pack into a chromatographic column. A mixture of cyclohexane and dichloromethane (70:30, v:v) is suitable for clean-up of soil samples. As a general rule, the beads should be swollen in the same solvent chosen as mobile phase, so 10 g of Bio-Beads S-X3 were swelled with 50 mL of cyclohexane and dichloromethane mixture (70:30, v:v) overnight. After the beads were fully swollen, they were packed into a chromatographic column. Before sample cleanup, GPC column was equilibrated with the desired solvent mixture, flushing it almost three times the column volume at 1 mL/min. Cleanup method was performed with AZURA® GPC Cleanup System, which is operated with the Mobile Control Chrom® Software running on a tablet directly mounted on the system. The identification and quantification of PAHs was carried out by GC-MS/MS analysis. Calibration curves were constructed in the concentration range from 10 μg/L to 130 μg/L. To perform GC separation and MRM acquisition, optimization of the best chromatographic and detection conditions was necessary.</p><h5><strong>Conclusion</strong></h5><p>This application shows how to perform GPC cleanup with KNAUER AZURA® GPC Cleanup System for the analysis of PAHs in soil samples. This report is very detailed to ensure good performance in GPC cleanup for application in environmental area. We can conclude that AZURA GPC Cleanup System is an helpful tool for sample preparation before instrumental analysis because, unlike other techniques, is very useful for the removal of high boiling materials which would contaminate injection ports and column heads, prolonging column life, stabilizing the instrument, and reducing column reactivity. It could be considered an universal cleanup technique for a broad range of semivolatile organics and pesticides. Moreover, AZURA GPC Cleanup System allows the customer to process many extracted samples, with a reduction in time for the cleanup procedures.</p><h4><strong>3. Shimadzu: Blood alcohol content (BAC) analysis using a liquid injection approach</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/AP_Blood_alcohol_content_via_liquid_injection_SCA_180_051_294d6843f8.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Blood alcohol analysis using liquid injection is an alternative to the headspace</li><li>analysis of blood samples for clinical purposes</li><li>It provides reliable results for whole blood and plasma samples without adverse matrix effects&nbsp;</li></ul><p>Blood alcohol content (BAC) is relevant for legal regulations regarding driving limits, but also investigated for forensic and clinical purposes with respect to poisoning. Blood alcohol analysis does not only focus on ethanol, which is the classical drinking alcohol, but also investigates other alcoholic substances like methanol and isopropanol as well as metabolites like acetone. Ethanol is present in alcoholic beverages, but also used for antiseptics, various daily life products, and pharmaceuticals. Being a central nervous system depressant, consumption can cause severe intoxication with toxic levels at above 100 mg/dL blood [1]. Methanol intoxication could originate from the consumption of counterfeit alcohol, with as few as 30 mL pure methanol consumed being potentially lethal [2]. Isopropanol is widely used as solvent or antiseptic in households and sometimes used as cheap substitute for ethanol by alcohol abusers. It is metabolized by alcohol dehydrogenase to acetone, which alike isopropanol is a central nervous depressant [3].</p><p>Blood alcohol analysis can be performed using gas chromatography (GC) with flame-ionization detection (FID). Due to the complexity of blood as matrix, headspace analysis is a widely used technique for simple sample transfer onto the GC column, which is especially valuable in forensics, where the matrix states investigated can drastically vary depending on the time the sample is taken. For clinical analysis, fresh blood is used, making the sample more uniform. In this approach, the analysis of BAC using a liquid injection technique as alternative to headspace sampling is presented.</p><h5><strong>The Package</strong></h5><p>The recommended analytical hardware and software configuration is listed below.</p><ul><li><strong>Main Unit</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=nEXIS+gc-2030+%28fid%29"><strong>Nexis GC-2030 with FID-2030</strong></a>: Gas chromatograph with flame ionization detector</li></ul></li><li><strong>Accessory</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=AOC-30i+"><strong>AOC-30i </strong></a>autosampler: Liquid autosampler with 30 vials capacity</li></ul></li><li><strong>Main Consumables</strong><ul><li>SH-BAC1 column (30 m x 0.32 mm x 1.8 µm;</li><li>P/N 221-76135-30)</li></ul></li><li><strong>Software</strong><ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=3&amp;search=LabSolutions+LCGC"><strong>LabSolutions LCGC</strong></a></li></ul></li></ul><h4><strong>Conclusion</strong></h4><p>Liquid sample injection presents a reliable alternative to headspace injection when analyzing blood samples for clinical purposes. Ethanol and methanol can be determined from whole blood, isopropanol and acetone from plasma samples without adverse matrix effects. Both whole blood and plasma analysis can be done using the same analytical method and one data processing approach, facilitating data evaluation and routine work.</p><h4><strong>4. Thermo Fisher Scientific: Trace analysis of volatile organic compounds in wastewater according to U.S. EPA Method 624.1&nbsp;</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/an_003068_gc_gc_ms_isq_7610_epa_624_1_an003068_na_en_2297d596f3.pdf"><strong>Full PDF for download</strong></a></li></ul><p>It is crucial that analytical testing laboratories monitor wastewater for the presence of volatile organic compounds (VOCs). VOCs are human-made contaminants used and produced in the processing of paints, adhesives, petroleum products, pharmaceuticals, and refrigerants. If they are released into wastewater from industrial activities, they can have an adverse effect on the natural environment and, ultimately, the public.<sup>1</sup> U.S. EPA Method 624.1 is an approved test method under the Clean Water Act<sup>2</sup> for determination of purgeable organic pollutants in industrial discharges and other environmental samples. The accurate detection and quantitation of VOCs via this method help ensure wastewater is not contaminated. Due to technological advances in analytical instrumentation and techniques, U.S. EPA Method 624.1 allows the analyst to modify P&amp;T parameters and GC/MS conditions. This can result in reduced sample run time and increased laboratory throughput in a 12-hour period.&nbsp;</p><p>To perform U.S. EPA Method 624.1, method acceptance criteria must be achieved. These criteria include creating a working calibration curve, method detection limits (MDLs), and Initial Demonstration of Capability (IDC) of accuracy and precision for target compounds. As the sample matrix is water, it is essential that moisture is reduced, limiting the impact on the analytical column as this could damage the column and affect the results.&nbsp;</p><p>The following evaluation describes the use of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=ISQ+7610"><strong>ISQ 7610</strong></a> GC-MS system coupled with a <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TRACE+1610"><strong>TRACE 1610 GC</strong></a> equipped with the Thermo Scientific™ HeSaver-H2 Safer™ split/splitless injector and a Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler for U.S. EPA Method 624.1 for the analysis of wastewater.</p><h5><strong>Experimental</strong></h5><h5><strong>GC-MS parameters&nbsp;</strong></h5><p>A TRACE 1610 GC was coupled to the ISQ 7610 MS equipped with a Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=NeverVent"><strong>NeverVent™ </strong></a>vacuum probe interlock (VPI) and a Thermo Scientific™ ExtractaBrite™ ion source. A Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?manufacturerItems=2&amp;search=TraceGOLD"><strong>TraceGOLD™ TG-VMS</strong></a>, 30 m × 0.25 mm, 1.4 µm film column (P/N 26080-3320) was used for compound separation. The HeSaver-H2 Safer injector was utilized which reduces the carrier gas consumption by decoupling the gas used for the chromatographic separation from the gas used to pressurize the inlet and maintain split and purge flows. The critical separations were maintained with a run time of under 13 minutes.&nbsp;</p><p>For this analysis, the ISQ 7610 MS was operated in full scan mode, ensuring the sensitivity needed for required the method detection limits. Nevertheless, the instrument could operate in Selected Ion Monitoring (SIM) mode for increased selectivity, if needed. Extended method parameters for the ISQ 7610 MS are shown in Table 2.</p><h5><strong>Conclusion</strong></h5><p>The ISQ 7610 MS system with the VPI coupled with the Teledyne LABS Tekmar Lumin P&amp;T concentrator paired with the AQUATek LVA autosampler exceeds all the requirements outlined in U.S. EPA Method 624.1 for analysis of VOCs in wastewater:</p><ul><li>MDLs calculated from n=7 repeat injections of 0.5 ppb water standards showed no interference from unwanted water entering the system and resulted in values &lt;0.15 ppb for most compounds.</li><li>Precision and accuracy for n=7 20 ppb water standards showed excellent results with %RSD &lt;20% and mean recovery of 93% for the compounds.</li><li>System robustness was tested by continuously acquiring 209 injections of water samples over two days with no user intervention at all. The average %RSD of the calculated concentration was 6.5% over this robustness study.</li><li>Utilizing the HeSaver-H2 Safer technology reduced helium consumption for the method by 4 times, reducing laboratory overheads.&nbsp;</li></ul><p>Further information on VOC analysis using the ISQ 7610 system and the Tekmar Lumin P&amp;T paired with the AQUATek LVA can be found in the Thermo Fisher Scientific AppsLab library.<sup>3</sup><br>&nbsp;</p>

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