News from LabRulezLCMS Library - Week 22, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 25th May 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies</strong>, <strong>Shimadzu &nbsp;</strong>and <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Analysis of Soil and Sediments by ICP-MS with Advanced Sample Introduction Tools</strong></h3><p><strong>Simplified sample preparation enabled by the Agilent Mira Mist Nebulizer and an In-Line Particle Filter</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_enviro_soil_sample_prep_9500_icp_qqq_5994_9126en_agilent_8299f007e9.pdf"><strong>Full PDF for download</strong></a></li></ul><p>ICP-MS is widely employed for monitoring inorganic elements in soil and sediments, with established methods such as US EPA 6020B providing a validated framework for the accurate, multi‑element analysis of environmental samples.<sup>1</sup> In a separate study, we demonstrated the outstanding performance capabilities of the <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 Triple Quadrupole ICP-MS</strong></a> (ICP-QQQ) in compliance with EPA 6020B requirements.<sup>2</sup> The instrument, which includes the Ultra High Matrix Introduction (UHMI) system for enhanced plasma stability and robustness, employed Advanced Helium Mode (AHM) and Air cell mode to achieve lower limits of detection (LODs) compared to conventional cell gas approaches.<sup>3,4</sup></p><p>The two collision/reaction cell (CRC) modes of operation were enabled by the Agilent Dual-Cell System (DCS) —a unique CRC that provides the following performance advantages when operated in AHM and Air cell mode: – AHM – This innovative He-based gas collision-cell mode significantly enhances sensitivity for low-mass analytes while providing robust interference removal across the entire mass range. – This single gas mode eliminates the need for multiple modes, replacing no gas, conventional He, and high energy (HE) He mode. – Air cell mode – Using oxygen (O2 ) from air and an integrated air filter for the 9500 ICP-QQQ, Air cell mode leverages reactions between O2 and analytes to improve detection limits (DLs) for oxygen-reactive species. – Air cell mode effectively eliminates interferences, including M++ that are challenging to resolve using He-based gas methods.5 – With an unlimited supply of O2 in air, Air cell mode eliminates the need for O2 gas cylinders, reducing operating costs and simplifying workflows.</p><p>Of all the ICP-MS nebulizers, the Agilent Mira Mist nebulizer offers the best resistance to concentrated acids and organic solvents. Its parallel path design ensures good tolerance to high levels of particulates and total dissolved solids (TDS), providing excellent resistance to clogging. In this study, the 9500 ICP-QQQ equipped with an in-line particle filter and Mira Mist nebulizer was used to determine trace and major elements in five environmental certified reference materials (CRMs) and a real sediment sample. The performance of the method was evaluated according to criteria set out in EPA Method 6020B.</p><h4><strong>Experimental&nbsp;</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><p>All measurements were performed using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 ICP-QQQ</strong></a> that includes the following standard components: nickel (Ni) interface cones and newly designed DCS cell. The design features and functionality of the 9500 and DCS are explained elsewhere.3,4 The 9500 was also equipped with the optional Agilent Advanced Valve System (AVS&nbsp;MS) discrete sampling system for improved productivity. The AVS&nbsp;MS system’s high-speed piston pump works seamlessly with the Agilent SPS 4 and SPS&nbsp;6 autosamplers for sample delivery, ensuring the high sample throughput necessary to meet the operational needs of most environmental testing laboratories.</p><p>To optimize signal stability with the Mira Mist nebulizer, the nebulizer pump speed was adjusted and a makeup gas was introduced (Table 1). In the 9500 ICP-QQQ, both the makeup gas and dilution gas can be added, enabling finer control of the plasma gas flow rates to optimize signal %RSD within the target sensitivity zone. The lens parameters were set automatically using the Autotune function in the software. The in-line filter’s internal volume is sufficiently small that its presence does not influence AVS MS sample introduction timing or method parameters. As a result, the same settings were used with and without the filter installed (Table 2).</p><h4><strong>Conclusion&nbsp;</strong></h4><p>In this study, sediment samples were analyzed in accordance with EPA Method 6020B using the Agilent 9500 ICP‑QQQ with UHMI and the optional AVS MS. The system was equipped with advanced sample introduction components, including the Mira Mist nebulizer and an in‑line particle filter.&nbsp;</p><p>The combination of the Mira Mist nebulizer and in-line filter enabled the analysis of sediment digests without a dedicated filtration step, reducing sample preparation time and consumable costs. At the same time, the configuration minimized the risk of sample introduction blockages, supporting robust and reliable long-term ICP-QQQ operation for complex environmental matrices.</p><p>Overall, the 9500 ICP-QQQ with the Mira Mist nebulizer and the in-line particle filter achieved excellent analytical data:&nbsp;</p><ul><li>Low detection limits in the low ng/L (ppt) range for most analytes&nbsp;</li><li>The same or similar washout efficiency of sticky elements as a standard sample introduction configuration&nbsp;</li><li>The same sample introduction timing, regardless of whether the filter was installed or not&nbsp;</li><li>Method robustness and reproducibility over more than eight hours of continuous measurements, as demonstrated by the recoveries of ISTDs and CCVs within the limits specified in EPA Method 6020B&nbsp;</li><li>Recoveries of all certified elements in the five environmental CRMs, matrix spike sample, and spiked real sediment sample within ±10%, confirming the effective control of interferences using AHM and Air cell mode&nbsp;</li></ul><p>The study has highlighted how the 9500 ICP-QQQ with the Mira Mist nebulizer and in‑line particle filter enhances sample preparation efficiency and analytical performance for the analysis of complex sediment digests.</p><h3><strong>2. Shimadzu: Analysis of Inorganic Elements in Urine Using EDXRF</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01007_en_c3bd71bbb3.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User Benefits</strong></h4><ul><li>Inorganic elements in urine can be quantified at the ppm level without any complicated sample pretreatment.</li><li>Qual-quantitative analysis is possible using the FP (Fundamental Parameter) method, which does not require standards.</li><li>Qual-quantitative results are obtained within 10 minutes per sample.</li></ul><p>Inorganic element poisoning, including heavy metals, is caused by accidents or criminal incidents, and the causative elements are diverse. Although some of these elements are highly toxic, there are cases in which it is difficult to distinguish them at an early stage because they lack specific symptoms of poisoning. Therefore, analytical methods for rapid screening of these elements are required in forensic research.&nbsp;</p><p>Inorganic elements are generally analyzed by ICP-AES or ICP-MS. Although these techniques allow trace-level quantitation, they require chemical pretreatment such as dilution and deproteinization, and the samples are limited to liquid specimens. In contrast, energy dispersive X-ray fluorescence spectrometer (EDXRF - <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=1&amp;search=EDX-7200"><strong>EDX-7200</strong></a>) offers sufficient sensitivity in the concentration range associated with poisoning and enables simple, non-destructive analysis in a short time.&nbsp;</p><p>This application describesthe results of quantitative analysis of 15 elements in urine by the calibration curve method, and qualquantitative analysis by the FP (Fundamental Parameter) method based on sensitivity coefficients installed in the instrument. The errors in the quantitative values obtained by the FP-based qualquantitative analysis method were approximately ±20 %, indicating that sufficient quantitative accuracy was achieved. Screening can be performed within 10 minutes persample.</p><h4><strong>Conclusion</strong></h4><p>The FP method demonstrated high accuracy for quantitation without calibration curves. Furthermore, urine samples do not require complicated pretreatment such as protein removal, and the analysis time is as short as approximately 10 minutes per sample. This method is well suited for poisoning screening in forensic research.</p><h3><strong>3. Thermo Fisher Scientific: Analysis of copper alloys with the </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1978"><strong>ARL X900 XRF Spectrometer</strong></a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/analysis_of_copper_alloys_arl_9900_an41427_203b52e126.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Copper alloys&nbsp;</strong></h4><p>are very important products because they are used for many applications and many manufacturing processes as described in the next few paragraphs. It is important to accurately analyze these materials to confirm compliance of their chemical specifications that imply physical properties, like conductivity, compressive strength, hardness, resistance to traction and to abrasion. High product quality and efficient production can be ensured with accurate analysis results. Copper alloys Pure copper is mixed with other elements to produce a wide range of alloys: Brasses (Cu-Zn), bronzes (Cu-Sn), gun metal (Cu-Sn-Zn) used for casting due to its excellent fluidity, for valves, taps and water fittings. Manganese bronzes (Cu-Zn-Mn) are not true bronzes as Sn is not the essential constituent. Used for rudders, propellers, and ship fittings. Cupro-nickel (Cu-Ni) used for coins, tubes, wires, electrical resistances, and thermocouples. Nickel silver (Cu-Ni-Zn) used for marine applications, car radiators and fittings.&nbsp;</p><h4><strong>Brass&nbsp;</strong></h4><p>One of the most important non-ferrous engineering alloys. It covers a large range of physical properties with multiple applications. Copper can hold about 39% of zinc in solid solution. Alloys containing less than 39% Zn are known as α-brasses. This brass (70/30) is very widely employed for cartridge, cases, condenser tubes, etc. From 39% to 46% of Zn, a β-solid solution gives αβ-brass. This alloy (60/40) is found in extensive engineering applications with enhanced corrosion resistance used in marine applications. Alloys containing more than 49% Zn are very hard and only used for brazing brasses.</p><h4><strong>Instrument parameters and conditions&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/1978"><strong>ARL X900 XRF Spectrometer</strong></a> can accommodate up to 24 fixed monochromator channels alongside the goniometer or up to 32 fixed monochromator channels when no goniometer is fitted. New high counting fixed channel monochromators using an SCX detector are available to further improve the precision of analysis, especially for elements like Cu, Zn and Ni.</p><p>Our unique proprietary Moiré fringe goniometer ensures speed, flexibility and reliability of analysis thanks to the clever frictionfree positioning system. Up to nine crystals and four collimators can be fitted. With the two detectors (flow proportional and scintillation counters), precise elemental analysis from Boron to Californium is possible.&nbsp;</p><p>The ARL X900 XRF spectrometer can be calibrated using commercially available certified reference materials (CRM) or well analyzed samples from the user. Calibrations can be delivered from the factory, hence reducing the commissioning time at the customer’s site.&nbsp;</p><p>It should be stressed that an XRF spectrometer is a very accurate comparator, but the accuracy of the final analysis is entirely dependent on the quality of the standards used for calibration and on the care and reproducibility of sample preparation which must be identical for CRMs and for routine samples as well.</p><p>This application note only includes data obtained mostly on fixed channels and on some goniometer channels. For more results using goniometer channels please refer to AN41426.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Analysis of all sorts of copper alloys can be performed with ease using the ARL X900 Simultaneous-Sequential XRF Spectrometer. The performance of the Moiré fringe goniometer is such that it can be used for analysis of any elements that are not fitted as fixed channels. The analysis on the goniometer is done while the fixed channels are measuring. In addition, it can be used as a backup in case of failure of any of the fixed channels.&nbsp;</p><p>Appropriate calibrations for copper alloys can be delivered turnkey from the Thermo Fisher Scientific factory. In this case the commissioning time of the spectrometer is reduced to a minimum.&nbsp;</p><p>The precision is excellent in these matrix types for routine or R&amp;D analysis, especially when the new high counting fixed channel monochromator is used for elements like Cu, Zn, and Ni.&nbsp;</p><p>Furthermore, operation is made easy through the innovative <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2029"><strong>Thermo Scientific™ OXSAS™ Software</strong></a> that operates with the latest Microsoft Windows® package.&nbsp;</p><p>Thermo Fisher Scientific’s long experience in metals analysis comes from an installed base of over 2,000 XRF spectrometers worldwide. The ARL X900 spectrometer is the answer to your metallurgical analysis needs, whether they involve incoming material control, metal QC, or production analysis. Working 24 hours a day and 7 days a week, the ARL X900 spectrometer delivers dependable performance year after year. The high performance of the ARL X900 XRF Spectrometer will meet your analytical needs today and in the future</p>

News from LabRulezICPMS Library - Week 22, 2026

<p><strong>In the week of June 1, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. AZoM: Infrared Measurement – Basic Principles</strong></h5><ul><li>Tu, 2.6.2026 16:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6223">Registration</a></li></ul><p>Discover non-contact IR temperature measurement. Learn the physical laws of infrared systems, why emissivity settings are key for accuracy, and how to reduce errors in your process.</p><h5><strong>2. AZoM: Simplifying Real-Time Natural Gas Monitoring with Integrated Process Raman and Flow Measurement</strong></h5><ul><li>We, 3.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6207">Registration</a></li></ul><p>Explore an integrated process Raman and flow measurement solution for real-time natural gas monitoring, compositional analysis, and operational optimization from wellhead to pipeline.</p><h5><strong>3. Agilent Technologies: Seeing Through the Barrier: Practical Limits and Best Practices for Raman Sample, Container, and Test Conditions</strong></h5><ul><li>Th, 4.6.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6051">Registration</a></li></ul><p>Discover what SORS-enabled Raman can and cannot measure. Learn how sample type, packaging, and conditions affect results and when FTIR may be the better analytical choice.</p>

Webinars LabRulezGCMS Week 23/2026

<p><strong>In the week of June 1, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Waters Corporation: Data handling and DMPK analysis with confidence</strong></h5><ul><li>Tu, 2.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6226">Registration</a></li></ul><p>Discover practical DMPK bioanalysis workflows in action and learn how modern software and MS systems improve efficiency, consistency, and confidence from sample to result.</p><h5><strong>2. SCIEX: Reliable quantitation of GLP-1 analogues in bioanalysis and IP 2026 updates</strong></h5><ul><li>We, 3.6.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6239">Registration</a></li></ul><p>Join us for an insightful webinar exploring reliable quantitation of GLP-1 analogues in bioanalysis and IP 2026 updates.</p><h5><strong>3. Waters Corporation: Enhancing Next-Gen Drug Discovery with High-Performance Inert LC Solutions</strong></h5><ul><li>We, 3.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6153">Registration</a></li></ul><p>Explore how MaxPeak Premier Columns enhance LC discovery workflows, improving characterization, reliability, and throughput for modern drug development.</p><h5><strong>4. Thermo Fisher Scientific: Supporting Efficient mAb Development with a Flexible Downstream Purification Toolkit</strong></h5><ul><li>Th, 4.6.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6228">Registration</a></li></ul><p>Accelerate mAb development with a flexible downstream purification toolkit. Learn strategies for buffer optimization and expanding chromatography options to overcome complex purification challenges.</p>

Webinars LabRulezLCMS Week 23/2026

<p><strong>In the week from June 1, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. AZoM: Infrared Measurement – Basic Principles</strong></h5><ul><li>Tu, 2.6.2026 16:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6223">Registration</a></li></ul><p>Discover non-contact IR temperature measurement. Learn the physical laws of infrared systems, why emissivity settings are key for accuracy, and how to reduce errors in your process.</p><h5><strong>2. Agilent Technologies: Isotope Ratio made easy: Optimizing Method Conditions in <sup>87</sup>Sr/<sup>86</sup>Sr Ratios with ICP-QQQ</strong></h5><ul><li>Tu, 2.6.2026 20:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6065">Registration</a></li></ul><p>Explore practical strategies for precise <sup>87</sup>Sr/<sup>86</sup>Sr isotope ratio analysis using ICP-QQQ. Learn how optimized reaction gases, tuning, and mass-shift approaches improve accuracy and reproducibility.</p><h5><strong>3. AZoM: Simplifying Real-Time Natural Gas Monitoring with Integrated Process Raman and Flow Measurement</strong></h5><ul><li>We, 3.6.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6207">Registration</a></li></ul><p>Explore an integrated process Raman and flow measurement solution for real-time natural gas monitoring, compositional analysis, and operational optimization from wellhead to pipeline.</p><h5><strong>4. Agilent Technologies: Seeing Through the Barrier: Practical Limits and Best Practices for Raman Sample, Container, and Test Conditions</strong></h5><ul><li>Th, 4.6.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6051">Registration</a></li></ul><p>Discover what SORS-enabled Raman can and cannot measure. Learn how sample type, packaging, and conditions affect results and when FTIR may be the better analytical choice.</p>

Webinars LabRulezICPMS Week 23/2026

Untargeted Chemical Profiling of Two-Dimensional Gas Chromatography Coupled with High-Resolution Mass Spectrometry Data for Botrytized Wines via Topological Data Analysis

Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry

Nutrient imbalances caused by industrial pollution were not affected by extreme climate events

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 1st June 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochure by <strong>Agilent Technologies</strong>, application note by<strong> Shimadzu, </strong>and<strong> </strong>presentation by <strong>MDCW / University of Washington!</strong></p><h3><strong>1. Agilent Technologies: </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890B"><strong>Agilent 8890B Gas Chromatograph</strong></a></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ds_8890_gas_chromatograph_5994_9064en_agilent_94b0175782.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>The Agilent 8890B GC delivers high‑performance gas chromatography through advanced electronic pneumatic control, precise oven temperature management, and Agilent capillary flow technology, which provides reliable, leak‑free, in‑oven connections and supports flexible system configurations with minimal method development time.&nbsp;</p><p>An upgrade, more responsive 7-inch capacitive touchscreen and a full Agilent GC Assist interface, offer real-time status, configuration, signal monitoring, and remote access for setup, troubleshooting, leak checking, maintenance, and method management across devices.&nbsp;</p><p>Sustainability features include programmable sleep and wake modes to reduce resource consumption, along with gas and power usage calculators that track method‑level efficiency. Known for reliability and long life, Agilent GC systems are supported by a 10‑year use guarantee to ensure a low cost of ownership.</p><h4><strong>GC system capabilities&nbsp;</strong></h4><ul><li><strong>Retention time repeatability: </strong>&lt; 0.008% or &lt; 0.0008 minutes&nbsp;</li><li><strong>Area repeatability:</strong> &lt; 0.5% RSD&nbsp;</li></ul><p>Built-in intelligence autonomously monitors the health of the system, alerts the user of potential issues before they affect chromatographic performance, and offers helpful step-by-step guides to resolve issues.&nbsp;</p><p>The 7-inch touch screen gives a visual report of the system configuration, letting you update the active method, perform maintenance routines, and check GC instrument status.&nbsp;</p><p>The GC Assist interface provides remote connectivity enabling you to monitor your smart GC system, check system logs, and perform diagnostics tests, from inside or outside the&nbsp;laboratory.&nbsp;</p><p>Maintenance and service modes, including autonomous leak checks, are easily accessed from the touchscreen and browser interface.&nbsp;</p><p>Atmospheric pressure and temperature compensation are built into every system, so results do not change, even when the laboratory environment does.</p><p>Automatic liquid sampling is fully integrated into mainframe control and includes up to 3-layer sandwich injections and sample preparation capabilities such as heating, mixing, standard addition, and derivatizations.&nbsp;</p><h5><strong>Simultaneously supports&nbsp;</strong></h5><ul><li>Two inlets&nbsp;</li><li>Five detectors&nbsp;</li><li>Four detectors (with additional large valve oven&nbsp;option)&nbsp;</li><li>Support for up to 10 valves&nbsp;</li><li>Six GC column Smart Key ports&nbsp;</li></ul><h5><strong>Instrument dimensions&nbsp;</strong></h5><ul><li><strong>Height: </strong>49 cm (19.2 in)&nbsp;</li><li><strong>Width: </strong>58 cm (22.9 in) with EPC inlet and detectors; 68&nbsp;cm (26.8 in) with detector as TCD or with certain valving options mounted on the left side of the GC&nbsp;</li><li><strong>Depth: </strong>51 cm (20.2 in)&nbsp;</li><li><strong>Typical weight:</strong> 49 kg (108 lb)&nbsp;</li></ul><h5><strong>Maintenance and support services&nbsp;</strong></h5><ul><li>Integrated early maintenance counters that allow planned maintenance and help eliminate unnecessary downtime&nbsp;</li><li>Instrument events or shutdowns displayed on keyboard display or data system</li><li>Remote diagnostics&nbsp;</li><li>Performance verification services&nbsp;</li><li>Easy parts identification and part number finder software (standalone software, does not require Agilent CDS)</li></ul></div></div></div></div></div></div></section><h3><strong>2. MDCW / University of Washington: Tile-based Analysis of GC×GC-TOFMS Data of SPME Sampled VOCs Produced from Pseudomonas aeruginosa and Aspergillus fumigatus</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/O_8_Wenjing_34786a3e4a.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>This presentation describes a novel chemometric approach for analyzing complex GC×GC-TOFMS datasets generated from volatile organic compounds (VOCs) released by the pathogens <i>Pseudomonas aeruginosa</i> and <i>Aspergillus fumigatus</i>. These microorganisms frequently coexist in the lungs of cystic fibrosis patients, where their interactions are associated with worsening respiratory function and poorer clinical outcomes. The study aims to identify VOC biomarkers that distinguish microbial monocultures, cocultures, and growth media controls, providing insights into pathogen interactions and potential diagnostic markers.</p><p>To achieve this, the researchers combined solid-phase microextraction (SPME) sampling with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (<a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/37"><strong>GC×GC-TOFMS</strong></a>). This analytical platform offers high chromatographic resolution, rapid spectral acquisition rates of up to 500 spectra per second, and rich three-dimensional datasets containing chromatographic and mass spectral information. However, each chromatogram can contain more than one million data points, creating significant challenges for data processing and interpretation.</p><p>The core of the work focuses on tile-based feature selection methods implemented through the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/348"><strong>ChromaTOF Tile software</strong></a>. The primary approach, tile-based Fisher Ratio (F-ratio) analysis, identifies analytes that differ statistically between sample classes by comparing between-class and within-class variance. Using this strategy, the authors discovered 576 VOC features capable of differentiating growth media, <i>P. aeruginosa</i> monocultures, <i>A. fumigatus</i> monocultures, and cocultures. Additional pairwise statistical testing was then used to determine which specific classes were responsible for the observed differences. Representative VOCs characteristic of each class were identified, including heptanal for <i>P. aeruginosa</i>, 1-octen-3-ol for <i>A. fumigatus</i>, and several unique compounds associated with coculture conditions.</p><p>The presentation also addresses practical challenges associated with high-throughput experimentation, where replicate measurements may be limited by time, cost, or sample availability. To overcome these constraints, the team developed complementary tile-based coefficient of variation (CV) and fold-change (FC) approaches that can identify important analytes using as little as a single replicate per sample class. The authors conclude that selecting the appropriate feature-selection strategy—F-ratio, CV, or fold-change—depends on the experimental design and available data. Future work will focus on advanced analyte identification using chemometric tools such as PARAFAC, enabling deeper biological interpretation of microbial VOC signatures and their relevance to cystic fibrosis research.</p><h3><strong>3. Shimadzu: Alcohol Determination of Sanitizer Gel Using </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2060"><strong>Nexis GC-2060</strong></a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01120_en_ed83896803.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The newly developed FID on the Nexis GC-2060 provides excellent linearity for high-concentration samples.</li><li>The Nexis GC-2060 enables rapid oven heating and cooling, allowing results to be obtained quickly.</li><li>A special liner for aqueous solutions and an Xtra Life Microsyringe enable highly repeatable data acquisition</li></ul><p>Methods for alcohol determination are specified in USP (United States Pharmacopeia) General Chapters &lt;611&gt; ALCOHOL DETERMINATION, which describes both a distillation and a gas chromatography method. In USP &lt;611&gt;, Method II (gas chromatography) includes a capillary column method (Method IIb).&nbsp;</p><p>For GC analysis of samples containing a large amount of water (e.g., sanitizing ethanol), sample vaporization may become unstable, resulting in abnormal peak shapes and poor repeatability. In addition, with a standard micro-syringe for AOC, the plunger may become stiff during aspiration and dispensing of aqueoussolutions, which can degrade repeatability.&nbsp;</p><p>This article presents an example of alcohol determination in sanitizing ethanol using the Nexis GC-2060 equipped with a newly developed FID. The Nexis GC-2060 can be configured with a newly developed FID that has high sensitivity and excellent linearity. In addition, a special liner for aqueous solutions and an Xtra Life Microsyringe were used to achieve repeatable analysis.</p><h5><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexis+GC-2060"><strong>Nexis GC-2060</strong></a><strong> and the Newly Developed FID</strong></h5><p>The Nexis GC-2060 is a gas chromatograph that combines world-class analytical performance with workflow optimization based on the latest technologies. Rapid oven heating and cooling shorten analysis cycle time and improve throughput. The GC-2060 can also be equipped with a newly developed FID (Fig. 1). This FID offers world-class sensitivity and improved linearity.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The alcohol concentration in a commercially available sanitizing gel was determined using the Nexis GC-2060 equipped with the newly developed FID. The results met the system suitability requirements of USP &lt;611&gt; Method IIb, confirming the effectiveness of the Nexis GC2060 equipped with the new FID, along with the special liner for aqueous solutions, and the Xtra Life Microsyringe for repeatable analysis of aqueoussamples</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 23, 2026

News from LabRulezLCMS Library - Week 23, 2026

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News from LabRulezLCMS Library - Week 23, 2026

News from LabRulezGCMS Library - Week 23, 2026

Nutrient imbalances caused by industrial pollution were not affected by extreme climate events

Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry

Untargeted Chemical Profiling of Two-Dimensional Gas Chromatography Coupled with High-Resolution Mass Spectrometry Data for Botrytized Wines via Topological Data Analysis

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