[ APPLICATION NOTE ] Development of pH Gradient Mobile Phase Concentrates for Robust, High Resolution mAb Charge Variant Analysis Qi Wang, Susan C. Rzewuski, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ INTRODUCTION Platform method…
[ APPLICATION NOTE ] Designing a New Particle Technology for Robust Charge Variant Analysis of mAbs Matthew A. Lauber, Susan C. Rzewuski, Qi Wang, Hua Yang, Stephan Koza, MingCheng Xu, Mike Morris, Justin McLaughlin, Steve Shiner, and Bei Niu Waters…
METHOD DEVELOPMENT OF IONIC-STRENGTH GRADIENT CATION EXCHANGE CHROMATOGRAPHY FOR MONOCLONAL ANTIBODY CHARGE VARIANT ANALYSIS Authors: Hua Yang, Bill Warren and Stephan M. Koza Affiliations: Waters Corporation, Milford, MA 01757 INTRODUCTION Charge heterogeneity in therapeutic proteins including monoclonal antibodies (mAbs) needs…
[ APPLICATION NOTE ] Auto•Blend Plus Technology for Ion-Exchange Chromatography Method Development and Robustness Testing Hua Yang, Bill Warren, and Stephan Koza Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ INTRODUCTION Auto•Blend™ Plus Technology Ion-exchange chromatography (IEX) is widely used…
